ORCID Profile
0000-0003-0356-9342
Current Organisations
CentraleSupelec
,
CSIRO
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Horticultural Production | Plant Biochemistry And Physiology | Wine Chemistry and Wine Sensory Science | Oenology And Viticulture | Plant Physiology | Plant Growth And Development | Oenology and Viticulture
ANZSRC Socio-Economic Objective (SEO)
Beverages (excl. Fruit Juices) | Grapes | Expanding Knowledge in the Agricultural and Veterinary Sciences | Biological sciences | Wine Grapes |
Related Links
Publications
Supplementary Figure S5 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489975.V1
Abstract: Radiological feature impact on survival. Radiological features include progression of target lesions 20%, progression of non-target lesions 50% and the emergence of new lesions.
Objective measures of grape quality: From Cabernet Sauvignon grape composition to wine sensory characteristics
Publisher: Elsevier BV
Date: 04-2020
Toward semi-automatic biologically effective dose treatment plan optimisation for Gamma Knife radiosurgery
Publisher: IOP Publishing
Date: 17-10-2022
Abstract: Objective. Dose-rate effects in Gamma Knife radiosurgery treatments can lead to varying biologically effective dose (BED) levels for the same physical dose. The non-convex BED model depends on the delivery sequence and creates a non-trivial treatment planning problem. We investigate the feasibility of employing inverse planning methods to generate treatment plans exhibiting desirable BED characteristics using the per iso-centre beam-on times and delivery sequence. Approach. We implement two dedicated optimisation algorithms. One approach relies on mixed-integer linear programming (MILP) using a purposely developed convex underestimator for the BED to mitigate local minima issues at the cost of computational complexity. The second approach (local optimisation) is faster and potentially usable in a clinical setting but more prone to local minima issues. It sequentially executes the beam-on time (quasi-Newton method) and sequence optimisation (local search algorithm). We investigate the trade-off between time to convergence and solution quality by evaluating the resulting treatment plans’ objective function values and clinical parameters. We also study the treatment time dependence of the initial and optimised plans using BED 95 (BED delivered to 95% of the target volume) values. Main results. When optimising the beam-on times and delivery sequence, the local optimisation approach converges several orders of magnitude faster than the MILP approach (minutes versus hours–days) while typically reaching within 1.2% (0.02–2.08%) of the final objective function value. The quality parameters of the resulting treatment plans show no meaningful difference between the local and MILP optimisation approaches. The presented optimisation approaches remove the treatment time dependence observed in the original treatment plans, and the chosen objectives successfully promote more conformal treatments. Significance. We demonstrate the feasibility of using an inverse planning approach within a reasonable time frame to ensure BED-based objectives are achieved across varying treatment times and highlight the prospect of further improvements in treatment plan quality.
$n$ D Variational Restoration of Curvilinear Structures With Prior-Based Directional Regularization
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2019
Comparison of major volatile compounds from Riesling and Cabernet Sauvignon grapes (Vitis vinifera L.) from fruitset to harvest
Publisher: Hindawi Limited
Date: 06-2010
Supplementary Figure S7 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489969.V1
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones
Shiraz Wines Made from Grape Berries (Vitis vinifera) Delayed in Ripening by Plant Growth Regulator Treatment Have Elevated Rotundone Concentrations and “Pepper” Flavor and Aroma
Publisher: American Chemical Society (ACS)
Date: 18-02-2015
DOI: 10.1021/JF505491D
Abstract: Preveraison treatment of Shiraz berries with either 1-naphthaleneacetic acid (NAA) or Ethrel delayed the onset of ripening and harvest. NAA was more effective than Ethrel, delaying harvest by 23 days, compared to 6 days for Ethrel. Sensory analysis of wines from NAA-treated fruit showed significant differences in 10 attributes, including higher "pepper" flavor and aroma compared to those of the control wines. A nontargeted analysis of headspace volatiles revealed modest differences between wines made from control and NAA- or Ethrel-treated berries. However, the concentration of rotundone, the metabolite responsible for the pepper character, was below the level of detection by solid phase microextraction-gas chromatography-mass spectrometry in control wines, low in Ethrel wines (2 ng/L), and much higher in NAA wines (29 ng/L). Thus, NAA, and to a lesser extent Ethrel, treatment of grapes during the preveraison period can delay ripening and enhance rotundone concentrations in Shiraz fruit, thereby enhancing wine "peppery" attributes.
Supplementary Figure S3 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489981
Abstract: Organ involvement's impact on survival. The organs selected were the ones most affected in our study's patients. The tests are for the survival of patients whether an organ has a tumor or not. The organs were: A) Liver B) Lung C) Subdiaphragm lymph nodes D) Supra Diaphragm lymph nodes E) Peritoneal Carcinosis and F) Bone.
Supplementary Figure S5 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633108.V1
Abstract: Radiological feature impact on survival. Radiological features include progression of target lesions 20%, progression of non-target lesions 50% and the emergence of new lesions.
Supplementary Figure S3 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489981.V1
Abstract: Organ involvement's impact on survival. The organs selected were the ones most affected in our study's patients. The tests are for the survival of patients whether an organ has a tumor or not. The organs were: A) Liver B) Lung C) Subdiaphragm lymph nodes D) Supra Diaphragm lymph nodes E) Peritoneal Carcinosis and F) Bone.
Supplementary Figure S2 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489984
Abstract: Correlation tables of our criteria. Bottom left are spearman coefficients, top right are Phi_K coefficients.
Peduncle-girdling of Shiraz (Vitis viniferaL.) bunches and sugar concentration at the time of girdling affect wine volatile compounds
Publisher: Hindawi Limited
Date: 28-11-2017
DOI: 10.1111/AJGW.12319
Supplementary Figure S10 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489987
Abstract: Log hazard ratios (HR) computed by cox model. The variables studied were: GRIm, RMH, NLR BL & the iPD score. The only significant variable was the iPD score (HR = 2, p 0.005).
Supplementary Figure S10 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633120.V1
Abstract: Log hazard ratios (HR) computed by cox model. The variables studied were: GRIm, RMH, NLR BL & the iPD score. The only significant variable was the iPD score (HR = 2, p 0.005).
Supplementary Figure S4 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489978
Abstract: Log Hazard ratio (HR) of each parameter obtained from a cox model fitted to predict survival.
The relationship between sensory attributes and wine composition for Australian Cabernet Sauvignon wines
Publisher: Hindawi Limited
Date: 15-08-2011
Chemical and sensory profiling of Shiraz wines co-fermented with commercial non-Saccharomyces inocula
Publisher: Hindawi Limited
Date: 28-12-2018
DOI: 10.1111/AJGW.12320
Supplementary Figure S1 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2202
DOI: 10.1158/1078-0432.22489990.V1
Abstract: Distribution of primary cancer types in the development set (n=107).
A Novel Tool for Studying Auxin-Metabolism: The Inhibition of Grapevine Indole-3-Acetic Acid-Amido Synthetases by a Reaction Intermediate Analogue
Publisher: Public Library of Science (PLoS)
Date: 23-05-2012
Machine Learning-Based Pipeline for High Accuracy Bioparticle Sizing
Publisher: MDPI AG
Date: 07-12-2020
DOI: 10.3390/MI11121084
Abstract: High accuracy measurement of size is essential in physical and biomedical sciences. Various sizing techniques have been widely used in sorting colloidal materials, analyzing bioparticles and monitoring the qualities of food and atmosphere. Most imaging-free methods such as light scattering measure the averaged size of particles and have difficulties in determining non-spherical particles. Imaging acquisition using camera is capable of observing in idual nanoparticles in real time, but the accuracy is compromised by the image defocusing and instrumental calibration. In this work, a machine learning-based pipeline is developed to facilitate a high accuracy imaging-based particle sizing. The pipeline consists of an image segmentation module for cell identification and a machine learning model for accurate pixel-to-size conversion. The results manifest a significantly improved accuracy, showing great potential for a wide range of applications in environmental sensing, biomedical diagnostical, and material characterization.
Origins of Grape and Wine Aroma. Part 2. Chemical and Sensory Analysis
Publisher: American Society for Enology and Viticulture
Date: 23-01-2014
Predicting immunotherapy outcomes in patients with MSI tumors using NLR and CT global tumor volume
Publisher: Frontiers Media SA
Date: 25-10-2022
Abstract: Anti-PD-(L)1 treatment is indicated for patients with mismatch repair-deficient (MMRD) tumors, regardless of tumor origin. However, the response rate is highly heterogeneous across MMRD tumors. The objective of the study is to find a score that predicts anti-PD-(L)1 response in patients with MMRD tumors. Sixty-one patients with various origin of MMRD tumors and treated with anti-PD-(L)1 were retrospectively included in this study. An expert radiologist annotated all tumors present at the baseline and first evaluation CT-scans for all the patients by circumscribing them on their largest axial axis (single slice), allowing us to compute an approximation of their tumor volume. In total, 2120 lesions were annotated, which led to the computation of the total tumor volume for each patient. The RECIST sum of target lesions’ diameters and neutrophile-to-lymphocyte (NLR) were also reported at both examinations. These parameters were determined at baseline and first evaluation and the variation between the first evaluation and baseline was calculated, to determine a comprehensive score for overall survival (OS) and progression-free survival (PFS). Total tumor volume at baseline was found to be significantly correlated to the OS (p-value: 0.005) and to the PFS (p-value:& .001). The variation of the RECIST sum of target lesions’ diameters, total tumor volume and NLR were found to be significantly associated to the OS (p-values:& .001, 0.006,& .001 respectively) and to the PFS (& .001,& .001, 0.007 respectively). The concordance score combining total tumor volume and NLR variation was better at stratifying patients compared to the tumor volume or NLR taken in idually according to the OS (pairwise log-rank test p-values: 0.033,& .001, 0.002) and PFS (pairwise log-rank test p-values: 0.041,& .001, 0.003). Total tumor volume appears to be a prognostic biomarker of anti-PD-(L)1 response to immunotherapy in metastatic patients with MMRD tumors. Combining tumor volume and NLR with a simple concordance score stratifies patients well according to their survival and offers a good predictive measure of response to immunotherapy.
Auxin treatment of pre-veraison grape (Vitis vinifera L.) berries both delays ripening and increases the synchronicity of sugar accumulation
Publisher: Hindawi Limited
Date: 30-09-2010
Methoxypyrazine concentrations in the grape bunch rachis of Vitis vinifera L. Cv Shiraz: Influence of rootstock, region and light
Publisher: Elsevier BV
Date: 05-2023
Supplementary Figure S3 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633114.V1
Abstract: Organ involvement's impact on survival. The organs selected were the ones most affected in our study's patients. The tests are for the survival of patients whether an organ has a tumor or not. The organs were: A) Liver B) Lung C) Subdiaphragm lymph nodes D) Supra Diaphragm lymph nodes E) Peritoneal Carcinosis and F) Bone.
Histone modifications at the grapevine VvOMT3 locus, which encodes an enzyme responsible for methoxypyrazine production in the berry
Publisher: CSIRO Publishing
Date: 2017
DOI: 10.1071/FP16434
Abstract: Some herbaceous characters in wine are attributed to the presence of aroma compounds collectively known as methoxypyrazines (MPs). In grape berries their formation has been hypothesised to start from a reaction of two amino acids or an amino acid and an unknown 1,2-dicarbonyl compound, leading to the formation of hydroxypyrazine, which is then enzymatically methylated to form a MP. The enzyme responsible of the formation of 3-isobutyl-2-methoxypyrazine has been recently identified as VvOMT3 whose regulation is still not understood. The concentration of MPs in grapes is known to be influenced by development, environmental stimuli and most importantly grape variety. In order to investigate the chromatin arrangement of that region a chromatin immunoprecipitation analysis has been performed and putative differences in epigenetic regulation of VvOMT3 spatially between the skin and flesh tissues and also temporally during fruit development have been detected. There are also allelic differences in VvOMT3 histone modifications which are maintained in subsequent generations. This study provides evidence of histone tail modification of the VvOMT3 locus in grapevine, which may play a role in the spatial and developmental regulation of the expression of this gene.
Sample preparation optimization in wine and grapes
Publisher: Elsevier BV
Date: 05-2008
DOI: 10.1016/J.CHROMA.2008.03.053
Abstract: Most headspace solid-phase microextraction (HS-SPME) volatile analysis methods have been developed for aqueous s les and have been either adapted or applied to complex matrices. This study examines s le/headspace equilibrium based on realistic (non-spiked) concentration levels in real complex s le matrices (grapes and wine) with a systematic multivariate statistical approach. The presence and absence of matrix effects are explained through exponential and linear relationships, respectively. The potential of over- and underestimating volatile compounds in a diluted s le is illustrated and the common dilution equation (C1V1=C2V2) is shown to not always apply to headspace volatile analysis. Additionally, s le dilution was shown to be more sensitive to matrix effects than s le/headspace volume variations with the latter showing analyte dependency. An optimum s le size of 6.9-8.6g in a 20mL vial without dilution was observed. This study shows that sensitivity and limit of detection (LOD) can be improved to a limit with a subsequent loss - an extension to existing theory. The study further illustrates that in trying to bring an analyte within linear range through s le dilution, sensitivity and LOD can be lost with a probable shift in optimum ranges and s le/headspace equilibrium.
Integrating deep learning CT-scan model, biological and clinical variables to predict severity of COVID-19 patients
Publisher: Springer Science and Business Media LLC
Date: 27-01-2021
DOI: 10.1038/S41467-020-20657-4
Abstract: The SARS-COV-2 pandemic has put pressure on intensive care units, so that identifying predictors of disease severity is a priority. We collect 58 clinical and biological variables, and chest CT scan data, from 1003 coronavirus-infected patients from two French hospitals. We train a deep learning model based on CT scans to predict severity. We then construct the multimodal AI-severity score that includes 5 clinical and biological variables (age, sex, oxygenation, urea, platelet) in addition to the deep learning model. We show that neural network analysis of CT-scans brings unique prognosis information, although it is correlated with other markers of severity (oxygenation, LDH, and CRP) explaining the measurable but limited 0.03 increase of AUC obtained when adding CT-scan information to clinical variables. Here, we show that when comparing AI-severity with 11 existing severity scores, we find significantly improved prognosis performance AI-severity can therefore rapidly become a reference scoring approach.
Supplementary Figure S4 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489978.V1
Abstract: Log Hazard ratio (HR) of each parameter obtained from a cox model fitted to predict survival.
Determining the Methoxypyrazine Biosynthesis Variables Affected by Light Exposure and Crop Level in Cabernet Sauvignon
Publisher: American Society for Enology and Viticulture
Date: 19-08-2013
Development of a sensitive non-targeted method for characterizing the wine volatile profile using headspace solid-phase microextraction comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry
Publisher: Elsevier BV
Date: 2011
DOI: 10.1016/J.CHROMA.2010.11.008
Abstract: Future understanding of differences in the composition and sensory attributes of wines require improved analytical methods which allow the monitoring of a large number of volatiles including those present at low concentrations. This study presents the optimization and application of a headspace solid-phase microextraction (HS-SPME) method for analysis of wine volatiles by comprehensive two-dimensional gas chromatography (GC×GC) time-of-flight mass spectrometry (TOFMS). This study demonstrates an important advancement in wine volatile analysis as the method allows for the simultaneous analysis of a significantly larger number of compounds found in the wine headspace compared to other current single dimensional GC-MS methodologies. The methodology allowed for the simultaneous analysis of over 350 different tentatively identified volatile and semi-volatile compounds found in the wine headspace. These included potent aroma compound classes such as monoterpenes, norisoprenoids, sesquiterpenes, and alkyl-methoxypyrazines which have been documented to contribute to wine aroma. It is intended that wine aroma research and wine sensory research will utilize this non-targeted method to assess compositional differences in the wine volatile profile.
Incrementally Semi-Supervised Classification of Arthritis Inflammation on a Clinical Dataset
Publisher: IEEE
Date: 16-10-2022
Supplementary Figure S6 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489972
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones.
Supplementary Figure S5 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489975
Abstract: Radiological feature impact on survival. Radiological features include progression of target lesions 20%, progression of non-target lesions 50% and the emergence of new lesions.
Supplementary Figure S1 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633123.V1
Abstract: Distribution of primary cancer types in the development set (n=107).
Supplementary Figure S7 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489969
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones
Changes in transcription of cytokinin metabolism and signalling genes in grape (Vitis vinifera L.) berries are associated with the ripening-related increase in isopentenyladenine
Publisher: Springer Science and Business Media LLC
Date: 16-09-2015
Evidence that methoxypyrazine accumulation is elevated in Shiraz rachis grown on Ramsey rootstock, increasing ‘green’ flavour in wine
Publisher: Hindawi Limited
Date: 27-03-2022
DOI: 10.1111/AJGW.12551
Supplementary Figure S9 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489963.V1
Abstract: Survival of pseudo-PD vs confirmed PD in our cohort.
ZeBraInspector, a platform for the automated segmentation and analysis of body and brain volumes in whole 5 days post-fertilization zebrafish following simultaneous visualization with identical orient
Publisher: Elsevier BV
Date: 10-2022
DOI: 10.1016/J.YDBIO.2022.07.004
Abstract: In recent years, the zebrafish has become a well-established laboratory model. We describe here the ZeBraInspector (ZBI) platform for high-content 3D imaging (HCI) of 5 days post-fertilization zebrafish eleuthero-embryos (EEs). This platform includes a mounting method based on 3D-printed st s to create a grid of wells in an agarose cast, facilitating batch acquisitions with a fast-confocal laser scanning microscope. We describe reference labeling in cleared fish with a fluorescent lipophilic dye. Based on this labeling, the ZBI software registers. EE 3D images, making it possible to visualize numerous identically oriented EEs on a single screen, and to compare their morphologies and any fluorescent patterns at a glance. High-resolution 2D snapshots can be extracted. ZBI software is therefore useful for erse high-content analyses (HCAs). Following automated segmentation of the lipophilic dye signal, the ZBI software performs volumetric analyses on whole EEs and their nervous system white matter. Through two ex les, we illustrate the power of these analyses for obtaining statistically significant results from a small number of s les: the characterization of a phenotype associated with a neurodevelopmental mutation, and of the defects caused by treatments with a toxic anti-cancer compound.
Supplementary Figure S2 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489984.V1
Abstract: Correlation tables of our criteria. Bottom left are spearman coefficients, top right are Phi_K coefficients.
A Maximum-Flow Model for Digital Elastica Shape Optimization
Publisher: Springer International Publishing
Date: 2021
Insights into the Uptake, Distribution, and Metabolism of 3-Isobutyl-2-hydroxypyrazine in Grapevine Using a Stable Isotope Tracer
Publisher: American Chemical Society (ACS)
Date: 20-04-2023
Ripening of grape berries can be advanced or delayed by reagents that either reduce or increase ethylene levels
Publisher: CSIRO Publishing
Date: 2013
DOI: 10.1071/FP12347
Abstract: Grape (Vitis vinifera L.) berries are considered to be nonclimacteric fruit as they do not exhibit a large rise in ethylene production or respiration rate at the onset of ripening (veraison). However, ethylene may still play a role in berry development and in ripening in particular. (2-Chloroethyl)phosphonic acid (CEPA), an ethylene-releasing reagent, delayed ripening when applied early in berry development. In agreement with a role for ethylene in controlling the timing of ripening, the application of an inhibitor of ethylene biosynthesis, aminoethoxyvinylglycine (AVG), advanced ripening, as did abscisic acid, when applied during the preveraison period. Applications of CEPA nearer to the time of veraison enhanced berry colouration. Changes in the expression of ethylene biosynthesis and receptor genes were observed throughout berry development. Transcript levels of some of these genes were increased by CEPA and decreased by AVG, suggesting changes in ethylene synthesis and perception during the preveraison period that might contribute to the biphasic response to CEPA (ethylene). The significant delay of ripening in field-grown grapes through the application of CEPA also indicates that this may be useful in controlling the timing of veraison, and therefore harvest date, in warmer climates.
Auxin treatment of grapevine (Vitis vinifera L.) berries delays ripening onset by inhibiting cell expansion
Publisher: Springer Science and Business Media LLC
Date: 10-02-2020
Additional targets of the Arabidopsis autonomous pathway members, FCA and FY
Publisher: Oxford University Press (OUP)
Date: 15-09-2006
DOI: 10.1093/JXB/ERL073
Abstract: A central player in the Arabidopsis floral transition is the floral repressor FLC, the MADS-box transcriptional regulator that inhibits the activity of genes required to switch the meristem from vegetative to floral development. One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK. Rather than a hierarchical set of activities the autonomous promotion pathway comprises sub-pathways of genes with different biochemical functions that all share FLC as a target. One sub-pathway involves FCA and FY, which interact to regulate RNA processing of FLC. Several of the identified components (FY, FVE, and FLD) are homologous to yeast and mammalian proteins with rather generic roles in gene regulation. So why do mutations in these genes specifically show a late-flowering phenotype in Arabidopsis? One reason, found during the analysis of fy alleles, is that the mutant alleles identified in flowering screens can be hypomorphic, they still have partial function. A broader role for the autonomous promotion pathway is supported by a microarray analysis which has identified genes mis-regulated in fca mutants, and whose expression is also altered in fy mutants.
Distribution of 3-Isobutyl-2-methoxypyrazine across Rachis Components of Vitis vinifera Shiraz and Cabernet Sauvignon
Publisher: Hindawi Limited
Date: 18-04-2023
DOI: 10.1155/2023/2428791
Abstract: Rootstock can significantly alter the concentration of methoxypyrazines (MPs) in the bunch stem (rachis) of Vitis vinifera L. cv. Cabernet Sauvignon and Shiraz, which has implications for winemaking and wine style. The distribution of MPs across the rachis is an important consideration, but such information was not available. This study aimed to address this research question by comparing MP concentrations in different rachis components throughout grape maturation and in the absence of ambient light. Shiraz and Cabernet Sauvignon bunches were s led throughout development, segmented into four components (peduncle, top rachis, bottom rachis, and pedicel), and 3-isobutyl-2-methoxypyrazine (IBMP) was quantified in each. For both cultivars, IBMP showed a negative correlation with grape maturity, with concentrations in pedicel at harvest being significantly higher than other rachis components. Additionally, light exclusion significantly increased IBMP concentrations in all rachis segments. The concentration of IBMP varied significantly between different rachis components. The greatest concentrations were measured in the pedicel, which also contributed the largest proportion among the components to total rachis by weight. Due to elevated IBMP concentrations in rachis and the difficulties in excluding matter other than grape from a fermentor, the presence of pedicel during fermentation could produce Shiraz and Cabernet Sauvignon wines with higher concentrations of MPs, thereby potentially increasing vegetal sensory characteristics.
Machine‐Learning‐Assisted Intelligent Imaging Flow Cytometry: A Review
Publisher: Wiley
Date: 26-07-2021
Abstract: Imaging flow cytometry has been widely adopted in numerous applications such as optical sensing, environmental monitoring, clinical diagnostics, and precision agriculture. The system, with the assistance of machine learning, shows unprecedented advantages in automated image analysis, thus enabling high‐throughput measurement, identification, and sorting of biological entities. Recently, with the burgeoning developments of machine learning algorithms, deep learning has taken over most of data analysis and promised tremendous performance in intelligent imaging flow cytometry. Herein, an overview of the basic knowledge of intelligent imaging flow cytometry, the evolution of machine learning and the typical applications, and how machine learning can be applied to assist intelligent imaging flow cytometry is provided. Perspectives of emerging machine learning algorithms in implementing future intelligent imaging flow cytometry are also discussed.
Transformer Graph Network for Coronary Plaque Localization in CCTA
Publisher: IEEE
Date: 28-03-2022
Supplementary Figure S2 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633117.V1
Abstract: Correlation tables of our criteria. Bottom left are spearman coefficients, top right are Phi_K coefficients.
Post‐veraison restriction of phloem import into Riesling (Vitis vinifera L.) berries induces transient and stable changes to fermentation‐derived and varietal wine volatiles
Publisher: Hindawi Limited
Date: 05-2019
DOI: 10.1111/AJGW.12392
Tendrils, inflorescences and fruitfulness: A molecular perspective
Publisher: Hindawi Limited
Date: 07-2000
Linking sensory properties and chemical composition of Vitis vinifera cv. Cabernet Sauvignon grape berries to wine
Publisher: American Society for Enology and Viticulture
Date: 23-03-2017
Supplementary Figure S9 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633096
Abstract: Survival of pseudo-PD vs confirmed PD in our cohort.
Supplementary Figure S8 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633099
Abstract: Effect of the removal of each criterion on the accuracy of a multinomial logistic regression fit to predict the category of each patient. The minimal losses are underlined, and the maximum are written in bold.
Associations between the Sensory Attributes and Volatile Composition of Cabernet Sauvignon Wines and the Volatile Composition of the Grapes Used for Their Production
Publisher: American Chemical Society (ACS)
Date: 18-02-2011
DOI: 10.1021/JF103584U
Abstract: The sensory properties of wine are influenced by the chemical composition of the grapes used to produce them. Identification of grape and wine chemical markers associated with the attributes perceived by the consumer of the wine will enable better prediction of the potential of a parcel of grapes to produce wine of a certain flavor. This study explores the relationships between Cabernet Sauvignon grape volatile composition and wine volatile profiles with the sensory properties of wines. Twenty grape s les were obtained from nine vineyard sites across three vintages and wines vinified from these parcels using controlled winemaking methods. The volatile composition of the grapes were analyzed by SBSE-GCMS, the wines were analyzed by SPME-GCMS, and these data sets were compared to that obtained from the sensory analysis of the wines. Statistical treatment of the data to account for vintage and region effects allowed underlying relationships to be seen between wine sensory attributes and wine or grape volatile components. The observed associations between grape or wine volatile compounds and wine sensory attributes has revealed target compounds and pathways whose levels may reflect the biochemical effects on grape composition by differing growth conditions during berry development and ripening. The compounds identified in this study may be useful grape or wine markers for potential wine sensory characteristics.
Grape Heterogeneity Index: Assessment of Overall Grape Heterogeneity Using an Aggregation of Multiple Indicators
Publisher: MDPI AG
Date: 24-03-2023
Abstract: Uniform grape maturity can be sought by producers to minimise underripe and/or overripe proportions of fruit and limit any undesirable effects on wine quality. Considering that grape heterogeneity is a multifaceted phenomenon, a composite index summarising overall grape heterogeneity was developed to benefit vineyard management and harvest date decisions. A grape heterogeneity index (GHI) was constructed by aggregating the sum of absolute residuals multiplied by the range of values from measurements of total soluble solids, pH, fresh weight, total tannins, absorbance at 520 nm (red colour), 3-isobutyl-2-methoxypyrazine, and malic acid. Management of grape heterogeneity was also studied, using Cabernet Sauvignon grapes grown under four viticultural regimes (normal/low crop load, full/deficit irrigation) during the 2019/2020 and 2020/2021 seasons. Comparisons of GHI scores showed grape variability decreased throughout ripening in both vintages, then significantly increased at the harvest time point in 2020, but plateaued on s le dates nearing the harvest date in 2021. Irrigation and crop load had no effect on grape heterogeneity by the time of harvest in both vintages. Larger vine yield, leaf area index, and pruning weight significantly increased GHI score early in ripening, but no significant relationship was found at the time of harvest. Differences in the Ravaz index, normalised difference vegetation index, and soil electrical conductivity did not significantly change the GHI score.
DWARFING AND FLORAL INDUCTION IN VITIS VINIFERA
Publisher: International Society for Horticultural Science (ISHS)
Date: 11-2012
Origins of grape and wine aroma. Part 1. Chemical components and viticultural impacts
Publisher: American Society for Enology and Viticulture
Date: 10-12-2014
The effect of grape juice dilution on oenological fermentation
Publisher: Cold Spring Harbor Laboratory
Date: 30-07-2020
DOI: 10.1101/2020.07.29.226142
Abstract: The impact of water addition to grape juice in winemaking, on both alcoholic and malolactic fermentation duration and outcome has been examined using commercial wine yeasts, Lalvin EC1118™ and Lalvin R2™ and malolactic bacteria Lalvin VP41™. As expected, dilution with water did not impede fermentation, instead resulted in shortened duration, or in the case of malolactic fermentation enabled completion in these conditions. Addition of complex organic nutrient further shortened alcoholic fermentation by Lalvin R2™ and in some conditions also reduced the duration of malolactic fermentation. In general, volatile compounds and some major yeast metabolites were present at lower concentrations at the end of fermentation where juices were diluted and the addition of organic complex nutrient also influenced the concentration of some compounds in wine. These findings are significant to commercial winemaking, highlighting that winemakers should consider potential impacts of juice dilution on processing efficiencies along with wine flavour and aroma. Grape juice dilution shortened both alcoholic and malolactic fermentation In some conditions addition of commercial nutrient decreased fermentation duration In general wine volatiles decrease with grape juice dilution Isoamyl acetate can be decreased in wine by grape juice dilution
Supplementary Figure S7 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633102.V1
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones
Grape Contribution to Wine Aroma: Production of Hexyl Acetate, Octyl Acetate, and Benzyl Acetate during Yeast Fermentation Is Dependent upon Precursors in the Must
Publisher: American Chemical Society (ACS)
Date: 29-02-2012
DOI: 10.1021/JF2042517
Abstract: Wine is a complex consumer product produced predominately by the action of yeast upon grape juice musts. Model must systems have proven ideal for studies of the effects of fermentation conditions on the production of certain wine volatiles. To identify grape-derived precursors to acetate esters, model fermentation systems were developed by spiking precursors into model must at different concentrations. Solid-phase microextraction-gas chromatgraphy mass spectrometry analysis of the fermented wines showed that a variety of grape-derived aliphatic alcohols and aldehydes are precursors to acetate esters. The C6 compounds hexan-1-ol, hexenal, (E)-2-hexen-1-ol, and (E)-2-hexenal are all precursors to hexyl acetate, and octanol and benzyl alcohol are precursors to octyl acetate and benzyl acetate, respectively. In these cases, the postfermentation concentration of an acetate ester increased proportionally with the prefermentation concentration of the respective precursor in the model must. Determining viticultural or winemaking methods to alter the prefermentation concentration of precursor compounds or change the precursor-to-acetate ester ratio will have implications upon the final flavor and aroma of wines.
Supplementary Figure S10 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489987.V1
Abstract: Log hazard ratios (HR) computed by cox model. The variables studied were: GRIm, RMH, NLR BL & the iPD score. The only significant variable was the iPD score (HR = 2, p 0.005).
Interactions between wine volatile compounds and grape and wine matrix components influence aroma compound headspace partitioning
Publisher: American Chemical Society (ACS)
Date: 11-11-2009
DOI: 10.1021/JF902586N
Abstract: A full-factorial design was used to assess the matrix effects of ethanol, glucose, glycerol, catechin, and proline on the volatile partitioning of 20 volatile compounds considered to play a role in wine aroma. Analysis of variance showed that the two-way interactions of ethanol and glucose, ethanol and glycerol, and glycerol and catechin significantly influenced headspace partitioning of volatiles. Experiments were conducted to observe the effect of varied ethanol and glucose concentrations on headspace partitioning of a constant concentration of volatiles. Analysis of variance and linear regression analysis showed that the presence of glucose increased the concentration of volatiles in the headspace, whereas increasing ethanol concentration was negatively correlated with headspace partitioning of volatiles. A subsequent study assessed the effect of diluting white and red wines with water and ethanol. It was again observed that increased ethanol concentration significantly reduced the relative abundance of volatile compounds in the s le headspace. This study investigates some of the complex matrix interactions of the major components of grape and wine that influence volatile compound headspace partitioning. The magnitude of each matrix-volatile interaction was ethanol > glucose > glycerol > catechin, whereas proline showed no apparent interaction. The results clearly identify that increasing ethanol concentrations significantly reduce the headspace concentration of volatile aroma compounds, which may contribute to explaining recent sensory research observations that indicate ethanol can suppress the fruit aroma attributes in wine.
Deep learning‐enabled imaging flow cytometry for high‐speed Cryptosporidium and Giardia detection
Publisher: Wiley
Date: 20-02-2021
DOI: 10.1002/CYTO.A.24321
Abstract: Imaging flow cytometry has become a popular technology for bioparticle image analysis because of its capability of capturing thousands of images per second. Nevertheless, the vast number of images generated by imaging flow cytometry imposes great challenges for data analysis especially when the species have similar morphologies. In this work, we report a deep learning‐enabled high‐throughput system for predicting Cryptosporidium and Giardia in drinking water. This system combines imaging flow cytometry and an efficient artificial neural network called MCellNet, which achieves a classification accuracy .6%. The system can detect Cryptosporidium and Giardia with a sensitivity of 97.37% and a specificity of 99.95%. The high‐speed analysis reaches 346 frames per second, outperforming the state‐of‐the‐art deep learning algorithm MobileNetV2 in speed (251 frames per second) with a comparable classification accuracy. The reported system empowers rapid, accurate, and high throughput bioparticle detection in clinical diagnostics, environmental monitoring and other potential biosensing applications.
Comparison of major volatile compounds from Riesling and Cabernet Sauvignon grapes (Vitis vinifera L.) from fruit-set to harvest.
Publisher: No publisher found
Date: 2010
Effect of ‘loss of function’ mutation in SER1 in wine yeast: fermentation outcomes in co-inoculation with non-Saccharomyces
Publisher: Universite de Bordeaux
Date: 20-04-2022
DOI: 10.20870/OENO-ONE.2022.56.2.4908
Abstract: In wine fermentation, improved wine complexity and sensorial properties can arise from the use of non-Saccharomyces yeast. Generally less alcohol tolerant, such strains often do not finish fermentation, therefore requiring a second inoculation with the more robust Saccharomyces cerevisiae, usually added on Day 3. This sequential approach affords non-Saccharomyces time to make an impact before being overtaken by S. cerevisiae. However, two inoculations are inconvenient therefore the identification of a slow growing S. cerevisiae strain that can be used in a single co-inoculation with the non-Saccharomyces yeast is highly attractive. In this study we investigated the use of the naturally occurring ‘loss of function’ SER1 variant, identified in a Sake yeast, for the purposes of carrying out co-inoculated wine fermentations. The SER1-232(G C G78R) change was introduced into the commonly used wine strain, EC1118, via CRISPR/Cas9 editing. In a chemically defined grape juice medium, the SER1(G78R) mutant grew and fermented more slowly and increased acetic acid, succinic acid and glycerol concentrations. Simultaneous inoculation with the slower-growing mutant with a Metschnikowia pulcherrima or Lachancea thermotolerans strain in sterile Sauvignon blanc juice resulted in differences in sensorial compounds, most likely derived from the presence of non-Saccharomyces yeasts. The EC1118 SER1 (G78R) mutant completed fermentation with M. pulcherrima, MP2, and in fact improved the viability of MP2 compared to when it was used as a monoculture. The SER1 (G78R) mutant also promoted both the growth of the SO2-sensitive L. thermotolerans strain, Viniflora® Concerto™, in a juice high in SO2 and its subsequent dominance during fermentation. In co-fermentations with wild-type EC1118, the Concerto™ population was substantially reduced with no significant changes in wine properties. This research adds to our understanding of the use of a novel slow-growing S. cerevisiae yeast in wine fermentations co-inoculated with non-Saccharomyces strains.
Influence of Fruit Maturity at Harvest on the Intensity of Smoke Taint in Wine
Publisher: MDPI AG
Date: 18-05-2015
Oenological traits of Lachancea thermotolerans show signs of domestication and allopatric differentiation
Publisher: Springer Science and Business Media LLC
Date: 04-10-2018
DOI: 10.1038/S41598-018-33105-7
Abstract: The yeast Lachancea thermotolerans (previously Kluyveromyces thermotolerans ) is a species of large, yet underexplored, oenological potential. This study delivers comprehensive oenological phenomes of 94 L. thermotolerans strains obtained from erse ecological niches worldwide, classified in nine genetic groups based on their pre-determined microsatellite genotypes. The strains and the genetic groups were compared for their alcoholic fermentation performance, production of primary and secondary metabolites and pH modulation in Chardonnay grape juice fermentations. The common oenological features of L. thermotolerans strains were their glucophilic character, relatively extensive fermentation ability, low production of acetic acid and the formation of lactic acid, which significantly affected the pH of the wines. An untargeted analysis of volatile compounds, used for the first time in a population-scale phenotyping of a non- Saccharomyces yeast, revealed that 58 out of 90 volatiles were affected at an L. thermotolerans strain level. Besides the remarkable extent of intra-specific ersity, our results confirmed the distinct phenotypic performance of L. thermotolerans genetic groups. Together, these observations provide further support for the occurrence of domestication events and allopatric differentiation in L. thermotolerans population.
Understanding the regulation of VvDXS gene expression
Publisher: International Society for Horticultural Science (ISHS)
Date: 04-2017
Cloning and Characterization of Vitis vinifera UDP-Glucose:Flavonoid 3- O -Glucosyltransferase, a Homologue of the Enzyme Encoded by the Maize Bronze-1 Locus That May Primarily Serve to Glucosylate Anthocyanidins in Vivo
Publisher: Elsevier BV
Date: 04-1998
Application of sequential and orthogonalised-partial least squares (SO-PLS) regression to predict sensory properties of Cabernet Sauvignon wines from grape chemical composition
Publisher: Elsevier BV
Date: 08-2018
DOI: 10.1016/J.FOODCHEM.2018.02.120
Abstract: The current study determined the applicability of sequential and orthogonalised-partial least squares (SO-PLS) regression to relate Cabernet Sauvignon grape chemical composition to the sensory perception of the corresponding wines. Grape s les (n = 25) were harvested at a similar maturity and vinified identically in 2013. Twelve measures using various (bio)chemical methods were made on grapes. Wines were evaluated using descriptive analysis with a trained panel (n = 10) for sensory profiling. Data was analysed globally using SO-PLS for the entire sensory profiles (SO-PLS2), as well as for single sensory attributes (SO-PLS1). SO-PLS1 models were superior in validated explained variances than SO-PLS2. SO-PLS provided a structured approach in the selection of predictor chemical data sets that best contributed to the correlation of important sensory attributes. This new approach presents great potential for application in other explorative metabolomics studies of food and beverages to address factors such as quality and regional influences.
Supplementary Figure S1 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2200
DOI: 10.1158/1078-0432.22489990
Abstract: Distribution of primary cancer types in the development set (n=107).
Source/Sink Relationships and Molecular Biology of Sugar Accumulation in Grape Berries
Publisher: BENTHAM SCIENCE PUBLISHERS
Date: 14-05-2012
Exploring the influence of grape tissues on the concentration of wine volatile compounds
Publisher: Hindawi Limited
Date: 14-10-2021
DOI: 10.1111/AJGW.12524
Influence of geographic origin on the sensory characteristics and wine composition of Vitis vinifera cv. Cabernet Sauvignon wines from Australia
Publisher: American Society for Enology and Viticulture
Date: 25-06-2012
A cDNA from grapevine (Vitis vinifera L.), which shows homology to AGAMOUS and SHATTERPROOF, is not only expressed in flowers but also throughout berry development
Publisher: Springer Science and Business Media LLC
Date: 2001
Abstract: An AGAMOUS/SHATTERPROOF homologue (Vvmads1) was isolated from grapevine by differential display between berry and leaf mRNA. The predicted protein sequence of the full-length clone shows a high degree of homology to PLENA (77% identity) and to SHP1 and SHP2 (75% and 74% identity respectively), and is grouped with AGAMOUS/PLENA homologues when the conserved MADS and K domains are compared. Vvmads1 is expressed only in the later stages of flower development and throughout berry development, although expression is reduced after ripening commenced. When Vvmads1 was over-expressed in tobacco, the resulting plants display altered morphologies in the outer two floral whorls. In the most extreme cases, the inner whorls were surrounded by a carpelloid structure created by the modified sepals. Within these sepals were petals which had been split into sections and which were attached at the base of the flower by structures with the appearance of filaments. The results of this study suggest that Vvmads1 has a regulatory role in flower development before fertilisation and a role in fruit development after fertilisation.
Timing of auxin treatment affects grape berry growth, ripening timing and the synchronicity of sugar accumulation
Publisher: Hindawi Limited
Date: 21-10-2021
DOI: 10.1111/AJGW.12528
Treatment of Grape Berries, a Nonclimacteric Fruit with a Synthetic Auxin, Retards Ripening and Alters the Expression of Developmentally Regulated Genes
Publisher: Oxford University Press (OUP)
Date: 11-1997
Abstract: Treatment of grape (Vitis vinifera L.) berries with the synthetic auxin-like compound benzothiazole-2-oxyacetic acid (BTOA) caused a delay in the onset of ripening of approximately 2 weeks. This was manifested as a retardation of the increases in berry weight, color, deformability, and hexose concentration. BTOA treatment also delayed by 2 weeks the increase in abscisic acid level that normally accompanies ripening and altered the expression of a number of developmentally regulated genes. A putative vacuolar invertase, which is normally expressed from berry set until ripening and turned off after ripening commences, remained expressed throughout development in BTOA-treated grape berries. This elevated expression resulted in increased levels of invertase activity. In contrast, the up-regulation of four other genes normally switched on at the time of ripening was delayed in BTOA-treated fruit. These included chalcone synthase and UDP-glucose-flavonoid 3-O-glucosyl transferase, both of which are involved in anthocyanin synthesis, a chitinase, and a ripening-related gene of an unknown function. These observations support the view that auxins (perhaps in conjunction with abscisic acid) may have a role in the control of grape berry ripening by affecting the expression of genes involved in the ripening process.
Extraction Properties of New Polymeric Sorbents Applied to Wine
Publisher: American Chemical Society (ACS)
Date: 17-09-2018
Abstract: Polymeric sorbents are frequently used in wine, either as solid phase extraction materials for isolation of analytes or as sorptive materials for removal of undesirable compounds (amelioration). Six new polymeric sorbents were produced thermally or in a microwave from various ratios of methacrylic acid, acrylic acid, and 4-vinylbenzoic acid as hydrophilic monomers, together with ethylene glycol dimethacrylate as cross-linker, using different porogen solvents. The relationship between physicochemical properties (pore size, surface area, and polarity) of the sorbents and their sorption properties for compounds in wine was investigated and compared to four commercially available sorbents. With some similarities to their commercial counterparts depending on hydrophobic and hydrophilic characteristics, the six new sorbents showed specificity toward different groups of compounds (e.g., volatiles and phenolics) and could be applied for targeted purposes. The results provide insight into the selection and utilization of new polymeric materials for extraction of components from wine.
Supplementary Figure S6 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633105.V1
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones.
Increase in Cytokinin Levels during Ripening in Developing Vitis vinifera cv. Shiraz Berries
Publisher: American Society for Enology and Viticulture
Date: 19-08-2013
Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation
Publisher: Oxford University Press (OUP)
Date: 24-08-2011
DOI: 10.1093/JXB/ERR231
Interactions between ethylene and auxin are crucial to the control of grape (Vitis vinifera L.) berry ripening
Publisher: Springer Science and Business Media LLC
Date: 12-2013
Abstract: Fruit development is controlled by plant hormones, but the role of hormone interactions during fruit ripening is poorly understood. Interactions between ethylene and the auxin indole-3-acetic acid (IAA) are likely to be crucial during the ripening process, since both hormones have been shown to be implicated in the control of ripening in a range of different fruit species. Grapevine ( Vitis vinifera L.) homologues of the TRYPTOPHAN AMINOTRANSFERASE RELATED (TAR) and YUCCA families, functioning in the only characterized pathway of auxin biosynthesis, were identified and the expression of several TAR genes was shown to be induced by the pre-ripening application of the ethylene-releasing compound Ethrel. The induction of TAR expression was accompanied by increased IAA and IAA-Asp concentrations, indicative of an upregulation of auxin biosynthesis and conjugation. Exposure of ex planta, pre-ripening berries to the ethylene biosynthesis inhibitor aminoethoxyvinylglycine resulted in decreased IAA and IAA-Asp concentrations. The delayed initiation of ripening observed in Ethrel-treated berries might therefore represent an indirect ethylene effect mediated by increased auxin concentrations. During berry development, the expression of three TAR genes and one YUCCA gene was upregulated at the time of ripening initiation and/or during ripening. This increase in auxin biosynthesis gene expression was preceded by high expression levels of the ethylene biosynthesis genes 1-aminocyclopropane-1-carboxylate synthase and 1-aminocyclopropane-1-carboxylate oxidase. In grape berries, members of both gene families involved in the two-step pathway of auxin biosynthesis are expressed, suggesting that IAA is produced through the combined action of TAR and YUCCA proteins in developing berries. The induction of TAR expression by Ethrel applications and the developmental expression patterns of auxin and ethylene biosynthesis genes indicate that elevated concentrations of ethylene prior to the initiation of ripening might lead to an increased production of IAA, suggesting a complex involvement of this auxin and its conjugates in grape berry ripening.
Generative adversarial networks (GAN)-based data augmentation of rare liver cancers: The SFR 2021 Artificial Intelligence Data Challenge
Publisher: Elsevier BV
Date: 2023
DOI: 10.1016/J.DIII.2022.09.005
Abstract: The 2021 edition of the Artificial Intelligence Data Challenge was organized by the French Society of Radiology together with the Centre National d'Études Spatiales and CentraleSupélec with the aim to implement generative adversarial networks (GANs) techniques to provide 1000 magnetic resonance imaging (MRI) cases of macrotrabecular-massive (MTM) hepatocellular carcinoma (HCC), a rare and aggressive subtype of HCC, generated from a limited number of real cases from multiple French centers. A dedicated platform was used by the seven inclusion centers to securely upload their anonymized MRI examinations including all three cross-sectional images (one late arterial and one portal-venous phase T1-weighted images and one fat-saturated T2-weighted image) in compliance with general data protection regulation. The quality of the database was checked by experts and manual delineation of the lesions was performed by the expert radiologists involved in each center. Multidisciplinary teams competed between October 11 A total of 91 MTM-HCC datasets of three images each were collected from seven French academic centers. Six teams with a total of 28 in iduals participated in this challenge. Each participating team was asked to generate one thousand 3-image cases. The qualitative evaluation was performed by three radiologists using the Likert scale on ten randomly selected cases generated by each participant. A quantitative evaluation was also performed using two metrics, the Frechet inception distance and a leave-one-out accuracy of a 1-Nearest Neighbor algorithm. This data challenge demonstrates the ability of GANs techniques to generate a large number of images from a small s le of imaging examinations of a rare malignant tumor.
Selection of optimal sensor/temperature conditions for winegrape analysis using generalized additive modeling of thermally cycled metal oxide sensors
Publisher: IEEE
Date: 10-2009
Rootstock, Vine Vigor, and Light Mediate Methoxypyrazine Concentrations in the Grape Bunch Rachis of Vitis vinifera L. cv. Cabernet Sauvignon
Publisher: American Chemical Society (ACS)
Date: 20-04-2022
Abstract: Ramsey rootstock has previously been implicated in an approximate 8-fold increase of 3-isobutyl-2-methoxypyrazine (IBMP) levels in the rachis (grape bunch stem) of
Automatic coronary artery calcium scoring from unenhanced-ECG-gated CT using deep learning
Publisher: Elsevier BV
Date: 11-2021
Supplementary Figure S9 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633096.V1
Abstract: Survival of pseudo-PD vs confirmed PD in our cohort.
The use of molecular biology techniques to study and manipulate the grapevine: Why and how?
Publisher: Hindawi Limited
Date: 07-2000
Erratum to: Two O-methyltransferases involved in the biosynthesis of methoxypyrazines: grape-derived aroma compounds important to wine flavour
Publisher: Springer Science and Business Media LLC
Date: 08-02-2013
Supplementary Figure S4 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633111.V1
Abstract: Log Hazard ratio (HR) of each parameter obtained from a cox model fitted to predict survival.
The effect of grape juice dilution and complex nutrient addition on oenological fermentation and wine chemical composition
Publisher: Elsevier BV
Date: 2022
Expression of anthocyanin biosynthesis pathway genes in red and white grapes
Publisher: Springer Science and Business Media LLC
Date: 11-1996
DOI: 10.1007/BF00019111
Abstract: In an ideal world, everyone would receive medical resources in accordance with their needs. In reality, resources are often scarce and have an alternative use. Thus, we are forced to prioritize. Although Norway is one of the leading countries in normative priority setting work, few descriptive studies have been conducted in the country. To increase legitimacy in priority setting, knowledge about laypeople's attitudes is central. The aim of the study is therefore to assess the general population's attitudes towards a broad spectrum of issues pertinent to priority setting in the Norwegian publicly financed health care system. We developed an electronic questionnaire that was distributed to a representative s le of 2 540 Norwegians regarding their attitudes towards priority setting in Norway. A total of 1 035 responded (response rate 40.7%). Data were analyzed with descriptive statistics and binary logistic regression. A majority (73.0%) of respondents preferred increased funding of publicly financed health services at the expense of other sectors in society. Moreover, a larger share of the respondents suggested either increased taxes (37.0%) or drawing from the Government Pension Fund Global (31.0%) as sources of funding. However, the respondents were ided on whether it was acceptable to say "no" to new cancer drugs when the effect is low and the price is high: 38.6% somewhat or fully disagreed that this was acceptable, while 46.5% somewhat or fully agreed. Lastly, 84.0% of the respondents did not find it acceptable that the Norwegian municipalities have different standards for providing care services. Although the survey suggests support for priority setting among Norwegian laypeople, it has also revealed that a significant minority are reluctant to accept it.
Biosynthesis of Methoxypyrazines: Elucidating the Structural/Functional Relationship of Two Vitis viniferaO-Methyltransferases Capable of Catalyzing the Putative Final Step of the Biosyn
Publisher: American Chemical Society (ACS)
Date: 09-06-2011
DOI: 10.1021/JF200542W
Abstract: 3-Alkyl-2-methoxypyrazines (MPs) are an important food constituent and have been associated with detrimental herbaceous flavors in red wines by consumers and the wine industry. The Vitis vinifera genes O-methyltransferase 1 and 2 (VvOMT1 and VvOMT2) have been isolated in the grapevine cultivar Carmenere. These genes encode S-adenosyl-l-methionine (SAM)-dependent O-methyltransferases, which have the ability to methylate 3-alkyl-2-hydroxypyrazines (HPs)-the putative final step in MPs production. Atomic studies were performed in order to explain the differences in these VvOMT activities through their structural/functional relationship in MPs biosynthesis. Differences in enthalpy energy observed between the proteins may be due to changes of equivalent residues in the active sites of VvOMT1 (F319, L322) and VvOMT2 (L319, V322). However, docking simulations and QM/MM analyses described how residues H272 and M182 could explain the main functional differentiation observed between VvOMT1 and VvOMT2 through steric impediment, which limits the formation of the transition state in enzymes encoded by VvOMT2. Therefore, this finding could explain the decreasing catalytic efficiency observed for VvOMT2.
Influence of Kazachstania spp. on the chemical and sensory profile of red wines
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.IJFOODMICRO.2021.109496
Abstract: We report the fermentative traits of two Kazachstania species (K. aerobia and K. servazzii) in non-sterile red wine and the resulting chemical and sensory properties. This builds on our previous work which revealed that Kazachstania spp. increased acetate esters in sterilised white wine. In this study Kazachstania spp. were initially evaluated in laboratory-scale fermentations (500 mL) in Merlot must to assess whether similar increases in chemical/volatile compounds would occur. The impact of malolactic fermentation (MLF) by Oenococcus oeni (VP41) on aroma composition was considered and found to reduce ester profiles in Merlot wines. The sensory implications of sequential inoculation with Kazachstania spp., followed by Saccharomyces cerevisiae, were then evaluated in small-lot fermentations (7 kg) of Shiraz must. Fungal ersity was monitored during early fermentation stages and was influenced by the early implantation of Kazachstania spp., followed by the dominance of S. cerevisiae. The effect of MLF in Shiraz wines was inconclusive due to high ethanol levels providing an inhospitable environment for lactic acid bacteria. When compared to S. cerevisiae alone, Kazachstania spp. significantly increased acetate esters, particularly phenylethyl acetate and isoamyl acetate, in both Merlot and Shiraz. The Shiraz wines fermented with Kazachstania spp. had higher jammy and red fruit aroma/flavour compared to S. cerevisiae (monoculture) wines. No influence was observed on colour one-year post-bottling. Results from this study show the contribution of Kazachstania spp. to the aroma profile of red wines and demonstrate their potential as starter cultures for improving the aromatic complexity of wines.
Supplementary Figure S4 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633111
Abstract: Log Hazard ratio (HR) of each parameter obtained from a cox model fitted to predict survival.
The R2R3-MYB Transcription Factors MYB14 and MYB15 Regulate Stilbene Biosynthesis in Vitis vinifera
Publisher: Oxford University Press (OUP)
Date: 10-2013
Distributed algorithms for scalable proximity operator computation and application to video denoising
Publisher: Elsevier BV
Date: 08-2022
Supplementary Figure S3 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633114
Abstract: Organ involvement's impact on survival. The organs selected were the ones most affected in our study's patients. The tests are for the survival of patients whether an organ has a tumor or not. The organs were: A) Liver B) Lung C) Subdiaphragm lymph nodes D) Supra Diaphragm lymph nodes E) Peritoneal Carcinosis and F) Bone.
Association of dwarfism and floral induction with a grape ‘green revolution’ mutation
Publisher: Springer Science and Business Media LLC
Date: 04-2002
DOI: 10.1038/416847A
Use of auxin to delay ripening: sensory and biochemical evaluation of Cabernet Sauvignon and Shiraz
Publisher: Hindawi Limited
Date: 19-08-2021
DOI: 10.1111/AJGW.12516
An apple polyphenol oxidase cDNA is up-regulated in wounded tissues
Publisher: Springer Science and Business Media LLC
Date: 1995
DOI: 10.1007/BF00020197
Two O-methyltransferases involved in the biosynthesis of methoxypyrazines: grape-derived aroma compounds important to wine flavour
Publisher: Springer Science and Business Media LLC
Date: 23-06-2010
DOI: 10.1007/S11103-010-9655-Y
Abstract: Methoxypyrazines (MPs) are volatile, grape-derived aroma compounds that contribute to the distinct herbaceous characters of some wines. Although the full pathway leading to MP production has not been elucidated, there is strong evidence that the final step involves the methylation of non-volatile hydroxypyrazine (HP) precursors. Two cDNA encoding O-methyltransferases (OMTs) that have homology to an enzyme previously purified and shown to catalyse the methylation of HPs were isolated from Cabernet Sauvignon. Recombinant protein from the cDNAs (VvOMT1 and VvOMT2) was produced in E. coli and activity assays demonstrated that both encode OMTs able to methylate HPs to produce MPs, however both showed greatest activity against the flavonol quercetin. VvOMT1 has higher catalytic activity against isobutyl hydroxypyrazine compared to isopropyl hydroxypyrazine, whereas the converse is true for VvOMT2. The timing of the expression of VvOMT1 in the skin and the flesh of developing Cabernet Sauvignon grape berries was associated with the period of MP accumulation in these tissues, while VvOMT2 expression was greatest in roots, which were found to contain high levels of MPs. The MP composition of these tissues also reflects the relative levels of expression of these genes and their substrate preference. The identification of genes responsible for MP production in grapevine will help in understanding the effect of different viticultural and environmental factors on MP accumulation.
Supplementary Figure S2 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633117
Abstract: Correlation tables of our criteria. Bottom left are spearman coefficients, top right are Phi_K coefficients.
A methyltransferase essential for the methoxypyrazine‐derived flavour of wine
Publisher: Wiley
Date: 21-05-2013
DOI: 10.1111/TPJ.12224
Abstract: Methoxypyrazines are a family of potent volatile compounds of erse biological significance. They are used by insects and plants in chemical defence, are present in many vegetables and fruit and, in particular, impart herbaceous/green/vegetal sensory attributes to wines of certain varieties, including Cabernet Sauvignon. While pathways for methoxypyrazine biosynthesis have been postulated, none of the steps have been confirmed genetically. We have used the F2 progeny of a cross between a rapid flowering grapevine dwarf mutant, which does not produce 3-isobutyl-2-methoxypyrazine (IBMP), and Cabernet Sauvignon to identify the major locus responsible for accumulation of IBMP in unripe grape berries. Two candidate methyltransferase genes within the locus were identified and one was significantly associated with berry IBMP levels using association mapping. The enzyme encoded by this gene (VvOMT3) has high affinity for hydroxypyrazine precursors of methoxypyrazines. The gene is not expressed in the fruit of Pinot varieties, which lack IBMP, but is expressed in Cabernet Sauvignon at the time of accumulation of IBMP in the fruit. The results suggest that VvOMT3 is responsible for the final step in methoxypyrazine synthesis in grape berries and is the major determinant of IBMP production.
Shaping for PET image analysis
Publisher: Elsevier BV
Date: 03-2020
Data from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.C.6533077.V1
Abstract: AbstractPurpose: The objective of the study is to propose the immunotherapy progression decision (iPD) score, a practical tool based on patient features that are available at the first evaluation of immunotherapy treatment, to help oncologists decide whether to continue the treatment or switch rapidly to another therapeutic line when facing a progressive disease patient at the first evaluation. Experimental Design: This retrospective study included 107 patients with progressive disease at first evaluation according to RECIST 1.1. Clinical, radiological, and biological data at baseline and first evaluation were analyzed. An external validation set consisting of 31 patients with similar baseline characteristics was used for the validation of the score. Results: Variables were analyzed in a univariate study. The iPD score was constructed using only independent variables, each considered as a worsening factor for the survival of patients. The patients were stratified in three groups: good prognosis (GP), poor prognosis (PP), and critical prognosis (CP). Each group showed significantly different survivals (GP: 11.4, PP: 4.4, CP: 2.3 months median overall survival, i P /i 0.001, log-rank test). Moreover, the iPD score was able to detect the pseudoprogressors better than other scores. On the validation set, CP patients had significantly worse survival than PP and GP patients ( i P /i 0.05, log-rank test). Conclusions: The iPD score provides oncologists with a new evaluation, computable at first progression, to decide whether treatment should be continued (for the GP group), or immediately changed for the PP and CP groups. Further validation on larger cohorts is needed to prove its efficacy in clinical practice. /
Data from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.C.6533077.V2
Abstract: AbstractPurpose: The objective of the study is to propose the immunotherapy progression decision (iPD) score, a practical tool based on patient features that are available at the first evaluation of immunotherapy treatment, to help oncologists decide whether to continue the treatment or switch rapidly to another therapeutic line when facing a progressive disease patient at the first evaluation. Experimental Design: This retrospective study included 107 patients with progressive disease at first evaluation according to RECIST 1.1. Clinical, radiological, and biological data at baseline and first evaluation were analyzed. An external validation set consisting of 31 patients with similar baseline characteristics was used for the validation of the score. Results: Variables were analyzed in a univariate study. The iPD score was constructed using only independent variables, each considered as a worsening factor for the survival of patients. The patients were stratified in three groups: good prognosis (GP), poor prognosis (PP), and critical prognosis (CP). Each group showed significantly different survivals (GP: 11.4, PP: 4.4, CP: 2.3 months median overall survival, i P /i 0.001, log-rank test). Moreover, the iPD score was able to detect the pseudoprogressors better than other scores. On the validation set, CP patients had significantly worse survival than PP and GP patients ( i P /i 0.05, log-rank test). Conclusions: The iPD score provides oncologists with a new evaluation, computable at first progression, to decide whether treatment should be continued (for the GP group), or immediately changed for the PP and CP groups. Further validation on larger cohorts is needed to prove its efficacy in clinical practice. /
The Production of Flavour & Aroma Compounds in Grape Berries
Publisher: Springer Netherlands
Date: 2009
Molecular Biology Of Anthocyanin Accumulation In Grape Berries
Publisher: Springer Netherlands
Date: 2009
Supplementary Figure S8 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633099.V1
Abstract: Effect of the removal of each criterion on the accuracy of a multinomial logistic regression fit to predict the category of each patient. The minimal losses are underlined, and the maximum are written in bold.
A grapevine TFL1 homologue can delay flowering and alter floral development when overexpressed in heterologous species
Publisher: CSIRO Publishing
Date: 2006
DOI: 10.1071/FP05191
Abstract: Grapevines (Vitis vinifera L.) have unusual plant architecture in that the shoot apical meristem produces both vegetative structures and primordia that are capable of forming inflorescences at regular intervals. These primordia are termed ‘uncommitted’ and differentiate into inflorescences or tendrils depending on the environment in which they are produced. To investigate the molecular relationship between tendrils and inflorescences and vine architecture, we cloned a TFL1 homologue from grapevine (VvTFL1). VvTFL1 is expressed in shoot apices early in latent bud development and in buds soon after bud burst. The grapevine homologue of LEAFY, VFL, is expressed at the same stages as VvTFL1 as well as in the later stages of inflorescence development. Neither VvTFL1 nor VFL were detected in tendrils. VvTFL1 was overexpressed in tobacco and Arabidopsis to confirm that it was functionally similar to TFL1 and not the close homologue FT. Flowering was delayed significantly in tobacco and Arabidopsis transformants overexpressing VvTFL1. However, an unexpected phenotype was observed in some of the transgenic Arabidopsis lines where the floral meristem became indeterminate and a new inflorescence would emerge from within the developing silique. Our findings suggest that VvTFL1 is a repressor of floral development. The nucleotide sequence reported in this paper has been submitted to GenBank under the accession number AF378127 (VvTFL1).
Potential grape-derived contributions to volatile ester concentrations in wine
Publisher: MDPI AG
Date: 29-04-2015
Supplementary Figure S10 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633120
Abstract: Log hazard ratios (HR) computed by cox model. The variables studied were: GRIm, RMH, NLR BL & the iPD score. The only significant variable was the iPD score (HR = 2, p 0.005).
Supplementary Figure S1 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633123
Abstract: Distribution of primary cancer types in the development set (n=107).
Effect of grape heterogeneity on wine chemical composition and sensory attributes for Vitis vinifera cv. Cabernet Sauvignon
Publisher: Hindawi Limited
Date: 06-12-2021
DOI: 10.1111/AJGW.12469
Prediction of wine sensory properties using mid-infrared spectra of Cabernet Sauvignon and Chardonnay grape berries and wines
Publisher: Elsevier BV
Date: 05-2021
New insights into grapevine flowering
Publisher: CSIRO Publishing
Date: 2003
DOI: 10.1071/FP02112
Abstract: The study of grapevine (Vitis spp.) flowering has unique challenges owing to the unique shoot architecture of the plant and the arrest of the flowering process during winter. The grapevine flowering process: inflorescence number per vine, flower number per inflorescence, fruit set and growth has a major impact on fruitfulness (berries per hectare) and hence yield. This review brings together past research into the biology and physiology of grapevine flowering with recent investigations of genes involved in flowering. Genes involved in floral induction and inhibition by gibberellins (GA insensitive), meristem identity (LEAFY, TERMINAL FLOWER1) and organ identity (MADS-box genes) are discussed. An understanding of the function of key genes controlling the development of uncommitted primordia, floral induction and development, and fruit set in grapevine will provide new opportunities for improving vineyard fruitfulness. Understanding the grapevine floral genetic network will also offer insight into the different evolutionary strategies employed by plants to ensure reproduction.
Anthocyanin composition and anthocyanin pathway gene expression in grapevine sports differing in berry skin colour
Publisher: Hindawi Limited
Date: 10-1996
FUNCTIONAL CHARACTERIZATION OF TERPENE SYNTHASES OF 'AROMATIC' AND 'NON-AROMATIC' GRAPEVINE CULTIVARS
Publisher: International Society for Horticultural Science (ISHS)
Date: 07-2014
Acyl substrate preferences of an IAA-amido synthetase account for variations in grape (Vitis vinifera L.) berry ripening caused by different auxinic compounds indicating the importance of auxin conjugation in plant development
Publisher: Oxford University Press (OUP)
Date: 04-05-2011
DOI: 10.1093/JXB/ERR134
Evolution of Volatile Compounds during the Development of Cabernet Sauvignon Grapes (Vitis vinifera L.)
Publisher: American Chemical Society (ACS)
Date: 23-03-2009
DOI: 10.1021/JF803471N
Abstract: The evolution of volatile compounds was explored in grape berries at fortnightly intervals from fruit-set to late ripening to identify when biosynthetic pathways may be targeted for enhancement of grape and wine aroma. Stepwise linear discriminant analysis (SLDA) fully recognized patterns in berry physiological developmental stages with most of the variance (>99.0%) explained. The preveraison berry developmental stage was identified as a transition stage for volatile compound biosynthesis when most compounds were potentially sequestered to nonvolatile conjugates and berries lost their potential to synthesize esters and terpenes. Terpenes (predominantly eucalyptol, beta-caryophyllene, and alpha-humulene) characterized early berry development, whereas benzene derivatives (2-phenylethanol and 2-phenylethanal) appeared toward late ripening. Furthermore, C(6) volatile compounds changed from acetate esters to aldehydes and finally to alcohols during early, middle, and late berry developmental stages, respectively. The dominance of alcohols in the late stages of berry development, preceded by aldehydes, offers an opportunity for alcohols to aldehydes ratios to be used in the prediction of harvest timing for enhanced grape and wine aroma. The evolution of volatile compounds during berry development suggests a greater dependency on enzyme activity and specificity than extent of fatty acid unsaturation. The dependence of the stage of berry development on the accumulation of the products of alcohol dehydrogenase (ADH), alcohol acetyl transferase (AAT), and enal isomerase enzyme activity from the lipoxygenase pathway raises possibilities for the manipulation of aroma profiles in grapes and wines.
Prediction of Early Response to Immunotherapy: DCE-US as a New Biomarker
Publisher: MDPI AG
Date: 04-03-2022
Abstract: Purpose: The objective of our study is to propose fast, cost-effective, convenient, and effective biomarkers using the perfusion parameters from dynamic contrast-enhanced ultrasound (DCE-US) for the evaluation of immune checkpoint inhibitors (ICI) early response. Methods: The retrospective cohort used in this study included 63 patients with metastatic cancer eligible for immunotherapy. DCE-US was performed at baseline, day 8 (D8), and day 21 (D21) after treatment onset. A tumor perfusion curve was modeled on these three dates, and change in the seven perfusion parameters was measured between baseline, D8, and D21. These perfusion parameters were studied to show the impact of their variation on the overall survival (OS). Results: After the removal of missing or suboptimal DCE-US, the Baseline-D8, the Baseline-D21, and the D8-D21 groups included 37, 53, and 33 patients, respectively. A decrease of more than 45% in the area under the perfusion curve (AUC) between baseline and D21 was significantly associated with better OS (p = 0.0114). A decrease of any amount in the AUC between D8 and D21 was also significantly associated with better OS (p = 0.0370). Conclusion: AUC from DCE-US looks to be a promising new biomarker for fast, effective, and convenient immunotherapy response evaluation.
Changes in the Volatile Compound Production of Fermentations Made from Musts with Increasing Grape Content
Publisher: American Chemical Society (ACS)
Date: 27-01-2010
DOI: 10.1021/JF9023646
Abstract: Wine is a complex consumer product produced predominately by the action of yeast upon grape juice. Model must systems have proven to be ideal for studies into the effects of fermentation conditions on the production of certain wine volatiles. To clarify the contribution of grape juice to the production of wine volatiles, we have employed a model must system spiked with increasing amounts of grape juice (Riesling or Cabernet Sauvignon). The resulting fermented wines were analyzed by SPME-GC-MS and the data obtained grouped using ANOVA and cluster analyses to reveal those compounds that varied in concentration with reproducible trends relative to juice concentration. Such grouping highlights those compounds that are grape-dependent or for which production is modulated by grape composition. In some cases, increasing the proportion of grape juice in the fermentations stimulated the production of certain esters to levels between 2- and 140-fold higher than those seen in fermentations made with model grape juice media alone. The identification of the grape components responsible for the increased production of these wine volatiles will have implications for the impact of grape production and enology on wine flavor and aroma.
Induction of secondary metabolism in grape cell cultures by jasmonates
Publisher: CSIRO Publishing
Date: 2009
DOI: 10.1071/FP08280
Abstract: The use of a genetic approach to study the biosynthetic pathways leading to the production of secondary metabolites in grapes is difficult given the long generation times and difficulty in transforming this species. In the present study, GC/MS and microarray experiments were used to identify compounds produced in grape cell cultures in response to jasmonates and to examine the expression of genes from pathways that produce these secondary metabolites. Methyl jasmonate (MeJA) and jasmonic acid (JA) treatments resulted in the production of at least 25 compounds with sesquiterpene-like mass spectra in the cell cultures. A significantly greater amount of proanthocyanidins was produced in the MeJA-treated cell cultures compared with controls and stilbene biosynthesis was induced in both MeJA- and JA-treated cells. Salicylic acid (SA) suppressed the MeJA-associated increase in sesquiterpenes and proanthocyanidins, but SA did not suppress the stilbene production induced by MeJA treatment. The mechanism by which jasmonates induced secondary metabolite production in cultured grape cells varied depending on the pathway. The increased production of proanthocyanidins and stilbenes was associated with the induction of all of the genes in associated biosynthesis pathways, including those involved in the production of phenylalanine, whereas increased sesquiterpene synthesis was linked to the induction of certain genes from relevant biosynthesis pathways.
A deep learning model for the diagnosis of sacroiliitis according to Assessment of SpondyloArthritis International Society classification criteria with magnetic resonance imaging
Publisher: Elsevier BV
Date: 07-2023
Use of Machine Learning with Fused Spectral Data for Prediction of Product Sensory Characteristics: The Case of Grape to Wine
Publisher: MDPI AG
Date: 09-02-2023
Abstract: Generations of sensors have been developed for predicting food sensory profiles to circumvent the use of a human sensory panel, but a technology that can rapidly predict a suite of sensory attributes from one spectral measurement remains unavailable. Using spectra from grape extracts, this novel study aimed to address this challenge by exploring the use of a machine learning algorithm, extreme gradient boosting (XGBoost), to predict twenty-two wine sensory attribute scores from five sensory stimuli: aroma, colour, taste, flavour, and mouthfeel. Two datasets were obtained from absorbance-transmission and fluorescence excitation-emission matrix (A-TEEM) spectroscopy with different fusion methods: variable-level data fusion of absorbance and fluorescence spectral fingerprints, and feature-level data fusion of A-TEEM and CIELAB datasets. The results for externally validated models showed slightly better performance using only A-TEEM data, predicting five out of twenty-two wine sensory attributes with R2 values above 0.7 and fifteen with R2 values above 0.5. Considering the complex biotransformation involved in processing grapes to wine, the ability to predict sensory properties based on underlying chemical composition in this way suggests that the approach could be more broadly applicable to the agri-food sector and other transformed foodstuffs to predict a product’s sensory characteristics from raw material spectral attributes.
Comparison of consecutive harvests versus blending treatments to produce lower alcohol wines from Cabernet Sauvignon grapes: Impact on wine volatile composition and sensory properties
Publisher: Elsevier BV
Date: 09-2018
DOI: 10.1016/J.FOODCHEM.2018.03.118
Abstract: This study extends previous work on Cabernet Sauvignon wines of lowered alcohol concentrations produced by pre-fermentatively substituting proportions of juice from an overripe crop with "green harvest wine" or water to adjust initial sugar concentrations. Resulting wines were assessed for their volatile compositions and sensory characteristics to evaluate the suitability of this winemaking approach to managing wine alcohol concentrations in warm viticulture regions. Wines from water or green harvest wine substitution were also compared to wines of similar alcohol content produced from earlier harvested grapes. Implementation of water substitution in particular resulted in minor alterations of wine volatile composition compared to the control, and positive aroma and flavour characteristics were preserved. However, overripe sensory attributes such as 'hotness' and 'port wine' were conserved whereas they were absent in wines of similar alcohol level made from earlier harvested grapes, thereby emphasising the relevance of grape (over)maturity when producing lower alcohol wines.
Using Separated Inputs for Multimodal Brain Tumor Segmentation with 3D U-Net-like Architectures
Publisher: Springer International Publishing
Date: 2020
Generation of Patient-Specific Cardiac Vascular Networks: A Hybrid Image-Based and Synthetic Geometric Model
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2019
Supplementary Figure S9 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489963
Abstract: Survival of pseudo-PD vs confirmed PD in our cohort.
Myocardial Perfusion Simulation for Coronary Artery Disease: A Coupled Patient-Specific Multiscale Model
Publisher: Springer Science and Business Media LLC
Date: 12-2020
DOI: 10.1007/S10439-020-02681-Z
Abstract: Patient-specific models of blood flow are being used clinically to diagnose and plan treatment for coronary artery disease. A remaining challenge is bridging scales from flow in arteries to the micro-circulation supplying the myocardium. Previously proposed models are descriptive rather than predictive and have not been applied to human data. The goal here is to develop a multiscale patient-specific model enabling blood flow simulation from large coronary arteries to myocardial tissue. Patient vasculatures are segmented from coronary computed tomography angiography data and extended from the image-based model down to the arteriole level using a space-filling forest of synthetic trees. Blood flow is modeled by coupling a 1D model of the coronary arteries to a single-compartment Darcy myocardium model. Simulated results on five patients with non-obstructive coronary artery disease compare overall well to [ $$^{15}$$ 15 O] $$\\text {H}_{{2}}$$ H 2 O PET exam data for both resting and hyperemic conditions. Results on a patient with severe obstructive disease link coronary artery narrowing with impaired myocardial blood flow, demonstrating the model’s ability to predict myocardial regions with perfusion deficit. This is the first report of a computational model for simulating blood flow from the epicardial coronary arteries to the left ventricle myocardium applied to and validated on human data.
Supplementary Figure S8 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489966
Abstract: Effect of the removal of each criterion on the accuracy of a multinomial logistic regression fit to predict the category of each patient. The minimal losses are underlined, and the maximum are written in bold.
Linking the sensory properties of chardonnay grape Vitis vinifera cv. Berries to wine characteristics
Publisher: American Society for Enology and Viticulture
Date: 15-12-2018
Influence of Magnetic Field Strength on Magnetic Resonance Imaging Radiomics Features in Brain Imaging, an In Vitro and In Vivo Study
Publisher: Frontiers Media SA
Date: 20-01-2021
Abstract: The development and clinical adoption of quantitative imaging biomarkers (radiomics) has established the need for the identification of parameters altering radiomics reproducibility. The aim of this study was to assess the impact of magnetic field strength on magnetic resonance imaging (MRI) radiomics features in neuroradiology clinical practice. T1 3D SPGR sequence was acquired on two phantoms and 10 healthy volunteers with two clinical MR devices from the same manufacturer using two different magnetic fields (1.5 and 3T). Phantoms varied in terms of gadolinium concentrations and textural heterogeneity. 27 regions of interest were segmented (phantom: 21, volunteers: 6) using the LIFEX software. 34 features were analyzed. In the phantom dataset, 10 (67%) out of 15 radiomics features were significantly different when measured at 1.5T or 3T (student’s t-test, p & 0.05). Gray levels res ling, and pixel size also influence part of texture features. These findings were validated in healthy volunteers. According to daily used protocols for clinical examinations, radiomic features extracted on 1.5T should not be used interchangeably with 3T when evaluating texture features. Such confounding factor should be adjusted when adapting the results of a study to a different platform, or when designing a multicentric trial.
Influence of Production Method on the Chemical Composition, Foaming Properties, and Quality of Australian Carbonated and Sparkling White Wines
Publisher: American Chemical Society (ACS)
Date: 13-02-2017
Abstract: The chemical composition (protein, polysaccharide, amino acid, and fatty acid/ethyl ester content), foaming properties, and quality of 50 Australian sparkling white wines, representing the four key production methods, that is, Méthode Traditionelle (n = 20), transfer (n = 10), Charmat (n = 10), and carbonation (n = 10), were studied. Méthode Traditionelle wines were typically rated highest in quality and were higher in alcohol and protein contents, but lower in residual sugar and total phenolics, than other sparkling wines. They also exhibited higher foam volume and stability, which might be attributable to higher protein concentrations. Bottle-fermented Méthode Traditionelle and transfer wines contained greater proportions of yeast-derived mannoproteins, whereas Charmat and carbonated wines were higher in grape-derived rhamnogalacturonans however, total polysaccharide concentrations were not significantly different between sparkling wine styles. Free amino acids were most abundant in carbonated wines, which likely reflects production via primary fermentation only and/or the inclusion of nontraditional grape varieties. Fatty acids and their esters were not correlated with foaming properties, but octanoic and decanoic acids and their ethyl esters were present in Charmat and carbonated wines at significantly higher concentrations than in bottle-fermented wines and were negatively correlated with quality ratings. Research findings provide industry with a better understanding of the compositional factors driving the style and quality of sparkling white wine.
Sensory profiling and quality assessment of research Cabernet Sauvignon and Chardonnay wines; quality discrimination depends on greater differences in multiple modalities
Publisher: Elsevier BV
Date: 04-2018
Sequestration of auxin by the indole-3-acetic acid-amido synthetase GH3-1 in grape berry (Vitis vinifera L.) and the proposed role of auxin conjugation during ripening
Publisher: Oxford University Press (OUP)
Date: 25-06-2010
DOI: 10.1093/JXB/ERQ174
Abstract: In fleshy fruit, levels of indole-3-acetic acid (IAA), the most abundant auxin, decline towards the onset of ripening. The application of auxins to immature fruit can delay the ripening processes. However, the mechanisms by which the decrease in endogenous IAA concentrations and the maintenance of low auxin levels in maturing fruit are achieved remain elusive. The transcript of a GH3 gene (GH3-1), encoding for an IAA-amido synthetase which conjugates IAA to amino acids, was detected in grape berries (Vitis vinifera L.). GH3-1 expression increased at the onset of ripening (veraison), suggesting that it might be involved in the establishment and maintenance of low IAA concentrations in ripening berries. Furthermore, this grapevine GH3 gene, responded positively to the combined application of abscisic acid and sucrose and to ethylene, linking it to the control of ripening processes. Levels of IAA-aspartic acid (IAA-Asp), an in vitro product of recombinant GH3-1, rose after veraison and remained high during the following weeks of the ripening phase when levels of free IAA were low. A similar pattern of changes in free IAA and IAA-Asp levels was detected in developing tomatoes (Solanum lycopersicum Mill.), where low concentrations of IAA and an increase in IAA-Asp concentrations coincided with the onset of ripening in this climacteric fruit. Since IAA-Asp might be involved in IAA degradation, the GH3 catalysed formation of this conjugate at, and after, the onset of ripening could represent a common IAA inactivation mechanism in climacteric and non-climacteric fruit which enables ripening.
Transcriptional analysis of late ripening stages of grapevine berry
Publisher: Springer Science and Business Media LLC
Date: 18-11-2011
Abstract: The composition of grapevine berry at harvest is a major determinant of wine quality. Optimal oenological maturity of berries is characterized by a high sugar/acidity ratio, high anthocyanin content in the skin, and low astringency. However, harvest time is still mostly determined empirically, based on crude biochemical composition and berry tasting. In this context, it is interesting to identify genes that are expressed/repressed specifically at the late stages of ripening and which may be used as indicators of maturity. Whole bunches and berries sorted by density were collected in vineyard on Chardonnay (white cultivar) grapevines for two consecutive years at three stages of ripening (7-days before harvest (TH-7), harvest (TH), and 10-days after harvest (TH+10)). Microvinification and sensory analysis indicate that the quality of the wines made from the whole bunches collected at TH-7, TH and TH+10 differed, TH providing the highest quality wines. In parallel, gene expression was studied with Qiagen/Operon microarrays using two types of s les, i.e. whole bunches and berries sorted by density. Only 12 genes were consistently up- or down-regulated in whole bunches and density sorted berries for the two years studied in Chardonnay. 52 genes were differentially expressed between the TH-7 and TH s les. In order to determine whether these genes followed a similar pattern of expression during the late stages of berry ripening in a red cultivar, nine genes were selected for RT-PCR analysis with Cabernet Sauvignon grown under two different temperature regimes affecting the precocity of ripening. The expression profiles and their relationship to ripening were confirmed in Cabernet Sauvignon for seven genes, encoding a carotenoid cleavage dioxygenase, a galactinol synthase, a late embryogenesis abundant protein, a dirigent-like protein, a histidine kinase receptor, a valencene synthase and a putative S-adenosyl-L-methionine:salicylic acid carboxyl methyltransferase. This set of up- and down-regulated genes characterize the late stages of berry ripening in the two cultivars studied, and are indirectly linked to wine quality. They might be used directly or indirectly to design immunological, biochemical or molecular tools aimed at the determination of optimal ripening in these cultivars.
Jasmonic acid‐isoleucine formation in grapevine (Vitis vinifera L.) by two enzymes with distinct transcription profiles
Publisher: Wiley
Date: 12-02-2015
DOI: 10.1111/JIPB.12321
Abstract: The plant hormone jasmonic acid (JA) is essential for stress responses and the formation of reproductive organs, but its role in fruit development and ripening is unclear. Conjugation of JA to isoleucine is a crucial step in the JA signaling pathway since only JA-Ile is recognized by the jasmonate receptor. The conjugation reaction is catalyzed by JA-amido synthetases, belonging to the family of Gretchen Hagen3 (GH3) proteins. Here, in vitro studies of two grapevine (Vitis vinifera L. cv Shiraz) GH3 enzymes, VvGH3-7 and VvGH3-9, demonstrated JA-conjugating activities with an overlapping range of amino acid substrates, including isoleucine. Expression studies of the corresponding genes in grape berries combined with JA and JA-Ile measurements suggested a primary role for JA signaling in fruit set and cell ision and did not support an involvement of JA in the ripening process. In response to methyl JA (MeJA) treatment, and in wounded and unwounded (distal) leaves, VvGH3-9 transcripts accumulated, indicating a participation in the JA response. In contrast, VvGH3-7 was unresponsive to MeJA and local wounding, demonstrating a differential transcriptional regulation of VvGH3-7 and VvGH3-9. The transient induction of VvGH3-7 in unwounded, distal leaves was suggestive of the involvement of an unknown mobile wound signal.
Evaluation of indigenous non-Saccharomyces yeasts isolated from a South Australian vineyard for their potential as wine starter cultures
Publisher: Elsevier BV
Date: 2020
DOI: 10.1016/J.IJFOODMICRO.2019.108373
Abstract: The use of non-Saccharomyces yeast in conjunction with Saccharomyces cerevisiae in wine fermentation is a growing trend in the wine industry. Non-Saccharomyces, through their distinctive production of secondary metabolites, have the potential to positively contribute to wine sensory profile. To discover new candidate strains for development as starter cultures, indigenous non-Saccharomyces were isolated from un-inoculated fermenting Shiraz musts from a South Australian vineyard (McLaren Vale wine region) and characterised. Among the 77 isolates, 7 species belonging to 5 genera (Kazachstania, Aureobasidium, Meyerozyma, Wickerhamomyces and Torulaspora) were identified by sequencing the internal transcribed spacer regions of the 5.8S rRNA gene (ITS1-5.8S-ITS2 region). The indigenous isolates were evaluated for oenological properties, namely, ethanol tolerance, enzyme activity, and H
Cloning and characterisation of grapevine (Vitis vinifera L.) MADS-box genes expressed during inflorescence and berry development
Publisher: Elsevier BV
Date: 06-2002
An Elastica-Driven Digital Curve Evolution Model for Image Segmentation
Publisher: Springer Science and Business Media LLC
Date: 13-09-2020
Machine learning for classifying and predicting grape maturity indices using absorbance and fluorescence spectra
Publisher: Elsevier BV
Date: 03-2023
DOI: 10.1016/J.FOODCHEM.2022.134321
Abstract: Absorbance-transmission and fluorescence excitation-emission matrix (A-TEEM) spectroscopy was investigated as a rapid method for predicting maturity indices using Cabernet Sauvignon grapes produced under four viticulture treatments during two growing seasons. Machine learning models were developed with fused spectral data to predict 3-isobutyl-2-methoxypyrazine (IBMP), pH, total tannins (Tannin), total soluble solids (TSS), and malic and tartaric acids based on the results from traditional analysis methods. Extreme gradient boosting (XGB) regression yielded R
FLAVOUR BIOSYNTHESIS PATHWAYS IN GRAPE CELL CULTURES: SESQUITERPENES BIOSYNTHESIS
Publisher: International Society for Horticultural Science (ISHS)
Date: 05-2009
Various Influences of Harvest Date and Fruit Sugar Content on Different Wine Flavor and Aroma Compounds
Publisher: American Society for Enology and Viticulture
Date: 19-06-2014
Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 31-01-2023
DOI: 10.1158/1078-0432.CCR-22-0890
Abstract: The objective of the study is to propose the immunotherapy progression decision (iPD) score, a practical tool based on patient features that are available at the first evaluation of immunotherapy treatment, to help oncologists decide whether to continue the treatment or switch rapidly to another therapeutic line when facing a progressive disease patient at the first evaluation. This retrospective study included 107 patients with progressive disease at first evaluation according to RECIST 1.1. Clinical, radiological, and biological data at baseline and first evaluation were analyzed. An external validation set consisting of 31 patients with similar baseline characteristics was used for the validation of the score. Variables were analyzed in a univariate study. The iPD score was constructed using only independent variables, each considered as a worsening factor for the survival of patients. The patients were stratified in three groups: good prognosis (GP), poor prognosis (PP), and critical prognosis (CP). Each group showed significantly different survivals (GP: 11.4, PP: 4.4, CP: 2.3 months median overall survival, P & 0.001, log-rank test). Moreover, the iPD score was able to detect the pseudoprogressors better than other scores. On the validation set, CP patients had significantly worse survival than PP and GP patients (P & 0.05, log-rank test). The iPD score provides oncologists with a new evaluation, computable at first progression, to decide whether treatment should be continued (for the GP group), or immediately changed for the PP and CP groups. Further validation on larger cohorts is needed to prove its efficacy in clinical practice.
Delaying Riesling grape berry ripening with a synthetic auxin affects malic acid metabolism and sugar accumulation, and alters wine sensory characters
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/FP12132
Abstract: An improved understanding of the hormonal control of grape (Vitis vinifera L.) berry ripening and the ability to manipulate it are of interest scientifically and commercially. Grapes are nonclimacteric fruit with ethylene unlikely to have a principal role in berry ripening but there are several other hormones thought to be involved. In this work, a significant delay in Riesling berry ripening was achieved through preripening treatments with the synthetic auxin 1-naphthaleneacetic acid (NAA). The initiation of sugar accumulation was delayed and the rate of sugar accumulation was lower in NAA-treated fruit, resulting in a 15-day delay in harvest. NAA treatments also reduced the rate of decline in malic acid levels that occurs during ripening, and increased the synchronicity of malic acid and berry sugar accumulation. Sensory panel assessment revealed a significant difference between wine made from control and NAA-treated fruit. Analysis of the volatile composition of the wines’ headspace showed that the concentration of several compounds was altered significantly by the NAA treatment. These data provide further support for the involvement of auxins in inhibiting ripening and suggest that auxin treatments may be useful in controlling both winery intake, and fruit and wine composition.
Supplementary Figure S6 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489972.V1
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones.
Shiraz (Vitis vinifera L.) Berry and Wine Sensory Profiles and Composition Are Modulated by Rootstocks
Publisher: American Society for Enology and Viticulture
Date: 07-09-2017
Does Super-Resolution Improve OCR Performance In The Real World? A Case Study On Images Of Receipts
Publisher: IEEE
Date: 10-2020
Understanding the control of grape berry ripening and developing opportunities for its manipulation
Publisher: International Society for Horticultural Science (ISHS)
Date: 04-2017
Object Detection With Component-Graphs in Multi-Band Images: Application to Source Detection in Astronomical Images
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Data from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.C.6533077
Abstract: AbstractPurpose: The objective of the study is to propose the immunotherapy progression decision (iPD) score, a practical tool based on patient features that are available at the first evaluation of immunotherapy treatment, to help oncologists decide whether to continue the treatment or switch rapidly to another therapeutic line when facing a progressive disease patient at the first evaluation. Experimental Design: This retrospective study included 107 patients with progressive disease at first evaluation according to RECIST 1.1. Clinical, radiological, and biological data at baseline and first evaluation were analyzed. An external validation set consisting of 31 patients with similar baseline characteristics was used for the validation of the score. Results: Variables were analyzed in a univariate study. The iPD score was constructed using only independent variables, each considered as a worsening factor for the survival of patients. The patients were stratified in three groups: good prognosis (GP), poor prognosis (PP), and critical prognosis (CP). Each group showed significantly different survivals (GP: 11.4, PP: 4.4, CP: 2.3 months median overall survival, i P /i 0.001, log-rank test). Moreover, the iPD score was able to detect the pseudoprogressors better than other scores. On the validation set, CP patients had significantly worse survival than PP and GP patients ( i P /i 0.05, log-rank test). Conclusions: The iPD score provides oncologists with a new evaluation, computable at first progression, to decide whether treatment should be continued (for the GP group), or immediately changed for the PP and CP groups. Further validation on larger cohorts is needed to prove its efficacy in clinical practice. /
Supplementary Figure S7 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633102
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones
Influence of yeast strain, canopy management, and site on the volatile composition and sensory attributes of cabernet sauvignon wines from Western Australia
Publisher: American Chemical Society (ACS)
Date: 03-03-2011
DOI: 10.1021/JF104324D
Abstract: Understanding what factors are the major influences on wine composition will assist in the successful management of grape composition in the vineyard and/or variables in the winery to produce wines with specific sensory attributes. A recently developed analytical method [headspace solid-phase microextraction comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry] was employed to analyze over 350 volatile compounds in research scale wines and was combined with descriptive sensory analysis. Both compositional and sensory results showed significant differences among the wines, and in many cases, multiple factors influenced the abundance of wine volatile compounds. Site had the most significant influence on sensory scores and wine composition, followed by canopy management. Unexpectedly, yeast strain had no significant sensory effect despite the fact that a number of volatile compounds were significantly different in the wines made from different strains. PLS analysis, combining the sensory and chemical analyses, also supports the concept of volatile compound interactions contributing to the aroma characteristics of Cabernet Sauvignon wine.
Supplementary Figure S8 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 04-2023
DOI: 10.1158/1078-0432.22489966.V1
Abstract: Effect of the removal of each criterion on the accuracy of a multinomial logistic regression fit to predict the category of each patient. The minimal losses are underlined, and the maximum are written in bold.
Supplementary Figure S6 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633105
Abstract: InterpretML Overall Importance using Explainable Boosting Machines (EBM). The mean absolute score reflects the overall importance assigned by the model to predict each patient's category. All features appear important, with the number of organs affected by metastasis and the emergence of new lesions as the most important ones.
Multiple pathways in the decision to flower: Enabling, promoting, and resetting
Publisher: Oxford University Press (OUP)
Date: 12-03-2004
DOI: 10.1105/TPC.015958
Rare bioparticle detection via deep metric learning
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1RA02869C
Abstract: Conventional deep neural networks use simple classifiers to obtain highly accurate results. However, they have limitations in practical applications. This study demonstrates a robust deep metric neural network model for rare bioparticle detection.
Clinical validation of a computer‐based approach for the quantification of the skin ageing process of women using in vivo confocal microscopy
Publisher: Wiley
Date: 05-08-2020
DOI: 10.1111/JDV.16810
Supplementary Figure S5 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/1078-0432.22633108
Abstract: Radiological feature impact on survival. Radiological features include progression of target lesions 20%, progression of non-target lesions 50% and the emergence of new lesions.
IDENTIFICATION OF AN R2R3 MYB TRANSCRIPTION FACTOR INVOLVED IN THE REGULATION OF THE STILBENE SYNTHASE PATHWAY IN GRAPEVINE
Publisher: International Society for Horticultural Science (ISHS)
Date: 07-2014
Fermentation of grapes throughout development identifies stages critical to the development of wine volatile composition
Publisher: Hindawi Limited
Date: 07-07-2018
DOI: 10.1111/AJGW.12296
Analysis of the Expression of Anthocyanin Pathway Genes in Developing Vitis vinifera L. cv Shiraz Grape Berries and the Implications for Pathway Regulation
Publisher: Oxford University Press (OUP)
Date: 08-1996
Abstract: Anthocyanin synthesis in Vitis vinifera L. cv Shiraz grape berries began 10 weeks postflowering and continued throughout berry ripening. Expression of seven genes of the anthocyanin biosynthetic pathway (phenylalanine ammonia lyase [PAL], chalcone synthase [CHS], chalcone isomerase [CHI], flavanone-3-hydroxylase [F3H], dihydroflavonol 4-reductase [DFR], leucoanthocyanidin dioxygen-ase [LDOX], and UDP glucose-flavonoid 3-o-glucosyl transferase [UFGT]) was determined. In flowers and grape berry skins, expression of all of the genes, except UFGT, was detected up to 4 weeks postflowering, followed by a reduction in this expression 6 to 8 weeks postflowering. Expression of CHS, CHI, F3H, DFR, LDOX, and UFGT then increased 10 weeks postflowering, coinciding with the onset of anthocyanin synthesis. In grape berry flesh, no PAL or UFGT expression was detected at any stage of development, but CHS, CHI, F3H, DFR, and LDOX were expressed up to 4 weeks postflowering. These results indicate that the onset of anthocyanin synthesis in ripening grape berry skins coincides with a coordinated increase in expression of a number of genes in the anthocyanin biosynthetic pathway, suggesting the involvement of regulatory genes. UFGT is regulated independently of the other genes, suggesting that in grapes the major control point in this pathway is later than that observed in maize, petunia, and snapdragon.
A grapevine anthocyanin acyltransferase, transcriptionally regulated by VvMYBA, can produce most acylated anthocyanins present in grape skins
Publisher: Oxford University Press (OUP)
Date: 22-09-2015
DOI: 10.1104/PP.15.01255
Homotopic Affine Transformations in the 2D Cartesian Grid
Publisher: Springer Science and Business Media LLC
Date: 02-06-2022
Unripe Berries and Petioles in Vitis vinifera cv. Cabernet Sauvignon Fermentations Affect Sensory and Chemical Profiles
Publisher: American Society for Enology and Viticulture
Date: 06-08-2015
Molecular Biology of Sugar and Anthocyanin Accumulation in Grape Berries
Publisher: Springer Netherlands
Date: 2001
Efficient Position Estimation of 3D Fluorescent Spherical Beads in Confocal Microscopy via Poisson Denoising
Publisher: Springer Science and Business Media LLC
Date: 19-11-2020
DOI: 10.1007/S10851-020-00994-1
Abstract: Particle estimation is a classical problem arising in many science fields, such as biophysics, fluid mechanics and biomedical imaging. Many interesting applications in these areas involve 3D imaging data: This work presents a technique to estimate the 3D coordinates of the center of spherical particles. This procedure has its core in the processing of the images of the scanned volume: It firstly applies denoising techniques to each frame of the scanned volume and then provides an estimation of both the center and the profile of the 2D intersections of the particles with the frames, by coupling the usage of Total Variation functional and of a regularized weighted Least Squares fit. Then, the 2D information is used to retrieve the 3D coordinates using geometrical properties. The experiments provide evidence that image denoising has a large impact on the performance of the particle tracking procedures, since they strongly depend on the quality of the initial acquisition. This work shows that the choice of tailored image denoising technique for Poisson noise leads to a better estimation of the particle positions.
Related Organisations
Massachusetts Institute Of Technology
Location: United States of America
Commonwealth Scientific And Industrial Research Organisation
Location: Australia
Related Funding Activities
Discovery Projects - Grant ID: DP0985378
Start Date: 2009
End Date: 12-2010
Amount: $100,000.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Training Centres - Grant ID: IC170100008
Start Date: 02-2018
End Date: 12-2024
Amount: $4,459,672.00
Funder: Australian Research Council
View Funded Activity