John Justin Gooding

Should There Be Minimum Information Reporting Standards for Sensors?

Publisher: American Chemical Society (ACS)

Date: 27-10-2017

DOI: 10.1021/ACSSENSORS.7B00737

Enzymatic synthesis of redox-labeled RNA and dual-potential detection at DNA-modified electrodes

Publisher: Wiley

Date: 12-05-2004

DOI: 10.1002/ANIE.200352977

Mesoporous silicon photonic crystal microparticles: Towards single-cell optical biosensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2011

DOI: 10.1039/C005340F

Nanoparticle mediated electron transfer across organic layers: From current understanding to applications

Publisher: Sociedade Brasileira de Quimica (SBQ)

Date: 2014

DOI: 10.5935/0103-5053.20130306

Happy 5th Anniversary for

Publisher: American Chemical Society (ACS)

Date: 24-01-2020

DOI: 10.1021/ACSSENSORS.0C00023

Electrochemical behavior of gold colloidal alkyl modified silicon surfaces

Publisher: American Chemical Society (ACS)

Date: 21-10-2009

DOI: 10.1021/AM900427W

Abstract: Herein, we report on the production of nanoelectrode arrays by attaching colloidal gold on silicon-bound mixed self-assembled monolayers of TFA-protected alkenylthiol (C(11)-S-TFA) and undecylenic acid (acid). Effective modification of the surface, tethering of the nanoparticles, and the direct influence of the deprotected alkenylthiol (C(11)-SH) /acid ratio on the number of adherent particles were demonstrated using X-ray photoelectron spectroscopy, electrochemistry, and atomic force microscopy. Cyclic voltammetry showed that the enhancement of electron transfer to the silicon surface by the presence of nanoparticles is influenced by the number of tethered nanoparticles.

Electrodeposited polytyramine as an immobilisation matrix for enzyme biosensors

Publisher: Elsevier BV

Date: 10-1998

DOI: 10.1016/S0956-5663(98)00033-5

Abstract: The application of an electrodeposited polytyramine film as an immobilisation matrix for the construction of enzyme biosensors is described. Glucose oxidase (used as a model enzyme) is covalently attached to free amine groups on the polytyramine film using the coupling reagents 1-ethyl-3(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide. The resultant recognition interface consisted of multilayers of GOx immobilised onto the polymer surface. This method of constructing enzyme biosensors is shown to produce a highly reproducible and stable device. The biosensor showed no loss in electrode response after four months of dry storage and exhibited only minor loss in response after 20 days of repeated use. The resultant biosensor had a linear range of 0.1-28 mM glucose and a detection limit of 0.01 mM.

Metal–Organic Framework-Enhanced Solid-Phase Microextraction Mass Spectrometry for the Direct and Rapid Detection of Perfluorooctanoic Acid in Environmental Water Samples

Publisher: American Chemical Society (ACS)

Date: 24-04-2020

DOI: 10.1021/ACS.ANALCHEM.9B05524

The Influence of Nanoconfinement on Electrocatalysis

Publisher: Wiley

Date: 31-05-2022

DOI: 10.1002/ANIE.202200755

Abstract: The use of nanoparticles and nanostructured electrodes are abundant in electrocatalysis. These nanometric systems contain elements of nanoconfinement in different degrees, depending on the geometry, which can have a much greater effect on the activity and selectivity than often considered. In this Review, we firstly identify the systems containing different degrees of nanoconfinement and how they can affect the activity and selectivity of electrocatalytic reactions. Then we follow with a fundamental understanding of how electrochemistry and electrocatalysis are affected by nanoconfinement, which is beginning to be uncovered, thanks to the development of new, atomically precise manufacturing and fabrication techniques as well as advances in theoretical modeling. The aim of this Review is to help us look beyond using nanostructuring as just a way to increase surface area, but also as a way to break the scaling relations imposed on electrocatalysis by thermodynamics.

Monitoring the heterogeneity in single cell responses to drugs using electrochemical impedance and electrochemical noise

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D0SC05489E

Abstract: A light addressable single-cell impedance technique for cell adhesion monitoring and measurement of a cell's drug response based on electrochemical noise is introduced.

Switching “on and off” faradaic electrochemistry at an otherwise passivated electrode using gold-coated magnetic nanoparticles

Publisher: Elsevier BV

Date: 12-2015

DOI: 10.1016/J.ELECOM.2015.10.012

Protein sensors based on reversible π–π stacking on basal plane HOPG electrodes

Publisher: Springer Science and Business Media LLC

Date: 20-08-2014

DOI: 10.1007/S10008-014-2606-9

Surface-bound norbornylogous bridges as molecular rulers for investigating interfacial electrochemistry and as single molecule switches

Publisher: American Chemical Society (ACS)

Date: 28-10-2014

DOI: 10.1021/AR400127G

Abstract: Electron transfer (ET) reactions through molecules attached to surfaces, whether they are through single molecules or ensembles, are the subject of much research in molecular electronics, bioelectronics, and electrochemistry. Therefore, understanding the factors that govern ET is of high importance. The availability of rigid hydrocarbon molecular scaffolds possessing well-defined configurations and lengths that can be systematically varied is crucial to the development of such devices. In this Account, we demonstrate how suitably functionalized norbornylogous (NB) systems can provide important insights into interfacial ET processes and electrical conduction through single molecules. To this end, we created NB bridges with vic-trans-bismethylenethiol groups at one end so they can assemble on gold electrodes and redox species at the distal ends. With these in hand, we then formed mixed self-assembled monolayers (SAMs) containing a small proportion of the NB bridges diluted with alkanethiols. As such, the NB bridges served as molecular rulers for probing the environment above the surface defined by the diluent species. Using this construct, we were able to measure the interfacial potential distribution above the diluent surface, and track how variation in the ionic distribution in the electrical double layer impacts ET kinetics. Using the same construct, but with a redox molecule that remains neutral in both oxidized and reduced states, we could explore the impact of the chemical environment near a surface on ET processes. These results are important, because with conventional surface constructs, ET occurs across this interfacial region. Such knowledge is therefore relevant to the design of molecular systems at surfaces involving ET. With a second family of molecules, we investigated aspects of single-molecule electrical conduction using NB bridges bearing vic-trans-bismethylenethiol groups at both ends of the bridge. This gave us insights into distance-dependent electron transport through single molecules and introduced a method of boosting the conductance of saturated molecules by incorporating aromatic moieties in their backbone. These partially conjugated NB molecules represent a new class of molecular wires with far greater stability than conventional completely conjugated molecular wires. Of particular note was our demonstration of a single molecule switch, using a NB bridge containing an embedded anthraquinone redox group, the switching mechanism being via electrochemically controlled quantum interference.

Aryldiazonium salt derived mixed organic layers: From surface chemistry to their applications

Publisher: Elsevier BV

Date: 2017

DOI: 10.1016/J.JELECHEM.2016.11.043

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSANM.0C01653

The Influence of Graphene on the Electrical Communication Through Organic Layers on Graphite and Gold Electrodes

Publisher: Wiley

Date: 20-09-2014

DOI: 10.1002/ELAN.201300246

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.ESTLETT.0C00316

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JOC.0C01426

ACS Sensors Has Two New Editors

Publisher: American Chemical Society (ACS)

Date: 25-03-2022

DOI: 10.1021/ACSSENSORS.2C00453

Role of Surface Capping Molecule Polarity on the Optical Properties of Solution Synthesized Germanium Nanocrystals

Publisher: American Chemical Society (ACS)

Date: 07-06-2017

DOI: 10.1021/ACS.LANGMUIR.7B01028

Abstract: The role surface capping molecules play in dictating the optical properties of semiconductor nanocrystals (NCs) is becoming increasingly evident. In this paper the role of surface capping molecule polarity on the optical properties of germanium NCs (Ge NCs) is explored. Capping molecules are split into two groups: nonpolar and polar. The NCs are fully characterized structurally and optically to establish the link between observed optical properties and surface capping molecules. Ge NC optical properties altered by surface capping molecule polarity include emission maximum, emission lifetime, quantum yield, and Stokes shift. For Ge NCs, this work also allows rational tuning of their optical properties through changes to surface capping molecule polarity, leading to improvements in emerging Ge based bioimaging and optoelectronic devices.

Emerging Investigators Special Issue

Publisher: Royal Society of Chemistry (RSC)

Date: 2006

DOI: 10.1039/B600451M

Self‐Propelled Initiative Collision at Microelectrodes with Vertically Mobile Micromotors

Publisher: Wiley

Date: 25-08-2022

DOI: 10.1002/ANGE.202209747

Abstract: Impact experiments enable single particle analysis for many applications. However, the effect of the trajectory of a particle to an electrode on impact signals still requires further exploration. Here, we investigate the particle impact measurements versus motion using micromotors with controllable vertical motion. With biocatalytic cascade reactions, the micromotor system utilizes buoyancy as the driving force, thus enabling more regulated interactions with the electrode. With the aid of numerical simulations, the dynamic interactions between the electrode and micromotors are categorized into four representative patterns: approaching, departing, approaching‐and‐departing, and departing‐and‐reapproaching, which correspond well with the experimentally observed impact signals. This study offers a possibility of exploring the dynamic interactions between the electrode and particles, shedding light on the design of new electrochemical sensors.

Towards single molecule biosensors using super-resolution fluorescence microscopy

Publisher: Elsevier BV

Date: 07-2016

DOI: 10.1016/J.BIOS.2016.10.048

Abstract: Conventional immunosensors require many binding events to give a single transducer output which represents the concentration of the analyte in the s le. Because of the requirements to selectively detect species in complex s les, immunosensing interfaces must allow immobilisation of antibodies while repelling nonspecific adsorption of other species. These requirements lead to quite sophisticated interfacial design, often with molecular level control, but we have no tools to characterise how well these interfaces work at the molecular level. The work reported herein is an initial feasibility study to show that antibody-antigen binding events can be monitored at the single molecule level using single molecule localisation microscopy (SMLM). The steps to achieve this first requires showing that indium tin oxide surfaces can be used for SMLM, then that these surfaces can be modified with self-assembled monolayers using organophosphonic acid derivatives, that the amount of antigens and antibodies on the surface can be controlled and monitored at the single molecule level and finally antibody binding to antigen modified surfaces can be monitored. The results show the amount of antibody that binds to an antigen modified surface is dependent on both the concentration of antigen on the surface and the concentration of antibody in solution. This study demonstrates the potential of SMLM for characterising biosensing interfaces and as the transducer in a massively parallel, wide field, single molecule detection scheme for quantitative analysis.

Importance of the indium tin oxide substrate on the quality of self-assembled monolayers formed from organophosphonic acids

Publisher: American Chemical Society (ACS)

Date: 11-02-2011

DOI: 10.1021/LA104464W

Impact of the Coverage of Aptamers on a Nanoparticle on the Binding Equilibrium and Kinetics between Aptamer and Protein

Publisher: American Chemical Society (ACS)

Date: 09-12-2020

DOI: 10.1021/ACSSENSORS.0C02212

Solution to the problem of interferences in electrochemical sensors using the fill-and-flow channel biosensor

Publisher: American Chemical Society (ACS)

Date: 28-12-2003

DOI: 10.1021/AC026072L

Abstract: A generic fill-and-flow channel biosensor with upstream electrodes to determine the extent of interferences in the s le is described. A pair of upstream electrodes poised at a suitable potential allows both the calculation of the extent of removal of interfering agents and the effect of interfering agents at the detector electrode. A model was developed and tested that predicts the concentrations of all species throughout the channel and, hence, the current at each electrode due to each species. This enables correction of the detector electrode current and a more accurate determination of the analyte concentration. The concept was applied to a biosensor for the determination of glucose in the presence of ascorbic acid, acetamidophenol, and uric acid, as well as glucose in wine s les containing polyphenolic interfering agents.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACS.BIOCHEM.0C00318

Optimising porous silicon Bragg reflectors for narrow spectral resonances

Publisher: AIP Publishing

Date: 25-10-2018

DOI: 10.1063/1.5048618

Abstract: Achieving sharp spectral resonances in porous silicon based photonic structures is of significant practical importance for improving the accuracy of refractive index-based sensing in chemical and biochemical applications. Here, we show that by compensating for depth related heterogeneities in the etching conditions, we are able to reduce the porosity modulation in Bragg reflectors to below 1% and achieve absorption limited spectral widths of 7 nm in the visible part of the spectrum. Such narrowband Bragg reflectors provide markedly improved sensing capability for real-time monitoring of refractive index changes compared with reflectors with broader spectral features.

Electrostatic Assembly of Multiarm PEG-Based Hydrogels as Extracellular Matrix Mimics: Cell Response in the Presence and Absence of RGD Cell Adhesive Ligands

Publisher: American Chemical Society (ACS)

Date: 24-02-2023

DOI: 10.1021/ACSBIOMATERIALS.2C01252

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JCIM.0C00683

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.INORGCHEM.0C01141

Characterisation of gold electrodes modified with self-assembled monolayers of L-cysteine for the adsorptive stripping analysis of copper

Publisher: Elsevier BV

Date: 12-2001

DOI: 10.1016/S0022-0728(01)00649-0

The molecular level modification of surfaces: From self-assembled monolayers to complex molecular assemblies

Publisher: Royal Society of Chemistry (RSC)

Date: 2011

DOI: 10.1039/C0CS00139B

Abstract: The modification of surfaces with self-assembled monolayers (SAMs) containing multiple different molecules, or containing molecules with multiple different functional components, or both, has become increasingly popular over the last two decades. This explosion of interest is primarily related to the ability to control the modification of interfaces with something approaching molecular level control and to the ability to characterise the molecular constructs by which the surface is modified. Over this time the level of sophistication of molecular constructs, and the level of knowledge related to how to fabricate molecular constructs on surfaces have advanced enormously. This critical review aims to guide researchers interested in modifying surfaces with a high degree of control to the use of organic layers. Highlighted are some of the issues to consider when working with SAMs, as well as some of the lessons learnt (169 references).

A flexible polyaniline-based bioelectronic patch

Publisher: Royal Society of Chemistry (RSC)

Date: 2018

DOI: 10.1039/C7BM00880E

Abstract: A flexible bioelectronic patch designed to have optimal electrical properties, biocompatibility and electroactivity after 2 week in vivo implantation.

Pd-Ru core-shell nanoparticles with tunable shell thickness for active and stable oxygen evolution performance

Publisher: Royal Society of Chemistry (RSC)

Date: 2018

DOI: 10.1039/C8NR03341B

Abstract: Pd–Ru nanoparticles with thin shells and a stable core are shown to improve stability in oxygen evolution reaction catalysis while retaining high activity.

Structure and properties of redox active self-assembled monolayers formed from norbornylogous bridges

Publisher: American Chemical Society (ACS)

Date: 21-05-2009

DOI: 10.1021/LA9012558

Abstract: Three different length rigid norbornylogous bridges with terminal ferrocene moieties were synthesized. Pure self-assembled monolayers (SAMs) of the norbornylogous bridges and SAMs with the bridges diluted using either hydroxyl-terminated or methyl-terminated diluents were formed for each length of norbornylogous bridge. The SAMs were imaged with scanning tunneling micrsocopy (STM) and the electrochemical properties were investigated. It was found that SAMs composed of only norbornylogous bridges were crystalline-like, while in mixed SAMs, where the norbornylogous bridge was diluted, the ferrocene stood above the surface of the diluent because of the rigidity of the norbornylogous bridges and were homogeneously distributed across the surface. Further, the rate of electron transfer of the norbornylogous bridges was observed to be similar to an alkanethiol-derived ferrocene whose construct was designed to be as close as possible to that of the norbornylogous bridge. Finally, the rate of electron transfer for the norbornylogous bridges in a diluted SAM was slower with a hydroxyl-terminated diluent than with a methyl-terminated diluent.

Light-activated electrochemistry without surface-bound redox species

Publisher: Elsevier BV

Date: 10-2017

DOI: 10.1016/J.ELECTACTA.2017.08.127

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSMATERIALSLETT.0C00159

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JCED.0C00559

Electrochemistry on Tribocharged Polymers Is Governed by the Stability of Surface Charges Rather than Charging Magnitude

Publisher: American Chemical Society (ACS)

Date: 18-03-2019

DOI: 10.1021/JACS.9B00297

Abstract: Electrically insulating objects gain a net electrical charge when brought in and out of contact. This phenomenon-triboelectricity-involves the flow of charged species, but conclusively establishing their nature has proven extremely difficult. Here, we demonstrate an almost linear relationship between a plastic s le's net negative charge and the amount of solution metal ions discharged to metallic particles with a coefficient of proportionality linked to its electron affinity (stability of anionic fragments). The maximum magnitude of reductive redox work is also material dependent: metallic particles grow to a larger extent over charged dielectrics that yield stable cationic fragments (smaller ionization energy). Importantly, the extent to which the s le can act as electron source greatly exceeds the net charging measured in a Faraday pail/electrometer set up, which brings direct evidence of triboeletricity being a mosaic of positive and negative charges rather than a homogeneous ensemble and defines for the first time their quantitative scope in electrochemistry.

Wet chemical routes to the assembly of organic monolayers on silicon surfaces via the formation of Si-C bonds: Surface preparation, passivation and functionalization

Publisher: Royal Society of Chemistry (RSC)

Date: 2010

DOI: 10.1039/B923890P

Evidence for why tri(ethylene oxide) functionalized Si-C linked monolayers on Si(111) have inferior protein antifouling properties relative to the equivalent alkanethiol monolayers assembled on gold

Publisher: CSIRO Publishing

Date: 2005

DOI: 10.1071/CH05121

Abstract: High quality methoxy-terminated monolayers containing a tri(ethylene oxide) moiety were formed on Si(111)–H surfaces in thermal hydrosilylation reactions. X-ray photoelectron spectroscopy, contact angle, and X-ray reflectivity measurements suggested that the suboptimal protein anti-fouling properties of these Si–C linked monolayers were due to a reduced lateral packing density of the chains resulting in a disordered layer with insufficient internal and external hydrophilicity.

High-resolution light-activated electrochemistry on amorphous silicon-based photoelectrodes

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/D0CC02959A

Abstract: The spatial resolution of silicon photoelectrochemistry is improved to 500 nm by using amorphous silicon, 60 times improvement as compared to crystalline silicon.

Rapid and ultrasensitive electrochemical detection of circulating tumor DNA by hybridization on the network of gold-coated magnetic nanoparticles

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1SC01044A

Abstract: This study introduces a new electrochemical sensing strategy for the rapid detection of circulating tumor DNA (ctDNA) from whole blood in combination with a network of DNA-Au@MNPs with high sensitivity and excellent selectivity.

Nanoscale Water Condensation on Click-Functionalized Self-Assembled Monolayers

Publisher: American Chemical Society (ACS)

Date: 04-08-2011

DOI: 10.1021/LA202359C

Abstract: We have examined the nanoscale adsorption of molecular water under ambient conditions onto a series of well-characterized functionalized surfaces produced by Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC or "click") reactions on alkyne-terminated self-assembled monolayers on silicon. Water contact angle (CA) measurements reveal a range of macroscopic hydrophilicity that does not correlate with the tendency of these surfaces to adsorb water at the molecular level. X-ray reflectometry has been used to follow the kinetics of water adsorption on these "click"-functionalized surfaces, and also shows that dense continuous molecular water layers are formed over 30 h. For ex le, a highly hydrophilic surface, functionalized by an oligo(ethylene glycol) moiety (with a CA = 34°) showed 2.9 Å of adsorbed water after 30 h, while the almost hydrophobic underlying alkyne-terminated monolayer (CA = 84°) showed 5.6 Å of adsorbed water over the same period. While this study highlights the capacity of X-ray reflectometry to study the structure of adsorbed water on these surfaces, it should also serve as a warning for those intending to characterize self-assembled monolayers and functionalized surfaces to avoid contamination by even trace amounts of water vapor. Moreover, contact angle measurements alone cannot be relied upon to predict the likely degree of moisture uptake on such surfaces.

A comparative study of electrochemical reduction of 4-nitrophenyl covalently grafted on gold and carbon

Publisher: Wiley

Date: 08-2010

DOI: 10.1002/ELAN.201000164

Electrochemical transduction of DNA hybridization by long-range electron transfer

Publisher: CSIRO Publishing

Date: 2005

DOI: 10.1071/CH04265

Abstract: For the detection of DNA hybridization, there are two main challenges that current research aims to overcome: lower detection limits and higher selectivity. We describe here the development of an electrochemical biosensor that used redox-active intercalators to transduce DNA hybridization by long-range electron transfer through DNA duplexes. This study outlines how the sensitivity and selectivity of the biosensor was tuned by careful control of the surface chemistry of the DNA-modified interface. The DNA-modified interface is composed of thiolated DNA and a diluent component, both of which are self-assembled onto a gold electrode. The resultant DNA biosensor has excellent selectivity towards single-base mismatch detection, whilst both the detection limit and sensitivity can easily be adjusted by varying the length of the diluent molecule relative to the length of the thiol linker at the 3´ end of the DNA. The one limitation of such a detection scheme is the slow assay time, which is a consequence of the slow kinetics of intercalation of the redox molecule into the duplexes. Approaches to reducing the assay time to a more commercially viable timescale are outlined.

Quantitative determination of target gene with electrical sensor

Publisher: Springer Science and Business Media LLC

Date: 24-07-2015

DOI: 10.1038/SREP12539

Abstract: Integrating loop-mediated isothermal lification (LAMP) with capacitively coupled contactless conductivity detection (C 4 D), we have developed an electrical sensor for the simultaneous lification and detection of specific sequence DNA. Using the O26- wzy gene as a model, the amount of initial target gene could be determined via the threshold time obtained by monitoring the progression of the LAMP reaction in real time. Using the optimal conditions, a detection limit of 12.5 copy/μL can be obtained within 30 min. Monitoring the LAMP reaction by C 4 D has not only all the advantages that existing electrochemical methods have, but also additional attractive features including being completely free of carryover contamination risk, high simplicity and extremely low cost. These benefits all arise from the fact that the electrodes are separated from the reaction solution, that is C 4 D is a contactless method. Hence in proof of principle, the new strategy promises a robust, simple, cost-effective and sensitive method for quantitative determination of a target gene, that is applicable either to specialized labs or at point-of-care.

Oxidative acetylenic coupling reactions as a surface chemistry tool

Publisher: Royal Society of Chemistry (RSC)

Date: 2011

DOI: 10.1039/C1CP21450K

The modification of glassy carbon and gold electrodes with aryl diazonium salt

Publisher: Elsevier BV

Date: 12-2005

DOI: 10.1016/J.CHEMPHYS.2005.03.033

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JPCA.0C05467

Engineering regioselectivity in the hydrosilylation of alkynes using heterobimetallic dual-functional hybrid catalysts

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D1CY01804C

Abstract: The synthesis and characterization of carbon black supported rhodium and iridium heterobimetallic hybrid catalysts and their application in the hydrosilylation of alkynes is described.

Distance-dependent electron transfer at passivated electrodes decorated by gold nanoparticles

Publisher: American Chemical Society (ACS)

Date: 20-12-2013

DOI: 10.1021/AC3029486

Abstract: The phenomenon of nanoparticles attached to an electrode passivated by an organic layer allowing efficient electron transfer between redox species in solution and the underlying electrode to be restored has resulted in Chazalviel and Allongue proposing a theory [Chazalviel, J.-N. Allongue, P. J. Am. Chem. Soc.2011, 133, 762-764] to explain this phenomenon. The theory suggests that with electrode-organic layer-nanoparticle constructs, high exchange current densities, compared with when the nanoparticles are absent, results in the rate of electron transfer being independent of the thickness of the organic layer until a threshold thickness is exceeded. Thereafter, the thicker the organic layer, the slower the rate of electron transfer. Herein we provide the first experimental data to support this theory using a single experimental system that can show the transition from thickness independent electron transfer kinetics to distant dependent kinetics. This was achieved using ethylenediamine electrodeposited on a glassy carbon electrode. Different numbers of deposition cycles were applied in order to fabricate different thicknesses of the organic film. The deposited films showed progressively greater blocking abilities toward ruthenium hexamine, as a redox active probe in solution, as the films got thicker. Electron transfer kinetics of nanoparticle-decorated surfaces showed a change from thickness independent to thickness dependent as the organic layer exceeded an average thickness of 20 Å. Electrochemical impedance spectroscopy, cyclic voltammetry, scanning electron microscopy, ellipsometry, and atomic force microscopy were used to characterize the fabricated surfaces.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.CHEMREV.0C00627

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSCHEMNEURO.0C00228

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.EST.0C03940

Functionalization of porous silicon based photonic crystals with organic monolayers

Publisher: IEEE

Date: 2005

DOI: 10.1109/COMMAD.2004.1577529

Versatile Fabrication Approach of Conductive Hydrogels via Copolymerization with Vinyl Monomers

Publisher: American Chemical Society (ACS)

Date: 07-12-2017

DOI: 10.1021/ACSAMI.7B15019

Abstract: Functionalized poly(ethylene dioxythiophene) (f-PEDOT) was copolymerized with two vinyl monomers of different hydrophilicity, acrylic acid and hydroxyethyl methacrylate, to produce electroconductive hydrogels with a range of physical and electronic properties. These hydrogels not only possessed tailored physical properties, such as swelling ratios and mechanical properties, but also displayed electroactivity dependent on the chemical composition of the network. Raman spectroscopy indicated that the functional PEDOT in the hydrogels is in an oxidized form, most likely accounting for the good electrochemical response of the hydrogels observed in physiological buffer. In vitro cell studies showed that cardiac cells respond differently when seeded on hydrogel substrates with different compositions. This study presents a facile approach for the fabrication of electroconductive hydrogels with a range of properties, paving the way for scaffolds that can meet the requirements of different electroresponsive tissues.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JPROTEOME.0C00436

Functionalization Strategies for Protease Immobilization on Magnetic Nanoparticles

Publisher: Wiley

Date: 31-05-2010

DOI: 10.1002/ADFM.201000188

Light-activated electrochemistry on alkyne-terminated Si(100) surfaces towards solution-based redox probes

Publisher: Elsevier BV

Date: 09-2016

DOI: 10.1016/J.ELECTACTA.2016.07.120

Elliptical supra-cellular topographies regulate stem cells migratory pattern and osteogenic differentiation

Publisher: Elsevier BV

Date: 12-2020

DOI: 10.1016/J.MTLA.2020.100870

Smart tissue culture: in situ monitoring of the activity of protease enzymes secreted from live cells using nanostructured photonic crystals

Publisher: American Chemical Society (ACS)

Date: 21-04-2009

DOI: 10.1021/NL900283J

Abstract: Monitoring enzyme secretion in tissue culture has proved challenging because to date the activity cannot be continuously measured in situ. In this Letter, we present a solution using biopolymer loaded photonic crystals of anodized silicon. Shifts in the optical response by proteolytic degradation of the biopolymer provide label-free sensing with unprecedented low detection limits (1 pg) and calculation of kinetic parameters. The enhancement in sensitivity relative to previous photonic crystal sensors constitutes a change in the sensing paradigm because here the entire pore space is responsive to the secreted enzyme rather than just the pore walls. In situ monitoring is demonstrated by detecting secretion of matrix metalloprotease 9 from stimulated human macrophages.

Controlling the Number of Branches and Surface Facets of Pd‐Core Ru‐Branched Nanoparticles to Make Highly Active Oxygen Evolution Reaction Electrocatalysts

Publisher: Wiley

Date: 12-10-2020

DOI: 10.1002/CHEM.202003561

Approaches Toward Allowing Electroanalytical Devices to be Used in Biological Fluids

Publisher: Wiley

Date: 05-05-2014

DOI: 10.1002/ELAN.201400097

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSCHEMBIO.0C00489

Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation

Publisher: Springer Science and Business Media LLC

Date: 11-02-2015

DOI: 10.1038/SREP08398

Abstract: Bacterial resistance to conventional antibiotics necessitates the identification of novel leads for infection control. Interference with extracellular phenomena, such as quorum sensing, extracellular DNA integrity and redox active metabolite release, represents a new frontier to control human pathogens such as Pseudomonas aeruginosa and hence reduce mortality. Here we reveal that the extracellular redox active virulence factor pyocyanin produced by P. aeruginosa binds directly to the deoxyribose-phosphate backbone of DNA and intercalates with DNA nitrogenous base pair regions. Binding results in local perturbations of the DNA double helix structure and enhanced electron transfer along the nucleic acid polymer. Pyocyanin binding to DNA also increases DNA solution viscosity. In contrast, antioxidants interacting with DNA and pyocyanin decrease DNA solution viscosity. Biofilms deficient in pyocyanin production and biofilms lacking extracellular DNA show similar architecture indicating the interaction is important in P. aeruginosa biofilm formation.

The use of a personal glucose meter for detecting procalcitonin through glucose encapsulated within liposomes

Publisher: Royal Society of Chemistry (RSC)

Date: 2019

DOI: 10.1039/C9AN01519A

Abstract: A glucose meter-based immunosensing platform that allows the quantification of procalcitonin in whole blood s les at clinically-relevant concentrations.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.IECR.0C03006

Scanning Electrochemical Microscopy of Cytochrome c Peroxidase through the Orientation‐Controlled Immobilisation of Cytochrome c

Publisher: Wiley

Date: 31-05-2016

DOI: 10.1002/CELC.201600195

Importance of monolayer quality for interpreting current transport through organic molecules: Alkyls on oxide-free Si

Publisher: American Chemical Society (ACS)

Date: 07-07-2006

DOI: 10.1021/LA060718D

Abstract: We study the effect of monolayer quality on the electrical transport through n-Si/C(n)H(2n+1)/Hg junctions (n = 12, 14, and 18) and find that truly high quality layers and only they, yield the type of data, reported by us in Phys. Rev. Lett. 2005, 95, 266807, data that are consistent with the theoretically predicted behavior of a Schottky barrier coupled to a tunnel barrier. By using that agreement as our starting point, we can assess the effects of changing the quality of the alkyl monolayers, as judged from ellipsometer, contact angle, XPS, and ATR-FTIR measurements, on the electrical transport. Although low monolayer quality layers are easily identified by one or more of those characterization tools, as well as from the current-voltage measurements, even a combination of characterization techniques may not suffice to distinguish between monolayers with minor differences in quality, which, nevertheless, are evident in the transport measurement. The thermionic emission mechanism, which in these systems dominates at low forward bias, is the one that is most sensitive to monolayer quality. It serves thus as the best quality control. This is important because, even where tunneling characteristics appear rather insensitive to slightly diminished quality, their correct analysis will be affected, especially if layers of different lengths are also of different quality.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSSENSORS.0C01217

ACS Sensors Hits the Road

Publisher: American Chemical Society (ACS)

Date: 25-05-2018

DOI: 10.1021/ACSSENSORS.8B00376

An Exciting Year Ahead for ACS Sensors

Publisher: American Chemical Society (ACS)

Date: 26-01-2018

DOI: 10.1021/ACSSENSORS.8B00013

Remembering Some of the Giants of Biosensing

Publisher: American Chemical Society (ACS)

Date: 26-11-2018

DOI: 10.1021/ACSSENSORS.8B01344

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSENERGYLETT.0C01302

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSAEM.0C01415

How Nanoparticles Transform Single Molecule Measurements into Quantitative Sensors

Publisher: Wiley

Date: 30-09-2020

DOI: 10.1002/ADMA.201904339

Abstract: Single molecule measurements are revolutionizing the understanding of the stochastics of behavior of single molecules. There is a common theme referred to as a near-field approach, in how many single molecule measurements are being performed in assays. The term near field is used because the measurement volume is typically very small such that a single molecule, or a single molecule binding pair, within that volume is of an appreciable concentration. The next development in detection will be performing many single molecule measurements at one time such that single molecule measurements can be used as the basis for quantitative analysis. There have already been some notable developments in this direction. Again, all have a common theme in that nanoparticles are used to create many near-field volumes that can be measured simultaneously. Herein, the coupled developments in nanoparticles and measurement strategies that allow nanoparticles to be the backbone of the next generation of sensing technologies are discussed.

Optical Nanopore Sensors for Quantitative Analysis

Publisher: American Chemical Society (ACS)

Date: 28-01-2022

DOI: 10.1021/ACS.NANOLETT.1C03976

Abstract: Nanopore sensors have received significant interest for the detection of clinically important biomarkers with single-molecule resolution. These sensors typically operate by detecting changes in the ionic current through a nanopore due to the translocation of an analyte. Recently, there has been interest in developing optical readout strategies for nanopore sensors for quantitative analysis. This is because they can utilize wide-field microscopy to independently monitor many nanopores within a high-density array. This significantly increases the amount of statistics that can be obtained, thus enabling the analysis of analytes present at ultralow concentrations. Here, we review the use of optical nanopore sensing strategies for quantitative analysis. We discuss optical nanopore sensing assays that have been developed to detect clinically relevant biomarkers, the potential for multiplexing such measurements, and techniques to fabricate high density arrays of nanopores with a view toward the use of these devices for clinical applications.

Celebrating Wolfgang Schuhmann's 65th Birthday

Publisher: Wiley

Date: 03-11-2021

DOI: 10.1002/CELC.202101368

August 2017: Two Years of Submissions

Publisher: American Chemical Society (ACS)

Date: 25-08-2017

DOI: 10.1021/ACSSENSORS.7B00539

The Impact of the Position of the Redox Label on Charge Transfer and Hybridization Efficiency at DNA Interfaces

Publisher: Wiley

Date: 16-05-2018

DOI: 10.1002/ELAN.201800197

Sensing Chemicals in Gas Phase-Addressing an Unmet Need

Publisher: American Chemical Society (ACS)

Date: 27-05-2016

DOI: 10.1021/ACSSENSORS.6B00288

Understanding and modelling the magnitude of the change in current of nanopore sensors.

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D1CS00972A

Abstract: Nanopores are promising sensing devices that can be used for the detection of analytes at the single molecule level. It is of importance to understand and model the current response of a nanopore sensor for improving the sensitivity of the sensor, a better interpretation of the behaviours of different analytes in confined nanoscale spaces, and quantitative analysis of the properties of the targets. The current response of a nanopore sensor, usually called a resistive pulse, results from the change in nanopore resistance when an analyte translocates through the nanopore. This article reviews the theoretical models used for the calculation of the resistance of the nanopore, and the corresponding change in nanopore resistance due to a translocation event. Models focus on the resistance of the pore cavity region and the access region of the nanopore. The influence of the sizes, shapes and surface charges of the translocating species and the nanopore, as well as the trajectory that the analyte follows are also discussed. This review aims to give a general guidance to the audience for understanding the current response of a nanopore sensor and the application of this class of sensor to a broad range of species with the theoretical models.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.BIOCHEM.0C00503

tagPAINT: covalent labelling of genetically encoded protein tags for DNA-PAINT imaging

Publisher: Cold Spring Harbor Laboratory

Date: 10-04-2019

DOI: 10.1101/604462

Abstract: Recently, DNA-PAINT single molecule localisation microscopy (SMLM) has shown great promise for quantitative imaging. However, labelling strategies so far have relied on approaches that are multivalent or affinity-based. Here, we demonstrate tagPAINT - the covalent labelling of expressed protein tags (SNAP tag and Halo tag) with single DNA docking strands for single molecule localisation microscopy via DNA-PAINT. We utilised tagPAINT for T-cell receptor signalling proteins at the immune synapse as a proof of principle.

Synthesis of hierarchical metal nanostructures with high electrocatalytic surface areas

Publisher: American Association for the Advancement of Science (AAAS)

Date: 11-01-2023

DOI: 10.1126/SCIADV.ADF6075

Abstract: 3D interconnected structures can be made with molecular precision or with micrometer size. However, there is no strategy to synthesize 3D structures with dimensions on the scale of tens of nanometers, where many unique properties exist. Here, we bridge this gap by building up nanosized gold cores and nickel branches that are directly connected to create hierarchical nanostructures. The key to this approach is combining cubic crystal–structured cores with hexagonal crystal–structured branches in multiple steps. The dimensions and 3D morphology can be controlled by tuning at each synthetic step. These materials have high surface area, high conductivity, and surfaces that can be chemically modified, which are properties that make them ideal electrocatalyst supports. We illustrate the effectiveness of the 3D nanostructures as electrocatalyst supports by coating with nickel-iron oxyhydroxide to achieve high activity and stability for oxygen evolution reaction. This work introduces a synthetic concept to produce a new type of high-performing electrocatalyst support.

Porous Graphene Oxide Films Prepared via the Breath-Figure Method: A Simple Strategy for Switching Access of Redox Species to an Electrode Surface

Publisher: American Chemical Society (ACS)

Date: 25-11-2020

DOI: 10.1021/ACSAMI.0C16811

Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/C9CC08972A

Abstract: Zero valent iron core–iron oxide shell nanoparticles coated with a multi-phosphonate brush co-polymer are shown to be small and effective magnetic nanoparticle imaging tracers.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.ESTLETT.0C00476

DNA Recognition Interfaces:  The Influence of Interfacial Design on the Efficiency and Kinetics of Hybridization

Publisher: American Chemical Society (ACS)

Date: 23-06-2005

DOI: 10.1021/LA050725M

Abstract: The effect of the surface chemistry of DNA recognition interfaces on DNA hybridization at a gold surface was investigated using both electrochemistry and the quartz crystal microbalance (QCM) technique. Different DNA recognition interfaces were prepared using a two-component self-assembled monolayer consisting of thiolated 20-mer probe single-stranded DNA (ss-DNA) containing either a 3'-mercaptopropyl or a 3'-mercaptohexyl linker group and an alcohol-terminated diluent layer with 2-, 6-, or 11-carbon length. The influence of the interfacial design on the hybridization efficiency, the affinity constant (Ka) describing hybridization, and the kinetics of hybridization was assessed. It was found that the further the DNA was above the surface defined by the diluent layer the higher the hybridization efficiency and Ka. The kinetics of DNA hybridization was assessed using both a QCM and an electrochemical approach to ascertain the influence of the interface on both the initial binding of target DNA to the surface and the formation of a complete duplex. These measurements showed that the length of the diluent layer has a large impact on the time taken to form a perfect duplex but no impact on the initial recognition of the target DNA by the immobilized probe DNA.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JPCA.0C03467

Emerging electrochemical methods at the nanointerface: general discussion

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2FD90003C

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSSUSCHEMENG.0C04430

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSBIOMATERIALS.0C00901

A Conducting polymer with enhanced electronic stability applied in cardiac models

Publisher: American Association for the Advancement of Science (AAAS)

Date: 04-11-2016

DOI: 10.1126/SCIADV.1601007

Abstract: Researchers develop sutureless conductive patch with enhanced biostability and effect on heart conduction velocity.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.CHEMMATER.0C02523

Locked nucleic acid molecular beacon for multiplex detection of loop mediated isothermal amplification

Publisher: Elsevier BV

Date: 09-2018

DOI: 10.1016/J.SNB.2018.04.081

So Long and Thanks for All (the Information from) the Fish

Publisher: American Chemical Society (ACS)

Date: 25-10-2019

DOI: 10.1021/ACSSENSORS.9B01910

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSCHEMBIO.0C00302

Electrochemical modulation of antigen-antibody binding

Publisher: Elsevier BV

Date: 09-2004

DOI: 10.1016/J.BIOS.2004.01.010

Nanoscale condensation of water on self-assembled monolayers

Publisher: Royal Society of Chemistry (RSC)

Date: 2011

DOI: 10.1039/C1SM05096F

'Dispersible electrodes': A solution to slow response times of sensitive sensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2010

DOI: 10.1039/C0CC02690E

Abstract: Herein, we introduce the concept of utilizing conductive gold-coated magnetic nanoparticles as 'dispersible electrodes', which serve as the active element in the selective capture and direct electro-analytical quantification of analytes. This concept reduces response times and decreases detection limits by bringing the sensor to the analyte rather than the conventional paradigm of the analyte finding the sensor.

Reproducible flaws unveil electrostatic aspects of semiconductor electrochemistry

Publisher: Springer Science and Business Media LLC

Date: 12-12-2017

DOI: 10.1038/S41467-017-02091-1

Abstract: Predicting or manipulating charge-transfer at semiconductor interfaces, from molecular electronics to energy conversion, relies on knowledge generated from a kinetic analysis of the electrode process, as provided by cyclic voltammetry. Scientists and engineers encountering non-ideal shapes and positions in voltammograms are inclined to reject these as flaws. Here we show that non-idealities of redox probes confined at silicon electrodes, namely full width at half maximum .6 mV and anti-thermodynamic inverted peak positions, can be reproduced and are not flawed data. These are the manifestation of electrostatic interactions between dynamic molecular charges and the semiconductor’s space-charge barrier. We highlight the interplay between dynamic charges and semiconductor by developing a model to decouple effects on barrier from changes to activities of surface-bound molecules. These findings have immediate general implications for a correct kinetic analysis of charge-transfer at semiconductors as well as aiding the study of electrostatics on chemical reactivity.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.OPRD.0C00287

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSEARTHSPACECHEM.0C00104

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy

Publisher: American Chemical Society (ACS)

Date: 13-05-2020

DOI: 10.1021/ACSNANO.0C02954

Challenges and Solutions in Developing Ultrasensitive Biosensors

Publisher: American Chemical Society (ACS)

Date: 21-11-2019

DOI: 10.1021/JACS.8B09397

Abstract: This Perspective focuses on the latest strategies and challenges for the development of bioanalytical sensors with sub-picomolar detection limits. Achieving sub-picomolar detection limits has three major challenges: (1) assay sensitivity, (2) response time, and (3) selectivity (including limiting background signals). Each of these challenges is discussed, along with how nanomaterials provide the solutions. One strategy to gain greater sensitivity involves confining the sensing volume to the nanoscale, as used in nanopore- or nanoparticle-based sensors, because nanoparticles are ubiquitous in lification. Methods to improve response time typically focus on obtaining an intimate mixture between the sensor and the s le either by extending the length scale of nanoscale sensors using nanostructuring or by dispersing magnetic nanoparticles through the s le to capture the analyte. Loading nanoparticles with many biorecognition species is one solution to help address the challenge of selectivity. Many ex les in this Perspective explore the detection of prostate-specific antigen which enables a comparison between strategies. Finally, exciting future opportunities in developing single-molecule sensors and the requirements to go even lower in concentration are explored.

Single Entity Electrochemistry Progresses to Cell Counting

Publisher: Wiley

Date: 06-10-2016

DOI: 10.1002/ANIE.201606459

Abstract: Red blood cells have been counted in an electrochemical collision experiment recently described by Compton and co-workers. As a cell collides with the electrode it lyses and a current is observed from the reduction of oxygen from within the cell.

A FRET sensor enables quantitative measurements of membrane charges in live cells

Publisher: Springer Science and Business Media LLC

Date: 13-03-2017

DOI: 10.1038/NBT.3828

Abstract: Membrane charge has a critical role in protein trafficking and signaling. However, quantification of the effective electrostatic potential of cellular membranes has remained challenging. We developed a fluorescence membrane charge sensor (MCS) that reports changes in the membrane charge of live cells via Förster resonance energy transfer (FRET). MCS is permanently attached to the inner leaflet of the plasma membrane and shows a linear, reversible and fast response to changes of the electrostatic potential. The sensor can monitor a wide range of cellular treatments that alter the electrostatic potential, such as incorporation and redistribution of charged lipids and alterations in cytosolic ion concentration. Applying the sensor to T cell biology, we used it to identify charged membrane domains in the immunological synapse. Further, we found that electrostatic interactions prevented spontaneous phosphorylation of the T cell receptor and contributed to the formation of signaling clusters in T cells.

Enhancing Quantum Dots for Bioimaging using Advanced Surface Chemistry and Advanced Optical Microscopy: Application to Silicon Quantum Dots (SiQDs)

Publisher: Wiley

Date: 31-08-2015

DOI: 10.1002/ADMA.201503223

Abstract: Fluorescence lifetime imaging microscopy is successfully demonstrated in both one- and two-photon cases with surface modified, nanocrystalline silicon quantum dots in the context of bioimaging. The technique is further demonstrated in combination with Förster resonance energy transfer studies where the color of the nanoparticles is tuned by using organic dye acceptors directly conjugated onto the nanoparticle surface.

Electroactive Self‐Assembled Monolayers of Unique Geometric Structures by Using Rigid Norbornylogous Bridges

Publisher: Wiley

Date: 23-11-2011

DOI: 10.1002/CHEM.201101588

Abstract: Herein, we describe the synthesis of straight (S) and L-shaped (L) norbornylogous bridges (NBs) with an anthraquinone moiety at the distal end as the redox-active head group and two thiol feet at the proximal end, by which the molecules assemble on gold surfaces. The NB molecules were shown to form self-assembled monolayers (SAMs) with a well-behaved surface redox process. The SAMs were characterized by using in situ IR spectroscopy, cyclic voltammetry, scanning tunnelling microscopy and electrochemical impedance spectroscopy. The surface selection rules associated with the IR band intensities allowed the estimation of the position of the anthraquinone moiety with respect to the surface and the tilt of the bridge with respect to the surface normal, both in pure and diluted monolayers. It is shown that the S- and L-NBs hold the plane of the anthraquinone moiety close to the surface normal or the surface tangent, respectively. Neither NB molecule changes its orientation if spaced by diluents on the surface. The difference in the structure of the S- and L-NB SAMs provides a suitable framework for the investigation of factors that govern electron transfer of anthraquinone moieties across self-assembled monolayers with limited structural ambiguity, as compared with the commonly used structurally flexible alkanethiol monolayers.

Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor

Publisher: Wiley

Date: 14-03-2016

DOI: 10.1002/ADHM.201600002

Abstract: Mesoporous silica nanocarriers with pH-switchable antifouling zwitterionic surface, enzyme responsive drug release properties and blue fluorescence are reported. Prolonged circulation in the blood system with zero premature release as well as efficient cellular uptake and intracellular drug release in tumor tissue are achieved.

Advances in the Application of Magnetic Nanoparticles for Sensing

Publisher: Wiley

Date: 19-09-2019

DOI: 10.1002/ADMA.201904385

Abstract: Magnetic nanoparticles (MNPs) are of high significance in sensing as they provide viable solutions to the enduring challenges related to lower detection limits and nonspecific effects. The rapid expansion in the applications of MNPs creates a need to overview the current state of the field of MNPs for sensing applications. In this review, the trends and concepts in the literature are critically appraised in terms of the opportunities and limitations of MNPs used for the most advanced sensing applications. The latest progress in MNP sensor technologies is overviewed with a focus on MNP structures and properties, as well as the strategies of incorporating these MNPs into devices. By looking at recent synthetic advancements, and the key challenges that face nanoparticle-based sensors, this review aims to outline how to design, synthesize, and use MNPs to make the most effective and sensitive sensors.

Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers.

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2CP03627D

Abstract: Single molecule experiments have recently attracted enormous interest. Many of these studies involve the encapsulation of a single molecule into nanoscale containers (such as vesicles, droplets and nanowells). In such cases, the single molecule encapsulation efficiency is a key parameter to consider in order to get a statistically significant quantitative information. It has been shown that such encapsulation typically follows a Poisson distribution and such theory of encapsulation has only been applied to the encapsulation of single molecules into perfectly sized monodispersed containers. However, experimentally nanocontainers are usually characterized by a size distribution, and often just a single binding pair (rather than a single molecule) is required to be encapsulated. Here the use of Poisson distribution is extended to predict the encapsulation efficiency of two different molecules in an association equilibrium. The Poisson distribution is coupled with a log-normal distribution in order to consider the effect of the container size distribution, and the effect of adsorption to the container is also considered. This theory will allow experimentalists to determine what single molecule encapsulation efficiency can be expected as a function of the experimental conditions. Two case studies, based on experimental data, are given to support the theoretical predictions.

A portable fill-and-flow channel biosensor with an electrode to predict the effect of interferences

Publisher: Wiley

Date: 08-2004

DOI: 10.1002/ELAN.200302943

Electroconductive Hydrogel Based on Functional Poly(Ethylenedioxy Thiophene)

Publisher: American Chemical Society (ACS)

Date: 26-08-2016

DOI: 10.1021/ACS.CHEMMATER.6B01298

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JPCLETT.0C01194

Solution Synthesis, Surface Passivation, Optical Properties, Biomedical Applications, and Cytotoxicity of Silicon and Germanium Nanocrystals

Publisher: Wiley

Date: 27-06-2016

DOI: 10.1002/CPLU.201600207

Abstract: Silicon and germanium nanocrystals (NCs) are attractive materials owing to their unique size and surface-dependent optical properties. The optical properties of silicon and germanium NCs make them highly suitable for a range of applications, including bioimaging, light-emitting diodes, and solar cells. In this review, the solution synthesis, surface passivation, optical properties, biomedical applications, and cytotoxicity of silicon and germanium NCs are compared and contrasted. Over the last 10 years, synthetic protocols have improved considerably, with size control readily achieved. Investigations have begun into a range of silicon and germanium nanostructures, including doped, alloy, and metal-semiconductor hybrid NCs, which represent the next generation of silicon and germanium nanomaterials. Silicon and germanium NCs are actively researched for a wide array of biomedical applications, including, long-term in vivo cellular imaging, fluorescent nanocarriers for drug delivery, and as contrast agents for magnetic resonance imaging (MRI). Cytotoxicity studies have shown the low toxicity of Si NCs, while demonstrating that Ge NCs are less toxic than CdSe NCs at similar concentrations, giving these materials a strong future in nanomedicine applications.

Click chemistry in mesoporous materials: Functionalization of porous silicon rugate filters

Publisher: American Chemical Society (ACS)

Date: 02-05-2008

DOI: 10.1021/LA800435D

Single injection of PTH improves osteoclastic parameters of remodeling at a stress fracture site in rats

Publisher: Wiley

Date: 21-03-2019

DOI: 10.1002/JOR.24262

Abstract: Stress fractures (SFx) result from repetitive cyclical loading of bone. They are frequent athletic injuries and underlie atypical femoral fractures following long-term bisphosphonate (BP) therapy. We investigated the effect of a single PTH injection on the healing of SFx in the rat ulna. SFx was induced in 120 female Wistar rats (300 ± 15 g) during a single loading session. A single PTH (8 µg.100g

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.CHEMMATER.0C01661

Electrochemically controlled blinking of fluorophores to enable quantitative stochastic optical reconstruction microscopy (STORM) imaging

Publisher: Research Square Platform LLC

Date: 29-09-2023

DOI: 10.21203/RS.3.RS-3394103/V1

The use of aryl diazonium salts in the fabrication of biosensors and chemical sensors

Publisher: Wiley

Date: 06-06-2012

DOI: 10.1002/9783527650446.CH9

Synthesis of gold-coated magnetic conglomerate nanoparticles with a fast magnetic response for bio-sensing

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D0TC04702C

Abstract: The versatile qualities of gold coated magnetic nanoparticles for both optical and electrochemical detection, as well as the separation of analytes, make them an excellent choice for ultrasensitive biosensing applications.

Stability of Chemically Passivated Silicon Electrodes in Aqueous Solutions: Interplay between Bias Voltage and Hydration of the Electrolyte

Publisher: American Chemical Society (ACS)

Date: 22-02-2016

DOI: 10.1021/ACS.JPCC.5B12454

Single-molecule electrical contacts on silicon electrodes under ambient conditions

Publisher: Springer Science and Business Media LLC

Date: 13-04-2017

DOI: 10.1038/NCOMMS15056

Abstract: The ultimate goal in molecular electronics is to use in idual molecules as the active electronic component of a real-world sturdy device. For this concept to become reality, it will require the field of single-molecule electronics to shift towards the semiconducting platform of the current microelectronics industry. Here, we report silicon-based single-molecule contacts that are mechanically and electrically stable under ambient conditions. The single-molecule contacts are prepared on silicon electrodes using the scanning tunnelling microscopy break-junction approach using a top metallic probe. The molecular wires show remarkable current–voltage reproducibility, as compared to an open silicon/nano-gap/metal junction, with current rectification ratios exceeding 4,000 when a low-doped silicon is used. The extension of the single-molecule junction approach to a silicon substrate contributes to the next level of miniaturization of electronic components and it is anticipated it will pave the way to a new class of robust single-molecule circuits.

Einzelmolekül‐Sensoren: Herausforderungen und Möglichkeiten für die quantitative Analyse

Publisher: Wiley

Date: 22-07-2016

DOI: 10.1002/ANGE.201600495

Proximity extension of circular DNA aptamers with real-time protein detection

Publisher: Oxford University Press (OUP)

Date: 23-03-2005

DOI: 10.1093/NAR/GNI063

Controlled fabrication of polyethylenimine-functionalized magnetic nanoparticles for the sequestration and quantification of free Cu 2+

Publisher: American Chemical Society (ACS)

Date: 08-06-2010

DOI: 10.1021/LA101196R

Abstract: Presented herein is a detailed study into the controlled adsorption of polyethylenimine (PEI) onto 50 nm crystalline magnetite nanoparticles (Fe(3)O(4) NPs) and how these PEI-coated Fe(3)O(4) NPs can be used for the magnetic capture and quantification of ultratrace levels of free cupric ions. We show the ability to systematically control the amount of PEI adsorbed onto the Fe(3)O(4) magnetic nanoparticle surfaces by varying the concentration of polymer during the adsorption process. This in turn allows for the tailoring of important colloidal properties such as the electrophoretic mobility and aggregation stability. Copper adsorption tests were carried out to investigate the effectiveness of PEI-coated Fe(3)O(4) NPs in copper remediation and detection. The study demonstrated that the NPs ability to bind with copper is highly dependent on the amount of PEI adsorbed on the NP surface. It was found that PEI-coated Fe(3)O(4) NPs were able to capture trace levels (approximately 2 ppb) of free cupric ions and concentrate the ions to allow for detection via ICP-OES. More importantly, it was found that due to the amine-rich structure of PEI, the PEI-coated Fe(3)O(4) NPs selectively adsorb toxic free cupric ions but not the less toxic EDTA complexed copper. This unique property makes PEI-coated Fe(3)O(4) NPs a novel solution for the challenge of separating and quantifying toxic cupric ions as opposed to the total copper concentration of a s le.

Single molecule conductance through rigid norbornylogous bridges with zero average curvature

Publisher: American Chemical Society (ACS)

Date: 28-05-2008

DOI: 10.1021/JP802328B

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSAELM.0C00317

Brief review of monitoring methods for loop-mediated isothermal amplification (LAMP)

Publisher: Elsevier BV

Date: 11-2014

DOI: 10.1016/J.BIOS.2014.05.039

Abstract: The loop-mediated isothermal lification (LAMP) technique has the potential to revolutionize molecular biology because it allows DNA lification under isothermal conditions and is highly compatible with point-of-care analysis. To achieve efficient genetic analysis of s les, the method of real-time or endpoint determination selected to monitor the biochemical reaction is of great importance. In this paper we briefly review progress in the development of monitoring methods for LAMP.

Sintered gold nanoparticles as an electrode material for paper-based electrochemical sensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2013

DOI: 10.1039/C3RA00102D

A Kinetic Model to Evaluate Cholesterol Efflux from THP-1 Macrophages to Apolipoprotein A-1

Publisher: American Chemical Society (ACS)

Date: 31-07-2001

DOI: 10.1021/BI010323N

Abstract: The kinetics (0 to 3 h) of cholesterol efflux to delipidated apolipoprotein A-1 were investigated, and the experimental data were best fitted to a mathematical model that involves two independent pathways of cholesterol efflux. The first pathway with a rate constant of 4.6 h(-1) is fast but removes only 3-5% of total cholesterol. After preconditioning apoA-1, it was found that this pathway remains, and hence it is a property of the cholesterol-loaded cells rather than due to modification on the apolipoprotein. This fast initial efflux does not seem to contribute to cholesterol efflux at later stages (>1 h) where a second pathway predominates. However, the fast initial efflux pool can be restored if apoA-1 is withdrawn. The second slower pathway (k(membrane--media) = 0.79 h(-1)) is associated with cholesterol ester hydrolysis whose rate constant could be experimentally verified (k(cal) = 0.43, k(exp) = 0.38 +/- 0.05). The model suggests that two different plasma membrane domains are involved in the two pathways. Loading of the cells with an oxysterol, 7-ketocholesterol (7K), inhibits efflux from both pathways. The model predicts that 7K decreases the initial efflux by decreasing the available cholesterol (by possibly affecting lipid packing), while all rate constants in the second pathway are decreased. In conclusion, the kinetic model suggests that cholesterol efflux to apoA-1 is a two-step process. In the first step, some of the plasma membrane cholesterol contributes to a fast initial efflux (possibly from lipid rafts) and leads to a second pathway that mobilizes intracellular cholesterol mobilization.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JAFC.0C02498

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JCED.0C00349

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.OPRD.0C00194

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSPTSCI.0C00067

A New Year Period Emphasizing the Need for Better Sensors

Publisher: American Chemical Society (ACS)

Date: 27-03-2020

DOI: 10.1021/ACSSENSORS.0C00456

Biomolecular Binding under Confinement: Statistical Predictions of Steric Influence in Absence of Long-Distance Interactions.

Publisher: Wiley

Date: 20-12-2022

DOI: 10.1002/CPHC.202100765

Abstract: We propose a theoretical model for the influence of confinement on biomolecular binding at the single-molecule scale at equilibrium, based on the change of the number of microstates (localization and orientation) upon reaction. Three cases are discussed: DNA sequences shorter and longer than the single strain DNA Kuhn length and spherical proteins, confined into a spherical container (liposome, droplet, etc.). The influence of confinement is found to be highly dependent on the molecular structure and significant for large molecules (relative to container size).

The influence of organic-film morphology on the efficient electron transfer at passivated polymer-modified electrodes to which nanoparticles are attached

Publisher: Wiley

Date: 12-04-2013

DOI: 10.1002/CPHC.201300047

Abstract: The impact of polymer-film morphology on the electron-transfer process at electrode/organic insulator/nanomaterial architectures is studied. The experimental data are discussed in the context of the most recent theory modelling the nanoparticle-mediated electron-transfer process at electrode/insulator/nanomaterial architectures proposed by Chazalviel and Allongue [J. Am. Chem. Soc. 2011, 133, 762-764]. A previous report [Anal. Chem. 2013, 85, 1073-1080] by us qualitatively verified the theory and demonstrates a transition from thickness-independent to thickness-dependent electron transfer as the layer thickness exceeds a certain threshold. This follow-up study explores a different polymer, poly(phenylenediamine), and focuses on the effect of the uniformity of organic film on electron transfer at these hybrid structures. Electron-transfer kinetics of modified surfaces, which were assessed using the redox species Ru(NH3)6(3+) in aqueous solution, showed that a thickness-dependent electron-transfer regime is achieved with poly(phenylenediamine). This is attributed to the sufficiently thin films never being fabricated with this polymer. Rather, it is suggested that thin poly(phenylenediamine) layers have a globular structure with poor film homogeneity and pinhole defects.

A Glimpse into the Future of Sensing

Publisher: American Chemical Society (ACS)

Date: 23-03-2018

DOI: 10.1021/ACSSENSORS.8B00177

Membrane properties of acrylate bulk polymers for biosensor applications

Publisher: Elsevier BV

Date: 1996

DOI: 10.1016/0956-5663(96)87662-7

Gly‐Gly‐His Immobilized On Monolayer Modified Back‐Side Contact Miniaturized Sensors for Complexation of Copper Ions

Publisher: Wiley

Date: 26-04-2013

DOI: 10.1002/ELAN.201200667

Observing the Reversible Single Molecule Electrochemistry of Alexa Fluor 647 Dyes by Total Internal Reflection Fluorescence Microscopy

Publisher: Wiley

Date: 30-08-2019

DOI: 10.1002/ANGE.201907298

An introduction to electrochemical DNA biosensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2007

DOI: 10.1039/B701816A

Abstract: Electrochemical DNA biosensors exploit the affinity of single-stranded DNA for complementary strands of DNA and are used in the detection of specific sequences of DNA with a view towards developing portable analytical devices. Great progress has been made in this field but there are still numerous challenges to overcome. This review for researchers new to the field describes the components of electrochemical DNA biosensors and the important issues in their design. Methods of transducing DNA binding events are discussed along with future directions for DNA biosensors.

What Should an ACS Sensors Paper Look Like?

Publisher: American Chemical Society (ACS)

Date: 26-02-2016

DOI: 10.1021/ACSSENSORS.6B00086

Protein resistance of surfaces modified with oligo(ethylene glycol) aryl diazonium derivatives

Publisher: Wiley

Date: 06-05-2013

DOI: 10.1002/CPHC.201300040

Abstract: Anti-fouling surfaces are of great importance for reducing background interference in biosensor signals. Oligo(ethylene glycol) (OEG) moieties are commonly used to confer protein resistance on gold, silicon and carbon surfaces. Herein, we report the modification of surfaces using electrochemical deposition of OEG aryl diazonium salts. Using electrochemical and contact angle measurements, the ligand packing density is found to be loose, which supports the findings of the fluorescent protein labelling that aryl diazonium OEGs confer resistance to nonspecific adsorption of proteins albeit lower than alkane thiol-terminated OEGs. In addition to protein resistance, aryl diazonium attachment chemistry results in stable modification. In common with OEG species on gold electrodes, OEGs with distal hydroxyl moieties do confer superior protein resistance to those with a distal methoxy group. This is especially the case for longer derivatives where superior coiling of the OEG chains is possible.

Electrochemical data mining: from information to knowledge: general discussion

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2FD90001G

Mátrafüred 2022 International Conference on Chemical Sensors

Publisher: Wiley

Date: 06-2023

DOI: 10.1002/ELAN.202300060

Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor-Dynamic Therapy with Tumor Specificity

Publisher: Wiley

Date: 09-10-2018

DOI: 10.1002/ADVS.201801155

Electrochemical approach of anticancer drugs-DNA interaction

Publisher: Elsevier BV

Date: 02-2005

DOI: 10.1016/J.JPBA.2004.10.037

Abstract: The interaction of drugs with DNA is among the most important aspects of biological studies in drug discovery and pharmaceutical development processes. In recent years there has been a growing interest in the electrochemical investigation of interaction between anticancer drugs and DNA. Observing the pre and post electrochemical signals of DNA or drug interaction provides good evidence for the interaction mechanism to be elucidated. Also this interaction could be used for the quantification of these drugs and for the determination of new drugs targeting DNA. Electrochemical approach can provide new insight into rational drug design and would lead to further understanding of the interaction mechanism between anticancer drugs and DNA.

Surface Epitope Coverage Affects Binding Characteristics of Bisphenol-A Functionalized Nanoparticles in a Competitive Inhibition Assay

Publisher: Hindawi Limited

Date: 2015

DOI: 10.1155/2015/756056

Abstract: The biomolecule interface is a key element in immunosensor fabrication, which can greatly influence the sensor performance. This paper explores the effects of surface epitope coverage of small molecule functionalized nanoparticle on the apparent affinity (avidity) of antibody in a competitive inhibition assay using bisphenol-A (BPA) as a model target. An unconventional two-antibody competitive inhibition ELISA (ci-ELISA) using thiolated BPA modified gold nanoparticles (cysBPAv-AuNP) as a competing reagent was devised for this study. It was shown that the antibody complexation with cysBPAv-AuNPs required a minimum number of surface epitopes on the nanoparticle to form a sufficiently strong interaction and reliable detection. The binding of cysBPAv-AuNP to anti-BPA antibodies, for limited antibody binding sites, was enhanced by a greater number of epitope-modified nanoparticles (cysBPAv-AuNP) as well as with higher epitope coverage. Increasing the molar concentration of epitope present in an assay enhanced the binding between anti-BPA antibodies and cysBPAv-AuNP. This implies that, to increase the limit of detection of a competitive inhibition assay, a reduced molar concentration of epitope should be applied. This could be achieved by either lowering the epitope coverage on each cysBPAv-AuNP or the assay molar concentration of cysBPAv-AuNP or both of these factors.

Machine Learning Color Feature Analysis of a High Throughput Nanoparticle Conjugate Sensing Assay

Publisher: American Chemical Society (ACS)

Date: 10-04-2023

DOI: 10.1021/ACS.ANALCHEM.2C05292

Katharina Gaus 1972–2021

Publisher: Springer Science and Business Media LLC

Date: 12-04-2021

DOI: 10.1038/S41590-021-00915-3

Strategies for chemical modification of graphene and applications of chemically modified graphene

Publisher: Royal Society of Chemistry (RSC)

Date: 2012

DOI: 10.1039/C2JM31218B

Multifunctional modified silver nanoparticles as ion and pH sensors in aqueous solution

Publisher: Royal Society of Chemistry (RSC)

Date: 2012

DOI: 10.1039/C2AN35147A

Abstract: Silver nanoparticles capped with mercaptoacetic acid and 2-aminoethanethiol short-chain alkanethiols were prepared by a one-step method in aqueous solution for monitoring pH and a range of heavy metal ions. The mode of transduction is optical, based on the change in aggregation of the nanoparticles in solution. Because of the different ionic interactions between the modified nanoparticles, these nanoparticle sensors can rapidly detect Pb(2+), Cu(2+) and Fe(2+), with detection limits as low as 1 × 10(-5) M, 5 × 10(-7) M and 5 × 10(-5) M respectively, as well as having the ability to detect Cu(2+) ions from Pb(2+) and Fe(2+). Furthermore, the same functionalised nanoparticles are also sensitive to pH exhibiting a good linear dynamic response between pH 1 and 10.

Light‐Addressable Ion Sensing for Real‐Time Monitoring of Extracellular Potassium

Publisher: Wiley

Date: 27-11-2018

DOI: 10.1002/ANGE.201811268

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/JASMS.0C00135

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACS.CHEMREV.0C00326

Unclonable Plasmonic Security Labels Achieved by Shadow-Mask-Lithography-Assisted Self-Assembly

Publisher: Wiley

Date: 29-01-2016

DOI: 10.1002/ADMA.201505022

Abstract: An unclonable plasmonic anti-counterfeiting strategy is demonstrated, which involves the use of molecule-embedded metal@silica core-shell nanoparticles as information carriers. A shadow-mask-lithography-assisted self-assembly is developed for the fabrication of the plasmonic security labels. The produced security labels show multiple sets of coding information that are highly unique, technically unreplicable, and can be robustly decoded by portable microscopes within seconds.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSPTSCI.0C00037

Tandem click reactions at acetylene-terminated Si(100) monolayers

Publisher: American Chemical Society (ACS)

Date: 10-05-2011

DOI: 10.1021/LA2013733

Abstract: We demonstrate a simple method for coupling alkynes to alkynes. The method involves tandem azide-alkyne cycloaddition reactions ("click" chemistry) for the immobilization of 1-alkyne species onto an alkyne modified surface in a one-pot procedure. In the case presented, these reactions take place on a nonoxidized Si(100) surface although the approach is general for linking alkynes to alkynes. The applicability of the method in the preparation of electrically well-behaved functionalized surfaces is demonstrated by coupling an alkyne-tagged ferrocene species onto alkyne-terminated Si(100) surfaces. The utility of the approach in biotechnology is shown by constructing a DNA sensing interface by derivatization of the acetylenyl surface with commercially available alkyne-tagged oligonucleotides. Cyclic voltametry, electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and X-ray reflectometry are used to characterize the coupling reactions and performance of the final modified surfaces. These data show that this synthetic protocol gives chemically well-defined, electronically well-behaved, and robust (bio)functionalized monolayers on silicon semiconducting surfaces.

Development of a Competitive ELISA for the Detection of 4-tert-Octylphenol in Seafood

Publisher: Springer Science and Business Media LLC

Date: 07-01-2015

DOI: 10.1007/S12161-014-0053-Y

Nanostructuring electrodes with carbon nanotubes: A review on electrochemistry and applications for sensing

Publisher: Elsevier BV

Date: 05-2005

DOI: 10.1016/J.ELECTACTA.2004.08.052

An antifouling electrode based on electrode-organic layer-nanoparticle constructs: Electrodeposited organic layers versus self-assembled monolayers

Publisher: Elsevier BV

Date: 10-2015

DOI: 10.1016/J.JELECHEM.2016.01.031

Tuning the Mechanical Properties of Multiarm RAFT-Based Block Copolyelectrolyte Hydrogels via Ionic Cross-Linking for 3D Cell Cultures

Publisher: American Chemical Society (ACS)

Date: 14-12-2023

DOI: 10.1021/ACS.BIOMAC.2C00632

Zwitterionic phenyl layers: Finally, stable, anti-biofouling coatings that do not passivate electrodes

Publisher: American Chemical Society (ACS)

Date: 15-05-2013

DOI: 10.1021/AM400519M

Abstract: Organic coatings on electrodes that limit biofouling by proteins but are of sufficiently low impedance to still allow Faradaic electrochemistry to proceed at the underlying electrode are described for the first time. These organic coatings formed using simple aryl diazonium salts present a zwitterionic surface and exhibit good electrochemical stability. The layers represent a low impedance alternative to the oligo (ethylene glycol) (OEG)-based anti-biofouling coatings and are expected to find applications in electrochemical biosensors and implantable electrodes. Two different zwitterionic layers grafted to glassy carbon surfaces are presented and compared to a number of better-known surfaces, including OEG-based phenyl-layer-grafted glassy carbon surfaces and OEG alkanethiol SAMs coated on gold, to allow the performance of these new layers to be compared to the body of work on other anti-biofouling surfaces. The results suggest that phenyl-based zwitterionic coatings are as effective as the OEG SAMs at resisting the nonspecific adsorption of bovine serum albumin and cytochrome c, as representative anionic and cationic proteins at physiological pH, whereas the impedance of the zwitterionic phenyl layers are two orders of magnitude lower than OEG SAMs.

Understanding the Effect of Au in Au–Pd Bimetallic Nanocrystals on the Electrocatalysis of the Methanol Oxidation Reaction

Publisher: American Chemical Society (ACS)

Date: 13-09-2018

DOI: 10.1021/ACS.JPCC.8B05407

3D Bioprintable Hydrogel with Tunable Stiffness for Exploring Cells Encapsulated in Matrices of Differing Stiffnesses

Publisher: American Chemical Society (ACS)

Date: 16-10-2023

DOI: 10.1021/ACSABM.3C00334

Quantum Dots in Analysis Virtual Issue

Publisher: American Chemical Society (ACS)

Date: 25-10-2023

DOI: 10.1021/ACSSENSORS.3C02203

An electrochemical impedance immunosensor based on gold nanoparticle-modified electrodes for the detection of HbA1c in human blood

Publisher: Wiley

Date: 27-06-2012

DOI: 10.1002/ELAN.201200233

Expanding Your Editorial Team

Publisher: American Chemical Society (ACS)

Date: 26-07-2019

DOI: 10.1021/ACSSENSORS.9B01166

Modular photo-induced RAFT polymerised hydrogels via thiol-ene click chemistry for 3D cell culturing

Publisher: Royal Society of Chemistry (RSC)

Date: 2017

DOI: 10.1039/C7PY01038A

Abstract: Visible-light induced thiol–ene click gelation of RAFT polymers, creating a modular hydrogel system for 3D cell culture assays.

Cascade Reactions in Nanozymes: Spatially Separated Active Sites inside Ag-Core–Porous-Cu-Shell Nanoparticles for Multistep Carbon Dioxide Reduction to Higher Organic Molecules

Publisher: American Chemical Society (ACS)

Date: 25-08-2019

DOI: 10.1021/JACS.9B07310

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSABM.0C00735

Cubic-Core Hexagonal-Branch Mechanism To Synthesize Bimetallic Branched and Faceted Pd–Ru Nanoparticles for Oxygen Evolution Reaction Electrocatalysis

Publisher: American Chemical Society (ACS)

Date: 02-10-2018

DOI: 10.1021/JACS.8B09402

Abstract: A major synthetic challenge is to make metal nanoparticles with nanosized branches and well-defined facets for high-performance catalysts. Herein, we introduce a mechanism that uses the growth of hexagonal crystal structured branches off cubic crystal structured core nanoparticles. We control the growth to form Pd-core Ru-branch nanoparticles that have nanosized branches with low index Ru facets. We demonstrate that the branched and faceted structural features of the Pd-Ru nanoparticles retain high catalytic activity while also achieving high stability for the oxygen evolution reaction.

High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging

Publisher: American Chemical Society (ACS)

Date: 17-08-2018

DOI: 10.1021/ACSNANO.8B03726

Abstract: Two important challenges in the field of

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSEARTHSPACECHEM.0C00158

Toward biosensors for the detection of circulating microRNA as a cancer biomarker: an overview of the challenges and successes

Publisher: Wiley

Date: 22-12-2014

DOI: 10.1002/WNAN.1324

Abstract: Considerable attention has been dedicated to developing feasible point-of-care tests for cancer diagnosis and prognosis. An ideal biomarker for clinical use should be easily assayed with minimally invasive medical procedures but possess high sensitivity and specificity. The role of microRNAs (miRNAs) in the regulation of different cellular processes, the unique altered patterns in cancer patients and presence in body fluids in the stable form, points to their clinical utility as blood-based biomarkers for diagnosis, prognosis, and treatment of cancer. Although a variety of selective and sensitive laboratory-based methods are already exist for the detection of circulating miRNA, having a simple, low-cost and rapid assay, which could be routinely used in clinical practice, is still required. Among different approaches that have developed for circulating miRNA detection, biosensors, due to the high sensitivity, ease of use, short assay time, non-toxic experimental steps, and adaptability to point-of-care testing, exhibit very attractive properties for developing portable devices. With this view, we present an overview of some of the challenges that still need to be met to be able to use circulating miRNAs in clinical practice, including their clinical significance, s le preparation, and detection. In particular, we highlight the recent advances in the rapidly developing area of biosensors for circulating miRNA detection, along with future prospects and challenges.

Zellzählung mittels Einzelobjektelektrochemie

Publisher: Wiley

Date: 06-10-2016

DOI: 10.1002/ANGE.201606459

Different functionalization of the internal and external surfaces in mesoporous materials for biosensing applications using click chemistry

Publisher: American Chemical Society (ACS)

Date: 09-12-2011

DOI: 10.1021/LA102599M

Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

Publisher: Springer Science and Business Media LLC

Date: 06-11-2020

DOI: 10.1038/S41551-020-00637-1

The spread of resistance to imidacloprid is restricted by thermotolerance in natural populations of Drosophila melanogaster

Publisher: Springer Science and Business Media LLC

Date: 18-03-2019

DOI: 10.1038/S41559-019-0837-Y

Abstract: Imidacloprid, the world's most used insecticide, has caused considerable controversy due to harmful effects on non-pest species and increasing evidence showing that insecticides have become the primary selective force in many insect species. The genetic response to insecticides is heterogeneous across populations and environments, leading to more complex patterns of genetic variation than previously thought. This motivated the investigation of imidacloprid resistance at different temperatures in natural populations of Drosophila melanogaster originating from four climate extremes replicated across two continents. Population and quantitative genomic analysis, supported by functional tests, have revealed a mixed genetic architecture to resistance involving major genes (Paramyosin and Nicotinic-Acetylcholine Receptor Alpha 3) and polygenes with a major trade-off with thermotolerance. Reduced genetic differentiation at resistance-associated loci indicated enhanced gene flow at these loci. Resistance alleles showed stronger evidence of positive selection in temperate populations compared to tropical populations in which chromosomal inversions In(2 L)t, In(3 R)Mo and In(3 R)Payne harbour susceptibility alleles. Polygenic architecture and ecological factors should be considered when developing sustainable management strategies for both pest and beneficial insects.

A photoelectrochemical platform for the capture and release of rare single cells

Publisher: Springer Science and Business Media LLC

Date: 12-06-2018

DOI: 10.1038/S41467-018-04701-Y

Abstract: For many normal and aberrant cell behaviours, it is important to understand the origin of cellular heterogeneity. Although powerful methods for studying cell heterogeneity have emerged, they are more suitable for common rather than rare cells. Exploring the heterogeneity of rare single cells is challenging because these rare cells must be first pre-concentrated and undergo analysis prior to classification and expansion. Here, a versatile capture & release platform consisting of an antibody-modified and electrochemically cleavable semiconducting silicon surface for release of in idual cells of interest is presented. The captured cells can be interrogated microscopically and tested for drug responsiveness prior to release and recovery. The capture & release strategy was applied to identify rare tumour cells from whole blood, monitor the uptake of, and response to, doxorubicin and subsequently select cells for single-cell gene expression based on their response to the doxorubicin.

How important Is the interfacial chemical bond for electron transport through alkyl chain monolayers?

Publisher: American Chemical Society (ACS)

Date: 31-10-2006

DOI: 10.1021/NL062089Y

Abstract: We show that the electrode/molecule chemical bond does not change the tunneling barrier for charge transport through alkyl chain monolayers sandwiched between Si and Hg electrodes. This observation can be understood if the interfacial bond mainly governs the monolayer's structure, while the electronic states due to molecule-electrode bonding do not contribute significantly to tunneling. Yet, the nature of the bond affects the Schottky barrier inside the semiconductor due to changes in the interface dipole.

Surface-bound molecular rulers for probing the electrical double layer

Publisher: American Chemical Society (ACS)

Date: 17-04-2012

DOI: 10.1021/JA301509H

Abstract: Herein, we report the first experimental investigation on the effect of varying the position of redox-active moieties, within the electrical double layer, on the apparent formal potential and on the electron transfer rate constant. This was achieved using a rigid class of molecules, norbornylogous bridges, to place redox species (ferrocene) at a fixed position above the surface of the electrode. Cyclic voltammetry and alternating current voltammetry were used to calculate the apparent formal potential and the electron transfer rate constant for the electron transfer between the ferrocene and the gold electrode. We use the effect of electric field on the apparent formal potential measurement of the surface-bound redox species to calculate the potential drop from the initiation of the electrical double layer to different distances above it. It was found that self-assembled monolayers formed from ω-hydroxyalkanethiol have a potential profile very similar to that described by classical theories for bare metal electrodes. A steep drop in potential in the Stern layer was observed followed by a smaller potential drop in the Gouy-Chapman layer. The electron transfer rate constant was found to decrease as the distance between the ferrocene moiety and the initiation of the double layer is increased. Thus, the electron transfer rate constant appears to be dependent on ion concentration.

Modifying Porous Silicon with Self-Assembled Monolayers for Biomedical Applications: The Influence of Surface Coverage on Stability and Biomolecule Coupling

Publisher: Wiley

Date: 08-12-2008

DOI: 10.1002/ADFM.200800640

Direct-laser writing for subnanometer focusing and single-molecule imaging

Publisher: Springer Science and Business Media LLC

Date: 03-02-2022

DOI: 10.1038/S41467-022-28219-6

Abstract: Two-photon direct laser writing is an additive fabrication process that utilizes two-photon absorption of tightly focused femtosecond laser pulses to implement spatially controlled polymerization of a liquid-phase photoresist. Two-photon direct laser writing is capable of nanofabricating arbitrary three-dimensional structures with nanometer accuracy. Here, we explore direct laser writing for high-resolution optical microscopy by fabricating unique 3D optical fiducials for single-molecule tracking and 3D single-molecule localization microscopy. By having control over the position and three-dimensional architecture of the fiducials, we improve axial discrimination and demonstrate isotropic subnanometer 3D focusing ( .8 nm) over tens of micrometers using a standard inverted microscope. We perform 3D single-molecule acquisitions over cellular volumes, unsupervised data acquisition and live-cell single-particle tracking with nanometer accuracy.

Modification of Carbon Electrode Surfaces

Publisher: Wiley

Date: 12-10-2016

DOI: 10.1002/9783527697489.CH6

Multi-analyte sensing: a chemometrics approach to understanding the merits of electrode arrays versus single electrodes

Publisher: Royal Society of Chemistry (RSC)

Date: 2008

DOI: 10.1039/B804811H

Abstract: A peptide-modified electrode array with a different peptide on each electrode is compared with a single electrode modified with many peptides for the voltammetric measurement of concentrations of Cu(2+), Cd(2+) and Pb(2+) in solution. The single gold electrode was modified simultaneously with peptides Gly-Gly-His, glutathione and angiotensin I each coupled to thioctic acid, and thioctic acid itself, and the calibration of mixtures of ions was compared with previously published data from an array of four sensors each with an in idual modification. Calibration at the multi-peptide single-electrode sensor was by two-way partial least squares (voltammetric current measured with variables 's le' x 'potential') and for the electrode array by three-way NPLS1 ('s le' x 'potential' x 'electrode'). The advantage of designing experiments to yield multi-way data is demonstrated and discussed.

Antimicrobial activity of T4 bacteriophage conjugated indium tin oxide surfaces

Publisher: Elsevier BV

Date: 03-2018

DOI: 10.1016/J.JCIS.2017.12.029

Abstract: We report the antimicrobial activity of bare and surface functionalized indium tin oxide (ITO) conjugated with T4 bacteriophage towards E. coli. A ∼ 10

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACS.BIOMAC.0C00585

Core–Satellite Mesoporous Silica–Gold Nanotheranostics for Biological Stimuli Triggered Multimodal Cancer Therapy

Publisher: Wiley

Date: 06-06-2018

DOI: 10.1002/ADFM.201801961

A guide to the design of magnetic particle imaging tracers for biomedical applications

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2NR01897G

Abstract: This review outlines how nanoparticle structure and surface coating can be tailored to generate images with high signal and spatial resolution in vivo , which is crucial for developing magnetic particle imaging tracers for biomedical applications.

Advances in interfacial design for electrochemical biosensors and sensors: Aryl diazonium salts for modifying carbon and metal electrodes

Publisher: Wiley

Date: 03-2008

DOI: 10.1002/ELAN.200704124

Electrocatalytic Nanoparticles That Mimic the Three-Dimensional Geometric Architecture of Enzymes: Nanozymes

Publisher: American Chemical Society (ACS)

Date: 23-09-2018

DOI: 10.1021/JACS.8B08664

Abstract: Enzymes are characterized by an active site that is typically embedded deeply within the protein shell thus creating a nanoconfined reaction volume in which high turnover rates occur. We propose nanoparticles with etched substrate channels as a simplified enzyme mimic, denominated nanozymes, for electrocatalysis. We demonstrate increased electrocatalytic activity for the oxygen reduction reaction using PtNi nanoparticles with isolated substrate channels. The PtNi nanoparticles comprise an oleylamine capping layer that blocks the external surface of the nanoparticles participating in the catalytic reaction. Oxygen reduction mainly occurs within the etched channels providing a nanoconfined reaction volume different from the bulk electrolyte conditions. The oxygen reduction reaction activity normalized by the electrochemically active surface area is enhanced by a factor of 3.3 for the nanozymes compared to the unetched nanoparticles and a factor of 2.1 compared to mesoporous PtNi nanoparticles that possess interconnecting pores.

Demonstration of the advantages of using bamboo-like nanotubes for electrochemical biosensor applications compared with single walled carbon nanotubes

Publisher: Elsevier BV

Date: 12-2005

DOI: 10.1016/J.ELECOM.2005.10.007

Functionalization of acetylene-terminated monolayers on Si(100) surfaces: A click chemistry approach

Publisher: American Chemical Society (ACS)

Date: 27-07-2007

DOI: 10.1021/LA701035G

Integrating polymers with alkanethiol self-assembled monolayers (SAMs): Blocking SAM defects with electrochemical polymerisation of tyramine

Publisher: Elsevier BV

Date: 12-2002

DOI: 10.1016/S1388-2481(02)00496-4

Role of the Secondary Metal in Ordered and Disordered Pt–M Intermetallic Nanoparticles: An Example of Pt3Sn Nanocubes for the Electrocatalytic Methanol Oxidation

Publisher: American Chemical Society (ACS)

Date: 04-02-2021

DOI: 10.1021/ACSCATAL.0C05370

Flexible fiber-shaped non-enzymatic sensors with a graphene-metal heterostructure based on graphene fibres decorated with gold nanosheets

Publisher: Elsevier BV

Date: 09-2018

DOI: 10.1016/J.CARBON.2018.05.004

Spacing of integrin ligands influences signal transduction in endothelial cells

Publisher: Elsevier BV

Date: 08-2011

DOI: 10.1016/J.BPJ.2011.06.064

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.ANALCHEM.0C02570

Monitoring the progression of loop-mediated isothermal amplification using conductivity

Publisher: Elsevier BV

Date: 12-2014

DOI: 10.1016/J.AB.2014.08.002

Abstract: Loop-mediated isothermal lification (LAMP) yields a large amount of DNA, as well as magnesium pyrophosphate precipitate, causing a decrease in ionic strength that can be measured with a conductivity meter. There is a clear relationship between the conductivity of the LAMP mixture solution and the duration of biochemical reaction. Moreover, there is also a clear relationship between the change in conductivity and the amount of initial template DNA over the range of 0.08 to 3.2 ng. These results demonstrate the feasibility not only for detecting the LAMP product qualitatively but also for real-time monitoring the biochemical reaction progression quantitatively using conductivity measurements.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 11-08-2020

DOI: 10.1021/ACSESTWATER.0C00034

Extending the dynamic range of electrochemical sensors using multiple modified electrodes

Publisher: Springer Science and Business Media LLC

Date: 16-01-2007

DOI: 10.1007/S00216-006-1022-0

Abstract: Multiple electrodes, combined with a chemometric strategy to calibrate the measurement response, have been used for the determination of an analyte across a broader dynamic range than is possible with a single electrode. The model system used for the detection of copper comprised electrodes modified with a self-assembled monolayer. The electrodes were modified with the copper-complexing species (3-mercaptopropionic acid, thioctic acid, and the peptides cysteine and Gly-Gly-His) and copper was determined over concentrations ranging from nanomolar to millimolar using voltammetric analysis. We have demonstrated that by combining the calibration functions from the four electrodes a better estimate (i.e. with smaller variance) of the concentration of the analyte is obtained. Measurement uncertainty is expressed for independently prepared electrodes, which allows the possibility of commercial production and factory calibration. The principles of using multiple electrodes modified with recognition elements with different affinities for the target analyte to extend the dynamic range of sensors is a general one that could be applied to other analytes.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JPROTEOME.0C00263

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JCTC.0C00614

Facile Functionalization and Phase Reduction Route of Magnetic Iron Oxide Nanoparticles for Conjugation of Matrix Metalloproteinase

Publisher: Wiley

Date: 06-2010

DOI: 10.1002/ADEM.200980049

Sensors and Industry Virtual Issue

Publisher: American Chemical Society (ACS)

Date: 09-11-2020

DOI: 10.1021/ACSSENSORS.0C02265

Imaging of Tear Film Lipids Using Quantum Dots

Publisher: OSA

Date: 2018

DOI: 10.1364/3D.2018.JW4A.18

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSENERGYLETT.0C00847

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSAPM.0C00410

Using Molecular Level Modification To Tune the Conductivity of Graphene Papers

Publisher: American Chemical Society (ACS)

Date: 14-08-2012

DOI: 10.1021/JP304374R

An amperometric immunosensor based on a gold nanoparticle-diazonium salt modified sensing interface for the detection of hba1c in human blood

Publisher: Wiley

Date: 18-09-2013

DOI: 10.1002/ELAN.201200333

Approaches to Improving the Selectivity of Nanozymes

Publisher: Wiley

Date: 05-04-2023

DOI: 10.1002/ADMA.202211288

Abstract: Nanozymes mimic enzymes and that includes their selectivity. To achieve selectivity, significant inspiration for nanoparticle design can come from the geometric and molecular features that make enzymes selective catalysts. The two central features enzymes use are control over the arrangement of atoms in the active site and the placing of the active site down a nanoconfined substrate channel. The implementation of enzyme‐inspired features has already been shown to both improve activity and selectivity of nanoparticles for a variety of catalytic and sensing applications. The tuning and control of active sites on metal nanoparticle surfaces ranges from simply changing the composition of the surface metal to sophisticated approaches such as the immobilization of single atoms on a metal substrate. Molecular frameworks provide a powerful platform for the implementation of isolated and discrete active sites while unique diffusional environments further improve selectivity. The implementation of nanoconfined substrate channels around these highly controlled active sites offers further ability to control selectivity through altering the solution environment and transport of reactants and products. Implementing these strategies together offers a unique opportunity to improve nanozyme selectivity in both sensing and catalysis.

Some more observations on the unique electrochemical properties of electrode-monolayer-nanoparticle constructs

Publisher: Wiley

Date: 06-09-2010

DOI: 10.1002/CPHC.201000250

Abstract: Physical and electrochemical properties of gold nanoparticle-based electrodes are highlighted. Polycrystalline gold electrodes are passivated by a self-assembled monolayer, then the immobilization of gold nanoparticles "switch on" the electrochemical reactivity of ruthenium. Herein, gap-mode Raman studies show that the location of the nanoparticles is on the top of the monolayer, meaning that the "switching on" cannot be attributed to a direct electrical contact between nanoparticles and the gold support. This "switching on" feature is also not affected by the size of the gold nanoparticles with a range of diameters between 4 and 67 nm. Further, the charge of the nanoparticles is investigated by grafting chemical groups onto the nanoparticles which is observed to alter the electron-transfer kinetics. The variation in rate constant however is insufficient to attribute the "switching on" phenomenon to a possible adsorption of the redox species onto the nanoparticles.

Insights into adhesion biology using single-molecule localization microscopy

Publisher: Wiley

Date: 04-02-2014

DOI: 10.1002/CPHC.201301041

Abstract: Focal adhesions are complex multi-protein structures that mediate cell adhesion and cell migration in multicellular organisms. Most of the protein components involved in focal adhesion formation have been identified, but a major challenge remains: determination of the spatial and temporal dynamics of adhesion proteins in order to understand the molecular mechanisms of adhesion assembly, maturation, signal regulation, and disassembly. Progress in this field has been h ered by the limited resolution of fluorescence microscopy. Recent advances have led to the development of super-resolution techniques including single-molecule localization microscopy (SMLM). Here, we discuss how the application of these techniques has revealed important new insights into focal adhesion structure and dynamics, including the first description of the three-dimensional nano-architecture of focal adhesions and of the dynamic exchange of integrins in focal adhesions. Hence, SMLM has contributed to the refinement of existing models of adhesions as well as the establishment of novel models, thereby opening new research directions. With current improvements in SMLM instrumentation and analysis, it has become possible to study cellular adhesions at the single-molecule level.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSAELM.0C00513

Role of fullerene electron transport layer on the morphology and optoelectronic properties of perovskite solar cells

Publisher: Elsevier BV

Date: 11-2017

DOI: 10.1016/J.ORGEL.2017.08.001

Electrochemical switching of Si(100) modular assemblies

Publisher: American Chemical Society (ACS)

Date: 22-12-2012

DOI: 10.1021/JA210048X

Abstract: We report on a modular approach for producing well-defined and electrochemically switchable surfaces on Si(100). The switching of these surfaces is shown to change a Si(100) surface from resistant to cell adsorption to promoting cell adhesion. The electrochemical conversion of the modified electrode surface is demonstrated by X-ray photoelectron spectroscopy, X-ray reflectometry, contact angle and cell adhesion studies.

Synthesis of low- and high-index faceted metal (Pt, Pd, Ru, Ir, Rh) nanoparticles for improved activity and stability in electrocatalysis

Publisher: Royal Society of Chemistry (RSC)

Date: 2019

DOI: 10.1039/C9NR05802H

Abstract: High- and low-index faceted metal (Pt, Pd, Ru, Ir, Rh) nanoparticles designed for improved electrocatalytic activity and stability are reviewed.

Thiol-terminated monolayers on oxide-free Si: Assembly of semiconductor-alkyl-S-metal junctions

Publisher: American Chemical Society (ACS)

Date: 02-2007

DOI: 10.1021/LA063034E

Abstract: Self-assembled monolayers formed by thermal hydrosilylation of a trifluoroacetyl-protected alkenylthiol on Si-H surfaces, followed by removal of the protecting groups, yield essentially oxide-free monolayers suitable for the formation of Si-C11H22-S-Hg and Si-C11H22-S-Au junctions in which the alkyl chains are chemically bound to the silicon surface (via Si-C bonds) and the metal electrode (via Hg-S or Au-S bonds). Two barriers to charge transport are present in the system: at low bias the current is temperature activated and hence limited by thermionic emission over the Schottky barrier in the silicon, whereas as at high bias transport is limited by tunneling through the organic monolayer. The thiol-terminated monolayer on oxide-free silicon provides a well-characterized system allowing a careful study of the importance of the interfacial bond to the metal electrode for current transport through saturated molecules.

Heterogeneous electron-transfer kinetics for flavin adenine dinucleotide and ferrocene through alkanethiol mixed monolayers on gold electrodes

Publisher: American Chemical Society (ACS)

Date: 25-05-2004

DOI: 10.1021/JP037494H

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/JASMS.0C00230

Synthetic Strategies to Enhance the Electrocatalytic Properties of Branched Metal Nanoparticles

Publisher: American Chemical Society (ACS)

Date: 26-05-2022

DOI: 10.1021/ACS.ACCOUNTS.2C00140

Abstract: Branched metal nanoparticles have unique catalytic properties because of their high surface area with multiple branches arranged in an open 3D structure that can interact with reacting species and tailorable branch surfaces that can maximize the exposure of desired catalytically active crystal facets. These exceptional properties have led to the exploration of the roles of branch structural features ranging from the number and dimensions of branches at the larger scales to the atomic-scale arrangement of atoms on precise crystal facets. The fundamental significance of how larger-scale branch structural features and atomic-scale surface faceting influence and control the catalytic properties has been at the forefront of the design of branched nanoparticles for catalysis. Current synthetic advances have enabled the formation of branched nanoparticles with an unprecedented degree of control over structural features down to the atomic scale, which have unlocked opportunities to make improved nanoparticle catalysts. These catalysts have high surface areas with controlled size and surface facets for achieving exceedingly high activity and stability. The synthetic advancement has recently led to the use of branched nanoparticles as ideal substrates that can be decorated with a second active metal in the form of islands and single atoms. These decorated branched nanoparticles have new and highly effective catalytic active sites where both branch metal and decorating metal play essential roles during catalysis.In the opening half of this Account, we critically assess the important structural features of branched nanoparticles that control catalytic properties. We first discuss the role of branch dimensions and the number of branches that can improve the surface area but can also trap gas bubbles. We then investigate the atomic-scale structural features of exposed surface facets, which are critical for enhancing catalytic activity and stability. Well-defined branched nanoparticles have led to a fundamental understanding of how the branch structural features influence the catalytic activity and stability, which we highlight for the oxygen evolution reaction (OER) and biomass oxidation. In discussing recent breakthroughs for branched nanoparticles, we explore the opportunities created by decorated branched nanoparticles and the unique bifunctional active sites that are exposed on the branched nanoparticle surfaces. This class of catalysts is of rapidly growing importance for reactions including the hydrogen evolution reaction (HER) and methanol oxidation reaction (MOR), where two exposed metals are required for efficient catalysis. In the second half of this Account, we explore recent advances in the synthesis of branched nanoparticles and highlight the cubic-core hexagonal-branch growth mechanism that has achieved excellent control of all of the important structural features, including branch dimensions, number of branches, and surface facets. We discuss the slow precursor reduction as an effective strategy for decorating metal islands with controlled loadings on the branched nanoparticle surfaces and the spread of these metal islands to form single-atom active sites. We envisage that the key synthetic and structural advances identified in this Account will guide the development of the next-generation electrocatalysts.

Physical study of film-forming acrylate emulsion polymers for biosensor applications

Publisher: Elsevier BV

Date: 08-1997

DOI: 10.1016/S0003-2670(97)00282-1

Direct Growth of Highly Strained Pt Islands on Branched Ni Nanoparticles for Improved Hydrogen Evolution Reaction Activity

Publisher: American Chemical Society (ACS)

Date: 03-10-2019

DOI: 10.1021/JACS.9B07659

Abstract: The direct growth of Pt islands on lattice mismatched Ni nanoparticles is a major synthetic challenge and a promising strategy to create highly strained Pt atoms for electrocatalysis. By using very mild reaction conditions, Pt islands with tunable strain were formed directly on Ni branched particles. The highly strained 1.9 nm Pt-island on branched Ni nanoparticles exhibited high specific activity and the highest mass activity for hydrogen evolution (HER) in a pH 13 electrolyte. These results show the ability to synthetically tune the size of the Pt islands to control the strain to give higher HER activity.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSAPM.0C00650

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSNANO.0C03262

Der Einfluss von Nanoconfinement auf die Elektrokatalyse

Publisher: Wiley

Date: 31-05-2022

DOI: 10.1002/ANGE.202200755

Abstract: Die Verwendung von Nanopartikeln und nanostrukturierten Elektroden ist in der Elektrokatalyse weit verbreitet. Diese nanometrischen Systeme enthalten je nach Geometrie Elemente des Nanoconfinements in unterschiedlichem Ausmaß, was sich viel stärker auf die Aktivität und Selektivität auswirken kann, als oft angenommen wird. In diesem Aufsatz identifizieren wir zunächst die Systeme, die unterschiedliche Grade von Nanoconfinement enthalten, und zeigen, wie sie die Aktivität und Selektivität elektrokatalytischer Reaktionen beeinflussen können. Anschließend wird ein grundlegendes Verständnis der Auswirkungen des Nanoconfinements auf die Elektrochemie und Elektrokatalyse vermittelt, das dank der Entwicklung neuer, atomar präziser Herstellungs‐ und Fertigungstechniken und Fortschritten bei der theoretischen Modellierung allmählich erschlossen wird. Diese Übersicht soll dabei helfen, die Nanostrukturierung nicht nur zur Vergrößerung der Oberfläche zu nutzen, sondern auch die thermodynamisch bedingten Skalierungsbeziehungen in der Elektrokatalyse zu durchbrechen.

A sulfite biosensor fabricated using electrodeposited polytyramine: Application to wine analysis

Publisher: Royal Society of Chemistry (RSC)

Date: 1999

DOI: 10.1039/A907239J

Further development of an electrochemical DNA hybridization biosensor based on long-range electron transfer

Publisher: Elsevier BV

Date: 11-2005

DOI: 10.1016/J.SNB.2005.03.072

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSSUSCHEMENG.0C02908

A novel route to copper(ii) detection using 'click' chemistry-induced aggregation of gold nanoparticles

Publisher: Royal Society of Chemistry (RSC)

Date: 2012

DOI: 10.1039/C1AN15693D

Abstract: A simple colorimetric method for the detection of copper ions in water is described. This method is based on the 'click' copper(I)-catalyzed azide-alkyne cycloaddition reaction and its use in promoting the aggregation of azide-tagged gold nanoparticles by a dialkyne cross-linker is described. Nanoparticle cross-linking, evidenced as a colour change, is used for the detection of copper ions. The lowest detected concentration by the naked eye was 1.8 μM, with the response linear with log(concentration) between 1.8-200 μM. The selectivity relative to other potentially interfering ions was evaluated.

Voltammetric detection of cadmium ions at glutathione-modified gold electrodes

Publisher: Royal Society of Chemistry (RSC)

Date: 2005

DOI: 10.1039/B416831C

Abstract: An electrochemical sensor for the detection of cadmium ions is described using immobilized glutathione as a selective ligand. First, a self-assembled monolayer of 3-mercaptopropionic acid (MPA) was formed on a gold electrode. The carboxyl terminus then allowed attachment of glutathione (GSH)via carbodiimide coupling to give the MPA-GSH modified electrode. A cadmium ion forms a complex with glutathione via the free sulfhydryl group and also to the carboxyl groups. The complexed ion is reduced by linear and Osteryoung square wave voltammetry with a detection limit of 5 nM. The effect of the kinetics of accumulation of cadmium on the measured current was investigated and modeled. Increasing the temperature of accumulation and electrochemical analysis caused an increase in the voltammetric peak of approximately 4% per degrees C around room temperature. The modified electrode could be regenerated, being stable for more than 16 repeated uses and more than two weeks if used once a day. Some interference from Pb(2+) and Cu(2+) was observed but the effects of Zn(2+), Ni(2+), Cr(3+) and Ba(2+) were insignificant.

Functionalized Gold Nanorod Probes: A Sophisticated Design of SERS Immunoassay for Biodetection in Complex Media

Publisher: American Chemical Society (ACS)

Date: 14-09-2021

DOI: 10.1021/ACS.ANALCHEM.1C02557

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Publisher: Proceedings of the National Academy of Sciences

Date: 29-08-2016

DOI: 10.1073/PNAS.1607436113

Abstract: T-cell activation requires the translation of antigen binding to the T-cell receptor (TCR) into intracellular signaling. However, how antigen recognition and signal transduction are mechanistically linked is poorly understood. Here, we used single-molecule localization microscopy to link TCR clustering to signaling. We found that the likelihood of a single receptor to initiate signaling upon ligand binding depended on receptor-to-receptor spacing, with TCRs in dense clusters having the highest signaling efficiency. This means that antigen recognition must first be translated into a spatial reorganization of receptors into dense, signaling-competent clusters before signaling can begin. Thus, the quality of an antigen in terms of signaling is given by its ability to densely cluster receptors.

Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?

Publisher: Wiley

Date: 30-05-2021

DOI: 10.1002/ADFM.202007880

Abstract: Macropinocytosis is a consequence of oncogenic alterations of cancer cells while most healthy cells are non‐macropinocytic. It is currently unclear whether macropinocytic cancer cells can be targeted rather than healthy cells, by adjusting the shape and size of nanoparticles. Herein, the endocytosis of two differently shaped nanoparticles nanorods and nanospheres are compared in cancer and healthy cells. The cells are breast epithelial cancer cells (MCF7) and breast epithelial healthy cells (MCF10A) and pancreas cancer cells (PANC‐1 cells) and non‐tumourogenic patient‐derived cancer‐associated fibroblasts (CAFs). The endocytosis pathway is quantified by a combination of pair correlation microscopy and endocytosis inhibitors. MCF7 cells use clathrin‐mediated endocytosis and macropinocytosis to take up the nanorods while MCF10A cells use predominantly clathrin‐mediated endocytosis. Based on the comparison of endocytic behavior of cancer and healthy cells, MCF7 cells can be induced to take up more nanorods and suppress the metabolism and endocytosis of nanorods in MCF10A cells. The nanorods allow targeting to breast cancer MCF7 cells and pancreas cancer cells over the healthy cells. This study opens exciting possibilities for shape to target the cancer cells over healthy cells, by adjusting nanoparticle shape.

Synthesis, optical properties and theoretical modelling of discrete emitting states in doped silicon nanocrystals for bioimaging

Publisher: Royal Society of Chemistry (RSC)

Date: 2018

DOI: 10.1039/C8NR05071F

Abstract: The creation of multiple emission pathways in quantum dots (QDs) is an exciting prospect with fundamental interest and optoelectronic potential.

Protease sensing using nontoxic silicon quantum dots

Publisher: SPIE-Intl Soc Optical Eng

Date: 23-08-2017

DOI: 10.1117/1.JBO.22.8.087002

Electronic detection of target nucleic acids by a 2,6-disulfonic acid anthraquinone intercalator

Publisher: American Chemical Society (ACS)

Date: 10-06-2003

DOI: 10.1021/AC034129D

Abstract: A DNA hybridization biosensor based on long-range electron transfer that is capable of detecting DNA single-base mismatch is presented. A mixed self-assembled monolayer of single-stranded DNA (ss-DNA), thiolated at the 3' end, and 6-mercapto-1-hexanol was formed on a gold surface. This probe ss-DNA-modified gold surface was incubated in 2,6-disulfonic acid anthraquinone (AQDS) intercalator solution, rinsed, and placed in an AQDS-free buffer solution, whereupon voltammetric experiments were performed. No voltammetric peaks were observed for probe ss-DNA-modified gold electrodes. Upon DNA hybridization and incubation in AQDS, clear voltammetric peaks, consistent with the oxidation and reduction of AQDS, were observed. The absence of AQDS electrochemistry for ss-DNA-modified surfaces clearly shows the electrochemistry is due to long-range electron transfer through the DNA duplex. No peak currents were observed when the probe ss-DNA-modified surface was exposed to noncomplementary target DNA, but there was a diminution in current signal upon hybridization with C-A mismatched and a G-A mismatched targets.

Demonstrating the Use of Bisphenol A-functionalised Gold Nanoparticles in Immunoassays

Publisher: CSIRO Publishing

Date: 2013

DOI: 10.1071/CH13043

Abstract: Spherical gold nanoparticles (5-nm diameter) were modified with a small-molecule thiolated bisphenol A (BPA) ligand to achieve an estimated coverage of ~3.3 × 10–10 mol cm–2, or 180 ligands per particle. The modified particles were tested in an enzyme-linked immunosorbent assay (ELISA) format to measure functionality and were shown to bind specifically to anti-BPA antibody while resisting the non-specific adsorption of an antibody with no affinity for BPA. It was found that the use of 10 % ethanol as a co-solvent was required in the ELISA as aqueous buffers alone resulted in poor binding between anti-BPA antibody and the functionalised nanoparticles. This is likely due to the hydrophobic nature of the BPA ligand limiting its solubility, and therefore its availability for antibody interactions, in purely aqueous environments. To our knowledge, this is the first ex le of a nanoparticle modified with a small organic molecule being used in an ELISA assay.

How Do I Get My Paper to Stand Out and Be Noticed?

Publisher: American Chemical Society (ACS)

Date: 22-11-2017

DOI: 10.1021/ACSSENSORS.7B00811

Dual Signaling DNA Electrochemistry: An Approach To Understand DNA Interfaces

Publisher: American Chemical Society (ACS)

Date: 18-01-2018

DOI: 10.1021/ACS.LANGMUIR.7B02787

Abstract: Electrochemical DNA biosensors composed of a redox marker modified nucleic acid probe tethered to a solid electrode is a common experimental construct for detecting DNA and RNA targets, proteins, inorganic ions, and even small molecules. This class of biosensors generally relies on the binding-induced conformational changes in the distance of the redox marker relative to the electrode surface such that the charge transfer is altered. The conventional design is to attach the redox species to the distal end of a surface-bound nucleic acid strand. Here we show the impact of the position of the redox marker, whether on the distal or proximal end of the DNA monolayer, on the DNA interface electrochemistry. Somewhat unexpectedly, greater currents were obtained when the redox molecules were located on the distal end of the surface-bound DNA monolayer, notionally furthest away from the electrode, compared with currents when the redox species were located on the proximal end, close to the electrode. Our results suggest that a limitation in ion accessibility is the reason why smaller currents were obtained for the redox markers located at the bottom of the DNA monolayer. This understanding shows that to allow the quantification of the amount of redox labeled target DNA strand that hybridizes to probe DNA immobilized on the electrode surface, the redox species must be on the distal end of the surface-bound duplex.

Electrochemical microscopy based on spatial light modulators: A projection system to spatially address Electrochemical reactions at semiconductors

Publisher: The Electrochemical Society

Date: 30-12-2018

DOI: 10.1149/2.0111804JES

Is Cu instability during the CO₂ reduction reaction governed by the applied potential or the local CO concentration?

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D0SC05990K

Abstract: The stability of bimetallic AgCu and PdCu catalysts for electrochemical CO 2 RR is investigated using the combination of operando and ex situ TEM. The local CO concentration is identified as the main link between activity, stability and selectivity.

Correction to “Machine Learning Color Feature Analysis of a High Throughput Nanoparticle Conjugate Sensing Assay

Publisher: American Chemical Society (ACS)

Date: 15-05-2023

DOI: 10.1021/ACS.ANALCHEM.3C01892

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.ORGANOMET.0C00416

Application of N-PLS calibration to the simultaneous determination of Cu2+, Cd2+ and Pb2+ using peptide modified electrochemical sensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2006

DOI: 10.1039/B604690H

Abstract: The simultaneous determination of Cu(2+), Cd(2+) and Pb(2+) is demonstrated at four modified gold electrodes using N-PLS calibration. Three of the electrodes were modified with the peptides Gly-Gly-His, gamma-Glu-Cys Gly and human angiotensin I which were covalently attached to thioctic acid self-assembled monolayers and the fourth electrode was modified with thioctic acid only. Voltammetry at the modified electrodes in the presence of the three metal ions revealed one peak due to the reduction of copper and another due to the overlapping peaks of cadmium and lead which made quantification using conventional methods difficult. N-PLS was used to calibrate and predict trace concentrations (100 nM to 10 microM) of mixtures of Cu(2+), Cd(2+) and Pb(2+).

Changes to the Editorial Team at ACS Sensors

Publisher: American Chemical Society (ACS)

Date: 26-06-2020

DOI: 10.1021/ACSSENSORS.0C01157

Preparation and characterisation of an aligned carbon nanotube array on the silicon (100) surface

Publisher: Royal Society of Chemistry (RSC)

Date: 2006

DOI: 10.1039/B611016A

Reversible Thermoresponsive Plasmonic Core‐Satellite Nanostructures That Exhibit Both Expansion and Contraction (UCST and LCST)

Publisher: Wiley

Date: 25-09-2018

DOI: 10.1002/MARC.201800451

Abstract: The assembly of sophisticated gold nanoparticle constructs where thermoresponsive core-satellite nanostructures are created and the satellites are close enough to the core for strong surface plasmon resonance coupling to occur, has begun to be developed. The linker between the core and the satellites being a thermoresponsive polymer means that a dispersion of these nanostructures will show temperature-dependent optical properties as the distance between the core and the satellites changes. Unlike previous related thermoresponsive core-satellite systems that undergo a single thermoresponsive transition, herein a polymer system with dual thermoresponsive transitions (block copolymer with both lower critical solution temperature and upper critical solution temperature) is employed as a linker that modulates the gap distance between the "core" and "satellites" in response to the temperature. In this way, optical properties of dispersions can be dynamically tuned. The system permits wide and reversible control of the optical properties, which may render them excellent candidates for reversible nanosensors.

Analysis of self-assembled monolayer interfaces by electrospray mass spectrometry: A gentle approach

Publisher: American Chemical Society (ACS)

Date: 28-10-2003

DOI: 10.1021/AC0345897

Abstract: A general mass spectrometry technique for the characterization of alkanethiol-modified surfaces is presented. Alkanethiol self-assembled onto a gold surface (in this case, peptides were attached to the gold surface via a thiolate bond) was reductively desorbed in 0.05 M KOH in the presence of octadecyl-derivatized silica gel. The peptide adsorbed onto the silica gel, whereupon it could be filtered, washed to remove any salts, and then eluted using a mixture of 4:1 v/v methanol/water. The eluant containing the peptide was injected into a Fourier transform ion-cyclotron resonance mass spectrometer (FTICR/MS) via electrospray ionization. The spectrum showed no fragmentation of the peptide, demonstrating the gentleness of the technique. This simple procedure is not limited to FTICR/MS and could be adapted to other mass spectrometers.

Multipotential Electrochemical Detection of Primer Extension Reactions on DNA Self-Assembled Monolayers

Publisher: American Chemical Society (ACS)

Date: 13-03-2004

DOI: 10.1021/JA0319036

Abstract: Electroactive nucleoside triphosphates ("electrotides") have been incorporated into primers by DNA polymerase and detected on oligonucleotide surface-assembled monolayers. Four electrotides bearing three different electroactive moieties-ferrocene, vinylferrocene, and anthraquinone-are detected in four alternative formats.

Controlling hydrogen evolution reaction activity on Ni core–Pt island nanoparticles by tuning the size of the Pt islands

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D0CC07769K

Abstract: Pt islands with different sizes were grown on amorphous Ni nanoparticles, allowing the tuning of the Pt–Ni interface without changing the hydrogen binding energy of the Pt sites.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACS.ANALCHEM.0C01669

Antifouling behaviour of silicon surfaces modified with self-assembled monolayers containing both ethylene glycol and charged moieties

Publisher: Elsevier BV

Date: 08-2010

DOI: 10.1016/J.SUSC.2010.04.025

Targeted Drug Delivery: Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Healthcare Mater. 12/2016)

Publisher: Wiley

Date: 06-2016

DOI: 10.1002/ADHM.201670058

Light-Activated Electrochemistry for the Two-Dimensional Interrogation of Electroactive Regions on a Monolithic Surface with Dramatically Improved Spatial Resolution

Publisher: American Chemical Society (ACS)

Date: 09-06-2016

DOI: 10.1021/ACS.JPCC.6B02289

A multimodal optical and electrochemical device for monitoring surface reactions: Redox active surfaces in porous silicon Rugate filters

Publisher: Royal Society of Chemistry (RSC)

Date: 2012

DOI: 10.1039/C2CP43461J

Abstract: Herein, mesoporous silicon (PSi) is configured as a single sensing device that has dual readouts as a photonic crystal sensor in a Rugate filter configuration, and as a high surface area porous electrode. The as-prepared PSi is chemically modified to provide it with stability in aqueous media and to allow for the subsequent coupling of chemical species, such as via Cu(I)-catalyzed cycloaddition reactions between 1-alkynes and azides ("click" reactions). The utility of the bimodal capabilities of the PSi sensor for monitoring surface coupling procedures is demonstrated by the covalent coupling of a ferrocene derivative, as well as by demonstrating ligand-exchange reactions (LER) at the PSi surface. Both types of reactions were monitored through optical reflectivity measurements, as well as electrochemically via the oxidation/reduction of the surface tethered redox species.

Upconversion Nanoparticle-Based Cell Membrane-Coated cRGD Peptide Bioorthogonally Labeled Nanoplatform for Glioblastoma Treatment

Publisher: American Chemical Society (ACS)

Date: 27-10-2022

DOI: 10.1021/ACSAMI.2C11284

Abstract: Glioblastoma is hard to be eradicated partly because of the obstructive blood-brain barrier (BBB) and the dynamic autophagy activities of glioblastoma. Here, hydroxychloroquine (HDX)-loaded yolk-shell upconversion nanoparticle (UCNP)@Zn

Zwitterionic Phenyl Phosphorylcholine on Indium Tin Oxide: A Low-Impedance Protein-Resistant Platform for Biosensing

Publisher: Wiley

Date: 17-02-2015

DOI: 10.1002/ELAN.201400557

The biochemiresistor: An ultrasensitive biosensor for small organic molecules

Publisher: Wiley

Date: 25-05-2012

DOI: 10.1002/ANIE.201202350

Abstract: New sensation: A resistance-based biosensor uses gold-coated magnetic nanoparticles (Au@MNPs) functionalized with the antibiotic enrofloxin (see picture purple), which bind to anti-enrofloxin as analyte (blue). The Au@MNPs can be magnetically assembled between electrodes, and the measured resistance R is a function of analyte concentration.

Photolithographic strategy for patterning preformed, chemically modified, porous silicon photonic crystal using click chemistry

Publisher: American Chemical Society (ACS)

Date: 03-07-2013

DOI: 10.1021/AM4006012

Abstract: Porous silicon (PSi) is an ideal platform for label-free biosensing, and the development of porous silicon patterning will open a pathway to the development of highly parallel PSi biochips for detecting multiple analytes. The optical response of PSi photonic crystal is determined by the changes in the effective bulk refractive index resulting from reactions/events occurring within the internal pore space. Therefore, introducing precise chemical functionalities in the pores of PSi is essential to ensure device selectivity. Here we describe the fabrication of PSi patterns that possess discrete chemical functionalities that are restricted to precise locations. The key difference to previous patterning protocols for PSi is that the entire porous material is first modified with a self-assembled monolayer of a α,ω-diyne adsorbate prior to patterning using a microfabricated titanium mask. The distal alkyne moieties in the monolayer are then amenable to further selective modification by the archetypal "click" reaction, the copper catalyzed alkyne-azide cycloaddition (CuAAC), using the titanium mask as a resist. This type of patterning is suitable for further immobilization of biological recognition elements, and presents a new platform for highly parallel PSi biosensor for multiple detections.

His–Ser–Gln–Lys–Val–Phe as a selective ligand for the voltammetric determination of Cd2+

Publisher: Elsevier BV

Date: 2005

DOI: 10.1016/J.ELECOM.2004.11.016

Finally, a simple solution to biofouling

Publisher: Springer Science and Business Media LLC

Date: 11-11-2019

DOI: 10.1038/S41565-019-0573-0

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.MOLPHARMACEUT.0C00638

Functionalised porous silicon as a biosensor: Emphasis on monitoring cells in vivo and in vitro

Publisher: Royal Society of Chemistry (RSC)

Date: 2013

DOI: 10.1039/C3AN00081H

Abstract: Porous silicon photonics is the ideal platform for high sensitivity, high selectivity monitoring of biological molecules in a complex fluidic environment. The potential of this technology was identified almost 15 years ago, however, it has taken considerable advances in porous silicon surface chemistry, photonics, and micro-fabrication to create truly effective devices that can provide new insights into the behaviour of biological systems. In this review we provide a critical assessment of the development of porous silicon optical biosensors from the early demonstrations of affinity based sensing to the current trends in monitoring single cell activity and perspectives in the use of photonic microparticles for biomedical applications.

A graphene-based sensor for real time monitoring of sun exposure

Publisher: Elsevier BV

Date: 11-2018

DOI: 10.1016/J.CARBON.2018.06.010

Using an Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion

Publisher: Wiley

Date: 22-06-2012

DOI: 10.1002/ANIE.201202118

Abstract: Smart surfaces presenting both antifouling molecules with a charged functional group at their distal end, and molecules that are terminated by RGD peptides for cell adhesion, were fabricated and characterized (see picture). By applying potentials of +300 or -300 mV, the surfaces could be dynamically switched to make the peptide accessible or inaccessible to cells.

Ultraprecise single-molecule localization microscopy enables in situ distance measurements in intact cells

Publisher: American Association for the Advancement of Science (AAAS)

Date: 17-04-2020

DOI: 10.1126/SCIADV.AAY8271

Abstract: Feedback SMLM achieves ultrahigh localization precision and in situ distance measurements on the biological relevant scales.

Studies on the effect of solvents on self-assembled monolayers formed from organophosphonic acids on indium tin oxide

Publisher: American Chemical Society (ACS)

Date: 07-06-2012

DOI: 10.1021/LA3010129

Abstract: The preparation of self-assembled monolayers (SAMs) of organophosphonic acids on indium tin oxide (ITO) surfaces from different solvents (triethylamine, ethyl ether, tetrahydofuran (THF), pyridine, acetone, methanol, acetonitrile, dimethyl sulfoxide (DMSO), or water) has been performed with some significant differences observed. Cyclic voltammetry (CV), X-ray photoelectron spectroscopy (XPS), scanning tunneling microscopy (STM), and contact angle measurement demonstrated that the quality of SAMs depends critically on the choice of solvents. Higher density, more stable monolayers were formed from solvents with low dielectric constants and weak interactions with the ITO. It was concluded low dielectric solvents that were inert to the ITO gave monolayers that were more stable with a higher density of surface bound molecules because higher dielectric constant solvents and solvents that coordinate with the surface disrupted SAM formation.

Atomic Force Microscopy Imaging of Glucose Oxidase using Chemically Modified Tips

Publisher: CSIRO Publishing

Date: 2003

DOI: 10.1071/CH03122

Abstract: Atomic force microscopy (AFM) tips have been chemically modified using a variety of approaches mostly based on self-assembled monolayers (SAMs). Tips with both a hydrophobic and hydrophilic nature have been prepared and used to image glucose oxidase covalently attached to a self-assembled monolayer.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/JACS.0C04253

Effect of dialysis on the electrochemical properties of acid-oxidized single-walled carbon nanotubes

Publisher: American Chemical Society (ACS)

Date: 15-08-2008

DOI: 10.1021/JP7113785

Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species

Publisher: Springer Science and Business Media LLC

Date: 31-07-2017

DOI: 10.1186/S12915-017-0402-6

Biosensor technology for detecting biological warfare agents: Recent progress and future trends

Publisher: Elsevier BV

Date: 02-2006

DOI: 10.1016/J.ACA.2005.12.020

Immobilisation of enzyme throughout a polytyramine matrix: A versatile procedure for fabricating biosensors

Publisher: Elsevier BV

Date: 08-1999

DOI: 10.1016/S0003-2670(99)00291-3

The Effect of Interfacial Design on the Electrochemical Detection of DNA and MicroRNA Using Methylene Blue at Low‐Density DNA Films

Publisher: Wiley

Date: 02-12-2013

DOI: 10.1002/CELC.201300136

How to exploit different endocytosis pathways to allow selective delivery of anticancer drugs to cancer cells over healthy cells

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1SC04656J

Abstract: It was recently shown that it is possible to exploit the nanoparticle shape to selectively target endocytosis pathways found in cancer and not healthy cells.

Strategies to Achieve Control over the Surface Ratio of Two Different Components on Modified Electrodes Using Aryldiazonium Salts

Publisher: American Chemical Society (ACS)

Date: 03-03-2016

DOI: 10.1021/ACS.LANGMUIR.5B04550

Abstract: Controlling the composition of an interface is very important in tuning the chemical and physical properties of a surface in many applications including biosensors, biomaterials, and chemical catalysis. Frequently, this requires one molecular component to a minor component in a mixed layer. Such subtle control of composition has been difficult to achieve using aryldiazonium salts. Herein, aryldiazonium salts of carboxyphenyl (CP) and phenylphosphorylcholine (PPC), generated in situ from their corresponding anilines, are electrografted to form molecular platform that are available for further functionalization. These two components are chosen because CP provides a convenient functionality for further coupling of biorecognition species while PPC offers resistance to nonspecific adsorption of proteins to the surface. Mixed layers of CP and PPC were prepared by grafting them either simultaneously or consecutively. The latter strategy allows an interface to be developed in a controlled way where one component is at levels of less than 1% of the total layer.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.CGD.0C00826

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 10-2020

DOI: 10.1021/ACSESTENGG.0C00034

Introducing distinctly different chemical functionalities onto the internal and external surfaces of mesoporous materials

Publisher: Wiley

Date: 18-03-2008

DOI: 10.1002/ANIE.200704784

Exploring the use of the tripeptide Gly-Gly-His as a selective recognition element for the fabrication of electrochemical copper sensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2003

DOI: 10.1039/B212881K

Abstract: The modification of electrodes with the tripeptide Gly-Gly-His for the detection of copper in water s les is described in detail. The tripeptide modified electrode was prepared by first self-assembling 3-mercaptopropionic acid (MPA) onto the gold electrode followed by covalent attachment of the tripeptide to the self-assembled monolayer using carbodiimide coupling. The electrodes were characterized using electrochemistry, a newly developed mass-spectrometry method and quantum mechanical calculations. The mass spectrometry confirmed the modification to proceed as expected with peptide bonds formed between the carboxylic acids of the MPA and the terminal amine of the peptide. Electrochemical measurements indicated that approximately half the MPA molecules in a SAM are modified with the peptide. The peptide modified electrodes exhibited high sensitivity to copper which is attributed to the stable 4N coordinate complex the peptide formed around the metal ion to give copper the preferred tetragonal coordination. The formation of a 4 coordinate complex was predicted using quantum mechanical calculation and confirmed using mass spectrometry. The adsorption of the copper to the peptide modified electrode was consistent with a Langmuir isotherm with a binding constant of (8.1 +/- 0.4) 10(10) M(-1) at 25 degrees C.

Organic modification of mesoporous silicon rugate filters: The influence of nanoarchitecture on optical behaviour

Publisher: Inderscience Publishers

Date: 2008

DOI: 10.1504/IJNT.2008.016914

Carbon supported hybrid catalysts for controlled product selectivity in the hydrosilylation of alkynes

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D0CY02136A

Abstract: A series of Rh- and Ir-hybrid catalysts with varying tether lengths has been prepared by immobilization of Rh I , Rh III and Ir III complexes on carbon black, and applied in the hydrosilylation of alkynes.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSNANO.0C05013

Investigation of the Antifouling Properties of Phenyl Phosphorylcholine-Based Modified Gold Surfaces

Publisher: Wiley

Date: 19-05-2014

DOI: 10.1002/ELAN.201400102

The importance of surface chemistry in mesoporous materials: Lessons from porous silicon biosensors

Publisher: Royal Society of Chemistry (RSC)

Date: 2009

DOI: 10.1039/B815449J

Abstract: The ease of fabricating high quality photonic crystals from porous silicon and its biocompatibility have inspired the conception of various biosensing schemes using this material. However, the instability of porous silicon has significantly slowed progress in this area. Here we discuss the potential of different porous silicon photonic crystals for biosensing in the context of its surface chemistry and nanostructure, both of which need to be optimized to obtain sensitive and stable devices. Of particular promise are recent approaches that use porous silicon as sensors for enzymatic activity, for cell capture and concentration devices.

Comparison of different irrigation methods to synergistically improve maize’s yield, water productivity and economic benefits in an arid irrigation area

Publisher: Elsevier BV

Date: 2021

DOI: 10.1016/J.AGWAT.2020.106497

Cellobiose dehydrogenase aryl diazonium modified single walled carbon nanotubes: Enhanced direct electron transfer through a positively charged surface

Publisher: American Chemical Society (ACS)

Date: 18-03-2011

DOI: 10.1021/AC103250B

Silicon–SAM–AuNP electrodes: Electrochemical “switching” and stability

Publisher: Elsevier BV

Date: 09-2016

DOI: 10.1016/J.ELECOM.2016.06.014

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSAEM.0C00879

pH-Detachable Polymer Brushes Formed Using Titanium-Diol Coordination Chemistry and Living Radical Polymerization (RAFT)

Publisher: American Chemical Society (ACS)

Date: 30-03-2009

DOI: 10.1021/MA802256G

Selectively detecting attomolar concentrations of proteins using gold lined nanopores in a nanopore blockade sensor

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/D0SC04552G

Abstract: Selective detection of attomolar proteins was achieved using gold lined nanopores in a nanopore blockade sensor.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSABM.0C00433

Influence of Surface Topography on Alkanethiol SAMs Assembled from Solution and by Microcontact Printing

Publisher: American Chemical Society (ACS)

Date: 24-04-2001

DOI: 10.1021/LA001462T

Forming antifouling organic multilayers on porous silicon rugate filters towards in vivo/ex vivo biophotonic devices

Publisher: Wiley

Date: 15-10-2007

DOI: 10.1002/ADFM.200600790

A rapid readout for many single plasmonic nanoparticles using dark-field microscopy and digital color analysis

Publisher: Elsevier BV

Date: 10-2018

DOI: 10.1016/J.BIOS.2018.06.066

Abstract: The integration of plasmonic nanoparticles into biosensors has the potential to increase the sensitivity and dynamic range of detection, through the use of single nanoparticle assays. The analysis of the localized surface plasmon resonance (LSPR) of plasmonic nanoparticles has allowed the limit of detection of biosensors to move towards single molecules. However, due to complex equipment or slow analysis times, these technologies have not been implemented for point-of-care detection. Herein, we demonstrate an advancement in LSPR analysis by presenting a technique, which utilizes an inexpensive CMOS-equipped digital camera and a dark-field microscope, that can analyse the λ

Virus Detection: What Were We Doing before COVID-19 Changed the World?

Publisher: American Chemical Society (ACS)

Date: 29-05-2020

DOI: 10.1021/ACSSENSORS.0C01029

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.MOLPHARMACEUT.0C00420

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JMEDCHEM.0C00641

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSOMEGA.0C02890

Modifying porous silicon with self-assembled monolayers for biomedical applications

Publisher: Elsevier

Date: 2014

DOI: 10.1533/9780857097156.1.81

The application of alkanethiol self-assembled monolayers to enzyme electrodes

Publisher: Elsevier BV

Date: 08-1999

DOI: 10.1016/S0165-9936(99)00133-8

Versatile click chemistry Approach to functionalizing silicon quantum dots: Applications toward fluorescent cellular imaging

Publisher: American Chemical Society (ACS)

Date: 28-04-2014

DOI: 10.1021/LA500945F

Abstract: In this study, we describe a solution procedure for the preparation and surface modification of photostable colloidal silicon quantum dots (SiQDs) for imaging of cancer cells. Photoluminescent SiQDs were synthesized by reduction of halogenated silane precursors using a microemulsion process. It was shown that 1,8-nonadiyne molecules could be grafted onto the surface of hydrogen-terminated SiQDs via ultraviolet (UV)-promoted hydrosilylation, demonstrated by Fourier transform infrared spectroscopy (FTIR) measurements. In addition, various azide molecules were coupled onto nonadiyne-functionalized particles, rendering particles dispersible in selected polar and nonpolar solvents. The photoluminescence of functionalized SiQDs was stable against photobleaching and did not vary appreciably within biologically applicable pH and temperature ranges. To demonstrate compatibility with biological systems, water-soluble SiQDs were used for fluorescent imaging of HeLa cells. In addition, the SiQDs were shown to be non-cytotoxic at concentrations up to 240 μg/mL. The results presented herein provide good evidence for the versatility of functionalized SiQDs for fluorescent bioimaging application.

Electrochemical impedance immunosensor based on gold nanoparticles and aryl diazonium salt functionalized gold electrodes for the detection of antibody

Publisher: Elsevier BV

Date: 04-2011

DOI: 10.1016/J.BIOS.2011.02.026

Molecularly engineered surfaces for cell biology: From static to dynamic surfaces

Publisher: American Chemical Society (ACS)

Date: 22-11-2014

DOI: 10.1021/LA4037919

Abstract: Surfaces with a well-defined presentation of ligands for receptors on the cell membrane can serve as models of the extracellular matrix for studying cell adhesion or as model cell surfaces for exploring cell-cell contacts. Because such surfaces can provide exquisite control over, for ex le, the density of these ligands or when the ligands are presented to the cell, they provide a very precise strategy for understanding the mechanisms by which cells respond to external adhesive cues. In the present feature article, we present an overview of the basic biology of cell adhesion before discussing surfaces that have a static presentation of immobile ligands. We outline the biological information that such surfaces have given us, before progressing to recently developed switchable surfaces and surfaces that mimic the lipid bilayer, having adhesive ligands that can move around the membrane and be remodeled by the cell. Finally, the feature article closes with some of the biological information that these new types of surfaces could provide.

Sensors in China

Publisher: American Chemical Society (ACS)

Date: 22-12-2017

DOI: 10.1021/ACSSENSORS.7B00908

Cesium compounds as interface modifiers for stable and efficient perovskite solar cells

Publisher: Elsevier BV

Date: 2018

DOI: 10.1016/J.SOLMAT.2017.08.032

RF plasma functionalized carbon surfaces for supporting sensor architectures

Publisher: Elsevier BV

Date: 05-2008

DOI: 10.1016/J.CAP.2007.10.048

A Ruthenium Based Organometallic Complex for Biosensing that is both a Stable Redox Label and a Homobifunctional Linker

Publisher: Wiley

Date: 15-01-2015

DOI: 10.1002/ELAN.201400642

The impact of antibody/epitope affinity strength on the sensitivity of electrochemical immunosensors for detecting small molecules

Publisher: Springer Science and Business Media LLC

Date: 27-02-2013

DOI: 10.1007/S00216-013-6782-8

Abstract: A displacement immunoassay involves having a labelled analogue of the analyte (the epitope) already bound to the antibody. The presence of the analyte causes a competition for antibodies, and some of the antibodies dissociates from the epitope so that it can bind with the analyte. Herein, the influence of the affinity of the surface-bound epitope for the antibody on the sensitivity and selectivity of a displacement immunosensor is explored both theoretically and experimentally. An electrochemical immunosensor described previously, where the dissociation of antibodies from an electrode surface causes an increase in current from surface-bound ferrocene species, is used for this purpose. As expected, the ease and effectiveness of the bound antibody being displaced is inversely related to the affinity of the antibody to the surface-bound epitope relative to the analyte in solution as expected. However, if the affinity constant is too low, selectivity and/or sensitivity are compromised. Experimental results are qualitatively compared with a simple mass-action model.

Carbon quantum dots directly generated from electrochemical oxidation of graphite electrodes in alkaline alcohols and the applications for specific ferric ion detection and cell imaging

Publisher: Royal Society of Chemistry (RSC)

Date: 2016

DOI: 10.1039/C5AN02231B

Abstract: Carbon quantum dots (CQDs) are attracting tremendous interest owing to their low toxicity, water dispersibility, biocompatibility, optical properties and wide applicability.

Protein Electrochemistry Using Aligned Carbon Nanotube Arrays

Publisher: American Chemical Society (ACS)

Date: 07-2003

DOI: 10.1021/JA035722F

Abstract: The remarkable electrocatalytic properties and small size of carbon nanotubes make them ideal for achieving direct electron transfer to proteins, important in understanding their redox properties and in the development of biosensors. Here, we report shortened SWNTs can be aligned normal to an electrode by self-assembly and act as molecular wires to allow electrical communication between the underlying electrode and redox proteins covalently attached to the ends of the SWNTs, in this case, microperoxidase MP-11. The efficiency of the electron transfer through the SWNTs is demonstrated by electrodes modified with tubes cut to different lengths having the same electron-transfer rate constant.

Controlling Platinum Active Sites on Silver Nanoparticles for Hydrogen Evolution Reaction

Publisher: American Chemical Society (ACS)

Date: 12-10-2023

DOI: 10.1021/ACS.CHEMMATER.3C01765

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSCOMBSCI.0C00121

Porous silicon photonic crystals for detection of infections

Publisher: SPIE

Date: 10-10-2012

DOI: 10.1117/12.940757

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.IECR.0C01968

Single molecular switches: Electrochemical gating of a single anthraquinone-based norbornylogous bridge molecule

Publisher: American Chemical Society (ACS)

Date: 20-09-2012

DOI: 10.1021/JP3066458

Single nanoparticle plasmonic sensors

Publisher: MDPI AG

Date: 12-10-2015

DOI: 10.3390/S151025774

The rise of self-assembled monolayers for fabricating electrochemical biosensors-an interfacial perspective

Publisher: Wiley

Date: 30-11-2012

DOI: 10.1002/TCR.201100013

Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood

Publisher: Springer Science and Business Media LLC

Date: 27-08-2018

DOI: 10.1038/S41565-018-0232-X

Abstract: There is intense interest in quantifying the levels of microRNA because of its importance as a blood-borne biomarker. The challenge has been to develop methods that can monitor microRNA expression both over broad concentration ranges and in ultralow amounts directly in a patient's blood. Here, we show that, through electric-field-induced reconfiguration of a network of gold-coated magnetic nanoparticles modified by probe DNA (DNA-Au@MNPs), it is possible to create a highly sensitive sensor for direct analysis of nucleic acids in s les as complex as whole blood. The sensor is the first to be able to detect concentrations of microRNA from 10 aM to 1 nM in unprocessed blood s les. It can distinguish small variations in microRNA concentrations in blood s les of mice with growing tumours. The ultrasensitive and direct detection of microRNA using an electrically reconfigurable DNA-Au@MNPs network makes the reported device a promising tool for cancer diagnostics.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSOMEGA.0C01788

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACS.ACCOUNTS.0C00221

Biocompatible Gold Nanorods: One-Step Surface Functionalization, Highly Colloidal Stability, and Low Cytotoxicity

Publisher: American Chemical Society (ACS)

Date: 23-04-2015

DOI: 10.1021/ACS.LANGMUIR.5B00666

Abstract: The conjugation of gold nanorods (AuNRs) with polyethylene glycol (PEG) is one of the most effective ways to reduce their cytotoxicity arising from the cetyltrimethylammonium bromide (CTAB) and silver ions used in their synthesis. However, typical PEGylation occurs only at the tips of the AuNRs, producing partially modified AuNRs. To address this issue, we have developed a novel, facile, one-step surface functionalization method that involves the use of Tween 20 to stabilize AuNRs, bis(p-sulfonatophenyl)phenylphosphine (BSPP) to activate the AuNR surface for the subsequent PEGylation, and NaCl to etch silver from the AuNRs. This method allows for the complete removal of the surface-bound CTAB and the most active surface silver from the AuNRs. The produced AuNRs showed far lower toxicity than other methods to PEGylate AuNRs, with no apparent toxicity when their concentration is lower than 5 μg/mL. Even at a high concentration of 80 μg/mL, their cell viability is still four times higher than that of the tip-modified AuNRs.

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSINFECDIS.0C00426

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSCENTSCI.0C00794

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACSPHOTONICS.0C00962

An interface comprising molecular wires and poly(ethylene glycol) spacer units self-assembled on carbon electrodes for studies of protein electrochemistry

Publisher: American Chemical Society (ACS)

Date: 12-07-2006

DOI: 10.1021/LA0607510

Abstract: The characterization and application of a modified electrode interface for protein electrochemistry is reported. This generic interface is composed of a mixed monolayer of oligo(phenylethynylene) molecular wires (MWs) and poly(ethylene glycol) (PEG) deposited on glassy carbon electrodes by reductive adsorption of the respective aryl diazonium salts. Electrochemistry and scanning electron microscopy demonstrate that the PEG component exhibits a distinct decrease in nonspecific adsorption of blood serum and the proteins bovine serum albumin (BSA) and horseradish peroxidase (HRP) relative to a bare glassy carbon electrode. The ability of the MWs to facilitate efficient electron transfer through the PEG layer to the underlying electrode was demonstrated by covalently attaching ferrocenemethylamine to the end of the MWs. The calculated rate constant for this system was 229 +/- 30 s(-1). Covalent attachment of HRP to the MWs allowed direct electron transfer to the redox protein with almost ideal electrochemistry, indicating a specific interaction between the MW and HRP, with a rate constant of 13.4 +/- 2.3 s(-1). This rate constant is more rapid than previously reported for HRP shown to still be catalytically active. Retained catalytic activity of HRP was demonstrated by the enzyme responding to the addition of hydrogen peroxide. Similarly, by attaching myoglobin to the end of the MWs, a rate constant for this protein of 2 s(-1) was measured. The rigidity of the MWs, as well as it being longer than the PEG diluent, means this generic interface can be employed to investigate the electrochemistry of a wide range of redox proteins.

Unique Sensing Interface That Allows the Development of an Electrochemical Immunosensor for the Detection of Tumor Necrosis Factor α in Whole Blood

Publisher: American Chemical Society (ACS)

Date: 08-12-2016

DOI: 10.1021/ACSSENSORS.6B00532

Thiol functionalisation of gold-coated magnetic nanoparticles: Enabling the controlled attachment of functional molecules

Publisher: IEEE

Date: 02-2010

DOI: 10.1109/ICONN.2010.6045171

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JAFC.0C03806

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D1CS00707F

Abstract: Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs into the diseased cells. However, there has been less focus on exploiting the differences in the endocytosis pathways of cancer cells

Screen-printable films of graphene/CoS2/Ni3S4 composites for the fabrication of flexible and arbitrary-shaped all-solid-state hybrid supercapacitors

Publisher: Elsevier BV

Date: 05-2019

DOI: 10.1016/J.CARBON.2019.02.045

Facettierte verzweigte Nickel‐Nanopartikel mit variierbarer Verzweigungslänge für die hochaktive elektrokatalytische Oxidation von Biomasse

Publisher: Wiley

Date: 13-07-2020

DOI: 10.1002/ANGE.202005489

Towards the fabrication of label-free amperometric immunosensors using SWNTs

Publisher: Elsevier BV

Date: 10-2009

DOI: 10.1016/J.ELECOM.2009.08.033

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.BIOCONJCHEM.0C00358

Advances in 3D Bioprinting for Cancer Biology and Precision Medicine: From Matrix Design to Application.

Publisher: Wiley

Date: 15-08-2022

DOI: 10.1002/ADHM.202200690

Abstract: The tumor microenvironment is highly complex owing to its heterogeneous composition and dynamic nature. This makes tumors difficult to replicate using traditional 2D cell culture models that are frequently used for studying tumor biology and drug screening. This often leads to poor translation of results between in vitro and in vivo and is reflected in the extremely low success rates of new candidate drugs delivered to the clinic. Therefore, there has been intense interest in developing 3D tumor models in the laboratory that are representative of the in vivo tumor microenvironment and patient s les. 3D bioprinting is an emerging technology that enables the biofabrication of structures with the virtue of providing accurate control over distribution of cells, biological molecules, and matrix scaffolding. This technology has the potential to bridge the gap between in vitro and in vivo by closely recapitulating the tumor microenvironment. Here, a brief overview of the tumor microenvironment is provided and key considerations in biofabrication of tumor models are discussed. Bioprinting techniques and choice of bioinks for both natural and synthetic polymers are also outlined. Lastly, current bioprinted tumor models are reviewed and the perspectives of how clinical applications can greatly benefit from 3D bioprinting technologies are offered.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACS.BIOCONJCHEM.0C00236

Charge transfer through DNA: A selective electrochemical DNA biosensor

Publisher: American Chemical Society (ACS)

Date: 28-02-2006

DOI: 10.1021/AC0509096

Abstract: The charge-transfer properties of DNA duplexes are exploited to produce a fast, simple, sensitive, and selective DNA biosensor by exposing the DNA recognition interface to a s le containing target DNA and the redox-active intercalator, anthraquinonemonosulfonic acid (AQMS). Electrochemistry from electron transfer through the DNA to AQMS intercalated into DNA duplexes can be differentiated from electrochemistry due to direct access of the AQMS to the electrode surface due to the difference in the environment of the AQMS giving a shift in the potential at which the molecule is reduced. The ability to distinguish between the two electrochemical signals enables DNA hybridization to be monitored in real time. This in situ detection scheme has good selectivity, being able to differentiate between a complementary target DNA sequence and one containing either C-A or G-A single-base mismatches. The concentration detection limit of the biosensor is 0.5 nM (1 pmol) with an assay time of 1 h. The fact that the end user is only required to simultaneously add the s le containing the target DNA and AQMS gives a DNA biosensor that is highly compatible with PCR on chip technologies.

Comparing the reactivity of alkynes and alkenes on silicon 100 surfaces

Publisher: American Chemical Society (ACS)

Date: 09-07-2009

DOI: 10.1021/LA901526E

Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications

Publisher: SPIE

Date: 22-02-2017

DOI: 10.1117/12.2249592

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/JACS.0C06516

Incorporation of colloidal quantum dots into silicon photonic structures

Publisher: IEEE

Date: 02-2010

DOI: 10.1109/ICONN.2010.6045174

Ultralow- and Low-Background Surfaces for Single-Molecule Localization Microscopy of Multistep Biointerfaces for Single-Molecule Sensing

Publisher: American Chemical Society (ACS)

Date: 08-2018

DOI: 10.1021/ACS.LANGMUIR.8B01487

Abstract: Single-molecule localization microscopy (SMLM) has created the opportunity of pushing fluorescence microscopy from being a biological imaging tool to a surface characterization and possibly even a quantitative analytical tool. The latter could be achieved by molecular counting using pointillist SMLM data sets. However, SMLM is especially sensitive to background fluorescent signals, which influences any subsequent analysis. Therefore, fabricating sensing surfaces that resist nonspecific adsorption of proteins, even after multiple modification steps, has become paramount. Herein is reported two different ways to modify surfaces: dichlorodimethylsilane-biotinylated bovine serum albumin-Tween-20 (DbT20) and poly-l-lysine grafted polyethylene glycol (PLL-PEG) mixed with biotinylated PLL-PEG (PLL-PEG/PEGbiotin). The results show that the ability to resist nonspecific adsorption of DbT20 surfaces deteriorates with an increase in the number of modification steps required after the addition of the DbT20, which limits the applicability of this surface for SMLM. As such, a new surface for SMLM that employs PLL-PEG/PEGbiotin was developed that exhibits ultralow amounts of nonspecific protein adsorption even after many modification steps. The utility of the surface was demonstrated for human influenza hemagglutinin-tagged mEos2, which was directly pulled down from cell lysates onto the PLL-PEG/PEGbiotin surface. The results strongly indicated that the PLL-PEG/PEGbiotin surface satisfies the criteria of SMLM imaging of a negligible background signal and negligible nonspecific adsorption.

Surface reconstitution of glucose oxidase onto a norbornylogous bridge self-assembled monolayer

Publisher: Elsevier BV

Date: 05-2006

DOI: 10.1016/J.CHEMPHYS.2005.08.061

Development of an electrochemical immunosensor for the detection of HbA1c in serum

Publisher: Royal Society of Chemistry (RSC)

Date: 2012

DOI: 10.1039/C2AN16034J

Abstract: An electrochemical immuno-biosensor for detecting glycosylated haemoglobin (HbA1c) is reported based on glassy carbon (GC) electrodes with a mixed layer of an oligo(phenylethynylene) molecular wire (MW) and an oligo(ethylene glycol) (OEG). The mixed layer is formed from in situ-generated aryl diazonium cations. To the distal end of the MW, a redox probe 1,1'-di(aminomethyl)ferrocene (FDMA) was attached followed by the covalent attachment of an epitope N-glycosylated pentapeptide (GPP), an analogon to HbA1c, to which an anti-HbA1c monocolonal antibody IgG can selectively bind. HbA1c was detected by a competitive inhibition assay based on the competition for binding to anti-HbA1c IgG antibodies between the analyte in solution, HbA1c, and the surface bound epitope GPP. Exposure of the GPP modified sensing interface to the mixture of anti-HbA1c IgG antibody and HbA1c results in the attenuation of ferrocene electrochemistry due to free antibody binding to the interface. Higher concentrations of analyte led to higher Faradaic currents as less anti-HbA1c IgG is available to bind to the electrode surface. It was observed that there is a good linear relationship between the relative Faradaic current of FDMA and the concentration of HbA1c from 4.5% to 15.1% of total haemoglobin in serum without the need for washing or rinsing steps.

Step by step fabrication and characterization of Au (111) exposed single crystals

Publisher: IEEE

Date: 02-2010

DOI: 10.1109/ICONN.2010.6045176

What Is a real Sample?

Publisher: American Chemical Society (ACS)

Date: 28-09-2018

DOI: 10.1021/ACSSENSORS.8B00956

Confronting Racism in Chemistry Journals

Publisher: American Chemical Society (ACS)

Date: 19-06-2020

DOI: 10.1021/ACS.JPCC.0C05470

The role of oxygen in synthesizing monodisperse silver nanocubes

Publisher: CSIRO Publishing

Date: 2011

DOI: 10.1071/CH11241

Abstract: In this work, we report on silver nanocubes prepared by using the conventional polyol synthesis in the presence of hydrochloric acid and oxygen. We found that by controlling the headspace oxygen concentration in the s le vial at a temperature of 140°C, monodisperse silver nanocubes of 100–115 nm in edge length were produced. A specific headspace oxygen concentration along with the chloride ions promoted the oxidative etching of twinned particles so that only single crystal cubes were produced. At lower oxygen concentrations, nanorods and wires were obtained whereas at very high concentrations all the particles were completely etched away resulting in a solution with no nanoparticles. Electron diffraction and X-ray diffraction analysis was employed to study the structural characterization. Scanning electron microscopy was used to examine the morphology of the silver nanoparticles.

Wearable Sensors – An Exciting Area of Research for Sensor Scientists

Publisher: American Chemical Society (ACS)

Date: 22-07-2016

DOI: 10.1021/ACSSENSORS.6B00423

A high-throughput 3D bioprinted cancer cell migration and invasion model with versatile and broad biological applicability

Publisher: Cold Spring Harbor Laboratory

Date: 29-12-2021

DOI: 10.1101/2021.12.28.474387

Abstract: Understanding the underlying mechanisms of migration and metastasis is a key focus of cancer research. There is an urgent need to develop in vitro 3D tumor models that can mimic physiological cell-cell and cell-extracellular matrix interactions, with high reproducibility and that are suitable for high throughput (HTP) drug screening. Here, we developed a HTP 3D bioprinted migration model using a bespoke drop-on-demand bioprinting platform. This HTP platform coupled with tunable hydrogel systems enables (i) the rapid encapsulation of cancer cells within in vivo tumor mimicking matrices, (ii) in situ and real-time measurement of cell movement, (iii) detailed molecular analysis for the study of mechanisms underlying cell migration and invasion, and (iv) the identification of novel therapeutic options. This work demonstrates that this HTP 3D bioprinted cell migration platform has broad applications across quantitative cell and cancer biology as well as drug screening.

Abbreviations in Scientific Writing: Friend or Foe

Publisher: American Chemical Society (ACS)

Date: 23-09-2016

DOI: 10.1021/ACSSENSORS.6B00540

DNA biosensor concepts based on a change in the DNA persistence length upon hybridization

Publisher: Wiley

Date: 10-2006

DOI: 10.1002/ELAN.200603614

Abstract: Hybridization‐induced physical changes of DNA are exploited in the development of DNA switchable surfaces for electrochemical biosensing purposes. Two types of biosensing concepts are explored, both based on the same basic switchable surface. The interface is designed so that the end‐tethered DNA is able to switch from a flexible state to a rigid one upon hybridization. The first biosensing concept described is a label‐free system that uses air oxidation of the interface, followed by the change in accessibility of the surface upon hybridization to detect complementary target DNA. The second is a ferrocene‐labeled system exploiting the change in DNA flexibility alone. Atomic force microscopy studies of the DNA switching surface are described.

Probing the Effect of the Solution Environment around Redox-Active Moieties Using Rigid Anthraquinone Terminated Molecular Rulers

Publisher: American Chemical Society (ACS)

Date: 29-10-2012

DOI: 10.1021/JA307665K

Abstract: Herein, we report the influence of the position and the solution environment around surface-bound redox-active moieties on their redox reaction. The study was made possible by using rigid norbornylogous bridges, which possess anthraquinone (AQ) moieties. An L-shaped norbornylogous bridge (L-NB) and straight-shaped norbornylogous bridge (S-NB) were used to situate AQ moieties at well-defined position and environments above a mixed alkanethiol self-assembled monolayer (SAM) on Au (111) surfaces. Sum frequency generation (SFG) vibrational spectroscopy was employed to evaluate the interaction between the S-NB and L-NB with diluent molecules in the mixed SAMs. The SFG measurements demonstrated that hydrogen-bonding interactions were formed between AQ moieties of L-NB and diluent molecules terminated by hydroxyl group within a suitable separation. The SFG observations provided information about the relative position of the AQ moieties in each SAM, which significantly affects the thermodynamics and the kinetics of the electron transfer on the electrode/solution interface. The rate constant (k(et)) of the electron transfer between the AQ moiety and the gold surface and the apparent formal potential (E(0')) were studied using cyclic voltammetry (CV), alternating current voltammetry (ACV), and electrochemical impedance spectroscopy (EIS). It was found that the k(et) increases and E(0') shifts to more anodic values as the distance between the AQ moiety and the surface of the diluent was increased, for both methyl and hydroxyl terminated diluent. These results are discussed in relation to H-bonding interactions with water surrounding the AQ moieties.

Carbon Nanomaterials in Biosensors: Should You Use Nanotubes or Graphene?

Publisher: Wiley

Date: 15-03-2010

DOI: 10.1002/ANIE.200903463

Abstract: From diagnosis of life-threatening diseases to detection of biological agents in warfare or terrorist attacks, biosensors are becoming a critical part of modern life. Many recent biosensors have incorporated carbon nanotubes as sensing elements, while a growing body of work has begun to do the same with the emergent nanomaterial graphene, which is effectively an unrolled nanotube. With this widespread use of carbon nanomaterials in biosensors, it is timely to assess how this trend is contributing to the science and applications of biosensors. This Review explores these issues by presenting the latest advances in electrochemical, electrical, and optical biosensors that use carbon nanotubes and graphene, and critically compares the performance of the two carbon allotropes in this application. Ultimately, carbon nanomaterials, although still to meet key challenges in fabrication and handling, have a bright future as biosensors.

Light-addressable electrochemistry at semiconductor electrodes: redox imaging, mask-free lithography and spatially resolved chemical and biological sensing

Publisher: Royal Society of Chemistry (RSC)

Date: 2019

DOI: 10.1039/C8CS00762D

Abstract: Electrochemical reactions in 2D with one electrical lead and a single-channel potentiostat.

Using nanoparticle aggregation to give an ultrasensitive amperometric metal ion sensor

Publisher: Elsevier BV

Date: 10-2009

DOI: 10.1016/J.ELECOM.2009.08.043

Detection of trace nitroaromatic isomers using indium tin oxide electrodes modified using β-cyclodextrin and silver nanoparticles

Publisher: American Chemical Society (ACS)

Date: 03-10-2012

DOI: 10.1021/AC3014675

Abstract: The determination of nitroaromatic compounds in aqueous solution was investigated at β-cyclodextrin (β-CD)/silver nanoparticle (AgNPs) composite modified ITO electrodes. This method relies on the different reduction potentials for the various nitroaromatic isomers, the different binding strengths of the nitroaromatic isomer guests to the β-CD host, and excellent electron transfer ability of AgNPs. After incubation in a solution with different single nitroaromatic compounds, reduction peaks in the range from -550 to -913 mV were observed at the modified electrode, depending on the nitroaromatic compound present. The sensor exhibited selectivity for some isomers in a solution containing a mixture of nitroaromatic compounds. In particular, the sensor shows specificity for 4-nitroaniline and 1-chloro-2-nitrobenzene over other nitroaniline isomers and nitrochlorobenzene isomers, respectively. The results show that all the nitroaromatic compounds, 2-nitroaniline, 3-nitroaniline, 4-nitroaniline, 1-chloro-2-nitrobenzene, 1-chloro-3-nitrobenzene, and 1-chloro-4-nitrobenzene, could not only be detected but the electrode demonstrated a preference for the more strongly complexing species.

DNA-Hybridization Detection on Si(100) Surfaces Using Light-Activated Electrochemistry: A Comparative Study between Bovine Serum Albumin and Hexaethylene Glycol as Antifouling Layers

Publisher: American Chemical Society (ACS)

Date: 05-09-2018

DOI: 10.1021/ACS.LANGMUIR.8B02222

Abstract: Light can be used to spatially resolve electrochemical measurements on a semiconductor electrode. This phenomenon has been explored to detect DNA hybridization with light-addressable potentiometric sensors and, more recently, with light-addressable erometric sensors based on organic-monolayer-protected Si(100). Here, a contribution to the field is presented by comparing sensing performances when bovine serum albumin (BSA) and hexaethylene glycol (OEG

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSPHOTONICS.0C00628

Nanoconfinement Allows a Less Active Cascade Catalyst to Produce More C2+ Products in Electrochemical CO2 Reduction

Publisher: American Chemical Society (ACS)

Date: 03-01-2023

DOI: 10.1021/ACS.JPCC.2C07518

Strategies for fabricating a biorecognition interface for a label free electrochemical immunosensor

Publisher: IEEE

Date: 02-2010

DOI: 10.1109/ICONN.2010.6045168

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 22-04-2020

DOI: 10.1021/ACSSYNBIO.0C00216

Rod-shaped mesoporous silica nanoparticles for nanomedicine: recent progress and perspectives

Publisher: Informa UK Limited

Date: 02-09-2018

DOI: 10.1080/17425247.2018.1517748

Abstract: Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod-shaped mesoporous silica nanoparticles show improvements in drug delivery relative to spherical mesoporous silica nanoparticles. This review summarises the synthesis methods for producing rod-shaped mesoporous silica nanoparticles for use in nanomedicine. The second part covers recent progress of mesoporous silica nanorods by comparing the impact of sphere and rod-shape on drug delivery efficiency. As hollow mesoporous silica nanorods are capable of higher drug loads than most other drug delivery vehicles, such particles will reduce the amount of mesoporous silica in the body for efficient therapy. However, the importance of nanoparticle shape on drug delivery efficiency is not well understood for mesoporous silica. Studies that visualize and quantify the uptake pathway of mesoporous silica nanorods in specific cell types and compare the cellular uptake to the well-studied nanospheres should be the focus of research to better understand the role of shape in uptake.

Heterojunctions Based on Amorphous Silicon: A Versatile Surface Engineering Strategy To Tune Peak Position of Redox Monolayers on Photoelectrodes

Publisher: American Chemical Society (ACS)

Date: 12-12-2019

DOI: 10.1021/ACS.JPCC.9B11252

A comparative study of modifying gold and carbon electrode with 4-Sulfophenyl diazonium salt

Publisher: Wiley

Date: 08-06-2010

DOI: 10.1002/ELAN.200900615

Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

Publisher: American Association for the Advancement of Science (AAAS)

Date: 26-02-2021

DOI: 10.1126/SCIADV.ABD6740

Abstract: On-demand controlled miR-21-5p delivery system integrates immune modification and proangiogenesis assists MI therapy.

Fundamental Science Still Needed to Drive Sensing Forward

Publisher: American Chemical Society (ACS)

Date: 24-12-2021

DOI: 10.1021/ACSSENSORS.1C02542

Characterization of functionalized glass and indium tin oxide surfaces as substrates for super-resolution microscopy

Publisher: IOP Publishing

Date: 09-11-2019

DOI: 10.1088/1361-6463/AAE7C3

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.LANGMUIR.0C01135

Electrochemical biosensors exploiting long range electron transfer: Application to enzyme and DNA sensors

Publisher: IEEE

Date: 2003

DOI: 10.1109/ASENSE.2003.1225017

A comparison of cationic and anionic intercalators for the electrochemical transduction of DNA hybridization via long range electron transfer

Publisher: Elsevier BV

Date: 07-2004

DOI: 10.1016/J.ELECOM.2004.05.002

Hybrid lipid bilayers in nanostructured silicon: A biomimetic mesoporous scaffold for optical detection of cholera toxin

Publisher: Royal Society of Chemistry (RSC)

Date: 2007

DOI: 10.1039/B702762A

Abstract: Cholera toxin levels are optically detected by affinity capture within hybrid lipid bilayer membranes formed in the nanostructures of porous silicon photonic crystals.

Porous silicon based narrow line-width rugate filters

Publisher: Elsevier BV

Date: 02-2007

DOI: 10.1016/J.OPTMAT.2005.10.012

Demonstration of the importance of oxygenated species at the ends of carbon nanotubes for their favourable electrochemical properties

Publisher: Royal Society of Chemistry (RSC)

Date: 2005

DOI: 10.1039/B415051A

Abstract: Definitive evidence is presented for the favourable electrochemical properties of carbon nanotube modified electrodes arising from the ends of SWNTs due to oxygenated carbon species in general, and carboxylic acid moieties in particular, produced during acid purification.

Ultrasensitive and Specific Measurement of Protease Activity Using Functionalized Photonic Crystals

Publisher: American Chemical Society (ACS)

Date: 08-09-2015

DOI: 10.1021/ACS.ANALCHEM.5B02529

Abstract: Herein is presented a microsensor technology as a diagnostic tool for detecting specific matrix metalloproteinases (MMPs) at very low concentrations. MMP-2 and MMP-9 are detected using label free porous silicon (PSi) photonic crystals that have been made selective for a given MMP by filling the nanopores with synthetic polymeric substrates containing a peptide sequence for that MMP. Proteolytic cleavage of the peptide sequence results in a shift in wavelength of the main peak in the reflectivity spectrum of the PSi device, which is dependent on the amount of MMP present. The ability to detect picogram amounts of MMP-2 and MMP-9 released by primary retinal pigment epithelial (RPE) cells and iris pigment epithelial (IPE) cells stimulated with lipopolysaccharide (LPS) is demonstrated. It was found that both cell types secrete higher amounts of MMP-2 than MMP-9 in their stimulated state, with RPE cells producing higher amounts of MMPs than IPE cells. The microsensor performance was compared to conventional protease detection systems, including gelatin zymography and enzyme linked immunosorbent assay (ELISA). It was found that the PSi microsensors were more sensitive than gelatin zymography PSi microsensors detected the presence of both MMP-2 and MMP-9 while zymography could only detect MMP-2. The MMP-2 and MMP-9 quantification correlated well with the ELISA. This new method of detecting protease activity shows superior performance to conventional protease assays and has the potential for translation to high-throughput multiplexed analysis.

Recent Advances in Paper-Based Sensors

Publisher: MDPI AG

Date: 24-08-2012

DOI: 10.3390/S120911505

Zero-valent iron core-iron oxide shell nanoparticles coated with silica and gold with high saturation magnetization.

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1CC05165B

Abstract: A new type of gold-coated magnetic nanoparticle with strongly magnetic zero-valent iron core-iron oxide shell were synthesized. The small size of the magnetic cores and the zero-valent iron ensured superparamagnetic behaviour and high saturation magnetization of the overall nanoparticles. The nanoparticles showed stability against magnetic aggregation and good colloidal stability, which is important for many biomedical applications.

Adsorption of T4 bacteriophages on planar indium tin oxide surface via controlled surface tailoring

Publisher: Elsevier BV

Date: 04-2016

DOI: 10.1016/J.JCIS.2016.01.052

Abstract: The work investigates the influence of surface physicochemical properties of planar indium tin oxide (ITO) as a model substrate on T4 bacteriophage adsorption. A comparative T4 bacteriophage adsorption study shows a significant difference in bacteriophage adsorption observed on chemically modified planar ITO when compared to similarly modified particulate ITO, which infers that trends observed in virus-particle interaction studies are not necessarily transferrable to predict virus-planar surface adsorption behaviour. We also found that ITO surfaces modified with methyl groups, (resulting in increased surface roughness and hydrophobicity) remained capable of adsorbing T4 bacteriophage. The adsorption of T4 onto bare, amine and carboxylic functionalised planar ITO suggests the presence of a unique binding behaviour involving specific functional groups on planar ITO surface beyond the non-specific electrostatic interactions that dominate phage to particle interactions. The paper demonstrates the significance of physicochemical properties of surfaces on bacteriophage-surface interactions.

Effects of Surface Epitope Coverage on the Sensitivity of Displacement Assays that Employ Modified Nanoparticles: Using Bisphenol A as a Model Analyte

Publisher: MDPI AG

Date: 08-08-2016

DOI: 10.3390/BIOS6030043

Abstract: With the ever-increasing use of nanoparticles in immunosensors, a fundamental study on the effect of epitope density is presented herein, with a small molecule epitope, on the performance of the displacement assay format in an enzyme-linked immunosorbent assay (ELISA). Thiolated bisphenol A (BPA) functionalized gold nanoparticles (cysBPAv-AuNPs) and specific anti-BPA antibodies are employed for this purpose. It is shown that the displacement of cysBPAv-AuNPs bound to the immobilized antibodies was influenced by both the avidity of bound cysBPAv-AuNPs and the concentration of free BPA to displace it. The importance of surface epitope density was that it changed the number of epitopes in close proximity to the antibody-binding site. This then influenced the avidity of cysBPAv-AuNPs bound to the immobilized antibody. Furthermore, the molar epitope concentration in an assay appears to affect the degree of antibody binding site saturation. Controlling surface epitope density of the functionalized nanoparticles and molar epitope concentration in an assay leads to a decrease of the concentration of free BPA required to displace the bound cysBPAv-AuNP, and hence better assay performance with regards to the D50 value and dynamic range in the displacement assay.

Having a Whale of a Time with Sensors

Publisher: American Chemical Society (ACS)

Date: 25-01-2019

DOI: 10.1021/ACSSENSORS.9B00002

The NJ Tao We Knew

Publisher: American Chemical Society (ACS)

Date: 26-02-2021

DOI: 10.1021/ACSSENSORS.1C00118

Exploration of variables in the fabrication of pyrolysed photoresist

Publisher: Springer Science and Business Media LLC

Date: 03-06-2008

DOI: 10.1007/S10008-008-0577-4

Enhanced colloidal stability and protein resistance of layered double hydroxide nanoparticles with phosphonic acid-terminated PEG coating for drug delivery

Publisher: Elsevier BV

Date: 07-2018

DOI: 10.1016/J.JCIS.2018.03.006

Abstract: Conjugating nanoparticles with polyethylene glycol (PEG) is a useful strategy to improve the colloidal and biological stability of nanoparticles. However, studies on PEGylation of two-dimensional layered double hydroxide (LDH) nanoparticles are very limited. The present work reported two functionalization approaches to synthesize PEG-conjugated LDH nanoparticles by introducing phosphonic acid terminated PEG before and after LDH aging. The successful PEGylation was confirmed and suggested to be via electrostatic interaction and a ligand exchange process. Different functionalization approaches resulted in different binding types of PEG on/in LDH nanoparticles. The PEG coating maintained the dispersity of LDH nanoparticles in water and saline with the feeding mass ratio of 1:1. Further colloidal stability tests of PEGylated LDHs revealed that the PEGylated LDH dispersity was affected by the feeding mass ratio of PEG/LDH, the molar weight of PEG and anions intercalated in the LDHs. In a test to determine the extent of non-specific protein adsorption, the PEGylation was effective at resisting non-specific bovine serum albumin adsorption on LDH nanoparticles with both functionalization methods investigated. Moreover, PEGylated LDH nanoparticles had no effect on cell viability up to 500 µg/mL, and demonstrated enhanced cellular uptake in a SK-MEL-28 cell culture. The results in this work indicate that conjugating phosphonic acid-terminated PEG on LDH nanoparticles is a promising strategy to improve the colloidal and biological stability of LDHs for biomedical applications.

Update to Our Reader, Reviewer, and Author Communities—April 2020

Publisher: American Chemical Society (ACS)

Date: 23-04-2020

DOI: 10.1021/ACS.JCTC.0C00394

Single Pt atoms on Ru nanoparticles for CO-resistant methanol oxidation reaction electrocatalysis

Publisher: Research Square Platform LLC

Date: 19-01-2021

DOI: 10.21203/RS.3.RS-132040/V1

Abstract: Single Pt atom catalysts on non-active carbon supports have been key targets for electrochemical reactions because the high exposure of active Pt leads to record-high activities. PtRu alloy catalysts are the most active for the methanol oxidation reaction (MOR) as the Ru atoms decrease CO poisoning of the active Pt. To combine the exceptional activity of single atom Pt catalysts with the benefits of an active Ru support we must overcome the synthetic challenge of forming single Pt atoms on noble metal nanoparticles. We have developed a concept to grow and spreads Pt islands on faceted Ru branched nanoparticles to make single Pt atom on Ru catalysts. By following the spreading process with in situ TEM, we show that the formation of single atoms is thermodynamically driven by the formation of strong Pt-Ru bonds and a lowering of surface area. The single Pt atom on Ru catalysts successfully limit CO poisoning during MOR to produce record current density and mass activity over time.

Supercritical Fluid Extraction of Triglycerides