Grant Count
10
Highest Funding Involved
$21,000,000.00
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Start Date: 03-2012
End Date: 06-2015
Amount: $180,000.00
Summary: From sound to hearing: the integration of behavioural, neurophysiological, and neuroimaging research with computational models. McLachlan and Wilson have recently published a ground-breaking new model of the auditory system with important implications for treating deafness and understanding neurological disorders. In this research the predictions of the model will be experimentally validated using advanced neuroimaging techniques.
Funder: Australian Research Council
View Funded ActivityStart Date: 2013
End Date: 12-2016
Amount: $778,000.00
Summary: A novel approach to diffusion MRI for greatly improved imaging of brain white matter and its connectivity. In this project, innovative new imaging and reconstruction techniques will be developed to provide images of brain connectivity, with unprecedented detail. Such images will allow extremely detailed investigations into the white matter connections that allow brain regions to communicate, and improve our understanding of how the brain operates.
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2012
End Date: 12-2016
Amount: $510,000.00
Summary: Elucidating the neural pathways and genetic basis of speech. The project will elucidate the biological basis of speech, a unique feature of the human condition. The project will do this by i) discovering genes associated with speech disorder and ii) defining the neural pathways associated with speech production. This study will address critical questions regarding gene, brain and behaviour relationships in speech.
Funder: Australian Research Council
View Funded ActivityStart Date: 2012
End Date: 12-2014
Amount: $345,000.00
Summary: Deciphering the cellular defences against aggregating proteins in human disease. Cells have inbuilt defences for coping with proteins that bend into abnormal sticky shapes that form toxic clusters. In many diseases, including Huntington's, the clusters severely damage nerve cells. This project will identify the genes and mechanisms cells use to protect themselves from toxic clusters, which could provide new therapeutic targets.
Funder: Australian Research Council
View Funded ActivityStart Date: 11-2012
End Date: 06-2016
Amount: $260,000.00
Summary: Development of Insulin-like peptide 5 (INSL5) peptide analogues as novel therapeutics. Insulin-like peptide 5 (INSL5) is a naturally-occurring hormone in the body that likely plays a role in the control of appetite. This project aims to develop new molecules based on INSL5 that could be suitable for use as drugs to treat various appetite-related disorders, such as obesity (where patients eat too much) or anorexia (where patients eat too little).
Funder: Australian Research Council
View Funded ActivityStart Date: 02-2013
End Date: 06-2016
Amount: $415,000.00
Summary: Functional tracing of brain circuitry by a novel approach. A genetically modified virus is taken up by axon terminals (the 'output' part of a nerve cell) and transported by the cell back to the cell body (its 'input' part). Once there, it makes a protein that makes the cell sensitive to blue light. This new tool may be instrumental in answering questions about nerve connections that cannot be answered in other ways.
Funder: Australian Research Council
View Funded ActivityStart Date: 2012
End Date: 01-2016
Amount: $310,000.00
Summary: Genetic dissection of functional-structural connectivity using optogenetic fMRI and dMRI tractography. The project will map the connectivity pattern of genetically defined neurons in mouse brain by combining state of the art molecular and neuroscience imaging technology. The outcome will be a significant step toward building a complete functional and structural mapping resource, with application for examining dysfunction in neurological disease models.
Funder: Australian Research Council
View Funded ActivityStart Date: 2014
End Date: 12-2018
Amount: $754,920.00
Summary: Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is .... Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is focused on studying structural features of a range of peptides and their contributions to both activity and to resistance against degradation, with the aim to develop stabilised bioactive peptide sequences for in vivo applications, allowing the full potential of peptides as drugs to be realised. Read more Read less
Funder: Australian Research Council
View Funded ActivityStart Date: 2013
End Date: 06-2015
Amount: $670,000.00
Summary: Helium and neon ion microscope for sub nanometer imaging and fabrication. The project's proposed instrument would add a new desperately needed capability to Australia's high resolution microscopy centre and nano fabrication facility and enable a wide range of users to image, measure, build and design complex nanostructures at the atomic level and upwards.
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2011
End Date: 12-2019
Amount: $21,000,000.00
Summary: Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and .... Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders. Read more Read less
Funder: Australian Research Council
View Funded ActivityNo organisations have been discovered.