The Quinoline Antimalarials: Mechanisms Of Action And Resistance In Plasmodium Falciparum
Funder
National Health and Medical Research Council
Funding Amount
$316,650.00
Summary
Malaria is a debilitating parasitic disease that is responsible for the deaths of about two million children each year. As drugs, such as chloroquine, become increasingly useless due to the development of parasite resistance, there is an urgent need to understand the mode of action of these antimalarials so that replacement drugs can be designed. We propose to test the hypothesis that chloroquine acts by interfering with the detoxification of the by-products that are produced when the parasite f ....Malaria is a debilitating parasitic disease that is responsible for the deaths of about two million children each year. As drugs, such as chloroquine, become increasingly useless due to the development of parasite resistance, there is an urgent need to understand the mode of action of these antimalarials so that replacement drugs can be designed. We propose to test the hypothesis that chloroquine acts by interfering with the detoxification of the by-products that are produced when the parasite feeds on haemoglobin. We propose that the parasite develops resistance to chloroquine by excluding either the drug or the toxic by-products from the site of action. We further propose that proteins of the digestive vacuole of the parasite are involved in the development of resistance to chloroquine. We plan to identify and characterise these proteins and to use this information to design novel antimalarial drugs.Read moreRead less
Seafood Country Of Origin Labelling (CoOL) – NSW Food Service Industry Trial
Funder
Fisheries Research and Development Corporation
Funding Amount
$3,900.00
Summary
There are a number of proposals to extend compulsory seafood Country of Origin Labelling (CoOL), as currently exists in retail, to food service businesses. A number of stakeholder meetings have been held nationally and by individual states, to consider the proposal. There is a compulsory system in the Northern Territory and the NSW Government has agreed to consider the proposal for a CoOL scheme for seafood as part of its Fisheries Reform Package. The Restaurant & Catering Industry Associa ....There are a number of proposals to extend compulsory seafood Country of Origin Labelling (CoOL), as currently exists in retail, to food service businesses. A number of stakeholder meetings have been held nationally and by individual states, to consider the proposal. There is a compulsory system in the Northern Territory and the NSW Government has agreed to consider the proposal for a CoOL scheme for seafood as part of its Fisheries Reform Package. The Restaurant & Catering Industry Association considers that a concerted informational and educative campaign to increase the take-up of CoOL amongst food service businesses in the hospitality sector will deliver sustained results. Other stakeholders are not convinced that a voluntary system will work so have agreed to trial a campaign in NSW food service businesses during 2018 to evaluate the impact of such an initiative (intended and unintended). This project workshops the ToR of such a trial
Objectives: 1. To develop Request for Tender documentation to ensure an increase in the purchase and sales of seafood and increase consumer awareness of the origin of seafood in food service through an informative education campaign targeting food service businesses in NSW. Read moreRead less
Tactical Research Fund: Improving Efficiency In Generating Submissions And Consistency Of Outcomes For MSC Based Assessments
Funder
Fisheries Research and Development Corporation
Funding Amount
$63,939.00
Summary
The Government of WA, in collaboration with industry, has initiated an ambitious program to have all commercial fisheries in Western Australia undergo MSC certification. All commercial fisheries will undergo pre-assessment by the end of 2014. Any fishery that chooses to undergo full MSC assessment will have the initial certification costs funded which will begin in 2014. A number of issues have arisen during the establishment of this process that need to be addressed prior to the end of the pr ....The Government of WA, in collaboration with industry, has initiated an ambitious program to have all commercial fisheries in Western Australia undergo MSC certification. All commercial fisheries will undergo pre-assessment by the end of 2014. Any fishery that chooses to undergo full MSC assessment will have the initial certification costs funded which will begin in 2014. A number of issues have arisen during the establishment of this process that need to be addressed prior to the end of the pre-assessment process and especially before many fisheries move to full assessment.
Direct experience with MSC assessment process for the rock lobster fishery, plus reviews of the MSC process (MRAG, 2011) have shown that once initial ‘scores’ or opinions have been established for a fishery, these scores and opinions strongly dictate the outcome and the subsequent level of conditions established for the fishery to either gain or maintain certification. In going from pre to full assessments, the scores may go down, but almost never go up (MRAG, 2011). Lower scores that require undertaking activities to ‘close off’ conditions, especially for Principle 2 (ecological) criteria is where the costs of MSC certification can become prohibitive These costs can be significantly greater than the direct MSC assessment or audit costs; for rock lobster this has run into many $millions. It is essential, therefore, that the number of 'unecessary' conditions, particularly those requiring collection of more information (which is the most common condition applied, MRAG, 2011) are minimised to avoid unnecessary costs for industry and government.
An additional complexity is the Fishery Standard Review (FSR) currently being undertaken by MSC. This has proposed changes for P1 and P2 whcih could significantly alter how we approach MSC assessments and therefore need to directly test the impacts of these proposed changes. Objectives: 1. Increase the efficiency of generating submissions for MSC assessments. 2. Minimise the likelihood of unnecessary conditions being imposed during MSC assessments Read moreRead less
Seafood CRC: Australian Seafood Compositional Profiles Portal
Funder
Fisheries Research and Development Corporation
Funding Amount
$149,889.98
Summary
INDUSTRY NEEDS Seafood CRC participants need a common platform that provides easy accessible baseline compositional profiles in suitable formats about their products to enable them to meet their individual needs. The establishment of a secure web based portal will assist industry in identifying and removing barriers to uptake of labeling requirements.
The information needs to be robust, consistent and cover the minimum needs of the Seafood CRC participants for nutritional and contam ....INDUSTRY NEEDS Seafood CRC participants need a common platform that provides easy accessible baseline compositional profiles in suitable formats about their products to enable them to meet their individual needs. The establishment of a secure web based portal will assist industry in identifying and removing barriers to uptake of labeling requirements.
The information needs to be robust, consistent and cover the minimum needs of the Seafood CRC participants for nutritional and contaminant information. Existing information held by individual Seafood CRC participants will be able to be housed in the web portal. Additional testing beyond that in this project would need to funded elsewhere.
Where there is a need to develop new analytical capability this will be done outside this project in the related methods development project.
The project will assist in meeting industry needs for: - Promoting the public health benefits of seafood consumption more generally. - Rapid access to credible information to counter negative media claims. - Assist in addressing current and future technical market challenges. - Anticipate and quickly respond to market access threats.
NATIONAL ENGAGEMENT Seafood CRC participants require an expert facilitated process to undertake this activity. The panel fulfils a need of industry to have an entry point into national and international processes undertaken by State and Commonwealth agencies. Without the project the loss of market access share in international markets such as Hong Kong (due to labelling requirements being introduced currently) would be commercially damaging. For example the Food Standards Australia New Zealand (FSANZ) "Proposal P293 - Nutrition, Health and Related Claims" could be implemented with no seafood industry input or through this project a process of engagement with Commonwealth regulators could be initiated to secure industry outcomes. There is a need for any data capture activities to be compliant with FSANZ technical specifications. Objectives: 1. To establish by March 2010 a common scientifically robust information platform that provides Seafood CRC participants with timely access to information about the nutritional and contaminant compositional profiles of their traded products. Read moreRead less
The ability to distinguish hatchery-produced scallops from wild recruits is necessary to determine the survival and optimal size and time of deployment to the seabed in the scallop reseeding project FRDC 2002/48. Furthermore, to enable rigorous evaluation of commercial marine reseeding ventures, a means of identifying the released scallops upon recapture is required. Successful labelling of juvenile scallops will also allow researchers to estimate survival and dispersal of reseeded juveniles. ....The ability to distinguish hatchery-produced scallops from wild recruits is necessary to determine the survival and optimal size and time of deployment to the seabed in the scallop reseeding project FRDC 2002/48. Furthermore, to enable rigorous evaluation of commercial marine reseeding ventures, a means of identifying the released scallops upon recapture is required. Successful labelling of juvenile scallops will also allow researchers to estimate survival and dispersal of reseeded juveniles.
An identifying mark provides far greater sensitivity and accuracy than typical statistical-based assessment. There are a number of reported methods to discern hatchery produced animals but the methods we have chosen to test are relatively inexpensive and easy to apply to animals no greater than 4mm shell length (commercial release size). An alternative marking method, molecular analysis of scallop tissue, was evaluated and qualified opinions sought, but rejected on the basis of high expense and processing time compared with testing cheaper alternatives with demonstrated utility in other species.
Objectives: 1. To develop a method to mark hatchery reared saucer scallops to distinguish them from animals derived from wild populations. Read moreRead less
Improving Packaging Technology, Survival And Market Options For Kuruma Prawns
Funder
Fisheries Research and Development Corporation
Funding Amount
$33,750.00
Summary
Objectives: 1. To evaluate the temperature stability of technically advanced live prawn (seafood) package design (prototype and finished item), under a range of storage, transport and climatic conditions. 2. To ascertain/confirm upper lethal temperature limit for kuruma prawns 3. Determine if modifications to the preparation and packaging operations are likely to improve the survival rate of packaging prawns from high ambient temperature growout conditions. 4. To establish ....Objectives: 1. To evaluate the temperature stability of technically advanced live prawn (seafood) package design (prototype and finished item), under a range of storage, transport and climatic conditions. 2. To ascertain/confirm upper lethal temperature limit for kuruma prawns 3. Determine if modifications to the preparation and packaging operations are likely to improve the survival rate of packaging prawns from high ambient temperature growout conditions. 4. To establish the potential feasibility of transporting live kuruma prawns from one location to another to optimise growout conditions and optimise quality through climatic agistment. Read moreRead less