ORCID Profile
0000-0002-4441-5465
Current Organisations
University of Bern
,
Staatssekretariat für Wirtschaft Direktion für Arbeit
,
Universitat Bern
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Publisher: Oxford University Press (OUP)
Date: 06-01-2014
DOI: 10.1093/NDT/GFT507
Abstract: Drinking eight glasses of fluid or water each day is widely believed to improve health, but evidence is sparse and conflicting. We aimed to investigate the association between fluid consumption and long-term mortality and kidney function. We conducted a longitudinal analysis within a prospective, population-based cohort study of 3858 men and women aged 49 years or older residing in Australia. Daily fluid intake from food and beverages not including water was measured using a food frequency questionnaire. We did multivariable adjusted Cox proportional hazard models for all-cause and cardiovascular mortality and a boot-strapping procedure for estimated glomerular filtration rate (eGFR). Upper and lower quartiles of daily fluid intake corresponded to >3 L and <2 L, respectively. During a median follow-up of 13.1 years (total 43 093 years at risk), 1127 deaths (26.1 per 1000 years at risk) including 580 cardiovascular deaths (13.5 per 1000 years at risk) occurred. Daily fluid intake (per 250 mL increase) was not associated with all-cause [adjusted hazard ratio (HR) 0.99 (95% CI 0.98-1.01)] or cardiovascular mortality [HR 0.98 (95% CI 0.95-1.01)]. Overall, eGFR reduced by 2.2 mL/min per 1.73 m(2) (SD 10.9) in the 1207 (31%) participants who had repeat creatinine measurements and this was not associated with fluid intake [adjusted regression coefficient 0.06 mL/min/1.73 m(2) per 250 mL increase (95% CI -0.03 to 0.14)]. Fluid intake from food and beverages excluding water is not associated with improved kidney function or reduced mortality.
Publisher: Elsevier BV
Date: 03-2014
DOI: 10.1053/J.AJKD.2013.08.026
Abstract: Mortality risk for people with chronic kidney disease is substantially greater than that for the general population, increasing to a 7-fold greater risk for those on dialysis therapy. Higher body mass index, generally due to higher energy intake, appears protective for people on dialysis therapy, but the relationship between energy intake and survival in those with reduced kidney function is unknown. Prospective cohort study with a median follow-up of 14.5 (IQR, 11.2-15.2) years. Blue Mountains Area, west of Sydney, Australia. Participants in the general community enrolled in the Blue Mountains Eye Study (n = 2,664) who underwent a detailed interview, food frequency questionnaire, and physical examination including body weight, height, blood pressure, and laboratory tests. Relative energy intake, food components (carbohydrates, total sugars, fat, protein, and water), and estimated glomerular filtration rate (eGFR). Relative energy intake was dichotomized at 100%, and eGFR, at 60 mL/min/1.73 m(2). All-cause and cardiovascular mortality. All-cause and cardiovascular mortality using unadjusted and adjusted Cox proportional regression models. 949 people died during follow-up, 318 of cardiovascular events. In people with eGFR<60 mL/min/1.73 m(2) (n = 852), there was an increased risk of all-cause mortality (HR, 1.48 P = 0.03), but no increased risk of cardiovascular mortality (HR, 1.59 P = 0.1) among those with higher relative energy intake compared with those with lower relative energy intake. Increasing intake of carbohydrates (HR per 100g/d, 1.50 P = 0.04) and total sugars (HR per 100g/d, 1.62 P = 0.03) was associated significantly with increased risk of cardiovascular mortality. Under-reporting of energy intake, baseline laboratory and food intake values only, white population. Increasing relative energy intake was associated with increased all-cause mortality in patients with eGFR<60 mL/min/1.73 m(2). This effect may be mediated by increasing total sugars intake on subsequent cardiovascular events.
Publisher: Elsevier BV
Date: 2014
DOI: 10.1053/J.AJKD.2013.07.008
Abstract: Chronic kidney disease is associated with an increased risk of cancer, but whether reduced kidney function also leads to increased cancer mortality is uncertain. The aim of our study was to assess the independent effects of reduced kidney function on the risk of cancer deaths. Prospective population-based cohort study. Participants of the Blue Mountains Eye Study (n=4,077 aged 49-97 years). Estimated glomerular filtration rate (eGFR). Overall and site-specific cancer mortality. During a median follow-up of 12.8 (IQR, 8.6-15.8) years, 370 cancer deaths were observed in our study cohort. For every 10-mL/min/1.73 m(2) reduction in eGFR, there was an increase in cancer-specific mortality of 18% in the fully adjusted model (P<0.001). Compared with participants with eGFR ≥ 60 mL/min/1.73 m(2), the adjusted HR for cancer-specific mortality for those with eGFR<60 mL/min/1.73 m(2) was 1.27 (95% CI, 1.00-1.60 P=0.05). This excess cancer mortality varied with site, with the greatest risk for breast and urinary tract cancer deaths (adjusted HRs of 1.99 [95% CI, 1.05-3.85 P=0.01] and 2.54 [95% CI, 1.02-6.44 P=0.04], respectively). Residual confounding, such as from unmeasured socioeconomic factors and the potential effects of erythropoiesis-stimulating agents on cancer deaths, may have occurred. eGFR<60 mL/min/1.73m(2) appears to be a significant risk factor for death from cancer. These effects appear to be site specific, with breast and urinary tract cancers incurring the greatest risk of death among those with reduced kidney function.
Publisher: Hogrefe Publishing Group
Date: 11-2022
Location: Switzerland
No related grants have been discovered for Samuel Iff.