Timothy Scott

Nonequilibrium interfacial diffusion across microdroplet interface

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2LC00326K

Abstract: Increases in complexity attainable in molecular self-assembly necessitates both advanced molecular design as well as microenvironmental control.

Augmenting Primary and Secondary Education with Polymer Science and Engineering

Publisher: American Chemical Society (ACS)

Date: 24-07-2017

DOI: 10.1021/ACS.JCHEMED.6B00805

Radical-Mediated Ring-Opening Photopolymerization for Semicrystalline Thermoplastic Additive Manufacturing

Publisher: American Chemical Society (ACS)

Date: 04-05-2023

DOI: 10.1021/ACS.CHEMMATER.2C03352

Effect of Cholesterol on Biomimetic Membrane Curvature and Coronavirus Fusion Peptide Encapsulation

Publisher: American Chemical Society (ACS)

Date: 20-04-2023

DOI: 10.1021/ACSNANO.3C01095

Microfluidic enhancement of self-assembly systems

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1LC00038A

Abstract: A review of the advances in supramolecular chemistry achieved by the application of continuous and dispersed microfluidic approaches.

Rapid Gel Card Agglutination Assays for Serological Analysis Following SARS-CoV-2 Infection in Humans

Publisher: American Chemical Society (ACS)

Date: 16-07-2020

DOI: 10.1021/ACSSENSORS.0C01050

Mimicking DNA Functions with Abiotic, Sequence-Defined Polymers

Publisher: Informa UK Limited

Date: 28-12-2022

DOI: 10.1080/15583724.2021.2014519

Approaches and challenges in the synthesis of three-dimensional covalent-organic frameworks

Publisher: Springer Science and Business Media LLC

Date: 18-12-2018

DOI: 10.1038/S42004-018-0098-8

Abstract: Covalent organic frameworks, cross-linked crystalline polymers constructed from rigid organic precursors connected by covalent interactions, have emerged as a promising class of nanoporous materials owing to their highly desirable combination of attributes, including facile chemical tunability, structural ersity, and excellent stability. Despite the distinct advantages offered by three-dimensional covalent organic frameworks, research efforts have predominantly focused on the more synthetically-accessible, two-dimensional variants. Here we present an overview of synthetic approaches to yield three-dimensional covalent organic frameworks, identify synthetic obstacles that have hindered progress in the field and recently-employed methods to address them, and propose alternative techniques to circumvent these synthetic challenges.

Polygenic overlap between kidney function and large artery atherosclerotic stroke.

Publisher: Ovid Technologies (Wolters Kluwer Health)

Date: 12-2014

DOI: 10.1161/STROKEAHA.114.006609

Abstract: Epidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes. Polygenic models were derived using genome-wide association studies meta-analysis results for 3 kidney traits: estimated glomerular filtration rate using serum creatinine (eGFRcrea: n=73 998), eGFR using cystatin C (eGFRcys: n=22 937), and urinary albumin to creatinine ratio (n=31 580). For each, single nucleotide polymorphisms passing 10 P value thresholds were used to form profile scores in 4561 IS cases and 7094 controls from the United Kingdom, Germany, and Australia. Scores were tested for association with IS and its 3 aetiological subtypes: large artery atherosclerosis, cardioembolism, and small vessel disease. Polygenic scores correlating with higher eGFRcrea were associated with reduced risk of large artery atherosclerosis, with 5 scores reaching P .05 (peak P =0.004) and all showing the epidemiologically expected direction of effect. A similar pattern was observed for polygenic scores reflecting higher urinary albumin to creatinine ratio, of which 3 associated with large artery atherosclerosis (peak P =0.01) and all showed the expected directional association. One urinary albumin to creatinine ratio–based score also associated with small vessel disease ( P =0.03). The global pattern of results was unlikely to have occurred by chance ( P =0.02). This study suggests possible polygenic correlation between renal dysfunction and IS. The shared genetic components may be specific to stroke subtypes, particularly large artery atherosclerotic stroke. Further study of the genetic relationships between these disorders seems merited.

Temperature-mediated molecular ladder self-assembly employing Diels–Alder cycloaddition

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/D0PY01296C

Abstract: Thermal annealing of sequence-defined, maleimide- and furan-bearing oligomers enables sequence-selective hybridization to afford molecular ladders incorporating Diels–Alder adduct-based rungs.

Aqueous dynamic covalent assembly of molecular ladders and grids bearing boronate ester rungs

Publisher: Royal Society of Chemistry (RSC)

Date: 2019

DOI: 10.1039/C8PY01705K

Abstract: Mimicking the self-assembly of nucleic acid sequences into double-stranded molecular ladders that incorporate hydrogen bond-based rungs, dynamic covalent interactions enable the fabrication of molecular ladder and grid structures with covalent bond-based rungs.

Sequence-selective dynamic covalent assembly of information-bearing oligomers

Publisher: Springer Science and Business Media LLC

Date: 07-02-2020

DOI: 10.1038/S41467-020-14607-3

Abstract: Relatively robust dynamic covalent interactions have been employed extensively to mediate molecular self-assembly reactions however, these assembly processes often do not converge to a thermodynamic equilibrium, instead yielding mixtures of kinetically-trapped species. Here, we report a dynamic covalent self-assembly process that mitigates kinetic trapping such that multiple unique oligomers bearing covalently coreactive pendant groups are able to undergo simultaneous, sequence-selective hybridization with their complementary strands to afford biomimetic, in-registry molecular ladders with covalent rungs. Analogous to the thermal cycling commonly employed for nucleic acid melting and annealing, this is achieved by raising and lowering the concentration of a multi-role reagent to effect quantitative dissociation and subsequently catalyze covalent bond rearrangement, affording selective assembly of the oligomeric sequences. The hybridization specificity afforded by this process further enabled information encoded in oligomers to be retrieved through selective hybridization with complementary, mass-labeled sequences.

Rapid, Photomediated Healing of Hexaarylbiimidazole-Based Covalently Cross-Linked Gels

Publisher: American Chemical Society (ACS)

Date: 04-08-2017

DOI: 10.1021/ACS.CHEMMATER.7B02640

Modeling and Correcting Cure‐Through in Continuous Stereolithographic 3D Printing

Publisher: Wiley

Date: 21-10-2019

DOI: 10.1002/ADMT.201900700

Sequence-directed dynamic covalent assembly of base-4-encoded oligomers

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/D0CC01083A

Abstract: Molecular ladders and molecular grids were self-assembled employing two orthogonal dynamic covalent reactant pairs in an aqueous environment.

Rapid, continuous additive manufacturing by volumetric polymerization inhibition patterning

Publisher: American Association for the Advancement of Science (AAAS)

Date: 04-01-2019

DOI: 10.1126/SCIADV.AAU8723

Abstract: Photopatterning polymerization inhibition volumes by two-color irradiation enables exceptional 3D printing speed and functionality.

Volumetric Photopolymerization Confinement through Dual-Wavelength Photoinitiation and Photoinhibition

Publisher: American Chemical Society (ACS)

Date: 15-07-2019

DOI: 10.1021/ACSMACROLETT.9B00412

Abstract: Conventional photolithographic rapid prototyping approaches typically achieve reaction confinement in depth through patterned irradiation of a photopolymerizable resin at a wavelength where the resin strongly absorbs, such that only a very thin layer of material is solidified. Consequently, three-dimensional objects are fabricated by progressive, two-dimensional addition of material, curtailing fabrication rates and necessitating the incorporation of support structures to ensure the integrity of overhanging features. Here, we examine butyl nitrite as a UV-active photoinhibitor of blue light-induced photopolymerizations and explore its utilization to confine in depth the region polymerized in a volume of resin. By employing two perpendicular irradiation patterns at blue and near-UV wavelengths to independently effect either polymerization initiation or inhibition, respectively, we enable three-dimensional photopolymerization patterning in bulk resin, thereby complementing emergent approaches to volumetric 3D printing.

In situ deprotection and dynamic covalent assembly using a dual role catalyst

Publisher: Royal Society of Chemistry (RSC)

Date: 2017

DOI: 10.1039/C7CC01028A

Abstract: Sc(OTf) 3 is employed as a dual role catalyst to effect the in situ deprotection and dynamic covalent assembly of oligo(peptoid)s.

Monash University

Location: Australia

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University Of Michigan

Location: United States of America

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Discovery Projects - Grant ID: DP0877382

Start Date: 03-2008

End Date: 06-2012

Amount: $660,000.00

Funder: Australian Research Council

Discovery Projects - Grant ID: DP210100901

Start Date: 2021

End Date: 12-2023

Amount: $522,821.00

Funder: Australian Research Council

ARC Future Fellowships - Grant ID: FT200100880

Start Date: 06-2021

End Date: 06-2025

Amount: $1,065,000.00

Funder: Australian Research Council