ORCID Profile
0000-0002-4709-7423
Current Organisations
National Institutes of Health
,
Mizoram University
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Publisher: Wiley
Date: 12-11-2014
Abstract: The tris(pyrazolyl)methane compound HC(3-Ad-5-Mepz)3 [1, 3-Ad-5-Mepz=3-(1-adamantyl)-5-methylpyrazolyl] and its regioisomer, HC(3-Ad-5-Mepz)2 (3-Me-5-Adpz), were synthesized and crystallographically characterized. Deprotonation of 1 with MeLi afforded the lithium complex [{κ(3) -N-C(3-Ad-5-Mepz)3 }Li(thf)], which incorporates a tris(pyrazolyl)methanide ligand of unprecedented bulk. Reaction of 1 with MeMgI gave the ionic coordination complex [{κ(3) -N-HC(3-Ad-5-Mepz)3 }MgMe]I, which was readily deprotonated to afford the neutral compound [{κ(3) -N-C(3-Ad-5-Mepz)3 }MgMe]. The related magnesium butyl compound [{κ(3) -N-C(3-Ad-5-Mepz)3 }MgBu] was prepared from the reaction of 1 and MgBu2 . Treating this with LiAlH4 or LiAlD4 led to rare ex les of terminal magnesium hydride/deuteride complexes, [{κ(3) -N-C(3-Ad-5-Mepz)3 }MgH/D]. All neutral magnesium alkyl and hydride compounds were crystallographically authenticated. Reaction of [{κ(3) κN-C(3-Ad-5-Mepz)3 }Li(thf)] with [YbI2 (thf)2 ] yielded the first structurally characterized f-block tris(pyrazolyl)methanide complex, [{κ(3) -N-C(3-Ad-5-Mepz)3 }YbI(thf)].
Publisher: Springer Science and Business Media LLC
Date: 15-02-2021
Publisher: Cold Spring Harbor Laboratory
Date: 04-02-2020
DOI: 10.1101/2020.02.04.932335
Abstract: The genetic basis of variation in the rate of disease progression of primary tauopathies has not been determined. In two independent progressive supranuclear palsy cohorts, we show that common variation at the LRRK2 locus determines survival from motor symptom onset to death, possibly through regulation of gene expression. This links together genetic risk in alpha-synuclein and tau disorders, and suggests that modulation of proteostasis and neuro-inflammation by LRRK2 inhibitors may have a therapeutic role across disorders.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2CC37442K
Abstract: Reactions of [Pt(PCy(3))(2)] (Cy = cyclohexyl) with group 12 metal dihalides have afforded the novel metal only Lewis pair (MOLP) complexes, [(Cy(3)P)(2)Pt→MX(2)] (M = Zn or Cd, X = Br or I), or the oxidative addition product, trans-[(Cy(3)P)(2)(I)PtHgI]. The zinc complex represents the first MOLP to contain an unsupported Pt→Zn linkage.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3SC52242C
Publisher: Cold Spring Harbor Laboratory
Date: 19-09-2019
DOI: 10.1101/770339
Abstract: Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of childhood motor disorder with a heterogeneous clinical presentation. The underlying causes of this condition are poorly understood, hindering the development of effective therapies. In a whole-exome sequencing trio-family study of three unrelated juvenile patients diagnosed with ALS and failure to thrive, we identified de-novo mutations in SPTLC1 (p.Ala20Ser in two patients and p.Ser331Tyr) not present in their healthy parents or siblings. SPTLC1 encodes a subunit of the serine palmitoyltransferase complex, a key enzyme in sphingolipid biosynthesis. Mutations in this gene are known to cause hereditary sensory autonomic neuropathy, type 1A, with a characteristic increase in plasma levels of neurotoxic deoxymethyl-sphinganine. We found an increase of this metabolite in one of our patients carrying the p.Ala20Ser mutation. Treatment of one of the patients with high dose, oral L-serine led to an increase in body weight, suggesting that serine supplementation may be beneficial among patients carrying mutations in this gene.
Publisher: American Medical Association (AMA)
Date: 10-2021
Publisher: Elsevier BV
Date: 2019
DOI: 10.2139/SSRN.3399502
Publisher: Elsevier BV
Date: 03-2018
Publisher: Wiley
Date: 13-03-2019
DOI: 10.1002/ANA.25431
Publisher: American Chemical Society (ACS)
Date: 09-07-2015
DOI: 10.1021/JACS.5B06439
Abstract: This study details the formal hydrogenation of two magnesium(I) dimers {(Nacnac)Mg}2 (Nacnac = [{(C6H3R2-2,6)NCMe}2CH](-) R = Pr(i) ((Dip)Nacnac), Et ((Dep)Nacnac)) using 1,3-cyclohexadiene. These reactions afford the magnesium(II) hydride complexes, {(Nacnac)Mg(μ-H)}2. Their reactions with excess CO are sterically controlled and lead cleanly to different C-C coupled products, viz. the ethenediolate complex, ((Dip)Nacnac)Mg{κ(1)-O-[((Dip)Nacnac)Mg(κ(2)-O,O-O2C2H2)]}, and the first cyclopropanetriolate complex of any metal, cis-{((Dep)Nacnac)Mg}3{μ-C3(H3)O3}. Computational studies imply the CO activation processes proceed via very similar mechanisms to those previously reported for related reactions involving f-block metal hydride compounds. This work highlights the potential magnesium compounds hold for use in the "Fischer-Tropsch-like" transformation of CO/H2 mixtures to value added oxygenate products.
Publisher: Elsevier BV
Date: 02-2021
Location: Spain
No related grants have been discovered for Ruth Chia.