ORCID Profile
0000-0002-4441-5772
Current Organisations
Monash University
,
Guangzhou Medical University
,
University of Rochester
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Publications
Design Guidelines of Mobile Apps for Older Adults: Systematic Review and Thematic Analysis (Preprint)
Publisher: JMIR Publications Inc.
Date: 03-10-2022
Design Guidelines of Mobile Apps for Older Adults: Systematic Review and Thematic Analysis
Publisher: JMIR Publications Inc.
Date: 21-09-2023
DOI: 10.2196/43186
Emerging Lipoprotein-Related Therapeutics for Patients with Diabetes
Publisher: Springer International Publishing
Date: 2023
Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet
Publisher: Elsevier BV
Date: 11-2011
DOI: 10.1016/J.ABB.2011.08.006
Abstract: Tanshinone II-A (Tan), a bioactive diterpene isolated from Salvia miltiorrhiza Bunge (Danshen), possesses anti-oxidant and anti-inflammatory activities. The present study investigated whether Tan can decrease and stabilize atherosclerotic plaques in Apolipoprotein-E knockout (ApoE(-/-)) mice maintained on a high cholesterol diet (HCD). Six week-old mice challenged with a HCD were randomly assigned to 4 groups: (a) C57BL/6J (b) ApoE(-/-) (c) ApoE(-/-)+Tan-30 (30 mg/kg/d) (d) ApoE(-/-)+Tan-10 (10mg/kg/d). After 16 weeks of intervention, Tan treated mice showed decreased atherosclerotic lesion size in the aortic sinus and en face aorta. Furthermore, immunohistochemical analysis revealed that Tan rendered the lesion composition a more stable phenotype as evidenced by reduced necrotic cores, decreased macrophage infiltration, and increased smooth muscle cell and collagen contents. Tan also significantly reduced in situ superoxide anion production, aortic expression of NF-κB and matrix metalloproteinase-9 (MMP-9). In vitro treatment of RAW264.7 macrophages with Tan significantly suppressed oxidized LDL-induced reactive oxygen species production, pro-inflammatory cytokine (IL-6, TNF-α, MCP-1) expression, and MMP-9 activity. Tan attenuates the development of atherosclerotic lesions and promotes plaque stability in ApoE(-/-) mice by reducing vascular oxidative stress and inflammatory response. Our findings highlight Tan as a potential therapeutic agent to prevent atherosclerotic cardiovascular diseases.
Related Organisations
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