ORCID Profile
0000-0003-2767-7890
Current Organisation
SA Heart
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Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 17-11-2015
Publisher: Elsevier BV
Date: 06-2014
DOI: 10.1016/J.HLC.2013.11.012
Abstract: Perhexiline is a unique anti-anginal agent that is frequently used in the treatment of chronic refractory angina. Its utility has been limited because of its complex pharmacokinetics that were only appreciated following the development of a therapeutic perhexiline assay. Perhexiline is cleared primarily via formation of mono-hydroxy metabolites (OH-perhexiline) by cytochrome P450 2D6 (CYP2D6). Drugs that are inhibitors of CYP2D6 may therefore inhibit perhexiline metabolism, increase plasma perhexiline concentration and may consequently increase the risk of toxicity. We report a case of a rise in perhexiline plasma concentration to a toxic level following the introduction of terbinafine hydrochloride a moderate CYP2D6 inhibiting drug.
Publisher: Elsevier BV
Date: 11-2015
Publisher: Elsevier BV
Date: 09-2018
DOI: 10.1016/J.IJCARD.2018.04.077
Abstract: Coronary haemodynamic testing frequently identifies abnormal pathophysiological parameters in patients with angina and non-obstructed coronaries on angiography (NoCAD) but the clinical utility of these measures has received limited attention. This study aims to identify the clinical and coronary haemodynamic determinants of recurrent chest pain at one month in patients with NoCAD. Patients with angina, NoCAD ( 1.9. Multivariate logistic regression analysis identified frequent angina at baseline (OR: 68.9 [4.1, 1165.0], p = 0.003), previous unstable angina admission (OR: 43.9 [3.5, 547.9], p = 0.003) and a HMR > 1.9 (OR: 15.6 [2.1, 114.0], p = 0.007) as independent predictors of recurrent chest pain. In this small pilot study, an abnormal HMR was the only coronary haemodynamic parameter that was a determinant of ongoing angina at short-term follow-up.
Publisher: Elsevier BV
Date: 08-2015
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2018
No related grants have been discovered for Abdul Rauf Sheikh.