ORCID Profile
0000-0001-6977-3405
Current Organisations
Johns Hopkins Medicine
,
Lancashire Teaching Hospitals NHS Trust
,
CPRM
,
Rakai Health Sciences Program
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Publications
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Publisher: Springer Science and Business Media LLC
Date: 12-2021
DOI: 10.1038/S41591-021-01590-5
Abstract: Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and identify priority areas for research for the next 5 years.
The Social Media Index as an Indicator of Quality for Emergency Medicine Blogs: A METRIQ Study
Publisher: Elsevier BV
Date: 12-2018
DOI: 10.1016/J.ANNEMERGMED.2018.05.003
Abstract: Online educational resources such as blogs are increasingly used for education by emergency medicine clinicians. The Social Media Index was developed to quantify their relative impact. The Medical Education Translational Resources: Indicators of Quality (METRIQ) study was conducted in part to determine the association between the Social Media Index score and quality as measured by gestalt and previously derived quality instruments. Ten blogs were randomly selected from a list of emergency medicine and critical care Web sites. The 2 most recent clinically oriented blog posts published on these blogs were evaluated with gestalt, the Academic Life in Emergency Medicine Approved Instructional Resources (ALiEM AIR) score, and the METRIQ-8 score. Volunteer raters (including medical students, emergency medicine residents, and emergency medicine attending physicians) were identified with a multimodal recruitment methodology. The Social Media Index was calculated in February 2016, November 2016, April 2017, and December 2017. Pearson's correlations were calculated between the Social Media Index and the average rater gestalt, ALiEM AIR score, and METRIQ-8 score. A total of 309 of 330 raters completed all ratings (93.6%). The Social Media Index correlated moderately to strongly with the mean rater gestalt ratings (range 0.69 to 0.76) and moderately with the mean rater ALiEM AIR score (range 0.55 to 0.61) and METRIQ-8 score (range 0.53 to 0.57) during the month of the blog post's selection and for 2 years after. The Social Media Index's correlation with multiple quality evaluation instruments over time supports the hypothesis that it is associated with overall Web site quality. It can play a role in guiding in iduals to high-quality resources that can be reviewed with critical appraisal techniques.
Distribution of trace metals in stream sediments along the Trans-Amazonian Federal Highway, Pará State, Brazil
Publisher: Elsevier BV
Date: 10-2014
Related Organisations
University Of Sheffield
Location: United Kingdom of Great Britain and Northern Ireland
University Of Manchester
Location: United Kingdom of Great Britain and Northern Ireland
Lancashire Teaching Hospitals NHS Trust
Location: United Kingdom of Great Britain and Northern Ireland
Johns Hopkins Bloomberg School Of Public Health
Location: No location found
Johns Hopkins Bloomberg School Of Public Health
Location: United States of America
Related Funding Activities
No related grants have been discovered for Edward Nelson Kankaka.