ORCID Profile
0000-0002-5701-3203
Current Organisation
Curtin University
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Publisher: Wiley
Date: 12-04-2017
Abstract: Rhenium and ruthenium complexes containing N-heterocylic carbene (NHC) ligands and conjugated to indomethacin were prepared. The anticancer properties were probed against pancreatic cell lines, revealing a remarkable activity of the rhenium fragment as anticancer agent. The ruthenium complexes were found to be inactive against the same pancreatic cancer cell lines, either alone or in conjugation with indomethacin. An in-depth biological study revealed the origin of the anticancer properties of the rhenium tricarbonyl fragment, of which a complete elucidation had yet to be achieved. It was found that the rhenium complexes induce cell cycle arrest at the G2/M phase by inhibiting the phosphorylation of Aurora-A kinase. A preliminary study on the structure-activity relationship on a large family of these complexes revealed that the anticancer properties are mainly associated with the lability of the ancillary ligand, with inert complexes showing limited to no anticancer properties.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5DT04213E
Abstract: The twisted vs. linear conformation of newly synthesised silver and gold complexes of chelating C,N,C diethylaminotriazinyl-bridged bis(NHC) pincer ligands have been rationalised by computational studies.
Publisher: Wiley
Date: 15-04-2009
Abstract: A series of new N‐heterocyclic carbene (NHC)–palladium(II) complexes bearing electron‐rich benzimidazolin‐2‐ylidene ligands are described and structurally and spectroscopically characterised. These (benzimidazolin‐2‐ylidene)palladium complexes bear butoxy groups to increase the solubility and perhaps influence the catalytic activity by increasing the electron density around the metal centre. The effect of varying the ancillary ligands is investigated, although these ligands do not appear to significantly alter the activity of the complexes as precatalysts. Preliminary studies indicate the complexes act as precatalysts with moderate activity in the Mizoroki–Heck and Suzuki–Miyaura coupling reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Publisher: Wiley
Date: 19-01-2016
Publisher: Wiley
Date: 09-2016
Abstract: Live cell imaging can provide important information on cellular dynamics however, the full utilisation of this technology has been h ered by the limitations of imaging reagents. Metal-based complexes have the potential to overcome many of the issues common to many current imaging agents. The rhenium (I)-based complex fac-[Re(CO)3 (1,10-phenanthroline)(4-pyridyltetrazolate)], herein referred to as ReZolve-ER(™) , shows promise as a live cell imaging agent with rapid cell uptake, low cytotoxicity, resistance to photobleaching and compatibility with multicolour imaging. ReZolve-ER(™) localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short- or long-time courses.
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B908613G
Abstract: New PdBr(2)-bis(N-heterocyclic carbene) complexes derived from 4,7-dibutoxybenzimidazole and 5,6-dibutoxybenzimidazole have been synthesized and structurally and spectroscopically characterized. The complexes show much greater solubility compared to the parent complex derived from benzimidazole, and interesting structural characteristics dependent on the position of the butoxy substituents. The complexes display high activities in the coupling of aryl iodides in the Mizoroki-Heck reaction and moderate activities in the Suzuki-Miyaura coupling of inactivated aryl bromides at low catalyst loadings, although activity differences between pre-catalysts has been observed. Structural studies suggest electronic effects within the complexes to be strongly affected by steric interactions between the hydrogen atoms of the o-xylyl bridges and the benzimidazole components and their substituents.
Publisher: Royal Society of Chemistry (RSC)
Date: 23-10-2014
DOI: 10.1039/C4CC07892F
Abstract: The catalyst-free room temperature iClick reaction of an unsymmetrically 2,3-disubstituted oxanorbornadiene (OND) as a "masked" alkyne equivalent with [Mn(N3)(bpy(CH3,CH3))(CO)3] leads to isolation of a phenylalanine ester bioconjugate, in which the model amino acid is linked to the metal moiety via a N-2-coordinated triazolate formed in a cycloaddition-retro-Diels-Alder (crDA) reaction sequence, in a novel approach to bioorthogonal coupling reactions based on metal-centered reactivity.
Publisher: Wiley
Date: 02-2012
Abstract: Ruthenium alkynyl dendrimers up to second generation in size have been prepared by a ergent route and exploiting Sonogashira coupling. The cubic NLO properties have been examined by wide spectral range fs Z‐scan studies, revealing an NLO dendritic effect. The significant increase in NLO properties seen on generation increase is maintained when the coefficients are scaled by the number of metal atoms, the dendrimer molecular weights, or the number of “effective” (delocalizable π) electrons in the dendritic structures.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NJ03301B
Abstract: Rhenium NHC complexes bound to azide anions readily react with alkynes to form the corresponding triazolate complexes, a new class of photochemically active species.
Publisher: Elsevier BV
Date: 03-2013
Publisher: MDPI AG
Date: 10-02-2017
DOI: 10.3390/MI8020049
Publisher: Wiley
Date: 08-01-2019
Publisher: American Chemical Society (ACS)
Date: 21-07-2015
Publisher: Elsevier BV
Date: 06-2016
Publisher: Public Library of Science (PLoS)
Date: 23-08-2016
Publisher: Springer Science and Business Media LLC
Date: 05-2015
Publisher: Elsevier BV
Date: 12-2006
Publisher: Elsevier BV
Date: 04-2015
Publisher: American Chemical Society (ACS)
Date: 23-09-2013
DOI: 10.1021/IC401502F
Abstract: Metal cluster core expansion at tetrahedral group 6-group 9 mixed-metal clusters MIr3(μ-CO)3(CO)8(η(5)-L) (M = W, Mo, L = C5H5 M = Mo, L = C5Me5) with the iridium capping reagents Ir(CO)2(η(5)-L') (L' = C5Me5, C5Me4H) in refluxing toluene afforded the trigonal-bipyramidal clusters MIr4(μ-CO)3(CO)7(η(5)-C5H5)(η(5)-L') (M = Mo, L' = C5Me5, 1a M = W, L' = C5Me5, 1b M = Mo, L' = C5Me4H, 1c M = W, L' = C5Me4H, 1d) and MoIr4(μ3-H)(μ-CO)2(μ-η(1):η(5)-CH2C5Me4)(CO)7(η(5)-C5Me5) (2). Related reactions with M2Ir2(μ-CO)3(CO)7(η(5)-L)2 (M = W, Mo, L = C5H5 M = Mo, L = C5Me5) afforded M2Ir3(μ-CO)3(CO)6(η(5)-C5H5)2(η(5)-L') (M = Mo, L' = C5Me5, 3a M = W, L' = C5Me5, 3b M = Mo, L' = C5Me4H, 3c M = W, L' = C5Me4H, 3d), W2Ir3(μ-CO)4(CO)5(η(5)-C5H5)2(η(5)-C5Me4H) (4), and Mo2Ir3(μ-CO)3(CO)6(η(5)-C5Me5)3 (5). Single-crystal X-ray diffraction studies of 1a-1d, 2, 3a-3d, and 4 confirmed their molecular structures, including the μ-η(1):η(5)-CH2C5Me4 ligand at hydrido cluster 2, derived from a C-H bond activation of one of the methyl groups. Density functional theory (DFT) studies were employed to suggest the structure of 5. The redox behavior of the new clusters was examined through cyclic voltammetry all clusters exhibit oxidation and reduction processes (with respect to the resting state), with the oxidation processes being the more reversible, and increasingly so on decreasing Ir content of the clusters, replacing W by Mo, and increasing alkylation of the cyclopentadienyl ligands. In situ IR and UV-vis-near-IR spectroelectrochemical studies of the reversible oxidation processes in 1a and 3a were undertaken, with the spectra of the former suggesting progression to an all-terminal CO geometry concomitant with the first oxidation and a significant structural change upon the second oxidation step. DFT studies of 1a revealed that its crystallographically-confirmed Mo-equatorial core geometry is essentially isoenergetic with a possible Mo-apical isomer, and identified several bridging CO structures for the charged states.
Publisher: Wiley
Date: 21-01-2016
Abstract: Large increases in molecular two-photon absorption, the onset of measurable molecular three-photon absorption, and record molecular four-photon absorption in organic π-delocalizable frameworks are achieved by incorporation of bis(diphosphine)ruthenium units with alkynyl linkages. The resultant ruthenium alkynyl-containing dendrimers exhibit strong multiphoton absorption activity through the biological and telecommunications windows in the near-infrared region. The ligated ruthenium units significantly enhance solubility and introduce fully reversible redox switchability to the optical properties. Increasing the ruthenium content leads to substantial increases in multiphoton absorption properties without any loss of optical transparency. This significant improvement in multiphoton absorption performance by incorporation of the organometallic units into the organic π-framework is maintained when the relevant parameters are scaled by molecular weights or number of delocalizable π-electrons. The four-photon absorption cross-section of the most metal-rich dendrimer is an order of magnitude greater than the previous record value.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6MB00242K
Abstract: Localisation of a neutral rhenium( i ) tricarbonyl phenanthroline species to regions of high polar lipid concentrations is demonstrated by Fourier transform infrared (FTIR) microspectroscopy.
Publisher: American Chemical Society (ACS)
Date: 28-05-2009
DOI: 10.1021/OM8011745
Publisher: American Chemical Society (ACS)
Date: 09-03-2015
DOI: 10.1021/OM5012165
Publisher: American Chemical Society (ACS)
Date: 27-02-2017
DOI: 10.1021/ACS.INORGCHEM.6B02936
Abstract: We carried out time-resolved infrared (TR-IR) and emission lifetime measurements on a Re(I) carbonyl complex having an N-heterocyclic carbene ligand, namely, fac-[Re(CO)
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5DT03470A
Abstract: Thioalkyl-functionalised Re(I) tetrazolato complexes highlight good accumulation and lack of photobleaching in live He-La cells.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5DT00525F
Abstract: Trigonal-bipyramidal molybdenum/tungsten–iridium clusters undergo ligand substitution with isocyanides and triphenylphosphine, and react with alkynes with CC cleavage or triiridium-face-specific addition.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC06596A
Abstract: Rhenium tricarbonyl complexes bound to N-heterocyclic carbene ligands are emerging as a new class of complexes with promising applications in a wide variety of areas.
Publisher: Wiley
Date: 08-03-2011
Publisher: Wiley
Date: 14-07-2015
Abstract: The synthesis of fac-[Ir{N,C1′-(2,2′-NC5H4C6H3-5′-C≡C-1-C6H2-3,5-Et2-4-C≡CC6H4-4-C≡CH)}3] (10), which bears pendant ethynyl groups, and its reaction with [RuCl(dppe)2]PF6 to afford the heterobimetallic complex fac-[Ir{N,C1′-(2,2′-NC5H4C6H3-5′-C≡C-1-C6H2-3,5-Et2-4-C≡CC6H4-4-C≡C-trans-[RuCl(dppe)2])}3] (11) is described. Complex 10 is available from the two-step formation of iodo-functionalized fac-tris[2-(4-iodophenyl)pyridine]iridium(III) (6), followed by ligand-centered palladium-catalyzed coupling and desilylation reactions. Structural studies of tetrakis[2-(4-iodophenyl)pyridine-N,C1′](μ-dichloro)diiridium 5, 6, fac-[Ir{N,C1′-(2,2′-NC5H4C6H3-5′-C≡C-1-C6H2-3,5-Et2-4-C≡CH)}3] (8), and 10 confirm ligand-centered derivatization of the tris(2-phenylpyridine)iridium unit. Electrochemical studies reveal two (5) or one (6–10) Ir-centered oxidations for which the potential is sensitive to functionalization at the phenylpyridine groups but relatively insensitive to more remote derivatization. Compound 11 undergoes sequential Ru-centered and Ir-centered oxidation, with the potential of the latter significantly more positive than that of Ir(N,C′-NC5H4-2-C6H4-2)3. Ligand-centered π–π* transitions characteristic of the Ir(N,C′-NC5H4-2-C6H4-2)3 unit red-shift and gain in intensity following the iodo and alkynyl incorporation. Spectroelectrochemical studies of 6, 7, 9, and 11 reveal the appearance in each case of new low-energy LMCT bands following formal IrIII/IV oxidation preceded, in the case of 11, by the appearance of a low-energy LMCT band associated with the formal RuII/III oxidation process. Emission maxima of 6–10 reveal a red-shift upon alkynyl group introduction and arylalkynyl π-system lengthening this process is quenched upon incorporation of the ligated ruthenium moiety on proceeding to 11. Third-order nonlinear optical studies of 11 were undertaken at the benchmark wavelengths of 800 nm (fs pulses) and 532 nm (ns pulses), the results from the former suggesting a dominant contribution from two-photon absorption, and results from the latter being consistent with primarily excited-state absorption.
Publisher: Wiley
Date: 19-09-2013
Publisher: American Chemical Society (ACS)
Date: 17-02-2009
DOI: 10.1021/OM801144M
Publisher: Wiley
Date: 18-04-2014
No related grants have been discovered for Peter Simpson.