ORCID Profile
0000-0002-7191-0621
Current Organisation
The University of Edinburgh
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Publisher: Springer Science and Business Media LLC
Date: 03-10-2013
DOI: 10.1038/NCOMMS3537
Publisher: The Company of Biologists
Date: 2012
DOI: 10.1242/JCS.097790
Abstract: In vertebrates, two condensin complexes exist, condensin I and II, which have differing but unresolved roles in organizing mitotic chromosomes. To accurately dissect the role of each complex in mitosis, we have made and studied the first vertebrate conditional knockouts of the condensin I subunit CAP-H and condensin II subunit CAP-D3 in chicken DT40 cells. Live-cell imaging reveals highly distinct segregation defects. CAP-D3/condensin II KO results in masses of chromatin forming anaphase bridges. CAP-H/condensin I KO anaphases have a more subtle defect, with chromatids showing fine chromatin fibres that are associated with failure of cytokinesis and cell death. Super-resolution microscopy reveals condensin I-depleted mitotic chromosomes as wider and shorter with a diffuse chromosome scaffold, while condensin II-depleted chromosomes retain a more defined scaffold with chromosomes more stretched and seemingly lacking in axial rigidity. We conclude condensin II is required primarily to provide rigidity by establishing an initial chromosome axis around which condensin I can arrange loops of chromatin.
Publisher: Oxford University Press (OUP)
Date: 15-03-1993
Publisher: Elsevier BV
Date: 02-1999
Abstract: The centromere is a specialized region of the eukaryotic chromosome that is responsible for directing chromosome movements in mitosis and for coordinating the progression of mitotic events at the crucial transition between metaphase and anaphase. In this review, we will focus on recent advances in the understanding of centromere composition at the protein and DNA level and of the role of centromeres in sister-chromatid cohesion and mitotic checkpoint control.
Publisher: Elsevier BV
Date: 11-2016
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for William Earnshaw.