ORCID Profile
0000-0003-1412-1527
Current Organisations
TU Dresden
,
Technische Universität Dresden
,
Kansas City University
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Publisher: Pleiades Publishing Ltd
Date: 31-10-2022
Publisher: Wiley
Date: 04-2011
DOI: 10.1002/DVG.20727
Publisher: Public Library of Science (PLoS)
Date: 04-10-2012
Publisher: Elsevier BV
Date: 06-2021
Publisher: Proceedings of the National Academy of Sciences
Date: 05-09-2006
Abstract: Neural crest cells are a migratory cell population that give rise to the majority of the cartilage, bone, connective tissue, and sensory ganglia in the head. Abnormalities in the formation, proliferation, migration, and differentiation phases of the neural crest cell life cycle can lead to craniofacial malformations, which constitute one-third of all congenital birth defects. Treacher Collins syndrome (TCS) is characterized by hypoplasia of the facial bones, cleft palate, and middle and external ear defects. Although TCS results from autosomal dominant mutations of the gene TCOF1 , the mechanistic origins of the abnormalities observed in this condition are unknown, and the function of Treacle, the protein encoded by TCOF1 , remains poorly understood. To investigate the developmental basis of TCS we generated a mouse model through germ-line mutation of Tcof1 . Haploinsufficiency of Tcof1 leads to a deficiency in migrating neural crest cells, which results in severe craniofacial malformations. We demonstrate that Tcof1 /Treacle is required cell-autonomously for the formation and proliferation of neural crest cells. Tcof1 /Treacle regulates proliferation by controlling the production of mature ribosomes. Therefore, Tcof1 /Treacle is a unique spatiotemporal regulator of ribosome biogenesis, a deficiency that disrupts neural crest cell formation and proliferation, causing the hypoplasia characteristic of TCS craniofacial anomalies.
Publisher: MDPI AG
Date: 26-08-2022
Abstract: Seed dispersal and environmental heterogeneity, and the effects of their interaction, are perceived to be determinants of the spatial patterns of trees. We applied the spatial point process to analyse Vatica odorata (Griff.) Symington (Dipterocarpaceae) in Cuc Phuong National Park of Vietnam to understand its spatial patterns, and to decipher the main factors affecting seedling establishment of the species. We established a total of 12 replicated plots, each of which had one or two seed trees in the centre, and recorded all regeneration plants of V. odorata with their positions. A total of 671 regeneration plants were found. Covariates, including canopy, ground cover, and distance to seed trees, were measured on systematic grids of 4 × 4 m. In the context of the spatial point processes, we used a generalised linear mixed model, considering a random effect of the plot. In the model, the greatest distance observed is about 35 m from the seed tree. The canopy and ground cover have a significant impact on the regeneration of the species: The intensity of regenerating stems was greatest with a canopy cover of 70%. The ground cover range for good development of regenerating plants was between 10 and 30%.
Publisher: Annual Reviews
Date: 11-2006
DOI: 10.1146/ANNUREV.CELLBIO.22.010305.103814
Abstract: Neural crest cells are a multipotent, migratory cell population that generates an astonishingly erse array of cell types during vertebrate development. These include bones tendons neurons glia melanocytes and connective, endocrine, and adipose tissue. With a limited capacity for self-renewal and a wide range of differentiation fates, neural crest cells bear many of the hallmarks of stem cells and persist throughout embryonic and adult development. But are all neural crest cells true stem cells, or do the majority of neural crest cells more closely resemble progenitor cells? In this review we discuss recent advances in characterizing the properties of neural crest cells, together with their potential for tissue-specific repair.
Location: United States of America
Location: United States of America
No related grants have been discovered for Jennifer Dennis.