ORCID Profile
0000-0002-6724-2405
Current Organisations
University of Tokyo
,
Japanese Society for Bioinformatics
,
Japan Deep Learning Association
,
RIKEN
,
National Institute of Genetics
,
Waseda University
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Social Change | Labour Law | Industrial Relations | Business and Management
Publisher: Springer Science and Business Media LLC
Date: 13-09-2019
DOI: 10.1007/S00213-018-5033-2
Abstract: Fear learning and extinction are controlled by the activity of three interconnected regions: the amygdala, hippoc us, and prefrontal cortex. Of these, the medial prefrontal cortex modulates specific aspects in fear and extinction via a top-down regulation. In recent years, extensive progress has been made in our understanding of the neural circuits that mediate fear-related behaviors and their modulation by ascending systems. The development of new experimental techniques is now revealing the details of the intrinsic circuits within these structures as well as the connections between them. Here, we highlight recent advances in our understanding of how the prefrontal cortex may mediate such a top-down regulation.
Publisher: Proceedings of the National Academy of Sciences
Date: 11-09-2007
Abstract: Cell lineages of cnidarians including Hydra represent the fundamental cell types of metazoans and provides us a unique opportunity to study the evolutionary ersification of cell type in the animal kingdom. Hydra contains epithelial cells as well as a multipotent interstitial cell (I-cell) that gives rise to nematocytes, nerve cells, gland cells, and germ-line cells. We used cDNA microarrays to identify cell type-specific genes by comparing gene expression in normal Hydra with animals lacking the I-cell lineage, so-called epithelial Hydra . We then performed in situ hybridization to localize expression to specific cell types. Eighty-six genes were shown to be expressed in specific cell types of the I-cell lineage. An additional 29 genes were expressed in epithelial cells and were down-regulated in epithelial animals lacking I-cells. Based on the above information, we constructed a database ( hydra.lab.nig.ac.jp/hydra/ ), which describes the expression patterns of cell type-specific genes in Hydra . Most genes expressed specifically in either I-cells or epithelial cells have homologues in higher metazoans. By comparison, most nematocyte-specific genes and approximately half of the gland cell- and nerve cell-specific genes are unique to the cnidarian lineage. Because nematocytes, gland cells, and nerve cells appeared along with the emergence of cnidarians, this suggests that lineage-specific genes arose in cnidarians in conjunction with the evolution of new cell types required by the cnidarians.
Publisher: Association Internationale de management strategique (AIMS)
Date: 2005
Publisher: Association Internationale de management strategique (AIMS)
Date: 2004
Publisher: Informa UK Limited
Date: 09-11-2022
DOI: 10.1080/17483107.2022.2131914
Abstract: Although 3D food printing is expected to enable the creation of visually appealing pureed food for people with disability and dysphagia, little is known about the user experience in engaging with 3D food printing or the feasibility of use with populations who need texture-modified foods. The aim of this study was to explore the feasibility and usability of using domestic-scale 3D food printer as an assistive technology to print pureed food into attractive food shapes for people with dysphagia. In total, 16 participants engaged in the unfamiliar, novel process of using a domestic-scale 3D food printer (choosing, printing, tasting), designed for printing pureed food, and discussed their impressions in focus group or in idual interviews. Overall, results demonstrated that informed experts who were novice users perceived the 3D food printing process to be fun but time consuming, and that 3D food printers might not yet be suitable for people with dysphagia or their supporters. Slow response time, lack of user feedback, scant detail on the appropriate recipes for the pureed food to create a successful print, and small font on the user panel interface were perceived as barriers to accessibility for people with disability and older people. Participants expected more interactive elements and feedback from the device, particularly in relation to resolving printer or user errors. This study will inform future usability trials and food safety research into 3D printed foods for people with disability and dysphagia. IMPLICATIONS FOR REHABILITATION3D food printers potentially have a role as an assistive technology in the preparation of texture-modified foods for people with disability and dysphagia.To increase feasibility, 3D food printers should be co-designed with people with disability and their supporters and health professionals working in the field of dysphagia and rehabilitation.Experts struggled to be able to print 3D pureed shapes owing to relatively low usability of the 3D food printer tested with problems using the interface and resolving problems in the print.3D food printing is a fun and novel activity and may help to engage people with disability and dysphagia in making choices around the shape of the food to be printed.
Publisher: SAGE Publications
Date: 05-2013
Publisher: SAGE Publications, Inc.
Date: 2008
Publisher: Emerald
Date: 2006
DOI: 10.1108/09534810610643686
Abstract: Modern bureaucracies are under reconstruction, bureaucracy being no longer “modern” they are becoming “post” bureaucratic. Defining the post‐bureaucratic organization as a hybrid form provides insight into the intrinsic difficulties involved in the refurbishment of large complex organizations. The purpose of this paper is to examine these difficulties empirically. The paper describes the case of an Australian public sector agency, subject to “corporatization” – a metamorphosis from a strictly public sector outlook to one that was imputedly more commercial. It focuses on the transition from personnel management to strategic HRM in the HR function. A series of difficulties affected these changes: difficulties in inventing a new identity differences in perception of that identity organizational philosophy towards strategic HRM unsuitability of extent networks and identity conflicts. Two factors emerge as the core explanation for the difficulties encountered: the “stickiness of identity” and the difficulties associated with network development. The paper outlines the difficulties experienced in the putative “refurbishment” of a large public sector agency as it made its way to “corporatization”.
Publisher: Wiley
Date: 07-2018
DOI: 10.1002/BSE.2065
Publisher: SAGE Publications
Date: 12-2019
Abstract: While open innovation ecosystems allow a firm to harness external sources of value creation, these external ties can also constrain its ability to adapt its innovation strategy to pursue new opportunities. This article looks at how an incumbent firm approached such constraints, and used cognitive artifacts to transform its value chain into a collaborative ecosystem. It examines the case of a 3D printing-enabled shift to mass customization of orthopedic medical implants. The results demonstrate how firms can use artifacts to build a shared understanding across heterogeneous stakeholders as they explore and develop new open innovation models, and how this process can be managed flexibly to avoid adopting a locally (rather than globally) optimal strategy.
Publisher: SAGE Publications
Date: 28-02-2016
Abstract: The emergence and proliferation of network forms of organization has sparked interest and debate in organization studies. We have learned much about the effects of networks but our understanding of how they are formed, how they change, and how networks can themselves possess agential properties that make them complex social actants is limited. In selecting papers for this special issue, we were persuaded by arguments that our understanding of networks and their transformative power can benefit from greater attention to culture and discourse, which provide meaning and direction to network participants and are indispensable agentic resources. The special issue contains two sets of papers. The first set debates the articulation between the organized and emergent dynamics of networks and its impact on knowledge exchanges and innovation. The second set seeks to inform our understanding of the manifestations of power in network dynamics. For each section, we provide a tentative research agenda. Our hope is that this special issue will both advance our ability to conceptualize, measure and manage network evolution and enhance our understanding of the transformative impact of network dynamics on organizations and society.
Publisher: SAGE Publications
Date: 21-01-2022
DOI: 10.1177/00221856211066628
Abstract: While the efforts by actors on the buyer-side of value chains – such as brands and retailers – to address upstream labour abuses are well documented, there is a lack of research into how actors on the production-side of value chains – such as raw material producers – can identify and address downstream labour risks. This research presents the findings of an action research project that focused on the Australian cotton industry. By applying a sense-making lens, we propose four properties that can be used to identify labour risk in global value chains, providing insights into the capacity of producers to address downstream labour abuses. We suggest that there is a possibility for a ‘book-end’ approach that combines upstream and downstream actions by buyers and producers in global value chains.
Publisher: SAGE Publications
Date: 26-05-2021
DOI: 10.1177/0067205X211016575
Abstract: There is now an expanding body of literature on the significant problem of business non-compliance with minimum labour standards including ‘wage theft’. Extended liability regulation beyond the direct employer is seen as one solution to this non-compliance in fragmented but hierarchically organised industries—such as the cleaning industry. This article uses empirical evidence to assess the effectiveness of one such regulatory scheme, the Cleaning Accountability Framework (CAF), in addressing non-compliance with minimum labour standards (including provisions of the Fair Work Act 2009 (Cth) and the Cleaning Services Award 2020). We find that CAF has been successful in identifying and rectifying certain non-compliance, improving working conditions for some cleaners involved in the scheme. We synthesise the key success factors of CAF in view of envisioning the adoption of such co-regulation frameworks in other industries. We also propose legal reforms that will support change across the cleaning industry.
Publisher: Emerald
Date: 09-10-2017
Abstract: This research paper aims to examine how open innovation (OI) intermediaries facilitate knowledge collaboration between organizations and online user communities. Drawing on a Community of Practice (CoP) perspective on knowledge, the study lays out a framework of the knowledge boundary management mechanisms (and associated practices) that intermediaries deploy in enabling client organizations to engage in online community-based OI. This research is based on an exploratory case study of an OI intermediary and 18 client organizations that engage with online user communities on the intermediary’s platform. Results incorporate both the intermediary and clients’ perspective, based on analysis of intermediary and client interviews, clients’ online community projects and other archival data. Results reveal that OI intermediaries deploy three knowledge boundary management mechanisms – syntactic, semantic and pragmatic – each underpinned by a set of practices. Together, these mechanisms enable knowledge transfer, translation and transformation, respectively, and thus lead to cumulatively richer knowledge collaboration outcomes at the organization–community boundary. The findings show that the pragmatic mechanism reinforces both semantic and syntactic mechanisms, and is hence the most critical to achieving effective knowledge collaboration in community-based OI settings. The findings suggest that OI intermediaries have to implement all three boundary management mechanisms to successfully enable knowledge collaboration for community-based OI. More specifically, intermediaries need to expand their focus beyond the development of digital platforms, to include nuanced efforts at building organizational commitment to community engagement. Drawing on the CoP view, this study integrates the knowledge management literature into the OI literature to conceptualize the role of OI intermediaries in shaping knowledge collaboration between organizations and communities. In engaging with the interactive nature of knowledge exchange in such multi-actor settings, this research extends the firm-centric theorization of knowledge that currently dominates the existing OI research.
Publisher: SAGE Publications
Date: 03-2013
Publisher: Elsevier BV
Date: 2020
DOI: 10.2139/SSRN.3557255
Start Date: 02-2018
End Date: 12-2021
Amount: $170,000.00
Funder: Australian Research Council
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