ORCID Profile
0000-0002-5379-1980
Current Organisation
The University of Notre Dame Australia - Sydney Campus Broadway
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Publisher: Wiley
Date: 27-12-2019
DOI: 10.1111/ANS.15617
Publisher: Wiley
Date: 20-01-2020
DOI: 10.1111/ANS.15680
Abstract: The primary objective was evaluation of axillary ultrasound (AxUS) in preoperative staging of patients with invasive carcinoma undergoing breast-conserving surgery. This is a retrospective, observational cohort study of patients with clinically node-negative (cN0) biopsy-proven invasive breast carcinoma undergoing breast-conserving surgery between January 2011 and December 2014 who underwent AxUS with fine needle aspiration (FNA) biopsy of sonographically abnormal lymph nodes. Patient records were reviewed. A total of 713 cases were analysed. Four hundred and thirty-three patients underwent formal preoperative AxUS 100 underwent biopsy for abnormal findings. Of these, 32 had positive FNA biopsy result and underwent level II axillary dissection (axillary lymph node dissection (ALND)). Thirty were T1-2 tumours with AxUS scan/FNA demonstrating sensitivity of 25.2%, specificity of 100%, positive predictive value of 100% and negative predictive value of 76.6%. Forty-six patients had a positive sentinel lymph node (SLN) biopsy and axillary dissection. 34.8% of T1 tumours, 47.8% of T2 tumours and 100% of T3 tumours had further positive nodes. The average number of nodes involved per axilla was 1.8 for the T1 group, 4.1 for the T2 group and 4.6 in the T3 group. Macrometastases were a more common finding than micrometastases for all T stages undergoing ALND. A suspicious preoperative AxUS result was significantly associated with positive SLN. Other risk factors for positive SLN biopsy were oestrogen receptor positivity and lymphovascular invasion. AxUS identifies patients with high nodal burdens justifying immediate ALND. AxUS did not adversely affect women with histologically negative sentinel nodes. Three percent may have been overtreated.
Publisher: Pensoft Publishers
Date: 23-08-2022
DOI: 10.3897/BISS.6.91516
Abstract: The Australian National Species List (AuNSL) will bring together authoritative national taxonomies and supporting nomenclatural data for flora, fauna, fungi and algae. These data enable bio ersity infrastructures, such as the Atlas of Living Australia, to store information about taxa against a standard, permanently resolvable taxonomy, and to create linkages between them. The Bio ersity Data Repository (BDR) is a new Australian government infrastructure supporting environmental assessments under Australia's Environment Protection and Bio ersity Conservation Act. The BDR will bring together bio ersity data assets from a range of sources and enable decision making to be based on a more holistic view of taxa in Australia. To achieve its objectives, the BDR requires the ability to align disparate taxonomies to a national standard. To support the BDR we have restructured and consolidated the constituent datasets of the AuNSL and added a GraphQL interface from which we can provide machine access to the full suite of taxonomic and nomenclatural entities in the data and the linkages between them. Currently we provide a simple name check service for aligning supplied names with the standard AuNSL taxonomy and a full taxonomic backbone extract as a SKOS concept scheme expressed in JSON-LD. We are working towards an expanded set of taxonomic and nomenclatural services and a more generalised and complete graph of the AuNSL taxonomy, which can serve an increasing number of initiatives including the Australian Traits database (AusTraits), the Australian National DNA Library, and sensitive species data exchange mechanisms.
Publisher: Pensoft Publishers
Date: 24-08-2023
Abstract: The Australian National Species List (AuNSL) is the provider of names and taxonomy for significant national bio ersity data infrastructures including the Atlas of Living Australia, the Terrestrial Ecosystem Research Network, the Bio ersity Data Repository, and the Species Profile and Threats Database. The AuNSL mints persistent identifiers for names covered by the codes of nomenclature and name-like objects such as phrase names. To ensure sustainability of identifiers, a mapping service is provided to always resolve all AuNSL identifiers including historical and deprecated forms. Names are used as the building blocks for recording taxon name usages and taxon concepts. We provide services for matching, disambiguation and taxonomic resolution of names. The AuNSL does not exist in a vacuum and supports identifier mappings to external resources and related systems such as the International Plant Name Index (IPNI), Zoobank, the Bio ersity Heritage Library. To enable this integration, persistent identifiers from original and/or significant sources are required and this data is currently limited and incomplete within the AuNSL. To address this issue, we need to look backwards for improved ways of matching to existing persistent identifiers and forward to improving capture of taxonomic novelties and name-like objects and their identifiers.
Publisher: Springer Science and Business Media LLC
Date: 26-12-2016
DOI: 10.1038/NATURE20786
Abstract: Ash trees (genus Fraxinus, family Oleaceae) are widespread throughout the Northern Hemisphere, but are being devastated in Europe by the fungus Hymenoscyphus fraxineus, causing ash dieback, and in North America by the herbivorous beetle Agrilus planipennis. Here we sequence the genome of a low-heterozygosity Fraxinus excelsior tree from Gloucestershire, UK, annotating 38,852 protein-coding genes of which 25% appear ash specific when compared with the genomes of ten other plant species. Analyses of paralogous genes suggest a whole-genome duplication shared with olive (Olea europaea, Oleaceae). We also re-sequence 37 F. excelsior trees from Europe, finding evidence for apparent long-term decline in effective population size. Using our reference sequence, we re-analyse association transcriptomic data, yielding improved markers for reduced susceptibility to ash dieback. Surveys of these markers in British populations suggest that reduced susceptibility to ash dieback may be more widespread in Great Britain than in Denmark. We also present evidence that susceptibility of trees to H. fraxineus is associated with their iridoid glycoside levels. This rapid, integrated, multidisciplinary research response to an emerging health threat in a non-model organism opens the way for mitigation of the epidemic.
Location: Australia
No related grants have been discovered for Tamara Preda.