ORCID Profile
0000-0002-4483-7895
Current Organisations
Macquarie University
,
Australian National University
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Publisher: Springer International Publishing
Date: 2016
Publisher: IEEE
Date: 06-2018
Publisher: Springer Berlin Heidelberg
Date: 2014
Publisher: Springer International Publishing
Date: 2019
Publisher: IEEE
Date: 05-2013
Publisher: Wiley
Date: 07-03-2023
Abstract: Bone autografts remain the gold standard for bone grafting surgeries despite having increased donor site morbidity and limited availability. Bone morphogenetic protein‐loaded grafts represent another successful commercial alternative. However, the therapeutic use of recombinant growth factors has been associated with significant adverse clinical outcomes. This highlights the need to develop biomaterials that closely approximate the structure and composition of bone autografts, which are inherently osteoinductive and biologically active with embedded living cells, without the need for added supplements. Here, injectable growth factor‐free bone‐like tissue constructs are developed, that closely approximate the cellular, structural, and chemical composition of bone autografts. It is demonstrated that these micro‐constructs are inherently osteogenic, and demonstrate the ability to stimulate mineralized tissue formation and regenerate bone in critical‐sized defects in‐vivo. Furthermore, the mechanisms that allow human mesenchymal stem cells (hMSCs) to be highly osteogenic in these constructs, despite the lack of osteoinductive supplements, are assessed, whereby Yes activated protein (YAP) nuclear localization and adenosine signaling appear to regulate osteogenic cell differentiation. The findings represent a step toward a new class of minimally invasive, injectable, and inherently osteoinductive scaffolds, which are regenerative by virtue of their ability to mimic the tissue cellular and extracellular microenvironment, thus showing promise for clinical applications in regenerative engineering.
Publisher: IEEE
Date: 06-2018
Publisher: Association for Computational Linguistics
Date: 2018
DOI: 10.18653/V1/P18-2072
Publisher: Springer Berlin Heidelberg
Date: 2013
No related grants have been discovered for Genevieve Romanowicz.