ORCID Profile
0000-0002-1561-6989
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Publisher: Cold Spring Harbor Laboratory
Date: 05-03-2023
DOI: 10.1101/2023.03.03.23286728
Abstract: Objective: To establish the rate of bleeding disorders amongst women with confirmed endometriosis and clarify predictive features on history. Methods: Eight-two women with confirmed diagnosis of endometriosis were recruited from a tertiary womens hospital. General bleeding tendency was evaluated with a modified internationally standardised questionnaire, and a bleeding score was calculated. Menstrual loss was evaluated by obtaining current and heaviest-ever menses profile using Pictorial Blood loss Assessment Chart(PBAC). Forty-one women satisfied criteria for a significant bleeding tendency and underwent coagulation tests including Prothrombin time(PT), activated partial thromboplastin time(aPTT), Platelet Function Analyser-100(PFA-100) and von Willebrand factor(vWF)/Factor VIII(FVIII) studies. Results : The prevalence of abnormal screening haemostasis tests for the population was 17.72% (95% CI 10.04-27.94) for all tests, 8.54%(95% CI 3.50-16.80) for vWF tests, and 12.99%( 95% CI 6.41-22.59) for PFA-100. Receiver Operator Characteristic curve analysis demonstrated a very good performance of the bleeding score as a diagnostic test for haemostatic abnormalities for nulliparous women with endometriosis. Bleeding symptoms in idually were not predictive. Logistic regression suggested the combination of mittleschmerz, cutaneous bleeding symptoms, heavy menstrual bleeding and prolonged bleeding from minor wounds as predictive for haemostatic abnormalities (p=0.0197). Conclusion: The prevalence of abnormal bleeding tests in women with endometriosis on preliminary testing was higher than the population rate of bleeding abnormalities and thus people with histologically proven endometriosis warrant a higher index of suspicion with respect to testing for mild bleeding disorders.
Publisher: MDPI AG
Date: 21-01-2022
Abstract: Appraisals and emotional regulation play a central role in posttraumatic stress disorder (PTSD). Despite research demonstrating cultural differences in everyday appraisals and emotion regulation, little research has investigated the influence of culture on these processes in PTSD. This study examined cultural differences in the associations between appraisals, emotion regulation and PTSD symptoms using trauma survivors from an in idualistic Western culture (Australia) and a collectivistic Asian culture (Malaysia). Trauma survivors (N = 228 107 Australian with European cultural heritage, 121 Malaysian with Malay, Indian or Chinese cultural heritage) completed an on-line survey assessing PTSD (PTSD Checklist for the DSM-5 with Life Events Checklist), appraisals (trauma-related, fatalism, cultural beliefs about adversity) and emotion regulation (suppression, reappraisal, interpersonal). The Malaysian group reported significantly greater fatalism, cultural beliefs about adversity, suppression and interpersonal emotion regulation than the Australian group. Greater trauma-specific appraisals, greater suppression, fewer cultural beliefs about adversity, and less use of social skills to enhance positivity were generally associated with greater PTSD symptom severity, with little evidence of cultural group moderating these associations. Interdependent self-construal mediated the relationships between cultural adversity beliefs, enhanced positivity, reappraisal, perspective taking and PTSD symptoms. Independent self-construal mediated the relationships between fatalism and perspective taking and PTSD symptoms. Cultural group did not moderate these indirect effects. Interdependent self-construal mediated the associations between interpersonal regulation strategies of soothing and social modelling with PTSD symptoms for the Malaysian but not the Australian group. These findings demonstrate the importance of considering self-construal and culture in understanding factors associated with PTSD.
Publisher: American Society of Clinical Oncology (ASCO)
Date: 20-06-2023
DOI: 10.1200/JCO.22.02212
Publisher: Elsevier BV
Date: 06-2020
Publisher: SAGE Publications
Date: 16-07-2019
Abstract: This paper reviewed articles on autobiographical memories of veterans who fought several major battles around the world. A total of 28 articles, reporting 11 quantitative, 16 qualitative, and 1 mixed-methods study, were identified through a search conducted in 11 major databases. Convergent thematic analysis of the findings extracted five recurrent themes: (1) memory features, (2) memory content, (3) self and memory, (4) culture and memory, and (5) theoretical accounts. Veterans’ memories were mostly aligned with the hegemonic narratives, although many of them were the depiction of atrocities (theme 1). Veterans with post-traumatic stress disorder and other mental disorders recalled less specific and less coherent autobiographical memories (theme 2) their retrieval was influenced by split identity—combatant versus veteran identity, generational identity, and political ideology (theme 3). War outcome, dominant public narratives, political environment, and myths prevailing in the society influenced the memory recall (theme 4). While qualitative studies used Erickson’s identity theory to explain how personal identity in conjunction with social identity helped to construct veterans’ memories, quantitative studies used Car-Fa-X model to explain why veterans with various mental health conditions predominantly produced overgeneral memories (theme 5). Findings are discussed through the current theories of autobiographical memory.
Publisher: Elsevier BV
Date: 08-2021
Publisher: Wiley
Date: 29-09-2021
DOI: 10.1002/CAM4.4246
Abstract: Higher rates of death by suicide are recognized both in in iduals of any age with cancer and, separately, among adolescents and young adults (AYA) without cancer. Given this intersection, identifying risk factors associated with suicidal risk among AYA with cancer is critical. To identify characteristics associated with suicide among AYA with cancer. A retrospective analysis of AYA (aged 15–39) during 1975–2016 from the Surveillance, Epidemiology, and End Results database was conducted. Clinical and demographic factors associated with death by suicide among the AYA cancer population were compared to (i) US population normative data (standardized mortality ratios [SMRs]) and (ii) other AYA in iduals with cancer (odds ratios). In total, 922 suicides were found in 500,366 AYA with cancer (0.18%), observed for 3,198,261 person‐years. The SMR for AYA with cancer was 34.1 (95% confidence interval [CI]: 31.4–36.9). Suicide risk was particularly high in females (SMR = 43.4, 95% CI: 37.2–50.4), unmarried persons (SMR = 50.6, 95% CI: 44.7–57.1), those with metastatic disease (SMR = 45.2, 95% CI: 33.1–60.3), or certain histological subtypes (leukemia, central nervous system, and soft tissue sarcoma). Risk generally reduced over time, however remained elevated ≥5 years following a cancer diagnosis (SMR 5 years = 28.1, 95% CI: 25.4–31.0). When comparing those who died from suicide and those who did not, the following factors demonstrated significant associations: sex (males females), race (White ethnicity Black/other ethnicity), relationship status (never married other), and disease stage (distant localized). Death due to suicide/non‐accidental injury is high compared to normative data, requiring increased awareness among health‐care providers, suicide risk monitoring in AYA, and appropriately tailored psychosocial interventions.
Publisher: Springer Science and Business Media LLC
Date: 30-11-2021
Publisher: BMJ
Date: 02-2022
DOI: 10.1136/BMJOPEN-2021-049462
Abstract: Clinical education has moved to a ‘competency-based’ model with an emphasis on workplace-based learning and assessment which, in turn, depends on feedback to be effective. Further, the understanding of feedback has changed from information about a performance directed to the learner performing the task, to a dialogue, which enables the learner to act and develop. In health professional education, feedback is a complex interaction between trainee, supervisor and the healthcare system. Most published research on feedback in health professional education originates in Europe and North America. Our interest is on the impact of C ulture on this process, particularly in the context of Asian cultures. The (scientific) realist approach of Pawson and Tilley provides a means to examine complex interventions in social situations, and thus is an appropriate lens to use for this study. This is a protocol for a realist synthesis which asks how, why and in what circumstances do Asian Cultures influence health professional trainees to seek, respond to and use feedback given in the clinical environment, if at all. An initial search was performed to help define the scope of the review question and develop our initial programme theory. The formal electronic search was carried out in February 2020 and included: CINAHL, ERIC, Medline and PsycInfo, and repeated in October 2020. Retrieved articles were imported into Covidence for screening and data extraction, after which components of the Context–Mechanisms–Outcomes configurations will be sought to refine the initial programme theory. As this study is a literature review, ethics approval is not required. The findings will be documented in line with the RAMESES (Realist And MEta-narrative Evidence Syntheses: Evolving Standards) publications standards for Realist syntheses, and we plan to disseminate the findings by means of a peer-reviewed journal article and conference presentation(s).
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Shamsul Haque.