ORCID Profile
0000-0003-3915-7243
Current Organisations
Cardiff University
,
Royal College of Radiologists
,
University of Nottingham
,
Royal College of Physicians
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Publisher: Elsevier BV
Date: 11-2019
Publisher: Elsevier BV
Date: 02-2021
Publisher: BMJ
Date: 02-2014
Publisher: Elsevier BV
Date: 05-2021
Publisher: Springer Science and Business Media LLC
Date: 27-05-2012
DOI: 10.1038/NG.2293
Publisher: Massachusetts Medical Society
Date: 25-02-2021
Publisher: Oxford University Press (OUP)
Date: 18-12-2017
DOI: 10.1093/JNCI/DJX253
Publisher: Massachusetts Medical Society
Date: 19-07-2100
Publisher: BMJ
Date: 12-12-2017
DOI: 10.1136/GUTJNL-2017-315333
Abstract: Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science risk prevention early diagnosis and screening pathology curative treatment stage IV disease and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants. Fifteen critical RGs are summarised below: RG1 : Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment RG2 : Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk RG3 : Pressing need for prevention trials RG4 : Lack of integration of different prevention approaches RG5 : Lack of optimal strategies for CRC screening RG6 : Lack of effective triage systems for invasive investigations RG7 : Imprecise pathological assessment of CRC RG8 : Lack of qualified personnel in genomics, data sciences and digital pathology RG9 : Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices RG10 : Need for novel technologies/interventions to improve curative outcomes RG11 : Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment RG12 : Lack of reliable biomarkers to guide stage IV treatment RG13 : Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution RG14 : Lack of coordination of CRC research/funding RG15 : Lack of effective communication between relevant stakeholders. Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.
Publisher: Elsevier BV
Date: 05-2021
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Richard Adams.