ORCID Profile
0000-0003-1911-5134
Current Organisations
University of the Witwatersrand
,
North-West University , South Africa
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Publications
Inflammation and hypertension development: A longitudinal analysis of the African-PREDICT study
Publisher: Elsevier BV
Date: 12-2020
Distinct inflammatory mediator patterns in young black and white adults: The African-predict study
Publisher: Elsevier BV
Date: 02-2020
DOI: 10.1016/J.CYTO.2019.154894
Abstract: Inflammatory mediators have been implicated in the early stages of cardiovascular disease development, including hypertension. Since global reports reflect a higher hypertension prevalence in black than white populations, we hypothesise the involvement of specific inflammatory mediators. We therefore compared a detailed range of 22 inflammatory mediators between young black and white adults, and determined the relationship with blood pressure. We included 1197 adults (20-30 years 50% black 52% female) with detailed ambulatory blood pressures. Blood s les were analysed for 22 inflammatory mediators. For pro-inflammatory mediators, the black adults had higher C-reactive protein, interferon-inducible T-cell alpha chemoattractant, macrophage inflammatory protein 3 alpha (all p ≤ 0.008), but lower interferon-gamma, interleukin (IL)-1β, IL-8, IL-12, IL-17A, and tumour necrosis factor alpha (all p ≤ 0.048). For anti-inflammatory mediators the black group consistently had lower levels (IL-5, IL-10 and IL-13 (all p ≤ 0.012)), resulting in generally higher pro-to-anti-inflammatory ratios in black than white adults (p ≤ 0.001). In mediators with pro- and anti-inflammatory functions, the black group had lower granulocyte-macrophage colony-stimulating factor and IL-6 (both p ≤ 0.010). These patterns were confirmed after adjustment for age, sex and waist circumference, or when stratifying by hypertensive status, sex and socio-economic status. Multi-variable adjusted regression analyses and factor analysis yielded no relationship between inflammatory mediators and blood pressure in this young healthy population. Black and white ethnic groups each consistently presented with unique inflammatory mediator patterns regardless of blood pressure, sex or social class. No association with blood pressure was seen in either of the groups.
Dietary sodium intake and its relationship to adiposity in young black and white adults: The African‐PREDICT study
Publisher: Wiley
Date: 07-2018
DOI: 10.1111/JCH.13329
Inflammation and salt in young adults: the African-PREDICT study
Publisher: Springer Science and Business Media LLC
Date: 03-06-2020
DOI: 10.1007/S00394-020-02292-3
Abstract: Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K + ) intake was found to counter increase in blood pressure due to high salt intake and may potentially also have protective anti-inflammatory effects. To better understand these interactions under normal physiological conditions, we investigated the relationships between 22 inflammatory mediators with 24-h urinary K + in young healthy adults stratified by low, medium and high salt intake (salt tertiles). We stratified by ethnicity due to potential salt sensitivity in black populations. In 991 healthy black ( N = 457) and white ( N = 534) adults, aged 20–30 years, with complete data for 24-h urinary sodium and K + , we analysed blood s les for 22 inflammatory mediators. We found no differences in inflammatory mediators between low-, mid- and high-sodium tertiles in either the black or white groups. In multivariable-adjusted regression analyses in white adults, we found only in the lowest salt tertile that K + associated negatively with pro-inflammatory mediators, namely interferon gamma, interleukin (IL) -7, IL-12, IL-17A, IL-23 and tumour necrosis factor alpha (all p ≤ 0.046). In the black population, we found no independent associations between K + and any inflammatory mediator. In healthy white adults, 24-h urinary K + associated independently and negatively with specific pro-inflammatory mediators, but only in those with a daily salt intake less than 6.31 g, suggesting K + to play a protective, anti-inflammatory role in a low-sodium environment. No similar associations were found in young healthy black adults.
Related Organisations
North West University Faculty Of Health Sciences
Location: South Africa
University Of Pretoria School Of Biological Sciences
Location: South Africa
Related Funding Activities
No related grants have been discovered for Simone Crouch.