ORCID Profile
0000-0002-1268-2243
Current Organisations
University Hospitals of Leicester NHS Trust
,
University of Oxford
,
University of Leicester
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Publisher: Elsevier BV
Date: 07-2022
Publisher: Oxford University Press (OUP)
Date: 09-11-2022
DOI: 10.1093/CID/CIAC455
Abstract: Halting transmission of Mycobacterium tuberculosis (Mtb) by identifying infectious in iduals early is key to eradicating tuberculosis (TB). Here we evaluate face mask s ling as a tool for stratifying the infection risk of in iduals with pulmonary TB (PTB) to their household contacts. Forty-six sputum-positive PTB patients in The Gambia (August 2016–November 2017) consented to mask s ling prior to commencing treatment. Incident Mtb infection was defined in 181 of their 217 household contacts as QuantiFERON conversion or an increase in interferon-γ of ≥1 IU/mL, 6 months after index diagnosis. Multilevel mixed-effects logistical regression analysis with cluster adjustment by household was used to identify predictors of incident infection. Mtb was detected in 91% of PTB mask s les with high variation in IS6110 copies (5.3 × 102 to 1.2 × 107). A high mask Mtb level (≥20 000 IS6110 copies) was observed in 45% of cases and was independently associated with increased likelihood of incident Mtb infection in contacts (adjusted odds ratio, 3.20 [95% confidence interval, 1.26–8.12] P = .01), compared with cases having low-positive/negative mask Mtb levels. Mask Mtb level was a better predictor of incident Mtb infection than sputum bacillary load, chest radiographic characteristics, or sleeping proximity. Mask s ling offers a sensitive and noninvasive tool to support the stratification of in iduals who are most infectious in high-TB-burden settings. Our approach can provide better insight into community transmission in complex environments.
Publisher: Elsevier BV
Date: 09-2022
Publisher: Elsevier BV
Date: 12-2022
Publisher: Elsevier BV
Date: 02-2022
Publisher: Elsevier BV
Date: 2022
Publisher: Elsevier BV
Date: 10-2023
Publisher: Elsevier BV
Date: 05-2023
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Daniel Pan.