ORCID Profile
0000-0002-1696-6091
Current Organisation
Universidade Federal dos Vales do Jequitinhonha e Mucuri
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Publisher: American Medical Association (AMA)
Date: 2021
Publisher: Elsevier BV
Date: 08-2021
DOI: 10.1016/J.BBR.2021.113371
Abstract: Maternal high-fat diets (HFD) can generate inflammation in the offspring's amygdala, which can lead to anxiety-like behaviors. Conversely, lipopolysaccharide (LPS) tolerance can reduce neuroinflammation in the offspring caused by maternal high-fat diets. This study evaluated the combination of LPS tolerance and high-fat maternal diet on amygdala's inflammatory parameters and the anxiety-like behavior in adolescent offspring. Female pregnant Wistar rats received randomly a standard diet or a high-fat diet during gestation and lactation. On gestation days 8, 10, and 12, half of the females in each group were intraperitonially injected with LPS (0.1 mg.kg
Publisher: FapUNIFESP (SciELO)
Date: 2019
Publisher: American Physiological Society
Date: 2019
DOI: 10.1152/JAPPLPHYSIOL.00406.2018
Abstract: This study aims to investigate the cardiorespiratory responses to different vibration frequencies to characterize the intensity of exercise, as well as to compare the effect of two types of squatting exercises (static and dynamic) on the whole body vibration (WBV) exercise in in iduals with chronic obstructive pulmonary disease (COPD). Twenty-six subjects were ided and paired into healthy and COPD groups that performed static squatting associated with WBV (frequencies: 30, 35, and 40 Hz litude: 2 mm) and dynamic squatting associated with WBV (frequency: 35 Hz litude 2 mm) on a vertical vibration platform. Oxygen consumption (V̇o 2 ), heart rate (HR), minute ventilation (V̇e), ratio of minute ventilation to oxygen production (V̇e/V̇o 2 ), ratio of minute ventilation to carbon dioxide production (V̇e/V̇co 2 ), oxygen saturation (SpO 2 ), and rating of perceived exertion were measured. For both groups, there was a decrease in V̇e/V̇o 2 and V̇e/V̇co 2 ratios during static and dynamic squats, as well as an increase in other cardiorespiratory parameters, and no significant difference existed between them. There was an effect of the type of squat on the HR variation the values in the static squat were higher than those of the dynamic squat in both groups. There was a significant difference with a reduction in SpO 2 at 40 Hz frequency when compared with 30 Hz in the COPD group. The other variables behaved similarly between the frequencies. The WBV exercise, regardless of the frequencies used, represented a mild effort that promoted cardiorespiratory response in COPD, with greater responses in the static squat and no adverse effect. NEW & NOTEWORTHY This study showed that an acute session of light exercise of whole body vibration (WBV) can increase the cardiorespiratory responses in patients with chronic obstructive pulmonary disease (COPD), reaching values similar to that of the control group. The results might contribute, therefore, to the elaboration of exercise protocols with WBV for the treatment of patients with COPD during rehabilitation. Thus, future studies referring to training on the vibratory platform could use these exercise parameters and demonstrate possible long-term benefits.
Publisher: Elsevier BV
Date: 2022
DOI: 10.1016/J.PHYSBEH.2021.113628
Abstract: Lipopolysaccharide (LPS) tolerance can reduce the neuroinflammation caused by high fat maternal diets however, there are no reports that have evaluated the effects of prenatal LPS exposure on the memories of the offspring of high-fat diet fed dams. This study evaluated the effects of prenatal LPS exposure on the inflammatory parameters and redox status in the brain, as well as the object recognition memory of adolescent offspring of Wistar rat dams that were treated with a high-fat diet during gestation and lactation. Female pregnant Wistar rats randomly received a standard diet (17.5% fat) or a high-fat diet (45.0% fat) during gestation and lactation. On gestation days 8, 10, and 12, half of the females in each group were intraperitoneally treated with LPS (0.1 mg.kg
Publisher: Elsevier BV
Date: 09-2020
Publisher: American Physiological Society
Date: 08-2018
DOI: 10.1152/JAPPLPHYSIOL.01037.2017
Abstract: Whole body vibration training (WBVT) has been identified as an alternative intervention to improve exercise capacity and quality of life of patients with chronic obstructive pulmonary disease (COPD). However, the effect of WBVT on inflammatory-oxidative biomarkers remains unknown. The aim of this trial was to investigate the effects of WBVT on quality of life and physical and inflammatory-oxidative parameters in patients with COPD. Twenty patients were equally ided into 1) an intervention group (IG) that performed the WBVT, and 2) a control group (CG) that did not receive any intervention. Intervention consisted in performing static squatting on a vibrating platform, in six series of 30 s, 3 days/wk, for 12 wk. Patients were evaluated for plasma levels of IL-6, IL-8, IFN-γ, soluble receptors of TNF-α white cell count plasma levels of oxidant and antioxidant markers 6-min walking distance (6MWD) peak oxygen uptake (V̇o 2peak ) handgrip strength quality of life timed 5-chair sit-to-stand (5STS) and timed get-up and go test (TUG). After WBVT, patients from IG showed a significant increase in the 6MWD, V̇o 2peak , and handgrip strength ( P 0.05). Furthermore, patients from the IG reached minimal clinically important difference regarding quality of life. No significant differences were found in 5STS, TUG, inflammatory-oxidative biomarkers, and white cell count in the IG. The CG did not show significant improvement in all assessments ( P 0.05). Taken together, our results demonstrated that the WBVT induced clinically significant benefits regarding exercise capacity, muscle strength, and quality of life in patients with COPD that were not related to inflammatory-oxidative biomarker changes. NEW & NOTEWORTHY Whole body vibration training is a new option for nonpharmacological treatment of chronic obstructive pulmonary disease (COPD). This study showed the potential of this training to improve exercise capacity, quality of life, and muscle strength in patients with COPD. Furthermore, to our knowledge this was the first study showing that vibration exercise does not modify the plasma levels of inflammatory-oxidative biomarkers, suggesting that the beneficial effects on physical measures and quality of life are independent of changes in biomarkers.
Publisher: Elsevier BV
Date: 10-2018
DOI: 10.1016/J.JTHERBIO.2018.08.014
Abstract: There is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 µL of physostigmine (phy) or saline solution. Tail temperature (T
Publisher: Public Library of Science (PLoS)
Date: 12-2016
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.PHYSBEH.2019.112675
Abstract: It is known that a single session of high-intensity interval exercise (HIIE) contributes to the increase of the reactive species of oxygen, accompanied by a greater antioxidant activity. However, it is poorly understood if a single session of HIIE has similar effects on the brain tissue. This study evaluated the effects of a single HIIE on the hippoc al redox status. Sixteen males Wistar rats were allocated into HIIE (n = 8) and control (n = 8) groups. Maximum oxygen consumption (VO
Publisher: Public Library of Science (PLoS)
Date: 12-12-2018
Publisher: Public Library of Science (PLoS)
Date: 11-2018
Publisher: Elsevier BV
Date: 12-2019
DOI: 10.1016/J.BBR.2019.112181
Abstract: High-intensity interval training (HIIT) is associated with better physical performance, but there is limited information about the effects of HIIT on redox state of cerebellar tissue, cerebral cortex, and cognition. The aim of this study was to evaluate the effects of HIIT on redox state parameters in cerebellar tissue, cerebral cortex, and cognitive function of Wistar rats. Forty-three young male Wistar rats were housed under controlled environmental conditions with food, and water ad libitum. Animals were assigned to HIIT or Non-trained groups. HIIT protocol was performed during six weeks. Speed was determined through the assesstment of the maximum oxygen consumption (VO
Publisher: Walter de Gruyter GmbH
Date: 14-01-2020
Abstract: The salivary circadian diurnal cortisol plays an important role in growth and development. Inappropriate levels may induce changes associated with an increased risk of obesity later in life. It is unknown if there are differences in cortisol secretion pattern between overweight/obese infants when compared with theirs peers in infancy. Thus, this study aimed to compare the salivary cortisol secretion pattern in overweight/obese and normal-weight infants. Thirty-three (overweight/obese = 17 and normal weight = 16) infants between 6 and 24 months of age had saliva s les collected upon awakening (T1), 30 min after waking (T2), at 12:00 am or before the baby’s meal (T3), and prior to bedtime (T4). Highly sensitive enzyme immunoassays were used for cortisol analyses. Salivary cortisol levels were similar between the groups: T1 (p = 0.22 95% confidence interval [CI]: −5.65, 1.37), T2 (p = 0.24 95% CI: −8.23, 2.17), T3 (p = 0.95 95% CI: −3.16, 2.96), and T4 (p = 0.81 95% CI: −1.39, 1.08) and no differences were observed between area under the curve (AUC) (p = 0.80 95% CI: −4.58–13.66). The cortisol level reduced in T4 (95% CI: 1.35–2.96) compared to T1 (95% CI: 5.15–8.49) and T2 in the overweight/obese group (p 0.001 95% CI: 6.02–11.04). In the normal-weight group, the cortisol reduced in T3 (95% CI: 2.86–8.18) compared to T1 (95% CI: 5.64–12.28) and decreased until T4 (p = 0.001 95% CI: 1.25–3.37). The overweight/obese infant group presented a different pattern of cortisol secretion, although cortisol levels did not differ between the control group.
Publisher: Frontiers Media SA
Date: 25-06-2019
Publisher: Informa UK Limited
Date: 18-03-2021
Publisher: FapUNIFESP (SciELO)
Date: 2018
Publisher: Informa UK Limited
Date: 06-12-2020
Publisher: Frontiers Media SA
Date: 18-09-2019
Publisher: Hindawi Limited
Date: 30-11-2021
DOI: 10.1155/2021/7593802
Abstract: This study aimed to investigate the efficacy of whole-body vibration training (WBVT) on blood brain-derived neurotrophic factor (BDNF) levels and determine the clinical and functional outcomes in patients with fibromyalgia syndrome (FMS). Thirty-two women with FMS were randomized into an intervention group (IG), receiving 6 weeks of WBVT, or a control group (CG) with no intervention. The outcomes at the baseline and follow-up in both groups included blood BDNF levels, sit-to-stand test (STS), 6-minute walk test (6MWT), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and visual analogue scale (VAS). WBVT resulted in a group-by-time interaction effect. Thus, after the intervention time, the IG had increased blood BDNF levels ( p = 0.045 ), a higher number of repetitions on the STS test ( p = 0.011 ), and increased walking distance on the 6MWT ( p = 0.010 ), compared to CG. Moreover, there was a reduction in the scores of the FIQ ( p = 0.001 ), the PSQI ( p = 0.001 ), the BDI ( p = 0.017 ), and pain assessed using VAS ( p = 0.008 ) in IG. The results demonstrate that WBVT promotes an increase in blood BDNF levels, with concomitant improvement in lower limb muscle strength, aerobic capacity, clinical symptoms, and quality of life in women with FMS. This trial is registered with Brazilian Clinical Trials Registry (REBEC RBR-38nbbx) (ensaiosclinicos.gov.br/rg/RBR-38nbbx).
Publisher: Springer International Publishing
Date: 25-07-2019
Publisher: Elsevier BV
Date: 05-2017
DOI: 10.1016/J.BBR.2017.02.030
Abstract: This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development. A significant association was found among plasma leptin and sTNFR1 levels with cognitive composite scores, and these two independents variables together explained 37% of the variability of cognitive composite scores (p=0.001). Only plasma sTNFR1 levels were associated and explained 24% of the variability of motor composite scores (p=0.003). Plasma levels of sTNFR1 were associated with the increase in cognitive and motor development scores in infants between 6 and 24 months of age through a mechanism not directly related to excess body weight. Moreover, increase in plasma levels of leptin reduced the cognitive development in this age range.
Publisher: FapUNIFESP (SciELO)
Date: 2016
Publisher: Elsevier BV
Date: 10-2020
Publisher: Springer Science and Business Media LLC
Date: 08-2020
Publisher: Hindawi Limited
Date: 02-12-2021
DOI: 10.1155/2021/9774980
Abstract: Objective. Rheumatoid arthritis (RA) causes progressive changes in the musculoskeletal system compromising neuromuscular control especially in the hands. Whole-body vibration (WBV) could be an alternative for the rehabilitation in this population. This study investigated the immediate effect of WBV while in the modified push-up position on neural ratio (NR) in a single session during handgrip strength (HS) in women with stable RA. Methods. Twenty-one women with RA (diagnosis of disease: ±8 years, erythrocyte sedimentation rate: ±24.8, age: 54± 11 years, BMI: 28 ± 4 kg ·m-2) received three experimental interventions for five minutes in a randomized and balanced cross-over order: (1) control—seated with hands at rest, (2) sham—push-up position with hands on the vibration platform that remained disconnected, and (3) vibration—push-up position with hands on the vibration platform turned on (45 Hz, 2 mm, 159.73 m·s-2). At the baseline and immediately after the three experimental interventions, the HS, the electromyographic records (EMGrms), and range of motion (ROM) of the dominant hand were measured. The NR, i.e., the ratio between EMGrms of the flexor digitorum superficialis (FDS) muscle and HS, was also determined. The lower NR represented the greater neuromuscular efficiency (NE). Results. The NR was similar at baseline in the three experimental interventions. Despite the nonsignificance of within-interventions ( p = 0.0611 ) and interaction effect ( p = 0.1907 ), WBV exercise reduced the NR compared with the sham and control ( p = 0.0003 , F = 8.86 , η 2 = 0.85 , power = 1.00 ). Conclusion. Acute WBV exercise under the hands promotes neuromuscular modifications during the handgrip of women with stable RA. Thus, acute WBV exercise may be used as a preparatory exercise for the rehabilitation of the hands in this population. This trial is registered with trial registration 2.544.850 (ReBEC-RBR-2n932c).
Publisher: Public Library of Science (PLoS)
Date: 07-02-2019
Publisher: FapUNIFESP (SciELO)
Date: 2023
DOI: 10.1590/1809-2950/E22012423EN
Abstract: ABSTRACT Given the gap in the literature regarding the peak of oxygen consumption (VO2peak) for adolescents of both sexes, this study aimed to propose an equation to predict the VO2peak in healthy adolescents using the Modified Shuttle Test (MST). This is a cross-sectional study with 84 healthy adolescents between 12 and 18 years old, female and male. The MST is an external paced test, in which the speed increases at each minute. Two MST were performed with at least 30 minutes of rest between them. The test with the longest walked distance was considered for analysis. VO2 was directly monitored by an open circuit spirometry. Mean age was 14.67±1.82 and the walked distance was 864.86±263.48m. Variables included in the prediction equation were walked distance and sex, explaining the VO2peak variability of 53% during MST performance. The prediction equation for VO2peak with the MST was: predicted VO2peak=18.274+(0.18×Distance Walked, meters)+(7.733×Sex) R2=0.53 and p .0001 (sex: 0 for girls, 1 for boys). This MST equation, proposed to predict VO2peak in healthy adolescents of both sexes, can be used as a reference to assess exercise capacity in healthy adolescents and to investigate cardiopulmonary function in adolescents with reduced functional capacity.
Publisher: Springer International Publishing
Date: 25-07-2019
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.PHYSBEH.2017.10.027
Abstract: Although High Intensity Interval Training (HIIT) are being associated to increase cardiovascular and metabolic adaptation, there is controversy and limited information about the effects of HIIT on hippoc al oxidative stress, pro- and anti-inflammatory cytokines balance and neurotrophic status. Thus, this study evaluated the effects of six weeks of HIIT on hippoc al redox state (oxidative damage and enzymatic and non-enzymatic antioxidant defenses), neuroimmune mediators (TNFα, IL-6, IL-1β and IL-10) and brain-derived neurotrophic (BDNF) levels. After six weeks of HIIT young adults male Wistar rats presented reduced oxidative damage and increased enzymatic (superoxide dismutase) and non-enzymatic activity in hippoc us. Moreover HIIT induced a decrease in cytokine content (TNFα, IL-6, IL-1β and IL-10) and enhanced hippoc al BDNF levels. In conclusion, the present study showed for the first time a positive effect of six weeks of HIIT on reducing hippoc al oxidative stress by decreasing lipoperoxidation and inflammatory markers, as well enhancing antioxidant defenses and BDNF content.
Publisher: Elsevier BV
Date: 05-2019
Publisher: Frontiers Media SA
Date: 12-01-2021
DOI: 10.3389/FPHYS.2020.469499
Abstract: To compare the effect of Whole-Body Vibration Exercise (WBVE) applied in push-up modified and half-squat positions, on handgrip strength (HS) and on the electromyography registry (EMGrms) of the flexor digitorum superficialis muscle (FDSM) of the dominant hand. Nineteen healthy women (age 23.40 ± 4.03 years, bodyweight: 58.89 ± 9.87 kg), performed in a randomized order five different tests: (S1) Control (S2) Push-up modified (S3) Push-up placebo (S4) Half-squatting (S5) Half-squatting placebo. The HS and the EMGrms were assessed at baseline and immediately after the tests. ANOVA two-way design mixed test, with Tukey post hoc , was used to evaluate the HS, EMGrms and the ratio between EMGrms and HS, i.e., neural ratio (NR). Thus, the lower NR represents the greater neuromuscular modifications. The statistical significance level was set up at p & 0.05. WBVE on S2 increased HS compared to the stimulus applied to the S4 ( p = 0.0001). The increase in HS was associated with a reduction in the EMGrms of the FDSM ( p & 0.001) and a lower NR ( p & 0.0001), i.e., greater neuromuscular modifications, in the S2 compared to the S4 after the tests. The distance of the stimulus and the positioning on the vibratory platform influence the maximum muscular strength due to neuromuscular modifications of hands in healthy women.
Publisher: FapUNIFESP (SciELO)
Date: 2017
Publisher: MDPI AG
Date: 07-11-2022
Abstract: Introduction: COVID-19 is a public health emergency all around the world. Severe illness occurred in about 14% of patients and 5% of patients developed critical illness, but the prognosis for these patients remains unclear. Objective: To describe the prognosis in hospitalized adults with COVID-19. Methods: The MEDLINE, EMBASE, AMED, and COCHRANE databases were searched for studies published up to 28 June 2021 without language restrictions. Descriptors were related to “COVID-19” and “prognosis”. Prospective inception cohort studies that assessed morbidity, mortality and recovery in hospitalized people over 18 years old with COVID-19 were included. Two independent reviewers selected eligible studies and extracted the available data. Acute respiratory distress syndrome (ARDS) and multiple organ failure (MOFS) were considered as outcomes for morbidity and discharge was considered for recovery. The Quality in Prognosis Studies (QUIPS) tool was used to assess risk of bias. Analyses were performed using Comprehensive Meta-Analysis (version 2.2.064). Results: We included 30 inception cohort studies investigating 13,717 people hospitalized with COVID-19 from different countries. The mean (SD) age was 60.90 (21.87) years, and there was high proportion of males (76.19%) and people with comorbidities (e.g., 49.44% with hypertension and 29.75% with diabetes). Findings suggested a high occurrence of morbidity, mainly related to ARDS. Morbidity rates varied across studies from 19% to 36% in hospital wards, and from 13% to 90% in Intensive Care Units—ICU. Mortality rates ranged from 4% to 38% in hospital wards and from 8% to 51% in ICU. Recovery rates ranged up to 94% and 65% in hospital wards and ICU, respectively. The included studies had high risk of bias in the confounding domain. Conclusions: The prognosis of people hospitalized with COVID-19 is an issue for the public health system worldwide, with high morbidity and mortality rates, mainly in ICU and for patients with comorbidities. Its prognosis emphasizes the need for appropriate prevention and management strategies.
Publisher: Escola Bahiana de Medicina e Saude Publica
Date: 10-02-2021
DOI: 10.17267/2238-2704RPF.V11I1.3445
Abstract: BACKGROUND: Whole-body vibration (WBV) has been widely used as a therapeutic resource in pediatric rehabilitation. However, the cardiopulmonary responses are still unknown. OBJECTIVE: To investigate the intensity of dynamic squatting exercise with and without WBV in healthy adolescents in order to characterize cardiorespiratory responses. METHODS: This was a quasi-experimental study. Twenty-five adolescents (14.1 ± 1.7 years), 10 girls and 15 boys, underwent to oxygen consumption (VO2) and heart rate (HR) assessments during a protocol of squatting with and without vibration. Inclusion criteria were age between 12 and 18 years old of both sexes, have normal weight according to BMI. Exclusion criteria were to present chronic or acute, neurological, orthopedic, respiratory, cardiac and endocrine disease and no self-reported contraindication for WBV (i.e. deep vein thrombosis, metal implants, pacemaker, epilepsy, tumors, arterial aneurysm, or arrhythmia). RESULTS: WBV was able to significantly increase VO2, HR and perceived exertion during squatting exercise when compared to rest and squatting without-WBV. WBV associated with squatting reached 24.7% of the VO2max and 56% of the HRmax predicted for age. Subjects during WBV reported a perceived exertion score between somewhat hard and hard compared to between very light and light in the Without-WBV protocol. CONCLUSION: Squatting associated to WBV was considered a light intensity exercise that can be tolerated by healthy adolescents. This study provided valid results of this training modality and could be used as a tool to define the energy consumption spent in this training modality.
Location: Brazil
No related grants have been discovered for Vanessa Mendonça.