ORCID Profile
0000-0002-4688-3000
Current Organisations
Durham University
,
University of Oxford
,
Université Louis Pasteur
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Publisher: Elsevier BV
Date: 07-2004
Publisher: Wiley
Date: 22-12-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8DT04640A
Abstract: Cyclometallated Pt( ii ) complexes with tridentate N^C^N-coordinating ligands are shown to be effective sensitisers of near-infrared emission from lanthanide( iii ) ions following visible light absorption.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0DT01964J
Abstract: Ditopic bis- N ^ N ^ O -coordinating ligands, prepared by Schiff base chemistry, lead to dinuclear iridium complexes that emit much more brightly than their mononuclear counterparts.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9DT03156A
Abstract: Tridentate ligands, easily synthesised by condensation reactions of simple starting materials, can be used to prepare Pt( ii ) complexes that are luminescent in solution, emitting in the red or deep-red spectral region, according to the substituents.
Publisher: Elsevier BV
Date: 07-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2005
DOI: 10.1039/B418022D
Publisher: Proceedings of the National Academy of Sciences
Date: 21-10-2008
Abstract: This work explores time-resolved emission imaging microscopy (TREM) for noninvasive imaging and mapping of live cells on a hitherto uncharted microsecond time scale. Simple robust molecules for this purpose have long been sought. We have developed highly emissive, synthetically versatile, and photostable platinum(II) complexes that make TREM a practicable reality. [PtLCl], {HL = 1,3-di(2-pyridyl)benzene and derivatives}, are charge-neutral, small molecules that have low cytotoxicity and accumulate intracellularly within a remarkably short incubation time of 5 min, apparently under diffusion control. Their microsecond lifetimes and emission quantum yields of up to 70% are exceptionally high for transition metal complexes and permit the application of TREM to be demonstrated in a range of live cell types—normal human dermal fibroblast, neoplastic C8161 and CHO cells. [PtLCl] are thus likely to be suitable emission labels for any eukaryotic cell types. The high photostability of [PtLCl] under intense prolonged irradiation has allowed the development of tissue-friendly NIR two-photon excitation (TPE) in conjunction with transition metal complexes in live cells. A combination of confocal one-photon excitation, nonlinear TPE, and microsecond time-resolved imaging has revealed ( i ) preferential localization of the complexes to intracellular nucleic acid structures, in particular the nucleoli and ( ii ) the possibility of measuring intracellular emission lifetimes in the microsecond range. The combination of TREM, TPE, and Pt(II) complexes will be a powerful tool for investigating intracellular processes in vivo , because the long lifetimes allow discrimination from autofluorescence and open up the use of commonplace technology.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3DT00577A
Abstract: The first CPL-active square-planar Pt( ii ) complexes bearing a bidentate pentahelicenic NHC ligand have been prepared and characterized.
Publisher: Informa UK Limited
Date: 09-2004
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for J A Gareth Williams.