ORCID Profile
0000-0003-0791-9899
Current Organisations
Radboud University Nijmegen Medical Centre
,
University of Amsterdam
,
Centre François Baclesse Centre de Lutte Contre le Cancer
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Publications
F18-choline PET/CT guided surgery in primary hyperparathyroidism when ultrasound and MIBI SPECT/CT are negative or inconclusive: the APACH1 study
Publisher: Springer Science and Business Media LLC
Date: 22-12-2017
The importance of harmonizing interim positron emission tomography in non-Hodgkin lymphoma: focus on the Deauville criteria
Publisher: Ferrata Storti Foundation (Haematologica)
Date: 28-02-2014
Does PET SUV Harmonization Affect PERCIST Response Classification?
Publisher: Society of Nuclear Medicine
Date: 09-06-2016
DOI: 10.2967/JNUMED.115.171983
Abstract: Pre- and posttreatment PET comparative scans should ideally be obtained with identical acquisition and processing, but this is often impractical. The degree to which differing protocols affect PERCIST classification is unclear. This study evaluates the consistency of PERCIST classification across different reconstruction algorithms and whether a proprietary software tool can harmonize SUV estimation sufficiently to provide consistent response classification. Eighty-six patients with non-small cell lung cancer, colorectal liver metastases, or metastatic melanoma who were scanned for therapy monitoring purposes were prospectively recruited in this multicenter trial. Pre- and posttreatment PET scans were acquired in protocols compliant with the Society of Nuclear Medicine and Molecular Imaging and the European Association of Nuclear Medicine (EANM) acquisition guidelines and were reconstructed with a point spread function (PSF) or PSF + time-of-flight (TOF) for optimal tumor detection and also with standardized ordered-subset expectation maximization (OSEM) known to fulfill EANM harmonizing standards. After reconstruction, a proprietary software solution was applied to the PSF ± TOF data (PSF ± TOF.EQ) to harmonize SUVs with the OSEM values. The impact of differing reconstructions on PERCIST classification was evaluated. For the OSEM Reconstruction algorithm-dependent variability in PERCIST classification is a significant issue but can be overcome by harmonizing SULs using a proprietary software tool.
F18-Choline, a Novel PET Tracer for Parathyroid Adenoma?
Publisher: The Endocrine Society
Date: 08-2013
DOI: 10.1210/JC.2013-2084
Contrast-enhanced small-animal PET/CT in cancer research: strong improvement of diagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4–2008 image quality parameters
Publisher: Springer Science and Business Media LLC
Date: 17-01-2013
Abstract: The use of iodinated contrast media in small-animal positron emission tomography (PET)/computed tomography (CT) could improve anatomic referencing and tumor delineation but may introduce inaccuracies in the attenuation correction of the PET images. This study evaluated the diagnostic performance and accuracy of quantitative values in contrast-enhanced small-animal PET/CT ( CE PET/CT) as compared to unenhanced small animal PET/CT ( UE PET/CT). Firstly, a NEMA NU 4–2008 phantom (filled with 18 F-FDG or 18 F-FDG plus contrast media) and a homemade phantom, mimicking an abdominal tumor surrounded by water or contrast media, were used to evaluate the impact of iodinated contrast media on the image quality parameters and accuracy of quantitative values for a pertinent-sized target. Secondly, two studies in 22 abdominal tumor-bearing mice and rats were performed. The first animal experiment studied the impact of a dual-contrast media protocol, comprising the intravenous injection of a long-lasting contrast agent mixed with 18 F-FDG and the intraperitoneal injection of contrast media, on tumor delineation and the accuracy of quantitative values. The second animal experiment compared the diagnostic performance and quantitative values of CE PET/CT versus UE PET/CT by sacrificing the animals after the tracer uptake period and imaging them before and after intraperitoneal injection of contrast media. There was minimal impact on IQ parameters (%SD unif and spillover ratios in air and water) when the NEMA NU 4–2008 phantom was filled with 18 F-FDG plus contrast media. In the homemade phantom, measured activity was similar to true activity (−0.02%) and overestimated by 10.30% when vials were surrounded by water or by an iodine solution, respectively. The first animal experiment showed excellent tumor delineation and a good correlation between small-animal (SA)-PET and ex vivo quantification ( r 2 = 0.87, P 0.0001). The second animal experiment showed a good correlation between CE PET/CT and UE PET/CT quantitative values ( r 2 = 0.99, P 0.0001). Receiver operating characteristic analysis demonstrated better diagnostic accuracy of CE PET/CT versus UE PET/CT (senior researcher, area under the curve (AUC) 0.96 versus 0.77, P = 0.004 junior researcher, AUC 0.78 versus 0.58, P = 0.004). The use of iodinated contrast media for small-animal PET imaging significantly improves tumor delineation and diagnostic performance, without significant alteration of SA-PET quantitative accuracy and NEMA NU 4–2008 IQ parameters.
EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program
Publisher: Springer Science and Business Media LLC
Date: 30-05-2017
Harmonizing SUVs in multicentre trials when using different generation PET systems: prospective validation in non-small cell lung cancer patients
Publisher: Springer Science and Business Media LLC
Date: 06-04-2013
Harmonizing FDG PET quantification while maintaining optimal lesion detection: prospective multicentre validation in 517 oncology patients
Publisher: Springer Science and Business Media LLC
Date: 30-07-2015
Related Organisations
Centre François Baclesse Centre De Lutte Contre Le Cancer
Location: France
Related Funding Activities
No related grants have been discovered for Elske Quak.