ORCID Profile
0000-0002-6141-9329
Current Organisation
University of New England
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Pure Mathematics | Functions Of Several Complex Variables | Lie Groups, Harmonic and Fourier Analysis | Geometry | Real and Complex Functions (incl. Several Variables) | Group Theory And Generalisations (Incl. Topological Groups And Lie | Algebraic and Differential Geometry
Computer software and services not elsewhere classified | Expanding Knowledge in the Mathematical Sciences | Physical sciences | Mathematical sciences |
Publisher: Springer Science and Business Media LLC
Date: 09-2004
Publisher: Springer Science and Business Media LLC
Date: 09-2001
DOI: 10.1007/BF02922014
Publisher: Walter de Gruyter GmbH
Date: 05-07-2012
Publisher: Elsevier BV
Date: 11-2016
Publisher: Springer Science and Business Media LLC
Date: 12-1996
DOI: 10.1007/BF02921621
Publisher: Springer Science and Business Media LLC
Date: 09-1989
DOI: 10.1007/BF01159970
Publisher: Springer Science and Business Media LLC
Date: 09-12-2021
DOI: 10.1038/S41467-021-27234-3
Abstract: Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1 , PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1 , LDB2 , CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.
Publisher: Springer Science and Business Media LLC
Date: 09-12-2021
DOI: 10.1038/S41467-021-27198-4
Abstract: Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). The 100 replicated, epigenome-wide significant ( p 1.1E–7) CpGs explain 11.6% of the serum urate variance. At SLC2A9 , the serum urate locus with the largest effect in genome-wide association studies (GWAS), five CpGs are associated with SLC2A9 gene expression. Four CpGs at SLC2A9 have significant causal effects on serum urate levels and/or gout, and two of these partly mediate the effects of urate-associated GWAS variants. In other genes, including SLC7A11 and PHGDH , 17 urate-associated CpGs are associated with conditions defining metabolic syndrome, suggesting that these CpGs may represent a blood DNA methylation signature of cardiometabolic risk factors. This study demonstrates that EWAS can provide new insights into GWAS loci and the correlation of serum urate with other complex traits.
Publisher: The Optical Society
Date: 07-04-2014
DOI: 10.1364/OE.22.009087
Publisher: Springer Science and Business Media LLC
Date: 29-01-2008
Publisher: Springer Science and Business Media LLC
Date: 03-06-2015
Publisher: Informa UK Limited
Date: 15-11-2016
Publisher: Elsevier BV
Date: 03-2014
Publisher: Elsevier BV
Date: 09-2022
DOI: 10.1016/J.KINT.2022.05.021
Abstract: Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 in iduals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant-by-age interaction on eGFR cross section (further about 350,000 in iduals), which linked genetic associations for eGFR-decline with age-dependency of genetic cross-section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in-silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03-1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics.
Publisher: Springer Science and Business Media LLC
Date: 14-08-2015
Publisher: Steklov Mathematical Institute
Date: 1997
DOI: 10.4213/MZM1578
Publisher: Springer Science and Business Media LLC
Date: 25-04-2017
DOI: 10.1038/S41598-017-01164-X
Abstract: A deterministic variant of Bragg Coherent Diffraction Imaging is introduced in its kinematical approximation, for X-ray scattering from an imperfect crystal whose imperfections span no more than half of the volume of the crystal. This approach provides a unique analytical reconstruction of the object’s structure factor and displacement fields from the 3D diffracted intensity distribution centred around any particular reciprocal lattice vector. The simple closed-form reconstruction algorithm, which requires only one multiplication and one Fourier transformation, is not restricted by assumptions of smallness of the displacement field. The algorithm performs well in simulations incorporating a variety of conditions, including both realistic levels of noise and departures from ideality in the reference (i.e. imperfection-free) part of the crystal.
Publisher: Elsevier BV
Date: 12-2014
Publisher: Springer Science and Business Media LLC
Date: 1994
DOI: 10.1007/BF01459726
Publisher: American Association of Physics Teachers (AAPT)
Date: 12-01-2010
DOI: 10.1119/1.3253655
Abstract: A method for constructing the Green’s function for the Helmholtz equation in free space subject to Sommerfeld radiation conditions is presented. Unlike the methods found in many textbooks, the present technique allows us to obtain all of the possible Green’s functions before selecting the one that satisfies the choice of boundary conditions.
Publisher: Springer Berlin Heidelberg
Date: 2003
Publisher: Springer Science and Business Media LLC
Date: 14-03-2009
Publisher: Springer Singapore
Date: 2018
Publisher: Informa UK Limited
Date: 03-2009
Publisher: Elsevier BV
Date: 04-2020
Publisher: International Press of Boston
Date: 10-2007
Publisher: Springer Science and Business Media LLC
Date: 29-09-2005
Publisher: Pleiades Publishing Ltd
Date: 07-2006
Publisher: Pleiades Publishing Ltd
Date: 06-2007
Publisher: Steklov Mathematical Institute
Date: 2004
DOI: 10.4213/MZM575
Publisher: Elsevier BV
Date: 06-2017
Publisher: Wiley
Date: 1992
Publisher: Springer Science and Business Media LLC
Date: 10-08-2018
Publisher: Springer Science and Business Media LLC
Date: 05-1994
DOI: 10.1007/BF02572334
Publisher: Springer Science and Business Media LLC
Date: 15-07-2022
DOI: 10.1007/S10231-022-01241-7
Abstract: We improve results of Baouendi, Rothschild and Treves and of Hill and Nacinovich by finding a much weaker sufficient condition for a CR manifold of type ( n , k ) to admit a local CR embedding into a CR manifold of type $$(n+\\ell ,k-\\ell )$$ ( n + ℓ , k - ℓ ) . While their results require the existence of a finite dimensional solvable transverse Lie algebra of vector fields, we require only a finite dimensional extension.
Publisher: International Press of Boston
Date: 2003
Publisher: Springer Science and Business Media LLC
Date: 31-05-2012
Publisher: Springer International Publishing
Date: 2020
Publisher: Walter de Gruyter GmbH
Date: 07-2005
Publisher: Indiana University Mathematics Journal
Date: 2013
Publisher: Steklov Mathematical Institute
Date: 19-06-2008
Publisher: Elsevier BV
Date: 04-2021
Publisher: Steklov Mathematical Institute
Date: 06-2021
DOI: 10.1070/IM9046
Abstract: In this article we regard spherical hypersurfaces in with a fixed Reeb vector field as -dimensional Sasakian manifolds. We establish a correspondence between three different sets of parameters, namely, those arising from representing the Reeb vector field as an automorphism of the Heisenberg sphere, those used in Stanton’s description of rigid spheres, and those arising from the rigid normal forms. We also describe geometrically the moduli space for rigid spheres and provide a geometric distinction between Stanton hypersurfaces and those found in [1]. Finally, we determine the Sasakian automorphism groups of rigid spheres and detect the homogeneous Sasakian manifolds among them.
Publisher: Steklov Mathematical Institute
Date: 1999
DOI: 10.4213/MZM1203
Publisher: Steklov Mathematical Institute
Date: 2008
DOI: 10.4213/IM696
Publisher: Springer Science and Business Media LLC
Date: 24-07-2017
Publisher: Indiana University Mathematics Journal
Date: 2008
Publisher: Springer Science and Business Media LLC
Date: 10-1991
DOI: 10.1007/BF01137743
Location: Russian Federation
Location: Germany
Start Date: 2013
End Date: 2015
Funder: Australian Research Council
View Funded ActivityStart Date: 2004
End Date: 12-2006
Amount: $165,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2013
End Date: 12-2018
Amount: $258,000.00
Funder: Australian Research Council
View Funded Activity