ORCID Profile
0000-0003-2319-121X
Current Organisation
Yenepoya University
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Publisher: Oxford University Press (OUP)
Date: 23-07-2009
DOI: 10.1093/BIOINFORMATICS/BTP453
Abstract: Summary: We have developed PathBuilder, an open-source web application to annotate biological information pertaining to signaling pathways and to create web-based pathway resources. PathBuilder enables annotation of molecular events including protein–protein interactions, enzyme–substrate relationships and protein translocation events either manually or through automated importing of data from other databases. Salient features of PathBuilder include automatic validation of data formats, built-in modules for visualization of pathways, automated import of data from other pathway resources, export of data in several standard data exchange formats and an application programming interface for retrieving existing pathway datasets. Availability: PathBuilder is freely available for download at pathbuilder.sourceforge.net/ under the terms of GNU lesser general public license (LGPL: opyleft/lesser.html). The software is platform independent and has been tested on Windows and Linux platforms. Contact: pandey@jhmi.edu Supplementary information: Supplementary data are available at Bioinformatics online.
Publisher: Informa UK Limited
Date: 30-04-2013
DOI: 10.3109/15419061.2013.791683
Abstract: Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
Publisher: Oxford University Press (OUP)
Date: 04-2010
Publisher: Oxford University Press (OUP)
Date: 2009
DOI: 10.1093/NAR/GKN682
Publisher: Hindawi Limited
Date: 13-10-2014
DOI: 10.1155/2014/173026
Abstract: TEK tyrosine kinase is primarily expressed on endothelial cells and is most commonly referred to as TIE2. TIE2 is a receptor tyrosine kinase modulated by its ligands, angiopoietins, to regulate the development and remodeling of vascular system. It is also one of the critical pathways associated with tumor angiogenesis and familial venous malformations. Apart from the vascular system, TIE2 signaling is also associated with postnatal hematopoiesis. Despite the involvement of TIE2-angiopoietin system in several diseases, the downstream molecular events of TIE2-angiopoietin signaling are not reported in any pathway repository. Therefore, carrying out a detailed review of published literature, we have documented molecular signaling events mediated by TIE2 in response to angiopoietins and developed a network map of TIE2 signaling. The pathway information is freely available to the scientific community through NetPath, a manually curated resource of signaling pathways. We hope that this pathway resource will provide an in-depth view of TIE2-angiopoietin signaling and will lead to identification of potential therapeutic targets for TIE2-angiopoietin associated disorders.
Publisher: OMICS Publishing Group
Date: 2012
DOI: 10.4172/JPB.1000243
Publisher: Oxford University Press (OUP)
Date: 2009
DOI: 10.1093/NAR/GKN892
Publisher: Oxford University Press (OUP)
Date: 03-12-2013
DOI: 10.1093/NAR/GKT1251
Publisher: Oxford University Press (OUP)
Date: 03-10-2009
No related grants have been discovered for Rajesh Raju.