ORCID Profile
0000-0002-3165-0343
Current Organisations
International Islamic University Malaysia
,
Leibniz Universität Hannover
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Publications
Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
Publisher: Springer Science and Business Media LLC
Date: 29-02-2016
DOI: 10.1038/SREP22287
Abstract: Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxin-susceptible and polymyxin-resistant A. baumannii using untargeted metabolomics. The metabolome of each A. baumannii strain was measured using liquid chromatography-mass spectrometry. Multivariate and univariate statistics and pathway analyses were employed to elucidate metabolic differences between the polymyxin-susceptible and -resistant A. baumannii strains. Significant differences were identified between the metabolic profiles of the polymyxin-susceptible and -resistant A. baumannii strains. The lipopolysaccharide (LPS) deficient, polymyxin-resistant 19606R showed perturbation in specific amino acid and carbohydrate metabolites, particularly pentose phosphate pathway (PPP) and tricarboxylic acid (TCA) cycle intermediates. Levels of nucleotides were lower in the LPS-deficient 19606R. Furthermore, 19606R exhibited a shift in its glycerophospholipid profile towards increased abundance of short-chain lipids compared to the parent polymyxin-susceptible ATCC 19606. In contrast, in a pair of clinical isolates 03–149.1 (polymyxin-susceptible) and 03–149.2 (polymyxin-resistant, due to modification of lipid A), minor metabolic differences were identified. Notably, peptidoglycan biosynthesis metabolites were significantly depleted in both of the aforementioned polymyxin-resistant strains. This is the first comparative untargeted metabolomics study to show substantial differences in the metabolic profiles of the polymyxin-susceptible and -resistant A. baumannii .
Genome-scale metabolic modeling of responses to polymyxins inPseudomonas aeruginosa
Publisher: Oxford University Press (OUP)
Date: 13-03-2018
When Grades Are High but Self-Efficacy Is Low: Unpacking the Confidence Gap Between Girls and Boys in Mathematics
Publisher: Frontiers Media SA
Date: 07-10-2020
DOI: 10.3389/FPSYG.2020.552355
Abstract: Girls have much lower mathematics self-efficacy than boys, a likely contributor to the underrepresentation of women in STEM. To help explain this gender confidence gap, we examined predictors of mathematics self-efficacy in a s le of 1,007 9th graders aged 13–18 years (54.2% girls). Participants completed a standardized math test, after which they rated three indices of mastery: an affective component (state self-esteem), a meta-cognitive component (self-enhancement), and their prior math grade. Despite having similar grades, girls reported lower mathematics self-efficacy and state self-esteem, and were less likely than boys to self-enhance in terms of performance. Multilevel multiple-group regression analyses showed that the affective mastery component explained girls’ self-efficacy while cognitive self-enhancement explained boys’. Yet, a chi-square test showed that both constructs were equally relevant in the prediction of girls’ and boys’ self-efficacy. Measures of interpersonal sources of self-efficacy were not predictive of self-efficacy after taking the other dimensions into account. Results suggest that boys are advantaged in their development of mathematics self-efficacy beliefs, partly due to more positive feelings and more cognitive self-enhancement following test situations.
Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis
Publisher: Proceedings of the National Academy of Sciences
Date: 09-08-2016
Abstract: Acinetobacter baumannii is one of the most significant hospital-acquired bacterial pathogens, able to cause life-threatening infections and develop resistance to all currently available antibiotic agents. Here, we established zebrafish as a model to study real-time interactions between innate immune cells and A. baumannii during infection. We identified a bacterial metabolic pathway that, when inhibited, leads to enhanced immune responses toward the bacteria, improving bacterial clearance and reducing severity of disease. The enhanced immune response was secondary to accumulation of a metabolic by-product, which acted as a direct, bacterial-mediated attractant of neutrophils, the key immune cell important in response to bacterial infections. These results pave the way for novel therapeutic targeting of bacterial metabolism to stimulate immune responses to fight off infection.
Related Organisations
International Islamic University Malaysia
Location: No location found
Related Funding Activities
No related grants have been discovered for Mohd Hafidz Mahamad Maifiah.