ORCID Profile
0000-0002-2346-4970
Current Organisation
Monash University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Nanotechnology | Nanofabrication, Growth and Self Assembly | Nanomaterials | Nanobiotechnology | Functional Materials | Nanoscale Characterisation | Medical Biotechnology Diagnostics (incl. Biosensors) | Biomedical Instrumentation | Medical Devices | Biomechanical Engineering | Sensor Technology (Chemical aspects) | Nanochemistry and Supramolecular Chemistry | Membrane and Separation Technologies | Nanomaterials | Nanophotonics | Nanotechnology | Nanofabrication growth and self assembly | Medical Biotechnology | Automation and Control Engineering | Mechanical Engineering | Fluidisation and Fluid Mechanics | Interdisciplinary Engineering | Public Health and Health Services not elsewhere classified | Photonics, Optoelectronics and Optical Communications | Nanoelectromechanical Systems | Nanoelectronics | Nanobiotechnology
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in Technology | Expanding Knowledge in Engineering | Diagnostic Methods | Human Diagnostics | Manufacturing not elsewhere classified | Expanding Knowledge in the Physical Sciences | Scientific Instruments | Mental Health | Physical and Chemical Conditions of Water in Fresh, Ground and Surface Water Environments (excl. Urban and Industrial Use) | Expanding Knowledge in the Chemical Sciences | Integrated Circuits and Devices | Health Status (e.g. Indicators of Well-Being) |
Related Links
Publications
A Soft Resistive Acoustic Sensor Based on Suspended Standing Nanowire Membranes with Point Crack Design
Publisher: Wiley
Date: 30-04-2020
Soft Plasmene Helical Nanostructures
Publisher: Wiley
Date: 29-01-2023
Abstract: Plasmene is recently defined as 2D arrays of plasmonic nanoparticles, which could be fabricated by the bottom‐up self‐assembly approach and demonstrated a wide range of applications in sensing, energy harvesting, nanophotonics and encryption. Herein, this work further demonstrates a 3D helical plasmonic nanostructures that can be fabricated from 2D plasmene nanosheet. Inspired by chocolate curls‐making process, a micro‐spatula‐based strategy is developed to selectively scrape substrate‐supported plasmene to free space, which spontaneously folds the plasmene nanosheet into various complex helical nanostructures with controlled dimensions. 3D nanospirals can also be obtained by focus ion beam (FIB)‐based lithography on free‐standing plasmene. Helical plasmene structures are robust, exhibiting elastic mechanical properties and chiral optical response. This methodology represents a versatile fabrication route combining both bottom‐up and top‐down approaches to create soft plasmonic helical structures for potential applications in next‐generation flexible nanophotonic devices.
Self-assembled Janus plasmene nanosheets as flexible 2D photocatalysts
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0MH01275K
Abstract: A 2D flexible photocatalyst has been designed based on Janus plasmene nanosheets for continuous solar-to-chemical conversion.
Volume-invariant ionic liquid microbands as highly durable wearable biomedical sensors
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5MH00284B
Abstract: Non-volatile and flow properties of ionic liquids allow for simple ‘fill and seal’ approach to fabricate high-performance wearable sensors without materials delamination or cracking.
Evaporative self-assembly of gold nanorings via a surface acoustic wave atomization
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.903172
Omnidirectional Hydrogen Generation Based on a Flexible Black Gold Nanotube Array
Publisher: American Chemical Society (ACS)
Date: 31-08-2022
Abstract: Solar-driven hydrogen generation is emerging as an economical and sustainable means of producing renewable energy. However, current photocatalysts for hydrogen generation are mostly powder-based or rigid-substrate-supported, which suffer from limitations, such as difficulties in catalyst regeneration or poor omnidirectional light-harvesting. Here, we report a two-dimensional (2D) flexible photocatalyst based on elastomer-supported black gold nanotube (GNT) arrays with conformal CdS coating and Pt decoration. The highly porous GNT arrays display a strong light-trapping effect, leading to near-complete absorption over almost the entire range of the solar spectrum. In addition, they offer high surface-to-volume ratios promoting efficient photocatalytic reactions. These structural features result in high H
Electrostatic-assembly metallized nanoparticles network by DNA template
Publisher: Elsevier BV
Date: 2006
DOI: 10.1016/J.TALANTA.2005.05.024
Abstract: Eighteen-nanometer gold and 3.5-nm silver colloidal particles closely packed by cetyltrimethylammonium bromide (CTAB) to form its positively charged shell. The DNA network was formed on a mica substrate firstly. Later, CTAB-capped gold or silver colloidal solutions were cast onto DNA network surface. It was found that the gold or silver nanoparticles metallized networks were formed owing to the electrostatic-driven template assembling of positive charge of CTAB-capped gold and silver particles on the negatively charged phosphate groups of DNA molecules by the characterizations of AFM, XPS and UV-vis. This method may provide a novel and simple way to studying nanoparticles assembly conjugating DNA molecules and offer some potential promising applications in nanocatalysis, nanoelectronics, and nanosensor on the basis of the fabricated metal nanoparticles network.
Soft Plasmonics: Design, Fabrication, Characterization, and Applications
Publisher: Wiley
Date: 24-10-2021
Abstract: Plasmonic nanostructures are important building blocks in modern nanoscience and nanotechnology. Significant research efforts have been directed toward developing solution‐based or rigid‐substrate‐supported metallic nanostructures for novel applications in biophotonics, sensing, energy, and medicine. In parallel, there has been an increasing interest in the fabrication of plasmonic nanostructures on elastomeric substrates and exploring the impact of mechanical deformation including bending, torsion, and stretching on the collective plasmonic resonance properties. This burgeoning field may be defined as soft plasmonics (or soft mechanoplasmonics), analogous to soft electronics. This review describes the recent progress in the design, fabrication, characterization, properties, and applications of soft plasmonics. Soft plasmonics are expected to afford complementary features and functions to the field of soft electronics, enabling applications that are difficult or impossible to achieve with traditional rigid plasmonic structures, such as conformal attachment or integration with soft biological systems for real‐time sensing, actuation, and close‐loop feedback.
Bifunctional plasmonic-magnetic particles for an enhanced microfluidic SERS immunoassay
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR01511A
Abstract: Surface-Enhanced Raman Scattering (SERS) is emerging as a promising strategy for the quantification of immunoglobulin G (IgG) due to its inherent high sensitivity and specificity however, it remains challenging to integrate SERS detection with a microfluidic system in a simple, efficient and low-cost manner. Here, we report on a novel bifunctional plasmonic-magnetic particle-based immunoassay, in which plasmonic nanoparticles act as soluble SERS immunosubstrates, whereas magnetic particles are for promoting micromixing in a microfluidic chip. With this novel SERS immunosubstrate in conjunction with the unique microfluidic system, we could substantially reduce the assay time from 4 hours to 80 minutes as well as enhance the detection specificity by about 70% in comparison to a non-microfluidic immunoassay. Compared to previous microfluidic SERS systems, our strategy offers a simple microfluidic chip design with only one well for mixing, washing and detection.
Probing in Real Time the Soft Crystallization of DNA‐Capped Nanoparticles
Publisher: Wiley
Date: 28-12-2009
Nanoparticle Superlattices: The Roles of Soft Ligands
Publisher: Wiley
Date: 06-09-2018
Embedding Pinhole Vertical Gold Nanowire Electronic Skins for Braille Recognition
Publisher: Wiley
Date: 28-02-2019
Abstract: Electronic skins (e-skins) have the potential to be conformally integrated with human body to revolutionize wearable electronics for a myriad of technical applications including healthcare, soft robotics, and the internet of things, to name a few. One of the challenges preventing the current proof of concept translating to real-world applications is the device durability, in which the strong adhesion between active materials and elastomeric substrate or human skin is required. Here, a new strategy is reported to embed vertically aligned standing gold nanowires (v-AuNWs) into polydimethylsiloxane, leading to a robust e-skin sensor. It is found that v-AuNWs with pinholes can have an adhesion energy 18-fold greater than that for pinhole-free v-AuNWs. Finite element modeling results show that this is due to friction force from interfacial embedment. Furthermore, it is demonstrated that the robust e-skin sensor can be used for braille recognition.
Copper Nanowires as Conductive Ink for Low-Cost Draw-On Electronics
Publisher: American Chemical Society (ACS)
Date: 23-07-2015
Abstract: This work tackles the complicated problem of clump formation and entanglement of high aspect ratio copper nanowires, due to which a well dispersed solution for use as a true ink for drawable electronics has not been made until now. Through rheology studies even a hard to use material like copper nanowires was tailored to be made into a highly efficient conductive ink with only 2 vol % or 18.28 wt % loading which is far lower than existing nanoparticle based inks. This versatile ink can be applied onto various substrates such as paper, PET, PDMS and latex. By using the ink in a roller ball pen, a bending sensor device was simply drawn on paper, which demonstrated detection of various degrees of convex bending and was highly durable as shown in the 10,000 bending cycling test. A highly sensitive strain sensor which has a maximum gauge factor of 54.38 was also fabricated by simply painting the ink onto latex rubber strip using a paintbrush. Finally a complex conductive pattern depicting the Sydney Opera House was painted on paper to demonstrate the versatility and robustness of the ink. The use of Cu NWs is highly economical in terms of the conductive filler loading in the ink and the cost of copper itself as compared to other metal NPs, CNT, and graphene-based inks. The demonstrated e-ink, devices, and facile device fabrication methods push the field one step closer to truly creating cheap and highly reliable skin like devices "on the fly".
Enhanced Thermal Conductivity of Copper Nanofluids: The Effect of Filler Geometry
Publisher: American Chemical Society (ACS)
Date: 22-05-2017
Abstract: Nanofluids are colloidal dispersions that exhibit enhanced thermal conductivity at low filler loadings and thus have been proposed for heat transfer applications. Here, we systematically investigate how particle shape determines the thermal conductivity of low-cost copper nanofluids using a range of distinct filler particle shapes: nanospheres, nanocubes, short nanowires, and long nanowires. To exclude the potential effects of surface capping ligands, all the filler particles are kept with uniform surface chemistry. We find that copper nanowires enhanced the thermal conductivity up to 40% at 0.25 vol % loadings while the thermal conductivity was only 9.3% and 4.2% for the nanosphere- and nanocube-based nanofluids, respectively, at the same filler loading. This is consistent with a percolation mechanism in which a higher aspect ratio is beneficial for thermal conductivity enhancement. To overcome the surface oxidation of the copper nanomaterials and maintain the dispersion stability, we employed polyvinylpyrrolidone (PVP) as a dispersant and ascorbic acid as an antioxidant in the nanofluid formulations. The thermal performance of the optimized fluid formulations could be sustained for multiple heating-cooling cycles while retaining stability over 1000 h.
Orientation-Dependent Soft Plasmonics of Gold Nanobipyramid Plasmene Nanosheets
Publisher: American Chemical Society (ACS)
Date: 18-12-2021
Single-crystal caged gold nanorods with tunable broadband plasmon resonances
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CC45506H
Abstract: We report on the synthesis and characterization of single-crystal caged gold nanorods (CGNRs) which exhibited broadband plasmonic resonances. Redshift of plasmon resonance can be realized by increasing the length, whereas blueshift can be achieved by increasing either the overall width of the cage or the thickness of nanocage walls.
Poly(: N -isopropylacrylamide) capped plasmonic nanoparticles as resonance intensity-based temperature sensors with linear correlation
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7TC04051B
Abstract: Under aggregation-free conditions, linear relationships between longitudinal plasmonic peak intensity and temperature have been revealed for poly( N -isopropylacrylamide)-capped gold nanorods and nanobipyramids.
Effect of Organic Modification on Multiwalled Carbon Nanotube Dispersions in Highly Concentrated Emulsions
Publisher: American Chemical Society (ACS)
Date: 11-04-2019
Colloid Chemical Approach to Nanoelectrode Ensembles with Highly Controllable Active Area Fraction
Publisher: American Chemical Society (ACS)
Date: 25-06-2002
DOI: 10.1021/AC025661O
Abstract: A novel "bottom-up" approach to highly controllable nanoelectrode ensembles (NEEs) has been developed using colloidal nanoparticle self-assembly techniques. This solution-based strategy allows flexible control over nanoelectrode size, shape, and interspacing of the as-prepared NEEs. Atomic force microscopy (AFM) was proved to be a powerful tool to monitor the NEE topography, which yields parameters that can be used to calculate the fractional nanoelectrode area of the NEEs. AFM, ac impedance, and cyclic voltammetry studies demonstrate that most of nanoelectrodes on the NEEs (at least by 9-min self-assembly) are not diffusionally isolated under conventional ac frequency range and scan rates. As a result, the NEEs behave as "nanoelectrode-patch" assemblies. Besides, the as-prepared NEEs by different self-assembling times show an adjustable sensitivity to heterogeneous electron-transfer kinetics, which may be helpful to sensor applications. Like these NEEs constructed by other techniques, the present NEEs prepared by chemical self-assembly also exhibit the enhancement of electroanalytical detection limit consistent with NEE theory prediction.
Nanowire‐Based Soft Wearable Human–Machine Interfaces for Future Virtual and Augmented Reality Applications
Publisher: Wiley
Date: 02-2021
Abstract: A virtual world has now become a reality as augmented reality (AR) and virtual reality (VR) technology become commercially available. Similar to how humans interact with the physical world, AR and VR systems rely on human–machine interface (HMI) sensors to interact with the virtual world. Currently, this is achieved via state of‐the‐art wearable visual and auditory tools that are rigid, bulky, and burdensome, thereby causing discomfort during practical application. To this end, a skin sensory interface has the potential to serve as the next‐generation AR/VR technology because skin‐like wearable sensors have advantages in that they can be ultrathin, ultra‐soft, conformal, and imperceptible, which provides the ultimate comfort and immersive experience for users. In this progress report, nanowire‐based soft wearable HMI sensors including acoustic, strain, pressure sensors, and physiological sensors are reviewed that may be adopted as skin sensory inputs in future AR/VR systems. Further, nanowire‐based soft contact lenses, haptic force, and thermal and vibration actuators are covered as potential means of feedback for future AR/VR systems. Considering the possible effects of the virtual world on human health, skin‐like wearable artery pulses, glucose, and lactate sensors are also described, which may enable imperceptible health monitoring during future AR/VR practices.
Soft, Disruptive and Wearable Electrochemical Biosensors
Publisher: Bentham Science Publishers Ltd.
Date: 07-2022
DOI: 10.2174/1573411017666210706154521
Abstract: Soft wearable electrochemical biosensors are attracting increasing attention over the past several years due to their potential for non-invasive personalized health monitoring in real-time and in-situ. Herein, we cover the design, fabrication, and applications of soft electrochemical sensing systems. Firstly, we describe key design requirements for fabricating the mechanically compliant electrochemical biosensors. This is followed by a narration of typical sensor configurations and the detecting methodologies. Next, on-body soft electrochemical biosensing and cell/tissue-based “wearable” sensing applications are summarized. Detection of key biochemical markers, including metabolites (glucose, lactate, uric acid and ethanol), electrolytes (Na+ and K+), nutrients (vitamin C), hormones (cortisol) and proteins (TNF-α), as well as cellular signalling molecules (nitric oxide, hydrogen peroxide and serotonin), is the focus of the discussion in this review. We conclude the review with discussions on future opportunities and challenges of the soft and wearable electrochemical biosensors.
Stretchable gold fiber-based wearable electrochemical sensor toward pH monitoring
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TB02477H
Abstract: A stretchable gold fiber-based wearable electrochemical pH two-electrodes sensing system for human health monitoring.
Mechanically Strong, Optically Transparent, Giant Metal Superlattice Nanomembranes From Ultrathin Gold Nanowires
Publisher: Wiley
Date: 18-09-2012
Abstract: Metallic membranes of about 2.5 nm thick but with macroscopic lateral dimensions have been successfully fabricated from ultrathin gold nanowires. Such metallic nanomembranes are transparent, conductive and mechanically strong, with an optical transmittance of 90-97%, an electrical resistance of ∼1142 kΩ sq(-1) , and a breaking strength of ∼14 N m(-1) with a typical atomic force microscope probe.
Free‐Standing 2D Nanoassemblies
Publisher: Wiley
Date: 19-07-2019
A Facile Ion-Doping Strategy To Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics
Publisher: American Chemical Society (ACS)
Date: 26-12-2017
DOI: 10.1021/JACS.7B11114
Abstract: Integration of multiple therapeutic/diagnostic modalities into a single system holds great promise to improve theranostic efficiency for tumors, but still remains a technical challenge. Herein, we report a new multimodal theranostic nanoconstruct based on Fe-doped polydiaminopyridine nanofusiforms, built easily and on a large scale, which can dual-regulate intracellular oxygen and glutathione levels, transport iron ions, and simultaneously be used for thermal imaging and magnetic resonance imaging. Co-loading of dihydroartemisinin and methylene blue generates a superior multifunctional theranostic agent with enhanced photochemotherapy efficiency and biodegradability, leading to almost complete destruction of tumors with near-infrared light irradiation. This represents an attractive route to develop multimodal anticancer theranostics.
Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB01891J
Abstract: We coupled the photothermal and thermoresponsive properties in one nanoplatform by wrapping AuNRs@mSiO 2 with thermoresponsive lipid bilayer.
Pd-conformally coated, one-end-embedded gold nanowire percolation network for intrinsically stretchable, epidermal tattoo fuel cell
Publisher: Elsevier BV
Date: 02-2023
DOI: 10.1016/J.BIOS.2022.114924
Abstract: Soft, conformal and wearable epidermal fuel cells may offer promising energy solutions to power next-generation on-skin electronics on-demand anytime anywhere. However, it is non-trivial to design intrinsically stretchable electrode in order to maintain the fuel cell performance under real-world and dynamic mechanical deformations. Here, we present a tattoo-like epidermal fuel cell based on Pd conformally-coated, one-end-embedded percolation gold nanowire (EP-AuNW/EP-AuPdNW) networks, which are in essence the combination of in-plane percolation conductivity and out-plane anisotropic conductivity. Both EP-AuNW and EP-AuPdNW are intrinsically stretchable conductors for anode and cathode in fuel cell. Compared to non-conformal counterparts, a 6-times greater power density was achieved for conformal system. Importantly, EP-NW based fuel cell can function under various mechanical deformations including stretching, compression, bending, and twisting the power density showed negligible changes to the tensile strain up to ∼50% and could maintain its 75% performance even under 80% strain. Furthermore, a dragon-tattoo epidermal fuel cell was fabricated, demonstrating on-demand power generation with real-world ethanol sources.
A wearable and highly sensitive pressure sensor with ultrathin gold nanowires
Publisher: Springer Science and Business Media LLC
Date: 04-02-2014
DOI: 10.1038/NCOMMS4132
Abstract: Ultrathin gold nanowires are mechanically flexible yet robust, which are novel building blocks with potential applications in future wearable optoelectronic devices. Here we report an efficient, low-cost fabrication strategy to construct a highly sensitive, flexible pressure sensor by sandwiching ultrathin gold nanowire-impregnated tissue paper between two thin polydimethylsiloxane sheets. The entire device fabrication process is scalable, enabling facile large-area integration and patterning for mapping spatial pressure distribution. Our gold nanowires-based pressure sensors can be operated at a battery voltage of 1.5 V with low energy consumption (<30 μW), and are able to detect pressing forces as low as 13 Pa with fast response time ( 1.14 kPa(-1)) and high stability (>50,000 loading-unloading cycles). In addition, our sensor can resolve pressing, bending, torsional forces and acoustic vibrations. The superior sensing properties in conjunction with mechanical flexibility and robustness enabled real-time monitoring of blood pulses as well as detection of small vibration forces from music.
Two- and Three-Dimensional Au Nanoparticle/CoTMPyP Self-Assembled Nanotructured Materials: Film Structure, Tunable Electrocatalytic Activity, and Plasmonic Properties
Publisher: American Chemical Society (ACS)
Date: 17-11-2004
DOI: 10.1021/JP0466237
Resistive electronic skin
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7TC01169E
Abstract: Devices made from traditional conductive bulk materials using complex microfabrication methods often are restricted to being rigid and in some cases, flexible but not strethcable.
Transparent gold nano-membranes for the enhanced light trapping of the indium tin oxide films
Publisher: The Optical Society
Date: 17-01-2014
DOI: 10.1364/OME.4.000321
Spontaneous Fractal Aggregation of Gold Nanoparticles and Controlled Generation of Aggregate-Based Fractal Networks at Air/Water Interface
Publisher: American Chemical Society (ACS)
Date: 24-09-2005
DOI: 10.1021/JP052255A
Abstract: The spontaneous fractal aggregation of as-prepared cetytrimethylammonium bromide (CTAB)-capped gold nanoparticles was found to happen at the air/water interface after spreading their chloroform solution on water surfaces. Aided by Langmuir-Blodgett techniques, these fractal aggregates can be interconnected with each other to form aggregate-based fractal networks.
NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression
Publisher: Public Library of Science (PLoS)
Date: 10-10-2016
Enhanced enzymatic degradation resistance of plasmid DNA in ionic liquids
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA05518K
Abstract: Buffered ionic liquids can substantially enhance enzymatic degradation resistance of plasmid DNA, indicating the potential to serve as next-generation biological storage buffer at ambient temperature.
A Wearable Second Skin‐Like Multifunctional Supercapacitor with Vertical Gold Nanowires and Electrochromic Polyaniline
Publisher: Wiley
Date: 04-12-2018
Stretchable‐Fiber‐Confined Wetting Conductive Liquids as Wearable Human Health Monitors
Publisher: Wiley
Date: 18-04-2016
Matryoshka-caged gold nanorods: Synthesis, plasmonic properties, and catalytic activity
Publisher: Springer Science and Business Media LLC
Date: 22-01-2016
2D Binary Plasmonic Nanoassemblies with Semiconductor n/p‐Doping‐Like Properties
Publisher: Wiley
Date: 14-05-2018
Abstract: The electronic, optical, thermal, and magnetic properties of an extrinsic bulk semiconductor can be finely tuned by adjusting its dopant concentration. Here, it is demonstrated that such a doping concept can be extended to plasmonic nanomaterials. Using two-dimensional (2D) assemblies of Au@Ag and Au nanocubes (NCs) as a model system, detailed experimental and theoretical studies are carried out, which reveal collective semiconductor n -doping-like plasmonic properties. A threshold doping concentration of Au@Ag NCs is observed, below which p-doping dominates and above which n-doping prevails. Furthermore, Au@Ag NC dopants can be converted into corresponding Au seed "voids" dopants by selectively removing Ag without changing the overall structural integrity. The results show that the plasmonic doping concept may serve as a general design principle guiding synthesis and assembly of plasmonic metamaterials for programmable optoelectronic devices.
Plasmene nanosheets as optical skin strain sensors
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NH00393J
Abstract: A plasmonic skin has been demonstrated with an elastomer-supported, highly ordered, and closely packed plasmonic nanocrystal array (plasmene).
Two-dimensional bipyramid plasmonic nanoparticle liquid crystalline superstructure with four distinct orientational packing orders
Publisher: American Chemical Society (ACS)
Date: 08-01-2016
Abstract: Anisotropic plasmonic nanoparticles have been successfully used as constituent elements for growing ordered nanoparticle arrays. However, orientational control over their spatial ordering remains challenging. Here, we report on a self-assembled two-dimensional (2D) nanoparticle liquid crystalline superstructure (NLCS) from bipyramid gold nanoparticles (BNPs), which showed four distinct orientational packing orders, corresponding to horizontal alignment (H-NLCS), circular arrangement (C-NLCS), slanted alignment (S-NLCS), and vertical alignment (V-NLCS) of constituent particle building elements. These packing orders are characteristic of the unique shape of BNPs because all four packing modes were observed for particles with various sizes. Nevertheless, only H-NLCS and V-NLCS packing orders were observed for the free-standing ordered array nanosheets formed from a drying-mediated self-assembly at the air/water interface of a sessile droplet. This is due to strong surface tension and the absence of particle-substrate interaction. In addition, we found the collective plasmonic coupling properties mainly depend on the packing type, and characteristic coupling peak locations depend on particle sizes. Interestingly, surface-enhanced Raman scattering (SERS) enhancements were heavily dependent on the orientational packing ordering. In particular, V-NLCS showed the highest Raman enhancement factor, which was about 77-fold greater than the H-NLCS and about 19-fold greater than C-NLCS. The results presented here reveal the nature and significance of orientational ordering in controlling plasmonic coupling and SERS enhancements of ordered plasmonic nanoparticle arrays.
Tunable Broadband Optical Responses of Substrate-Supported Metal/Dielectric/Metal Nanospheres
Publisher: Springer Science and Business Media LLC
Date: 27-02-2014
Free-standing nanoparticle superlattice sheets controlled by DNA
Publisher: Springer Science and Business Media LLC
Date: 03-05-2009
DOI: 10.1038/NMAT2440
Abstract: Free-standing nanoparticle superlattices (suspended highly ordered nanoparticle arrays) are ideal for designing metamaterials and nanodevices free of substrate-induced electromagnetic interference. Here, we report on the first DNA-based route towards monolayered free-standing nanoparticle superlattices. In an unconventional way, DNA was used as a 'dry ligand' in a microhole-confined, drying-mediated self-assembly process. Without the requirement of specific Watson-Crick base-pairing, we obtained discrete, free-standing superlattice sheets in which both structure (inter-particle spacings) and functional properties (plasmonic and mechanical) can be rationally controlled by adjusting DNA length. In particular, the edge-to-edge inter-particle spacing for monolayered superlattice sheets can be tuned up to 20 nm, which is a much wider range than has been achieved with alkyl molecular ligands. Our method opens a simple yet efficient avenue towards the assembly of artificial nanoparticle solids in their ultimate thickness limit--a promising step that may enable the integration of free-standing superlattices into solid-state nanodevices.
Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NR07831H
Abstract: Despite widespread availability of cytotoxic chemotherapeutic agents, the killing of tumour cells without affecting healthy surrounding tissue remains elusive, although recent developments in terms of plasmonic nanoparticles capable of photothermal killing have some promise. Here we describe novel DNA aptamer-tethered gold nanorods (GNRs) that act as efficient photothermal therapeutics against tumour cells, but not their isogenic normal cell counterparts. A modified Cell-SELEX process was developed to select a novel DNA aptamer (KW16-13) that specifically recognised and was internalised by cells of the MCF10CA1h human breast ductal carcinoma line but not by those of its isogenic normal counterpart (MCF10A). GNRs conjugated to KW16-13 were readily internalized by the MCF10CA1h tumour cells with minimal uptake by MCF10A normal cells. Upon near infrared (NIR) light irradiation, tumour cell death of >96%, could be effected, compared to 71-fold tumor cell death than GNRs-targeted with a previously described aptamer. This demonstrates the significant potential for aptamer functionalised-GNRs to be used effective and above all selective anti-cancer photothermal therapeutics.
Manufacturable Conducting Rubber Ambers and Stretchable Conductors from Copper Nanowire Aerogel Monoliths
Publisher: American Chemical Society (ACS)
Date: 29-05-2014
DOI: 10.1021/NN502702A
Abstract: We report on a low-cost, simple yet efficient strategy to fabricate ultralightweight aerogel monoliths and conducting rubber ambers from copper nanowires (CuNWs). A trace amount of poly(vinyl alcohol) (PVA) substantially improved the mechanical robustness and elasticity of the CuNW aerogel while maintaining a high electrical conductivity. The resistivity was highly responsive to strains manifesting two distinct domains, and both followed a power law function consistent with pressure-controlled percolation theory. However, the values of the exponents were much less than the predicted value for 3D systems, which may be due to highly porous structures. Remarkably, the CuNW-PVA aerogels could be further embedded into PDMS resin, forming conducting rubber ambers. The ambers could be further manufactured simply by cutting into any arbitrary 1D, 2D, and 3D shapes, which were all intrinsically conductive without the need of external prewiring, a condition required in the previous aerogel-based conductors. The outstanding electrical conductivity in conjunction with high mechanical compliance enabled prototypes of the elastic piezoresistivity switches and stretchable conductors.
Metallic Nanoparticles as Advanced Electrocatalysts
Publisher: American Scientific Publishers
Date: 08-2012
Self-assembly and characterization of 2D plasmene nanosheets
Publisher: Springer Science and Business Media LLC
Date: 16-08-2019
DOI: 10.1038/S41596-019-0200-4
Abstract: Freestanding plasmonic nanoparticle (NP) superlattice sheets are novel 2D nanomaterials with tailorable properties that enable their use for broad applications in sensing, anticounterfeit measures, ionic gating, nanophotonics and flat lenses. We recently developed a robust, yet general, two-step drying-mediated approach to produce freestanding monolayer, plasmonic NP superlattice sheets, which are typically held together by holey grids with minimal solid support. Within these superlattices, NP building blocks are closely packed and have strong plasmonic coupling interactions hence, we termed such freestanding materials 'plasmene nanosheets'. Using the desired NP building blocks as starting material, we describe the detailed fabrication protocol, including NP surface functionalization by thiolated polystyrene and the self-assembly of NPs at the air-water interface. We also discuss various characterization approaches for checking the quality and optical properties of the as-obtained plasmene nanosheets: optical microscopy, spectrophotometry, transmission/scanning electron microscopy (TEM/SEM) and atomic force microscopy (AFM). With regard to different constituent building blocks, the key experimental parameters, including NP concentration and volume, are summarized to guide the successful fabrication of specific types of plasmene nanosheets. This protocol, from initial NP synthesis to the final fabrication and characterization, takes ~33.5 h.
Size Effect on Failure of Pre-stretched Free-Standing Nanomembranes
Publisher: Springer Science and Business Media LLC
Date: 15-05-2010
Free-Standing Bilayered Nanoparticle Superlattice Nanosheets with Asymmetric Ionic Transport Behaviors
Publisher: American Chemical Society (ACS)
Date: 22-10-2015
Abstract: Natural cell membranes can directionally and selectively regulate the ion transport, which is critical for the functioning of living cells. Here, we report on the fabrication of an artificial membrane based on an asymmetric nanoparticle superlattice bilayered nanosheet, which exhibits similar ion transport characteristics. The superlattice nanosheets were fabricated via a drying-mediated self-assembly of polystyrene-capped gold nanoparticles at the liquid-air interface. By adopting a layer-by-layer assembly process, an asymmetric nanomembrane could be obtained consisting of two nanosheets with different nanoparticle size. The resulting nanomembranes exhibit an asymmetric ion transport behavior, and diode-like current-voltage curves were observed. The asymmetric ion transport is attributed to the cone-like nanochannels formed within the membranes, upon which a simulation map was established to illustrate the relationship between the channel structure and the ionic selectivity, in consistency with our experimental results. Our superlattice nanosheet-based design presents a promising strategy for the fabrication of next-generation smart nanomembranes for rationally and selectively regulating the ion transport even at a large ion flux, with potential applications in a wide range of fields, including biosensor devices, energy conversion, biophotonics, and bioelectronics.
Substrate-Mediated Broadband Tunability in Plasmonic Resonances of Metal Nanoantennas on Finite High-Permittivity Dielectric Substrate
Publisher: Springer Science and Business Media LLC
Date: 26-05-2015
Local Crack‐Programmed Gold Nanowire Electronic Skin Tattoos for In‐Plane Multisensor Integration
Publisher: Wiley
Date: 25-08-2019
Abstract: Sensitive, specific, yet multifunctional tattoo-like electronics are ideal wearable systems for "any time, any where" health monitoring because they can virtually become parts of the human skin, offering a burdenless "unfeelable" wearing experience. A skin-like, multifunctional electronic tattoo made entirely from gold using a standing enokitake-mushroom-like vertically aligned nanowire membrane in conjunction with a programmable local cracking technology is reported. Unlike previous multifunctional systems, only a single material type is needed for the integrated gold circuits involved in interconnects and multiplexed specific sensors, thereby avoiding the use of complex multimaterials interfaces. This is possiblebecause the programmable local cracking technology allows for the arbitrary fine-tuning of the properties of elastic gold conductors from strain-insensitive to highly strain-sensitive simply by adjusting localized crack size, shape, and orientations-a capability impossible to achieve with previous bulk cracking technology. Furthermore, in-plane integration of strain ressure sensors, anisotropic orientation-specific sensors, strain-insensitive stretchable interconnects, temperature sensors, glucose sensors, and lactate sensors without the need of soldering or gluing are demonstrated. This strategy opens a new general route for the design of next-generation wearable electronic tattoos.
Effect of Incorporation of Multiwalled Carbon Nanotubes on the Microstructure and Flow Behavior of Highly Concentrated Emulsions
Publisher: American Chemical Society (ACS)
Date: 19-10-2018
Recent progress in stretchable supercapacitors
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA03988G
Abstract: This review summarizes recent developments in stretchable supercapacitors for applications in future wearable electronics.
Hairy gold nanorods: gold nanowire growth on nanosubstrates [Invited]
Publisher: Optica Publishing Group
Date: 08-01-2020
Abstract: We report on the synthesis of a new metallic nanoarchitecture, namely, hairy gold nanorods that were carefully designed and engineered the seed-mediated growth of gold nanowires on the sub-nanometer scale gold nanorod substrate. The thickness of the gold nanowires grown could be tuned from 5 to 9 nm by controlling the ratio of HAuCl 4 to 4-Mercaptobenzoic acid (MBA) from 2.5 to 25 while the length of gold nanowires could be controlled between 47 nm to 15 µm by varying the concentration of silica coated gold nanorod in the gold solution. The high-aspect-ratio hairy gold nanowires tethered to concentric gold nanorod could be used for fabrication of soft flexible high performance resistive strain sensors and soft surface-enhanced Raman scattering substrate.
A Janus gold nanowire electrode for stretchable micro-supercapacitors with distinct capacitances
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TA03664D
Abstract: Enokitake-like gold nanowires are used to fabricate stretchable micro-supercapacitors, showing discriminative capacitive features.
Softening gold for elastronics
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8CS00609A
Abstract: This review covers the latest research progress of “softening” gold materials for various applications in elastronics.
Machine learning based temperature prediction of poly(: N -isopropylacrylamide)-capped plasmonic nanoparticle solutions
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CP04544A
Abstract: Machine learning techniques can predict the solution temperature of thermosensitive polymer-capped nanoparticle solutions to within 1 °C of accuracy.
Free-Standing Plasmonic-Nanorod Superlattice Sheets
Publisher: American Chemical Society (ACS)
Date: 28-12-2011
DOI: 10.1021/NN204498J
Abstract: The self-assembly of monodisperse inorganic nanoparticles into highly ordered arrays (superlattices) represents an exciting route to materials and devices with new functions. It allows programming their properties by varying the size, shape, and composition of the nanoparticles, as well as the packing order of the assemblies. While substantial progress has been achieved in the fabrication of superlattice materials made of nanospheres, limited advances have been made in growing similar materials with anisotropic building blocks, which is particularly true for free-standing two-dimensional superlattices. In this paper, we report the controlled growth of free-standing, large-area, monolayered gold-nanorod superlattice sheets by polymer ligands in an entropy-driven interfacial self-assembly process. Furthermore, we experimentally characterize the plasmonic properties of horizontally aligned sheets (H-sheets) and vertically aligned sheets (V-sheets) and show that observed features can be well described using a theoretical model based on the discrete-dipole approximation. Our polymer-ligand-based strategy may be extended to other anisotropic plasmonic building blocks, offering a robust and inexpensive avenue to plasmonic nanosheets for various applications in nanophotonic devices and sensors.
Nanocomposite films containing Au nanoparticles formed by electrochemical reduction of metal ions in the multilayer films as electrocatalyst for dioxygen reduction
Publisher: Elsevier BV
Date: 04-2005
Toward Soft Skin‐Like Wearable and Implantable Energy Devices
Publisher: Wiley
Date: 17-07-2017
Building plasmonic nanostructures with DNA
Publisher: Springer Science and Business Media LLC
Date: 17-04-2011
Abstract: Plasmonic structures can be constructed from precise numbers of well-defined metal nanoparticles that are held together with molecular linkers, templates or spacers. Such structures could be used to concentrate, guide and switch light on the nanoscale in sensors and various other devices. DNA was first used to rationally design plasmonic structures in 1996, and more sophisticated motifs have since emerged as effective and versatile species for guiding the assembly of plasmonic nanoparticles into structures with useful properties. Here we review the design principles for plasmonic nanostructures, and discuss how DNA has been applied to build finite-number assemblies (plasmonic molecules), regularly spaced nanoparticle chains (plasmonic polymers) and extended two- and three-dimensional ordered arrays (plasmonic crystals).
Studies of electrochemical quantized capacitance charging of surface ensembles of silver nanoparticles
Publisher: Elsevier BV
Date: 05-2002
Freestanding ultrathin nano-membranes via self-assembly
Publisher: Elsevier BV
Date: 12-2009
Nanoparticle-Modified Electrode with Size- and Shape-Dependent Electrocatalytic Activities
Publisher: American Chemical Society (ACS)
Date: 20-02-2013
DOI: 10.1021/LA304616K
Abstract: The size, shape, composition, and crystalline structures of noble metal nanoparticles are the key parameters in determining their electrocatalytic performance. Here, we report on a robust chemical-tethering approach to immobilizing gold nanoparticles onto transparent indium tin oxide (ITO) glass electrode surfaces to systematically investigate their size- and shape-dependent electrocatalysis toward a methanol oxidation reaction (MOR) and an oxygen reduction reaction (ORR). Monodisperse 20 nm nanospheres (NS20s), 45 nm nanospheres (NS45s), and 20 nm × 63 nm nanorods (NRs), which could be chemically tethered to ITO-surface-forming submonolayers without any aggregation, were synthesized. These nanoparticle-modified ITO electrodes exhibited strong electrocatalytic activities toward MOR and ORR, but their mass current densities were highly dependent on the particle sizes and shapes. For particles with similar shapes, the size determined the mass current densities: smaller particle sizes led to greater catalytic current densities per unit mass because of the greater surface-to-volume ratio (NS20s > NS45s). For particles with comparable sizes, the shape or crystalline structure governed the selectivity of the electrocatalytic reactions: NS45 exhibited a higher mass current density in MOR than did NRs because its dominant (111) facets were exposed, whereas NRs exhibited a higher mass current density in ORR because its dominant (100) facets were exposed.
Design of Stretchable Holey Gold Biosensing Electrode for Real-Time Cell Monitoring
Publisher: American Chemical Society (ACS)
Date: 22-09-2020
Extensional viscosity of copper nanowire suspensions in an aqueous polymer solution
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5SM01940K
Abstract: Novel microfluidic experiments enabled the measurement of extensional viscosities of copper nanowire suspensions and their complex buffer, whose characterisation is essential for the development of advanced inkjet applications.
Tattoolike polyaniline microparticle-doped gold nanowire patches as highly durable wearable sensors
Publisher: American Chemical Society (ACS)
Date: 26-08-2015
Abstract: Wearable and highly sensitive strain sensors are essential components of electronic skin for future biomonitoring and human machine interfaces. Here we report a low-cost yet efficient strategy to dope polyaniline microparticles into gold nanowire (AuNW) films, leading to 10 times enhancement in conductivity and ∼8 times improvement in sensitivity. Simultaneously, tattoolike wearable sensors could be fabricated simply by a direct "draw-on" strategy with a Chinese penbrush. The stretchability of the sensors could be enhanced from 99.7% to 149.6% by designing curved tattoo with different radius of curvatures. We also demonstrated roller coating method to encapusulate AuNWs sensors, exhibiting excellent water resistibility and durability. Because of improved conductivity of our sensors, they can directly interface with existing wireless circuitry, allowing for fabrication of wireless flexion sensors for a human finger-controlled robotic arm system.
Cell Sheet-Like Soft Nanoreactor Arrays
Publisher: Wiley
Date: 14-12-2022
Abstract: Tissues, which consist of groups of closely packed cell arrays, are essentially sheet‐like biosynthesis plants. In tissues, in idual cells are discrete microreactors working under highly viscous and confined environments. Herein, soft polystyrene‐encased nanoframe (PEN) reactor arrays, as analogous nanoscale “sheet‐like chemosynthesis plants”, for the controlled synthesis of novel nanocrystals, are reported. Although the soft polystyrene (PS) is only 3 nm thick, it is elastic, robust, and permeable to aqueous solutes, while significantly slowing down their diffusion. PEN‐associated palladium (Pd) crystallization follows a diffusion‐controlled zero‐order kinetics rather than a reaction‐controlled first‐order kinetics in bulk solution. Each in idual PEN reactor has a volume in the zeptoliter range, which offers a unique confined environment, enabling a directional inward crystallization, in contrast to the conventional outward nucleation/growth that occurs in an unconfined bulk solution. This strategy makes it possible to generate a set of mono‐, bi‐, and trimetallic, and even semiconductor nanocrystals with tunable interior structures, which are difficult to achieve with normal systems based on bulk solutions.
A gold nanowire-integrated soft wearable system for dynamic continuous non-invasive cardiac monitoring
Publisher: Elsevier BV
Date: 06-2022
DOI: 10.1016/J.BIOS.2022.114072
Abstract: Blood pressure (BP) is a cardiovascular parameter which exhibits significant variability. Whilst continuous BP monitoring would be of significant clinical utility. This is particularly challenging outside the hospital environment. New wearable cuff-based and cuffless BP monitoring technologies provide some capacity, however they have a number of limitations including bulkiness, rigidity and discomfort, poor accuracy and motion artefact. Here, we report on a lightweight, user-friendly, non-invasive wearable cardiac sensing system based on deformation-insensitive conductive gold nanowire foam (G-foam) and pressure-sensitive resistive gold nanowire electronic skin (G-skin). The G-foam could serve as a new soft dry bioelectrode for electrocardiogram (ECG) monitoring a new soft button-based G-skin design could avoid manual holding for continuous pulse recording. They could be integrated seamlessly with everyday bandage for facile wireless recording of ECG and artery pulses under real-word dynamic environments including walking, running, deep squatting, and jogging. Further machine learning algorithm was developed for estimation of systolic and diastolic BP, showing comparable accuracy to commercial cuff-based sphygmomanometer. The measured dynamic BP changes correlated well with the volunteer's daily activities, indicating the potential applications of our soft wearable systems for real-time diagnostics of cardiovascular functions in complex dynamic real-world setting.
Soft piezoresistive pressure sensing matrix from copper nanowires composite aerogel
Publisher: Elsevier BV
Date: 10-2016
Dual-Coded Plasmene Nanosheets as Next-Generation Anticounterfeit Security Labels
Publisher: Wiley
Date: 09-2015
Plasmonic core–shell nanoparticles for SERS detection of the pesticide thiram: size- and shape-dependent Raman enhancement
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4NR06429A
Abstract: We systematically investigated the size- and shape-dependent SERS activities of plasmonic core-shell nanoparticles towards detection of the pesticide thiram. Monodisperse Au@Ag nanocubes (NCs) and Au@Ag nanocuboids (NBs) were synthesized and their Ag shell thickness was precisely adjusted from ∼1 nm to ∼16 nm. All these nanoparticles were used as SERS substrates for thiram detection, and the Raman intensities with three different lasers (514 nm, 633 nm and 782 nm) were recorded and compared. Our results clearly show that: (1) the excitation wavelength discriminated particle shapes regardless of particle sizes, and the maximized Raman enhancement was observed when the excitation wavelength approaches the SERS peak (provided there is significant local electric field confinement on the plasmonic nanostructures at that wavelength) (2) at the optimized laser wavelength, the maximum Raman enhancement was achieved at a certain threshold of particle size (or silver coating thickness). By exciting particles at their optimized sizes with the corresponding optimized laser wavelengths, we achieved a detection limit of roughly around 100 pM and 80 pM for NCs and NBs, respectively.
Vertically Aligned Gold Nanowires as Stretchable and Wearable Epidermal Ion-Selective Electrode for Noninvasive Multiplexed Sweat Analysis
Publisher: American Chemical Society (ACS)
Date: 18-02-2020
Site-specific Ag coating on concave Au nanoarrows by controlling the surfactant concentration
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8NH00431E
Abstract: Three distinct site-specific Ag-coated Au nanoarrows are achieved by simply controlling the CTAC concentration of growth solution and analyzed with electron microscopy as well as elemental mapping. The CTAC concentration-dependent, facet-specific passivation represents a new strategy to design particle morphology as well as composition.
Hierarchically Structured Vertical Gold Nanowire Array-Based Wearable Pressure Sensors for Wireless Health Monitoring
Publisher: American Chemical Society (ACS)
Date: 19-07-2019
Abstract: We have recently demonstrated that vertically aligned gold nanowires (v-AuNWs) are outstanding material candidates for wearable biomedical sensors toward real-time and noninvasive health monitoring because of their excellent tunable electrical conductivity, biocompatibility, chemical inertness, and wide electrochemical window. Here, we show that v-AuNWs could also be used to design a high-performance wearable pressure sensor when combined with rational structural engineering such as pyramid microarray-based hierarchical structures. The as-fabricated pressure sensor featured a low operation voltage of 0.1 V, high sensitivity in a low-pressure regime, a fast response time of <10 ms, and high durability with stable signals for the 10 000 cycling test. In conjunction with printed electrode arrays, we could generate a multiaxial map for spatial pressure detection. Furthermore, our flexible pressure sensor could be seamlessly connected with a Bluetooth low-energy module to detect high-quality artery pulses in a wireless manner. Our solution-based gold coating strategy offers the benefit of conformal coating of nanowires onto three-dimensional microstructured elastomeric substrates under ambient conditions, indicating promising applications in next-generation wearable biodiagnostics.
Nucleic Acid Engineering
Publisher: Wiley
Date: 15-04-2009
Mosquito-inspired design of resistive antennae for ultrasensitive acoustic detection
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2NR01622B
Abstract: A mosquito-inspired 1D acoustic sensor is reported, comprising repeating soft joints (cracked Pt film) and rigid segments (non-cracked Pt film). By adjusting the joint positions and densities, we can fine-tune the acoustic sensing performance.
Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain
Publisher: Elsevier BV
Date: 09-2015
DOI: 10.1016/J.NUCMEDBIO.2015.05.001
Abstract: The purpose of this study was to compare two amyloid imaging agents, [(11)C]BF227 and [(18)F]FACT (derivative from [(11)C]BF227) through quantitative pharmacokinetics analysis in human brain. Positron emission tomography studies were performed on six elderly healthy control (HC) subjects and seven probable Alzheimer's disease (AD) patients with [(11)C]BF227 and 10 HC subjects and 10 probable AD patients with [(18)F]FACT. Data from nine regions of interest were analyzed by several approaches, namely non-linear least-squared fitting methods with arterial input functions (one-tissue compartment model(1TCM), two-tissue compartment model (2TCM)), Logan plot, and linearized methods with reference region (Reference Logan plot (RefLogan), MRTM0, MRTM2). We also evaluated SUV and SUVR for both tracers. The parameters estimated by several approaches were compared between two tracers for detectability of differences between HC and AD patients. For [(11)C]BF227, there were no significant difference of VT (2TCM, 1TCM) and SUV in all regions (Student t-test p<0.05) and significant differences in the DVRs (Logan, RefLogan, and MRTM2) and SUVRs in six neocortical regions (p<0.05) between the HC and AD groups. For [(18)F]FACT, significant differences in DVRs (RefLogan, MRTM0, and MRTM2) were observed in more than four neocortical regions between the HC and AD groups (p<0.05), and the significant differences were found in SUVRs for two neocortical regions (inferior frontal coretex and lateral temporal coretex). Our results showed that both tracers can clearly distinguish between HC and AD groups although the pharmacokinetics and distribution patterns in brain for two tracers were substantially different. This study revealed that although the PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT have similar chemical and biological properties, they have different pharmacokinetics, and caution must be paid for usage of the tracers.
On-demand bioenergy from a fingertip
Publisher: Elsevier BV
Date: 10-2021
Wearable Smart Bandage-Based Bio-Sensors
Publisher: MDPI AG
Date: 06-04-2023
DOI: 10.3390/BIOS13040462
Abstract: Bandage is a well-established industry, whereas wearable electronics is an emerging industry. This review presents the bandage as the base of wearable bioelectronics. It begins with introducing a detailed background to bandages and the development of bandage-based smart sensors, which is followed by a sequential discussion of the technical characteristics of the existing bandages, a more practical methodology for future applications, and manufacturing processes of bandage-based wearable biosensors. The review then elaborates on the advantages of basing the next generation of wearables, such as acceptance by the customers and system approvals, and disposal.
Optically resonant magneto-electric cubic nanoantennas for ultra-directional light scattering
Publisher: AIP Publishing
Date: 24-02-2015
DOI: 10.1063/1.4907536
Abstract: Cubic dielectric nanoparticles are promising candidates for futuristic low-loss, ultra-compact, nanophotonic applications owing to their larger optical coefficients, greater packing density, and relative ease of fabrication as compared to spherical nanoparticles besides possessing negligible heating at nanoscale in contrast to their metallic counterparts. Here, we present the first theoretical demonstration of azimuthally symmetric, ultra-directional Kerker's-type scattering of simple dielectric nanocubes in visible and near-infrared regions via simultaneous excitation and interference of optically induced electric- and magnetic-resonances up to quadrupolar modes. Unidirectional forward-scattering by in idual nanocubes is observed at the first generalized-Kerker's condition for backward-scattering suppression, having equal electric- and magnetic-dipolar responses. Both directionality and magnitude of these unidirectional-scattering patterns get enhanced where matching electric- and magnetic-quadrupolar responses spectrally overlap. While preserving azimuthal-symmetry and backscattering suppression, a nanocube homodimer provides further directionality improvement for increasing interparticle gap, but with reduced main-lobe magnitude due to emergence of side-scattering lobes from diffraction-grating effect. We thoroughly investigate the influence of interparticle gap on scattering patterns and propose optimal range of gap for minimizing side-scattering lobes. Besides suppressing undesired side-lobes, significant enhancement in scattering magnitude and directionality is attained with increasing number of nanocubes forming a linear chain. Optimal directionality, i.e., the narrowest main-scattering lobe, is found at the wavelength of interfering quadrupolar resonances whereas the largest main-lobe magnitude is observed at the wavelength satisfying the first Kerker's condition. These unique optical properties of dielectric nanocubes thus can revolutionize their applications at visible and near-infrared regions in the fields of nanoantennas, nanolasers, photovoltaics, and even in biomedicine.
Conformal coating of CdS onto flexible enokitake-like standing gold nanowire arrays for omnidirectional low-light-intensity photocatalysis
Publisher: Elsevier BV
Date: 04-2023
Inhibited fragmentation of mAbs in buffered ionic liquids
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC01877C
Abstract: Choline-based buffered ionic liquids have been demonstrated to greatly inhibit enzymatic degradation of antibodies, and are promising as next-generation biological buffers.
Probing Soft Corona Structures of DNA-Capped Nanoparticles by Small Angle Neutron Scattering
Publisher: American Chemical Society (ACS)
Date: 05-08-2015
Mechanically-gated electrochemical ionic channels with chemically modified vertically aligned gold nanowires
Publisher: Elsevier BV
Date: 11-2021
Bioreducible PEI-functionalized glycol chitosan: A novel gene vector with reduced cytotoxicity and improved transfection efficiency
Publisher: Elsevier BV
Date: 11-2016
DOI: 10.1016/J.CARBPOL.2016.07.080
Abstract: Non-viral gene delivery has been well recognised as a potential way to address the main safety limitations of viral gene carriers. A new redox-responsive PEI derivative was designed, synthesized and evaluated for non-viral delivery applications of GFP DNA. Glycol chitosan was covalently attached to highly branched LMW PEI via bio-cleavable disulfide bonds to synthesize a new redox-responsive gene carrier (GCS-ss-PEI). Results showed the enhanced buffering capacity of GCS-ss-PEI, 43.1%, compared to the buffering capacities of both LMW PEI and HMW PEI, 23.2% and 31.5%, respectively, indicating more likely endosomal escape of the entrapped gene for GCS-ss-PEI. Moreover, electrophoretic gel retardation assay, performed to investigate the binding strength of GCS-ss-PEI to GFP DNA, showed stronger complexation with GFP DNA in GCS-ss-PEI at non-GSH condition. Employing GCS and incorporation of disulfide bonds in the structure of the PEI-based gene carrier resulted in improved redox-responsivity, reduced toxicity, enhanced endosomal escape and GFP DNA transfection. The facilitated intracellular gene release along with excellent redox-responsive characteristics and dropped cytotoxicity suggests the potential of GCS-ss-PEI as a candidate for developing highly efficient and safe gene vectors.
A pH-responsive asymmetric lipid vesicle as drug carrier
Publisher: Informa UK Limited
Date: 02-10-2016
DOI: 10.1080/02652048.2016.1242668
Abstract: In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.
Percolating Network of Ultrathin Gold Nanowires and Silver Nanowires toward “Invisible” Wearable Sensors for Detecting Emotional Expression and Apexcardiogram
Publisher: Wiley
Date: 02-05-2017
Lightweight, flexible, nanorod electrode with high electrocatalytic activity
Publisher: Elsevier BV
Date: 02-2013
Patterning Vertically Grown Gold Nanowire Electrodes for Intrinsically Stretchable Organic Transistors
Publisher: Wiley
Date: 24-10-2018
Large-Scale Self-Assembly and Stretch-Induced Plasmonic Properties of Core–Shell Metal Nanoparticle Superlattice Sheets
Publisher: American Chemical Society (ACS)
Date: 06-11-2014
DOI: 10.1021/JP508108A
Ultrathin Plasmene Nanosheets as Soft and Surface‐Attachable SERS Substrates with High Signal Uniformity
Publisher: Wiley
Date: 09-03-2015
Crystalline Gibbs Monolayers of DNA-Capped Nanoparticles at the Air–Liquid Interface
Publisher: American Chemical Society (ACS)
Date: 12-09-2011
DOI: 10.1021/NN202383B
Abstract: Using grazing-incidence small-angle X-ray scattering in a special configuration (parallel SAXS, or parSAXS), we mapped the crystallization of DNA-capped nanoparticles across a sessile droplet, revealing the formation of crystalline Gibbs monolayers of DNA-capped nanoparticles at the air-liquid interface. We showed that the spatial crystallization can be regulated by adjusting both ionic strength and DNA sequence length and that a modified form of the Daoud-Cotton model could describe and predict the resulting changes in interparticle spacing. Gibbs monolayers at the air-liquid interface provide an ideal platform for the formation and study of equilibrium nanostructures and may afford exciting routes toward the design of programmable 2D plasmonic materials and metamaterials.
Fine-tuning longitudinal plasmon resonances of nanorods by thermal reshaping in aqueous media
Publisher: IOP Publishing
Date: 21-02-2012
DOI: 10.1088/0957-4484/23/10/105602
Abstract: Metallic nanoparticles that support surface plasmons are potential building units for future nanophotonic circuits, metamaterials, high-density optical data storage, etc. Many of these applications require the ability to 'dial-up' the desired plasmonic resonance modes and frequencies with high precision. Here, we demonstrate a thermal reshaping route that can be used to tailor longitudinal plasmon resonance energies of gold nanorods almost continuously from ~800 to ~560 nm. The longitudinal plasmon resonance wavelength exhibits an exponential decay function of the thermal annealing time at a given temperature. This correlates with the transmission electron microscopy characterization (TEM) which showed that the nanorod aspect ratio decreases exponentially with time, accompanying a gradual shape transformation from rod to sphere. The exponential decay half-time decreases with increasing annealing temperatures, with a value of 1.43 × 10(5) s at 50 °C down to 0.02 × 10(5) s at 100 °C. Our experimental results show that the shape transformation could be attributed to desorption of silver ions and side facet-binding Ag-Br-CTA ligands, which therefore promote the side growth leading to nanorod fattening. Compared to other synthetic methodologies to tune plasmonics, our thermal reshaping approach presents a straightforward paradigm for precisely tailoring plasmon resonance energy with a single parameter.
Multiscale Soft–Hard Interface Design for Flexible Hybrid Electronics
Publisher: Wiley
Date: 29-08-2019
Abstract: Emerging next‐generation soft electronics will require versatile properties functioning under mechanical compliance, which will involve the use of different types of materials. As a result, control over material interfaces (particularly soft/hard interfaces) has become crucial and is now attracting intensive worldwide research efforts. A series of material and structural interface designs has been devised to improve interfacial adhesion, preventing failure of electromechanical properties under mechanical deformation. Herein, different soft/hard interface design strategies at multiple length scales in the context of flexible hybrid electronics are reviewed. The crucial role of soft ligands and/or polymers in controlling the morphologies of active nanomaterials and stabilizing them is discussed, with a focus on understanding the soft/hard interface at the atomic/molecular scale. Larger nanoscopic and microscopic levels are also discussed, to scrutinize viable intrinsic and extrinsic interfacial designs with the purpose of promoting adhesion, stretchability, and durability. Furthermore, the macroscopic device/human interface as it relates to real‐world applications is analyzed. Finally, a perspective on the current challenges and future opportunities in the development of truly seamlessly integrated soft wearable electronic systems is presented.
A Stretchable Gold Nanowire Sensor and Its Characterization Using Machine Learning for Motion Tracking
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2021
Vertical Gold Nanowires Stretchable Electrochemical Electrodes
Publisher: American Chemical Society (ACS)
Date: 11-10-2018
DOI: 10.1021/ACS.ANALCHEM.8B03423
Abstract: Conventional electrodes produced from gold or glassy carbon are outstanding electrochemical platforms for biosensing applications due to their chemical inertness and wide electrochemical window, but are intrinsically rigid and planar in nature. Hence, it is challenging to seamlessly integrate them with soft and curvilinear biological tissues for real-time wearable or implantable electronics. In this work, we demonstrate that vertically gold nanowires (v-AuNWs) possess an enokitake-like structure, with the nanoparticle (head) on one side and nanowires (tail) on the opposite side of the structure, and can serve as intrinsically stretchable, electrochemical electrodes due to the stronger nanowire-elastomer bonding forces preventing from interfacial delamination under strains. The exposed head side of the electrode comprising v-AuNWs can achieve a detection limit for H
Skin inspired fractal strain sensors using a copper nanowire and graphite microflake hybrid conductive network
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6NR04056J
Abstract: This work demonstrates a facile "paint-on" approach to fabricate highly stretchable and highly sensitive strain sensors by combining one-dimensional copper nanowire networks with two-dimensional graphite microflakes. This paint-on approach allows for the fabrication of electronic skin (e-skin) patches which can directly replicate with high fidelity the human skin surface they are on, regardless of the topological complexity. This leads to high accuracy for detecting biometric signals for applications in personalised wearable sensors. The copper nanowires contribute to high stretchability and the graphite flakes offer high sensitivity, and their hybrid coating offers the advantages of both. To understand the topological effects on the sensing performance, we utilized fractal shaped elastomeric substrates and systematically compared their stretchability and sensitivity. We could achieve a high stretchability of up to 600% and a maximum gauge factor of 3000. Our simple yet efficient paint-on approach enabled facile fine-tuning of sensitivity/stretchability simply by adjusting ratios of 1D vs. 2D materials in the hybrid coating, and the topological structural designs. This capability leads to a wide range of biomedical sensors demonstrated here, including pulse sensors, prosthetic hands, and a wireless ankle motion sensor.
A Moss‐Inspired Electroless Gold‐Coating Strategy Toward Stretchable Fiber Conductors by Dry Spinning
Publisher: Wiley
Date: 30-10-2018
One‐Dimensional Nanomaterials for Soft Electronics
Publisher: Wiley
Date: 30-12-2016
Unconventional Janus Properties of Enokitake-like Gold Nanowire Films
Publisher: American Chemical Society (ACS)
Date: 26-07-2018
Abstract: We report on unconventional Janus material properties of vertically aligned gold nanowire films that conduct electricity and interact with light and water in drastically different ways on its two opposing sides. These Janus-like properties originate from enokitake-like nanowire structures, causing the nanoparticle side ("head") to behave like bulk gold, yet the opposing nanowire side ("tail") behaves as discontinuous nanophases. Due to this Janus film structure, its head side is hydrophilic but its tail side is hydrophobic its head side reflects light like bulk gold, yet its tail side is a broadband superabsorber its tail side is less conductive but with tunable resistance. More importantly, the elastomer-bonded Janus film exhibits unusual mechatronic properties when being stretched, bent, and pressed. The tail-bonded elastomeric sheet can be stretched up to ∼800% strain while remaining conductive, which is about 10-fold that of head-bonded film. In addition, it is also more sensitive to bending forces and point loads than the corresponding tail-bonded film. We further demonstrate the versatility of nanowire-based Janus films for pressure sensors using bilayer structures in three different assembly layouts.
Ultra-sensitive photon sensor based on self-assembled nanoparticle plasmonic membrane resonator
Publisher: IEEE
Date: 2016
Power generation for wearable systems
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0EE03911J
Abstract: The mechanisms, figures of merit, and systems for wearable power generation are reviewed in this article. Future perspectives lie in breakthrough technologies of fiber electronics, fully printable, flexible SoC, and IoT-enabled self-awareness systems.
Free-Standing Polymer–Nanoparticle Superlattice Sheets Self-Assembled at the Air–Liquid Interface
Publisher: American Chemical Society (ACS)
Date: 03-10-2011
DOI: 10.1021/CG200867A
Shape Transformation of Constituent Building Blocks within Self-Assembled Nanosheets and Nano-origami
Publisher: American Chemical Society (ACS)
Date: 05-01-2018
Abstract: Self-assembly of nanoparticles represents a simple yet efficient route to synthesize designer materials with unusual properties. However, the previous assembled structures whether by surfactants, polymer, or DNA ligands are "static" or "frozen" building block structures. Here, we report the growth of transformable self-assembled nanosheets which could enable reversible switching between two types of nanosheets and even evolving into erse third generation nanosheet structures without losing pristine periodicity. Such in situ transformation of nanoparticle building blocks can even be achieved in a free-standing two-dimensional system and three-dimensional origami. The success in such in situ nanocrystal transformation is attributed to robust "plant-cell-wall-like" ion-permeable reactor arrays from densely packed polymer ligands, which spatially define and confine nanoscale nucleation/growth/etching events. Our strategy enables efficient fabrication of nanocrystal nanosheets with programmable building blocks for innovative applications in adaptive tactile metamaterials, optoelectronic devices, and sensors.
Enokitake Mushroom-like Standing Gold Nanowires toward Wearable Noninvasive Bimodal Glucose and Strain Sensing
Publisher: American Chemical Society (ACS)
Date: 28-02-2019
Abstract: We have recently demonstrated that Enokitake mushroom-like gold with nanoparticles as the "head" and nanowires as the "tail" could grow directly on elastomeric substrates, which are extremely stretchable electrodes that can be used as wearable sensors for detecting strain and pressure. In this work, we show that such electrodes can also be used as intrinsically stretchable glucose biosensors. By modifying the vertical gold nanowire electrodes with glucose oxidase and Prussian blue nanoparticles, a limit of detection of 10 μM, sensitivity of 23.72 μA·mM
High performance acetone sensor based on ZnO nanorods modified by Au nanoparticles
Publisher: Elsevier BV
Date: 08-2019
Unveiling ultrasharp scattering–switching signatures of layered gold–dielectric–gold nanospheres
Publisher: The Optical Society
Date: 11-07-2013
Highly Stretchable and Strain-Insensitive Fiber-Based Wearable Electrochemical Biosensor to Monitor Glucose in the Sweat
Publisher: American Chemical Society (ACS)
Date: 22-04-2019
DOI: 10.1021/ACS.ANALCHEM.9B00152
Abstract: Development of high-performance fiber-shaped wearable sensors is of great significance for next-generation smart textiles for real-time and out-of-clinic health monitoring. The previous focus has been mainly on monitoring physical parameters such as pressure and strains associated with human activities. Development of an enzyme-based non-invasive wearable electrochemical sensor to monitor biochemical vital signs of health such as the glucose level in sweat has attracted increasing attention recently, due to the unmet clinical needs for the diabetic patients. To achieve this, the key challenge lies in the design of a highly stretchable fiber with high conductivity, facile enzyme immobilization, and strain-insensitive properties. Herein, we demonstrate an elastic gold fiber-based three-electrode electrochemical platform that can meet the aforementioned criteria toward wearable textile glucose biosensing. The gold fiber could be functionalized with Prussian blue and glucose oxidase to obtain the working electrode and modified by Ag/AgCl to serve as the reference electrode and the nonmodified gold fiber could serve as the counter electrode. The as-fabricated textile glucose biosensors achieved a linear range of 0-500 μM and a sensitivity of 11.7 μA mM
Soft gold nanowire sponge antenna for battery-free wireless pressure sensors
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0NR07621J
Abstract: The past decade has witnessed growing interest in developing soft wearable pressure sensors with the ultimate goal of transforming today's hospital-centered diagnosis to tomorrow's patient-centered bio-diagnosis.
Iodine‐Induced Gold‐Nanoparticle Fusion/Fragmentation/Aggregation and Iodine‐Linked Nanostructured Assemblies on a Glass Substrate
Publisher: Wiley
Date: 27-01-2003
Electronic Skins Based on Liquid Metals
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2019
A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly.
Publisher: Springer Science and Business Media LLC
Date: 25-11-2022
DOI: 10.1038/S41467-022-34860-Y
Abstract: Time-lapse mechanical properties of stem cell derived cardiac organoids are important biological cues for understanding contraction dynamics of human heart tissues, cardiovascular functions and diseases. However, it remains difficult to directly, instantaneously and accurately characterize such mechanical properties in real-time and in situ because cardiac organoids are topologically complex, three-dimensional soft tissues suspended in biological media, which creates a mismatch in mechanics and topology with state-of-the-art force sensors that are typically rigid, planar and bulky. Here, we present a soft resistive force-sensing diaphragm based on ultrasensitive resistive nanocracked platinum film, which can be integrated into an all-soft culture well via an oxygen plasma-enabled bonding process. We show that a reliable organoid-diaphragm contact can be established by an ‘Atomic Force Microscope-like’ engaging process. This allows for instantaneous detection of the organoids’ minute contractile forces and beating patterns during electrical stimulation, resuscitation, drug dosing, tissue culture, and disease modelling.
Highly Stretchable Fiber-Shaped Supercapacitors Based on Ultrathin Gold Nanowires with Double-Helix Winding Design
Publisher: American Chemical Society (ACS)
Date: 15-11-2018
Abstract: The ability of developing highly durable fiber-shaped electronic devices is crucial for next-generation smart textile electronics. Past several years have witnessed encouraging progress made in stretchable fiber-shaped supercapacitors using carbon materials, transition metal oxides, and conducting polymers. Here, we report a dry-spun strategy to produce scalable ultrathin gold nanowire-based fibers, which can lead to highly stretchable fiber-based supercapacitors using a double-helix winding design. Hildebrand's and Hansen's solubility parameters of gold nanowire-binding oleylamine ligands match those of styrene-ethylene/butylene-styrene and tetrahydrofuran, enabling the formation of high-quality dry-spun fibers. In conjunction with conductivity enhancement by electroless plating and pseudocapacitance by polyaniline, we obtained fiber-shaped supercapacitors stretchable up to 360% with a capacitance of 16.80 mF cm
Hierarchically resistive skins as specific and multimetric on-throat wearable biosensors
Publisher: Springer Science and Business Media LLC
Date: 27-04-2023
Fine‐Tuning Au@Pd Nanocrystals for Maximum Plasmon‐Enhanced Catalysis
Publisher: Wiley
Date: 23-12-2021
Giant Plasmene Nanosheets, Nanoribbons, and Origami
Publisher: American Chemical Society (ACS)
Date: 02-10-2014
DOI: 10.1021/NN504615A
Abstract: We introduce Plasmene- in analogy to graphene-as free-standing, one-particle-thick, superlattice sheets of nanoparticles ("meta-atoms") from the "plasmonic periodic table", which has implications in many important research disciplines. Here, we report on a general bottom-up self-assembly approach to fabricate giant plasmene nanosheets (i.e., plasmene with nanoscale thickness but with macroscopic lateral dimensions) as thin as ∼40 nm and as wide as ∼3 mm, corresponding to an aspect ratio of ∼75,000. In conjunction with top-down lithography, such robust giant nanosheets could be milled into one-dimensional nanoribbons and folded into three-dimensional origami. Both experimental and theoretical studies reveal that our giant plasmene nanosheets are analogues of graphene from the plasmonic nanoparticle family, simultaneously possessing unique structural features and plasmon propagation functionalities.
Multicompartmentalized vesosomes containing DOX loaded liposomes and 5FU loaded liposomes for synergistic tumor treatment
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9NJ00238C
Abstract: A multicompartmentalized vesosome drug delivery system was developed for enhanced cancer treatments.
Ultralow-density copper nanowire aerogel monoliths with tunable mechanical and electrical properties
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3TA10969K
Biological stability and activity of siRNA in ionic liquids
Publisher: Royal Society of Chemistry (RSC)
Date: 05-09-2014
DOI: 10.1039/C4CC05086J
Abstract: We report substantially enhanced biological stability of siRNA in a hydrated ionic liquid (IL) based on buffered choline dihydrogen phosphate (CDP). The results show that hydrated CDP IL substantially prolongs the shelf-life of siRNA for up to three months in the presence of RNase A. Remarkably, siRNA stored in the IL remained active and eGFP siRNA exhibited clear gene knockdown effects in eGFP-expressing HeLa cells.
Multifunctional nanoarchitectures from DNA-based ABC monomers
Publisher: Springer Science and Business Media LLC
Date: 03-05-2009
Active strain engineering of soft plasmene nanosheets by thermoresponsive hydrogels
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC02709C
Abstract: Integration of soft plasmene nanosheets with thermoresponsive hydrogel enables omnidirectional strain engineering that leads to the dynamic manipulation of their plasmonic property by programming temperature.
Soft gold nanowire sponges for strain-insensitive conductors, wearable energy storage and catalytic converters
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC04080D
Abstract: We present a solution-based strategy to fabricate a gold nanowire sponge. This gold sponge is a multifunctional smart material, which can serve as a strain-insensitive conductor, a deformable supercapacitor and a recyclable 3D porous catalyst.
Dual effect of F-actin targeted carrier combined with antimitotic drug on aggressive colorectal cancer cytoskeleton: Allying dissimilar cell cytoskeleton disrupting mechanisms
Publisher: Elsevier BV
Date: 11-2016
DOI: 10.1016/J.IJPHARM.2016.09.056
Abstract: A recent approach to colon cancer therapy is to employ selective drugs with specific extra/intracellular sites of action. Alteration of cytoskeletal protein reorganization and, subsequently, to cellular biomechanical behaviour during cancer progression highly affects the cancer cell progress. Hence, cytoskeleton targeted drugs are an important class of cancer therapy agents. We have studied viscoelastic alteration of the human colon adenocarcinoma cell line, SW48, after treatment with a drug delivery system comprising chitosan as the carrier and albendazole as the microtubule-targeting agent (MTA). For the first time, we have evaluated the biomechanical characteristics of the cell line, using the micropipette aspiration (MA) method after treatment with drug delivery systems. Surprisingly, employing a chitosan-albendazole pair, in comparison with both neat materials, resulted in more significant change in the viscoelastic parameters of cells, including the elastic constants (K
Highly stretchy black gold e-skin nanopatches as highly sensitive wearable biomedical sensors
Publisher: Wiley
Date: 18-03-2015
Ultraflexible plasmonic nanocomposite aerogel
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1RA00532D
Seagrass-inspired design of soft photocatalytic sheets based on hydrogel-integrated free-standing 2D nanoassemblies of multifunctional nanohexagons
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1MH00753J
Abstract: A novel soft artificial seagrass-like 2D photocatalytic system is demonstrated by designing hydrogel-integrated Au–Pd–CdS multifunctional nanohexagon assemblies for flexible omnidirectional solar-to-chemical conversion.
Real-Time and In-Situ Monitoring of H2O2 Release from Living Cells by a Stretchable Electrochemical Biosensor Based on Vertically Aligned Gold Nanowires
Publisher: American Chemical Society (ACS)
Date: 24-09-2019
DOI: 10.1021/ACS.ANALCHEM.9B02610
Abstract: Traditional electrochemical biosensing electrodes (e.g., gold disk, glassy carbon electrode, etc.) can undergo sophisticated design to detect chemicals/biologicals from cells. However, such electrodes are typically rigid and nonstretchable, rendering it challenging to detect cellular activities in real-time and in situ when cells are in mechanically deformed states. Here, we report a new stretchable electrochemical cell-sensing platform based on vertically aligned gold nanowires embedded in PDMS (v-AuNWs/PDMS). Using H
Multilayered core–satellite nanoassemblies with fine-tunable broadband plasmon resonances
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4NR06756H
Abstract: We report on a robust nanotemplating approach to synthesize plasmonic multilayered core-satellite (MCS) nanoassemblies. Templated with gold nanorods, ultrathin Au/Ag alloy cages and satellite gold nanoparticles can be constructed sequentially by galvanic replacement reactions and electrostatic self-assembly, respectively, forming structurally well-defined MCS. The MCS nanoassemblies exhibit strong broadband plasmon resonances from ∼440 to ∼1100 nm, and their resonant features can be fine-tuned by adjusting the size and number density of satellite nanoparticles and by adjusting the thickness of the silica spacer between cage and satellite particles. Such fine-engineered MCS nanoassemblies enable precise programming of the strength and distribution of "hot spots" to maximize the overall enhancement of surface enhanced Raman scattering.
Synthesis and Self-Assembly of Cetyltrimethylammonium Bromide-Capped Gold Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 10-2003
DOI: 10.1021/LA034818K
A location- and sharpness-specific tactile electronic skin based on staircase-like nanowire patches
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NH00125A
Abstract: A new stretchable tactile electronic skin sensor that could sense touch, location and sharpness is presented.
Self-assembled gold nanorime mesh conductors for invisible stretchable supercapacitors
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR04256J
Abstract: Supercapacitors with high areal capacitance, high mechanical stretchability, and high optical transparency are achieved simultaneously using novel self-assembled gold nanorime mesh structures.
Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces
Publisher: American Chemical Society (ACS)
Date: 29-04-2015
DOI: 10.1021/ACS.ANALCHEM.5B00328
Abstract: We report on self-assembled nanocube-based plasmene nanosheets as new surface-enhanced Raman scattering (SERS) substrates toward direct identification of a trace amount of drugs sitting on topologically complex real-world surfaces. The uniform nanocube arrays (superlattices) led to low spatial SERS signal variances (∼2%). Unlike conventional SERS substrates which are based on rigid nanostructured metals, our plasmene nanosheets are mechanically soft and optically semitransparent, enabling conformal attachment to real-world solid surfaces such as banknotes for direct SERS identification of drugs. Our plasmene nanosheets were able to detect benzocaine overdose down to a parts-per-billion (ppb) level with an excellent linear relationship (R(2) > 0.99) between characteristic peak intensity and concentration. On banknote surfaces, a detection limit of ∼0.9 × 10(-6) g/cm(2) benzocaine could be achieved. Furthermore, a few other drugs could also be identified, even in their binary mixtures with our plasmene nanosheets. Our experimental results clearly show that our plasmene sheets represent a new class of unique SERS substrates, potentially serving as a versatile platform for real-world forensic drug identification.
Adaptive DNA-based materials for switching, sensing, and logic devices
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0JM03854G
Free‐Standing 1D Assemblies of Plasmonic Nanoparticles
Publisher: Wiley
Date: 29-05-2013
Abstract: A simple yet effective method to generate free-standing 1D assemblies of gold nanoparticles by a combined top-down and bottom-up approach in conjunction with superhydrophobicity-directed fluid drying is reported. The free-standing nanoparticle assemblies can be as thin ca. 45 nm and as long as ca. 30 μm, yet mechanically strong without collapsing when held at one end. Furthermore, the 1D nanoparticle assemblies could be used as plasmonic waveguides.
Intrinsically Stretchable Fuel Cell Based on Enokitake‐Like Standing Gold Nanowires
Publisher: Wiley
Date: 28-11-2020
Covalent-Cross-Linked Plasmene Nanosheets
Publisher: American Chemical Society (ACS)
Date: 30-05-2019
Abstract: Thiol-polystyrene (SH-PS)-capped plasmonic nanoparticles can be fabricated into free-standing, one-nanoparticle-thick superlattice sheets (termed plasmene) based on physical entanglement between ligands, which, however, suffer from irreversible dissociation in organic solvents. To address this issue, we introduce coumarin-based photo-cross-linkable moieties to the SH-PS ligands to stabilize gold nanoparticles. Once cross-linked, the obtained plasmene nanosheets consisting of chemically locked nanoparticles can well maintain structural integrity in organic solvents. Particularly, arising from ligand-swelling-induced enlargement of the interparticle spacing, these plasmene nanosheets show significant optical responses to various solvents in a specific as well as reversible manner, which may offer an excellent material for solvent sensing and dynamic plasmonic display.
Codelivery of doxorubicin and sodium tanshinone IIA sulfonate using multicompartmentalized vesosomes to enhance synergism and prevent doxorubicin-induced cardiomyocyte apoptosis
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB01136B
Abstract: Doxorubicin, one of the most effective antitumor drugs, causes serious adverse cardiac effects.
Effect of number density on optimal design of gold nanoshells for plasmonic photothermal therapy
Publisher: The Optical Society
Date: 05-12-2012
DOI: 10.1364/BOE.4.000015
Correction: Systematic investigation of the SERS efficiency and SERS hotspots in gas-phase deposited Ag nanoparticle assemblies
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CP90136D
Abstract: Correction for ‘Systematic investigation of the SERS efficiency and SERS hotspots in gas-phase deposited Ag nanoparticle assemblies’ by L. B. He et al. , Phys. Chem. Chem. Phys. , 2017, 19 , 5091–5101.
Synthesis of tellurium nanorods via spontaneous oxidation of NaHTe at room temperature
Publisher: Elsevier BV
Date: 09-2004
Technology Roadmap for Flexible Sensors
Publisher: American Chemical Society (ACS)
Date: 09-03-2023
A multifunctional biomimetic hybrid nanocarrier for the controlled delivery of chemotherapy drugs by near-infrared light
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8NJ05879B
Abstract: We have constructed a biocompatible magnetic nanoparticle-based nanocomposite material by integrating the features of Fe 3 O 4 nanoparticles, mesoporous silica and lipid bilayer for the treatment of tumor.
DNA based strategy to nanoparticle superlattices
Publisher: Elsevier BV
Date: 05-2014
DOI: 10.1016/J.YMETH.2014.01.017
Abstract: Over more than 20 years of development has led to the substantial progress made in the wet chemical synthesis of elementary nanoparticle building blocks including metal nanoparticles, quantum dots, and magnetic particles. However, it remains challenging to rationally assemble them into well-defined molecule-like architectures. DNA was first used to program nanomaterials synthesis in 1996, and more recently highly-ordered structures have emerged, including finite-number assemblies (nanoparticle molecules), regularly spaced nanoparticle chains (nanoparticle polymers) and extended two- and three-dimensional ordered arrays (nanoparticle superlattices). In this review, we largely focus on the use of DNA to grow nanoparticle superlattices. First, typical synthetic approaches and characterization methodologies for monodisperse nanoparticle building blocks used in DNA-based nanoparticle superlattices are described secondly, the viable conjugation and characterization methods are discussed finally, the three representative self-assembly strategies are introduced in detail.
Direct Imaging of Liquid–Nanoparticle Interfaces with Atom Probe Tomography
Publisher: American Chemical Society (ACS)
Date: 07-08-2020
A Review on Epidermal Nanogenerators: Recent Progress of the Future Self‐Powered Skins
Publisher: Wiley
Date: 22-05-2022
Abstract: Epidermal nanogenerators (ENGs), defined as nano‐enabled, thin, soft, and flexible skin‐like devices that can convert mechanical and thermal energy into electricity, are emerging as a promising self‐powered technology for wearable biomedical devices. This review covers the discussion of working mechanisms, design strategy, and major requirements of the state‐of‐the‐art ENGs including piezoelectric, triboelectric, pyroelectric, and hybrid. In addition, their representative applications in human–machine interface (HMI), wound healing, and wearable biomedical sensors are described. In particular, a focus has been on the narration of self‐powered ENG‐based biosensors for detecting physical, biochemical, and physiological signals. Despite the encouraging advances over the past decade, the field of ENGs remains in the early stage of development with limited real‐world adoption. There remain a number of challenges such as insufficient energy and power density for powering wearable devices, poor air permeability, limited washability, and durability under severe conditions. The future opportunity lies at the development of better materials and/or designs to tackle these challenges to generate real‐world impact.
Thermoresponsive chiral plasmonic nanoparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1NR08343K
Abstract: Poly( N -isopropylacrylamide) (PNIPAM) has been used to modify chiral plasmonic nanoparticles. The thermoresponsive studies reveal the impact of achiral dielectric nanoenvironment on chiral plasmonic responses.
Mimosa‐Inspired Design of a Flexible Pressure Sensor with Touch Sensitivity
Publisher: Wiley
Date: 12-12-2014
Abstract: A bio-inspired flexible pressure sensor is generated with high sensitivity (50.17 kPa(-1)), quick responding time (<20 ms), and durable stability (negligible loading-unloading signal changes over 10 000 cycles). Notably, the key resource of surface microstructures upon sensor substrates results from the direct molding of natural mimosa leaves, presenting a simple, environment-friendly and easy scale-up fabrication process for these flexible pressure sensors.
Site-Selective Self-assembly of MPA-Bridged CuHCF Multilayers on APTMS-Supported Gold Colloid Electrodes
Publisher: American Chemical Society (ACS)
Date: 07-06-2003
DOI: 10.1021/CM021052L
3D Sponge Electrodes for Soft Wearable Bioelectronics
Publisher: Wiley
Date: 18-08-2023
Abstract: By definition, a sponge refers to a soft and porous material, which is typically made from cellulose or synthetic polymers. Structurally, it is 3D offering a high surface‐to‐volume ratio mechanically, it is elastic and durable economically, it is inexpensive and can be produced at industrial scales. These attributes promote a strong research interest in exploring 3D sponges for applications in absorption, separation, catalysis, and electronics. This work is dedicated to the discussion of the recent progress in design of mechanically deformable sponge electrodes for their application in soft electronics. First, the characteristics and advantages of sponge electrodes are described, which is followed by the discussion of various active materials for fabricating 3D sponge electrodes, including carbon, metal, conductive polymers, MXenes, and their hybrids. Then, the viable fabrication methodologies are reviewed by comparing their advantages and disadvantages. Furthermore, the applications of 3D conductive sponges in stretchable conductors, sensors, energy storage devices, and integrated systems are discussed. Finally, the challenges and opportunities in future sponge‐based soft electronics are covered.
Key parameters governing metallic nanoparticle electrocatalysis
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5NR02298C
Abstract: Engineering metallic nanoparticles constitutes a powerful route to design next-generation electrocatalysts to be used in future energy and environmental industries. In this mini review, we cover recent advances in metallic nanoparticle electrocatalysis, with a focus on understanding how the parameters such as particle sizes, crystalline structures, shapes, compositions, nanoscale alloying and interfaces influence their electrocatalytic activity and selectivity. In addition, this review highlights viable approaches for fabrication of nanoparticle-based electrocatalytic electrodes and discusses their influences on the overall catalytic performances. Finally, we discuss the opportunities and challenges ahead to program these key parameters to achieve highly durable designer electrocatalysts in future.
Multiplexed detection of cancer biomarkers using a microfluidic platform integrating single bead trapping and acoustic mixing techniques
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR06367B
Abstract: The integration of acoustic micromixing and single bead trapping enables the identification of fluorescent signals from multiple biomarkers within minutes.
Black Gold: Broadband, High Absorption of Visible Light for Photochemical Systems
Publisher: Wiley
Date: 28-11-2017
2D Freestanding Janus Gold Nanocrystal Superlattices
Publisher: Wiley
Date: 09-05-2019
Abstract: 2D freestanding nanocrystal superlattices represent a new class of advanced metamaterials in that they can integrate mechanical flexibility with novel optical, electrical, plasmonic, and magnetic properties into one multifunctional system. The freestanding 2D superlattices reported to date are typically constructed from symmetrical constituent building blocks, which have identical structural and functional properties on both sides. Here, a general ligand symmetry-breaking strategy is reported to grow 2D Janus gold nanocrystal superlattice sheets with nanocube morphology on one side yet with nanostar on the opposite side. Such asymmetric metallic structures lead to distinct wetting and optical properties as well as surface-enhanced Raman scattering (SERS) effects. In particular, the SERS enhancement of the nanocube side is about 20-fold of that of the nanostar side, likely due to the combined "hot spot + lightening-rod" effects. This is nearly 700-fold of SERS enhancement as compared with the symmetric nanocube superlattices without Janus structures.
High-adhesion vertically aligned gold nanowire stretchable electrodes: Via a thin-layer soft nailing strategy
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9NH00336C
Abstract: A stretchable electrode is a crucial component in future elastronics ( i.e. stretchable electronics) with implications in soft actuators, healthcare monitoring, and robotics to name a few.
Fractal Gold Nanoframework for Highly Stretchable Transparent Strain-Insensitive Conductors
Publisher: American Chemical Society (ACS)
Date: 16-05-2018
DOI: 10.1021/ACS.NANOLETT.8B00694
Abstract: Percolation networks of one-dimensional (1D) building blocks (e.g., metallic nanowires or carbon nanotubes) represent the mainstream strategy to fabricate stretchable conductors. One of the inherent limitations is the control over junction resistance between 1D building blocks in natural and strained states of conductors. Herein, we report highly stretchable transparent strain-insensitive conductors using fractal gold (F-Au) nanoframework based on a one-pot templateless wet chemistry synthesis method. The monolayered F-Au nanoframework (∼20 nm in thickness) can be obtained from the one-pot synthesis without any purification steps involved and can be transferred directly to arbitrary substrates like polyethylene terephthalate, food-wrap, polydimethylsiloxane (PDMS), and ecoflex. The F-Au thin film with no capping agents leads to a highly conductive thin film without any post-treatment and can be stretched up to 110% strain without significantly losing conductivity yet with the optical transparency of 70% at 550 nm. Remarkably, the F-Au thin film shows the strain-insensitive behavior up to 20% stretching strain. This originates from the unique fractal nanomesh-like structure which can absorb external mechanical forces, thus maintaining electron pathways throughout the nanoframework. In addition, a semitransparent bilayered F-Au film on 100% prestrained PDMS could achieve to a high stretchability of 420% strain with negligible resistance changes under low-level strains.
DNA‐based plasmonic nanoarchitectures: from structural design to emerging applications
Publisher: Wiley
Date: 24-07-2012
DOI: 10.1002/WNAN.1184
Abstract: Plasmonic nanoarchitectures refer to the well-defined groupings of elementary metallic nanoparticle building blocks. Such nanostructures have a plethora of technical applications in diagnostics, energy-harvesting, and nanophotonic circuits, to name a few. Nevertheless, it remains challenging to construct plasmonic nanoarchitectures at will inexpensively. Bottom-up self-assembly is promising to overcome these limitations, but such methods often produce defects and low-yields. For these purposes, DNA has emerged as a powerful nanomaterial beyond its genetic function in biology to either program or template synthesis of plasmonic nanostructures, or act as a ligand to mediate large-area self-assembly. In conjunction with top-down lithography, DNA-based strategies can afford excellent control over internal and overall structures of plasmonic nanoarchitectures. In this review, we outline the representative methodologies for building various well-defined plasmonic nanoarchitectures and cover their recent exciting applications.
Disruptive, Soft, Wearable Sensors
Publisher: Wiley
Date: 13-11-2019
Abstract: The wearable industry is on the rise, with a myriad of technical applications ranging from real-time health monitoring, the Internet of Things, and robotics, to name but a few. However, there is a saying "wearable is not wearable" because the current market-available wearable sensors are largely bulky and rigid, leading to uncomfortable wearing experience, motion artefacts, and poor data accuracy. This has aroused a world-wide intensive research quest for novel materials, with the aim of fabricating next-generation ultra-lightweight and soft wearable devices. Such disruptive second-skin-like biosensing technologies may enable a paradigm shift from current wearable 1.0 to future wearable 2.0 products. Here, the state-of-the-art progress made in the key phases for future wearable technology, namely, wear → sense → communicate → analyze → interpret → decide, is summarized. Without a doubt, materials innovation is the key, which is the main focus of the discussion. In addition, emphasis is also given to wearable energy, multicomponent integration, and wireless communication.
Copper Nanowire‐Filled Soft Elastomer Composites for Applications as Thermal Interface Materials
Publisher: Wiley
Date: 10-07-2017
A General Approach to Free-Standing Nanoassemblies via Acoustic Levitation Self-Assembly
Publisher: American Chemical Society (ACS)
Date: 10-04-2019
Abstract: Droplets suspended by acoustic levitation provide genuine substrate-free environments for understanding unconventional fluid dynamics, evaporation kinetics, and chemical reactions by circumventing solid surface and boundary effects. Using a fully levitated air-water interface by acoustic levitation in conjunction with drying-mediated nanoparticle self-assembly, here, we demonstrate a general approach to fabricating free-standing nanoassemblies, which can totally avoid solid surface effects during the entire process. This strategy has no limitation for the sizes or shapes of constituent metallic nanoparticle building blocks and can also be applied to fabricate free-standing bilayered and trilayered nanoassemblies or even three-dimensional hollow nanoassemblies. We believe that our strategy may be further extended to quantum dots, magnetic particles, colloids, etc. Hence, it may lead to a myriad of homogeneous or heterogeneous free-standing nanoassemblies with programmable functionalities.
Correction to: Standing enokitake-like nanowire films for highly stretchable elastronics (ACS Nano (2018) 12:10 (9742-9749) DOI: 10.1021/acsnano.8b05019)
Publisher: American Chemical Society (ACS)
Date: 29-10-2018
1D Copper Nanostructures: Progress, Challenges and Opportunities
Publisher: Wiley
Date: 12-12-2014
Abstract: One-dimensional noble metal nanostructures are important components in modern nanoscience and nanotechnology due to their unique optical, electrical, mechanical, and thermal properties. However, their cost and scalability may become a major bottleneck for real-world applications. Copper, being an earth-abundant metallic element, is an ideal candidate for commercial applications. It is critical to develop technologies to produce 1D copper nanostructures with high monodispersity, stability and oxygen-resistance for future low-cost nano-enabled materials and devices. This article covers comprehensively the current progress in 1D copper nanostructures, most predominantly nanorods and nanowires. First, various synthetic methodologies developed so far to generate 1D copper nanostructures are thoroughly described the methodologies are in conjunction with the discussion of microscopic, spectrophotometric, crystallographic and morphological characterizations. Next, striking electrical, optical, mechanical and thermal properties of 1D copper nanostructures are highlighted. Additionally, the emerging applications of 1D copper nanostructures in flexible electronics, transparent electrodes, low cost solar cells, field emission devices are covered, amongst others. Finally, there is a brief discussion of the remaining challenges and opportunities.
Gold Nanoparticles as Fine Tuners of Electrochemical Properties of the Electrode/Solution Interface
Publisher: American Chemical Society (ACS)
Date: 09-11-2002
DOI: 10.1021/LA026022B
Fabrication, Characterization, and Application in SERS of Self-Assembled Polyelectrolyte−Gold Nanorod Multilayered Films
Publisher: American Chemical Society (ACS)
Date: 22-09-2005
DOI: 10.1021/JP052706R
Abstract: An effective and facile approach for the preparation of multilayered nanostructure of gold nanorods (Au NRs) has been demonstrated. Linear polyethylenimine (LPEI) was selected as a polymeric adhesive layer, and an anionic polyelectrolyte poly(sodium styrenesulfonate) (PSS) was used as the linker of the positively charged Au NRs in multilayered nanostructure. They were deposited onto the LPEI-modified indium-doped tin oxide (ITO) substrate alternately using the layer-by-layer assembly technique via electrostatic interactions. The plasmonic property of the multilayered nanostructure of Au NRs is tunable by the controlled self-assembly process. FE-SEM was used to study the morphologies of the resulted substrates with Au NRs monolayer membrane and with Au NRs multilayered membrane. More importantly, it was found that the multilayered NRs films could be used as a surface-enhanced Raman spectroscopy (SERS) substrate for probing 4-aminothiophenol (4-ATP).
Nanopatterning self-assembled nanoparticle superlattices by moulding microdroplets
Publisher: Springer Science and Business Media LLC
Date: 28-09-2008
Abstract: Highly ordered arrays of nanoparticles exhibit many properties that are not found in their disordered counterparts. However, these nanoparticle superlattices usually form in a far-from-equilibrium dewetting process, which precludes the use of conventional patterning methods owing to a lack of control over the local dewetting dynamics. Here, we report a simple yet efficient approach for patterning such superlattices that involves moulding microdroplets containing the nanoparticles and spatially regulating their dewetting process. This approach can provide rational control over the local nucleation and growth of the nanoparticle superlattices. Using DNA-capped gold nanoparticles as a model system, we have patterned nanoparticle superlattices over large areas into a number of versatile structures with high degrees of internal order, including single-particle-width corrals, single-particle-thickness microdiscs and submicrometre-sized 'supra-crystals'. Remarkably, these features could be addressed by micropatterned electrode arrays, suggesting potential applications in bottom-up nanodevices.
Preferences and User Experiences of Wearable Devices in Epilepsy
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 27-09-2022
DOI: 10.1212/WNL.0000000000200794
Abstract: To examine the preferences and user experiences of people with epilepsy and caregivers regarding automated wearable seizure detection devices. We performed a mixed-methods systematic review. We searched electronic databases for original peer-reviewed publications between January 1, 2000, and May 26, 2021. Key search terms included “epilepsy,” “seizure,” “wearable,” and “non-invasive.” We performed a descriptive and qualitative thematic analysis of the studies included according to the technology acceptance model. Full texts of the discussion sections were further analyzed to identify word frequency and word mapping. Twenty-two observational studies were identified. Collectively, they comprised responses from 3,299 participants including patients with epilepsy, caregivers, and healthcare workers. Sixteen studies examined user preferences, 5 examined user experiences, and 1 examined both experiences and preferences. Important preferences for wearables included improving care, cost, accuracy, and design. Patients desired real-time detection with a latency of ≤15 minutes from seizure occurrence, along with high sensitivity (≥90%) and low false alarm rates. Device-related costs were a major factor for device acceptance, where device costs of $300 USD and a monthly subscription fee of $20 USD were preferred. Despite being a major driver of wearable-based technologies, sudden unexpected death in epilepsy was rarely discussed. Among studies evaluating user experiences, there was a greater acceptance toward wristwatches. Thematic coding analysis showed that attitudes toward device use and perceived usefulness were reported consistently. Word mapping identified “specificity,” “cost,” and “battery” as key single terms and “battery life,” “insurance coverage,” “prediction/detection quality,” and the effect of devices on “daily life” as key bigrams. User acceptance of wearable technology for seizure detection was strongly influenced by accuracy, design, comfort, and cost. Our findings emphasize the need for standardized and validated tools to comprehensively examine preferences and user experiences of wearable devices in this population using the themes identified in this study. Greater efforts to incorporate perspectives and user experiences in developing wearables for seizure detection, particularly in community-based settings, are needed. PROSPERO Registration CRD42020193565.
Two-Dimensional Nanoassemblies from Plasmonic Matryoshka Nanoframes
Publisher: American Chemical Society (ACS)
Date: 09-12-2021
Plasmene Metasurface Absorbers: Electromagnetic Hot Spots and Hot Carriers
Publisher: American Chemical Society (ACS)
Date: 22-01-2019
Skin‐Like Stretchable Fuel Cell Based on Gold‐Nanowire‐Impregnated Porous Polymer Scaffolds
Publisher: Wiley
Date: 30-08-2020
Two-dimensional gold trisoctahedron nanoparticle superlattice sheets: Self-assembly, characterization and immunosensing applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7NR09443D
Abstract: Free-standing gold trisoctahedron superlattice nanosheet is successfully fabricated, characterized, which can serve as a novel immunosensor.
Depletable Peroxidase-like Activity of Fe3O4 Nanozymes Accompanied with Phase Transformation Triggered by Separate Migration of Electron and Iron Ion
Publisher: Research Square Platform LLC
Date: 24-01-2022
DOI: 10.21203/RS.3.RS-1270819/V1
Abstract: As the pioneering Fe 3 O 4 nanozymes, their explicit peroxidase (POD)-like catalytic mechanism remains elusive. Although many studies have proposed the surface Fe 2+ -induced Fenton-like reactions accounting for their POD-like activity, few focus on the internal atomic changes and their contribution to the catalytic reaction. Here we report that Fe 2+ within Fe 3 O 4 transfers electrons to the surface via the Fe 2+ -O-Fe 3+ chain, regenerating the surface Fe 2+ and enabling a sustained POD-like catalytic reaction. This process occurs with the outward migration of excess oxidized Fe 3+ from the lattice, which is a rate-limiting step. After prolonged catalysis, Fe 3 O 4 nanozymes suffer the phase transformation to γ-Fe 2 O 3 with a depletable POD-like activity. This self-depleting characteristic of nanozymes with internal atoms involved in electrons transfer and ion migration is well-validated on lithium iron phosphate nanoparticles. We reveal a key yet ever ignored issue concerning the necessity of considering both surface and internal atoms when designing, modulating, and applying nanozymes.
Plasmonic caged gold nanorods for near-infrared light controlled drug delivery
Publisher: Royal Society of Chemistry (RSC)
Date: 18-09-2014
DOI: 10.1039/C4NR04400B
Abstract: A new near-infrared light-controlled drug delivery system based on caged gold nanorods (CGNRs) is demonstrated. The loading and release process of drug payloads into/from CGNR nanocarriers were systematically investigated. The drug-loaded CGNR constructs could enable combined chemotherapy and photo-thermal effects in killing tumor cells upon light irradiation, therefore, enhance the killing efficiency. In conjunction with visibility under quenching-free dark-field imaging, CGNRs may serve as multifunctional theranostic reagents towards cancer diagnostics and therapeutics.
Direct electron transfer between hemoglobin and a glassy carbon electrode facilitated by lipid-protected gold nanoparticles
Publisher: Elsevier BV
Date: 12-2002
DOI: 10.1016/S0005-2728(02)00372-9
Abstract: We synthesized a kind of gold nanoparticle protected by a synthetic lipid (didodecyldimethylammonium bromide, DDAB). With the help of these gold nanoparticles, hemoglobin can exhibit a direct electron transfer (DET) reaction. The formal potential locates at -169 mV vs. Ag/AgCl. Spectral data indicated the hemoglobin on the electrode was not denatured. The lipid-protected gold nanoparticles were very stable (for at least 8 months). Their average diameter is 6.42 nm. It is the first time to use monolayer-protected nanoparticles to realize the direct electrochemistry of protein.
Tree-like alumina nanopores generated in a non-steady-state anodization
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B709618F
Well-ordered end-to-end linkage of gold nanorods
Publisher: IOP Publishing
Date: 16-08-2005
DOI: 10.1088/0957-4484/16/10/032
Abstract: In this study, it is found that as-prepared gold nanorods can be linked to each other in an end-to-end way by using cysteine as a molecular bridge. Both transmission electron microscopy and UV-visible optical spectroscopy demonstrated the uniaxial assembly of the gold nanorods. The controlled addition of cysteine into the gold nanorod solution resulted in their preferential binding to the two ends of the gold nanorods. As a result, end-to-end assembly was achieved through cooperative hydrogen bonding of bound cysteine molecules. The as-synthesized end-to-end linked assembly of gold nanorods is well ordered and on a large scale. For comparison, three other neutral amino acids, glycine, alanine and valine, were also investigated but the orderliness of their assembly is not as good as that in the case of cysteine.
Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions
Publisher: Springer Science and Business Media LLC
Date: 12-09-2022
DOI: 10.1038/S41467-022-33098-Y
Abstract: As pioneering Fe 3 O 4 nanozymes, their explicit peroxidase (POD)-like catalytic mechanism remains elusive. Although many studies have proposed surface Fe 2+ -induced Fenton-like reactions accounting for their POD-like activity, few have focused on the internal atomic changes and their contribution to the catalytic reaction. Here we report that Fe 2+ within Fe 3 O 4 can transfer electrons to the surface via the Fe 2+ -O-Fe 3+ chain, regenerating the surface Fe 2+ and enabling a sustained POD-like catalytic reaction. This process usually occurs with the outward migration of excess oxidized Fe 3+ from the lattice, which is a rate-limiting step. After prolonged catalysis, Fe 3 O 4 nanozymes suffer the phase transformation to γ-Fe 2 O 3 with depletable POD-like activity. This self-depleting characteristic of nanozymes with internal atoms involved in electron transfer and ion migration is well validated on lithium iron phosphate nanoparticles. We reveal a neglected issue concerning the necessity of considering both surface and internal atoms when designing, modulating, and applying nanozymes.
Soft Wearable Healthcare Materials and Devices
Publisher: Wiley
Date: 21-05-2021
Abstract: In spite of advances in electronics and internet technologies, current healthcare remains hospital‐centred. Disruptive technologies are required to translate state‐of‐art wearable devices into next‐generation patient‐centered diagnosis and therapy. In this review, recent advances in the emerging field of soft wearable materials and devices are summarized. A prerequisite for such future healthcare devices is the need of novel materials to be mechanically compliant, electrically conductive, and biologically compatible. It is begun with an overview of the two viable design strategies reported in the literatures, which is followed by description of state‐of‐the‐art wearable healthcare devices for monitoring physical, electrophysiological, chemical, and biological signals. Self‐powered wearable bioenergy devices are also covered and sensing systems, as well as feedback‐controlled wearable closed‐loop biodiagnostic and therapy systems. Finally, it is concluded with an overall summary and future perspective.
Dynamically functioning and highly stretchable epidermal supercapacitor based on vertically aligned gold nanowire skins
Publisher: Wiley
Date: 27-03-2020
DOI: 10.1002/EOM2.12022
Standing Enokitake-like Nanowire Films for Highly Stretchable Elastronics
Publisher: American Chemical Society (ACS)
Date: 18-09-2018
Abstract: Stretchable electronics may enable electronic components to be part of our organs-ideal for future wearable/implantable biodiagnostic systems. One of key challenges is failure of the soft/rigid material interface due to mismatching Young's moduli, which limits stretchability and durability of current systems. Here, we show that standing enokitake-like gold-nanowire-based films chemically bonded to an elastomer can be stretched up to 900% and are highly durable, with >93% conductivity recovery even after 2000 stretching/releasing cycles to 800% strain. Both experimental and modeling reveal that this superior elastic property originates from standing enokitake-like nanowire film structures. The closely packed nanoparticle layer sticks to the top of the nanowires, which easily cracks under strain, whereas the bottom part of the nanowires is compliant with substrate deformation. This leads to tiny V-shaped cracks with a maintained electron transport pathway rather than large U-shaped cracks that are frequently observed for conventional metal films. We further show that our standing nanowire films can serve as current collectors in supercapacitors and second skin-like smart masks for facial expression detection.
Optimized gold nanoshell ensembles for biomedical applications
Publisher: Springer Science and Business Media LLC
Date: 28-03-2013
Abstract: We theoretically study the properties of the optimal size distribution in the ensemble of hollow gold nanoshells (HGNs) that exhibits the best performance at in vivo biomedical applications. For the first time, to the best of our knowledge, we analyze the dependence of the optimal geometric means of the nanoshells’ thicknesses and core radii on the excitation wavelength and the type of human tissue, while assuming lognormal fit to the size distribution in a real HGN ensemble. Regardless of the tissue type, short-wavelength, near-infrared lasers are found to be the most effective in both absorption- and scattering-based applications. We derive approximate analytical expressions enabling one to readily estimate the parameters of optimal distribution for which an HGN ensemble exhibits the maximum efficiency of absorption or scattering inside a human tissue irradiated by a near-infrared laser.
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