ORCID Profile
0000-0002-8840-176X
Current Organisations
University of Technology Sydney
,
UNSW Sydney
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Bioassays | Analytical biochemistry | Industrial biotechnology | Nanobiotechnology
Publisher: Elsevier BV
Date: 06-2021
Publisher: Elsevier BV
Date: 07-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1CC13106K
Abstract: We developed a novel method to determine the molecular composition of surface tethered carboxylated poly(OEGMA-r-HEMA), which in turn determines the swelling induced Au-S bond breakage (CBB) event. More accurate control over CBB will eventually lead to many applications in mechanochemistry and controlled release.
Publisher: Ivyspring International Publisher
Date: 2019
DOI: 10.7150/THNO.34692
Publisher: American Chemical Society (ACS)
Date: 07-10-2021
Publisher: MyJove Corporation
Date: 04-04-2013
DOI: 10.3791/50310
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0NR00081G
Abstract: We report a one-step method to prepare porous polymeric microcages from blend emulsion solutions via electrified jetting.
Publisher: American Chemical Society (ACS)
Date: 03-08-2023
Quality Assessment and Comparison of Plasma-Derived Extracellular Vesicles Separated by Three Commercial Kits for Prostate Cancer Diagnosis
Publisher: Informa UK Limited
Date: 12-2020
DOI: 10.2147/IJN.S283106
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NR00619J
Abstract: Low surface roughness and large metal grain sizes improve the sensitivity of a plasmonic nanohole array sensor.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0LC00431F
Abstract: Approaches, challenges and promising opportunities towards decoding the complexity of extracellular vesicle heterogeneity are discussed.
Publisher: American Chemical Society (ACS)
Date: 09-06-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CP43461J
Abstract: Herein, mesoporous silicon (PSi) is configured as a single sensing device that has dual readouts as a photonic crystal sensor in a Rugate filter configuration, and as a high surface area porous electrode. The as-prepared PSi is chemically modified to provide it with stability in aqueous media and to allow for the subsequent coupling of chemical species, such as via Cu(I)-catalyzed cycloaddition reactions between 1-alkynes and azides ("click" reactions). The utility of the bimodal capabilities of the PSi sensor for monitoring surface coupling procedures is demonstrated by the covalent coupling of a ferrocene derivative, as well as by demonstrating ligand-exchange reactions (LER) at the PSi surface. Both types of reactions were monitored through optical reflectivity measurements, as well as electrochemically via the oxidation/reduction of the surface tethered redox species.
Publisher: Springer Science and Business Media LLC
Date: 10-10-2022
DOI: 10.1186/S43593-022-00031-1
Abstract: Although small EVs (sEVs) have been used widely as biomarkers in disease diagnosis, their heterogeneity at single EV level has rarely been revealed. This is because high-resolution characterization of sEV presents a major challenge, as their sizes are below the optical diffraction limit. Here, we report that upconversion nanoparticles (UCNPs) can be used for super-resolution profiling the molecular heterogeneity of sEVs. We show that Er 3+ -doped UCNPs has better brightness and Tm 3+ -doped UCNPs resulting in better resolution beyond diffraction limit. Through an orthogonal experimental design, the specific targeting of UCNPs to the tumour epitope on single EV has been cross validated, resulting in the Pearson’s R-value of 0.83 for large EVs and ~ 65% co-localization double-positive spots for sEVs. Furthermore, super-resolution nanoscopy can distinguish adjacent UCNPs on single sEV with a resolution of as high as 41.9 nm. When decreasing the size of UCNPs from 40 to 27 nm and 18 nm, we observed that the maximum UCNPs number on single sEV increased from 3 to 9 and 21, respectively. This work suggests the great potentials of UCNPs approach “digitally” quantify the surface antigens on single EVs, therefore providing a solution to monitor the EV heterogeneity changes along with the tumour progression progress.
Publisher: American Chemical Society (ACS)
Date: 09-01-2023
Publisher: American Chemical Society (ACS)
Date: 02-05-0018
DOI: 10.1021/ACS.NANOLETT.2C00724
Abstract: Cancer-derived small extracellular vesicles (sEVs) are potential circulating biomarkers in liquid biopsies. However, their small sizes, low abundance, and heterogeneity in molecular makeups pose major technical challenges for detecting and characterizing them quantitatively. Here, we demonstrate a single-sEV enumeration platform using lanthanide-doped upconversion nanoparticles (UCNPs). Taking advantage of the unique optical properties of UCNPs and the background-eliminating property of total internal reflection fluorescence (TIRF) imaging technique, a single-sEV assay recorded a limit of detection 1.8 × 10
Publisher: American Chemical Society (ACS)
Date: 03-07-2013
DOI: 10.1021/AM4006012
Abstract: Porous silicon (PSi) is an ideal platform for label-free biosensing, and the development of porous silicon patterning will open a pathway to the development of highly parallel PSi biochips for detecting multiple analytes. The optical response of PSi photonic crystal is determined by the changes in the effective bulk refractive index resulting from reactions/events occurring within the internal pore space. Therefore, introducing precise chemical functionalities in the pores of PSi is essential to ensure device selectivity. Here we describe the fabrication of PSi patterns that possess discrete chemical functionalities that are restricted to precise locations. The key difference to previous patterning protocols for PSi is that the entire porous material is first modified with a self-assembled monolayer of a α,ω-diyne adsorbate prior to patterning using a microfabricated titanium mask. The distal alkyne moieties in the monolayer are then amenable to further selective modification by the archetypal "click" reaction, the copper catalyzed alkyne-azide cycloaddition (CuAAC), using the titanium mask as a resist. This type of patterning is suitable for further immobilization of biological recognition elements, and presents a new platform for highly parallel PSi biosensor for multiple detections.
Publisher: American Chemical Society (ACS)
Date: 19-11-2009
DOI: 10.1021/BM900955P
Abstract: Fabrication of poly(dimethylsiloxane) (PDMS) oly(methyl methacrylate) (PMMA) nanofibers is critical to harness the advantage of nanostructured membrane applied in protein microarrays. Electrospinning (ES) of PDMS nanofibers is challenging because of the relatively low molecular weight of PDMS prepolymer. We report a strategy to fabricate PDMS/PMMA nanofibers via ES by introducing carrier polymer PMMA into PDMS solutions to supplement the deficiency of chain entanglements in the PDMS prepolymer. The prepared PDMS/PMMA nanofibrous membrane (PDMS/PMMA NFM) was successfully used as substrates for protein microarrays. The results of immunoassays showed the superior performance of PDMS/PMMA NFM as 3D substrate for protein microarrays the limit-of-detection (LOD) on PDMS/PMMA NFM was 32 times lower than that on nitrocellulose membrane. The realization of ES PDMS extends the scope of ES materials from thermoplastic polymers to thermosetting materials. Given the simplicity, low cost, and high efficiency of ES technology, we believe that PDMS/PMMA NFM is a promising 3D substrate for protein microarrays.
Publisher: Wiley
Date: 08-02-2016
Publisher: Elsevier
Date: 2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3AN00081H
Abstract: Porous silicon photonics is the ideal platform for high sensitivity, high selectivity monitoring of biological molecules in a complex fluidic environment. The potential of this technology was identified almost 15 years ago, however, it has taken considerable advances in porous silicon surface chemistry, photonics, and micro-fabrication to create truly effective devices that can provide new insights into the behaviour of biological systems. In this review we provide a critical assessment of the development of porous silicon optical biosensors from the early demonstrations of affinity based sensing to the current trends in monitoring single cell activity and perspectives in the use of photonic microparticles for biomedical applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0CC04291A
Abstract: A weak polyelectrolyte coating, carboxylated poly(oligo(ethylene glycol)methacrylate-co-2-hydroxyethylmethacrylate), was prepared via surface initiated polymerization (SIP) from initiators immobilized to gold surface through the Au-S bonds. When dry thickness increased up to 75 nm, this polyelectrolyte coating was pulled off the Au substrate by simply exposing to phosphate buffer saline (PBS, pH = 7.4, [Na(+)] = 150 mM). This covalent bond breaking (CBB) behavior was monitored in situ using a quartz crystal microbalance (QCM) and CBB was associated with the swelling of the anchored polyelectrolyte chains.
Publisher: Frontiers Media SA
Date: 27-06-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2017
Publisher: Ivyspring International Publisher
Date: 2020
DOI: 10.7150/THNO.39486
Start Date: 2024
End Date: 12-2026
Amount: $450,000.00
Funder: Australian Research Council
View Funded Activity