ORCID Profile
0000-0003-1970-1192
Current Organisation
University of Colorado at Boulder
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Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5OB01077B
Abstract: A novel series of spiro[pyran-4,4′-quinoline]-2′,3′-dione derivatives have been synthesized in good yields with excellent diastereoselectivity through a cascade of Prins inacol reactions.
Publisher: Springer Science and Business Media LLC
Date: 12-2019
DOI: 10.1007/S10557-019-06921-W
Abstract: Drug-eluting balloon catheters (DEBc) coated with paclitaxel (PTX) have been associated with potential safety concerns. An efficacious but less toxic balloon coating may reduce these outcomes. We evaluated a novel DEBc, Epi-Solve, coated with metacept-3 (MCT-3), a member of the histone deacetylase inhibitor (HDACi) class of epigenetic agents, in a large animal model of neointimal hyperplasia (NIH). Plain balloon angioplasty (PABA) catheters were ultrasonically coated with MCT-3 to generate Epi-Solve DEBc. An ovine model of NIH formation was established utilising partial left common carotid artery (LCA) ligation. Twenty-eight days post neointima (NI) induction, PABA, Epi-Solve or PTX-coated DEBc were deployed at the site of induced NI formation. Twenty-eight days post-intervention, ligated vessels were evaluated for attenuation of NI formation, gene expression profiles and immunohistochemical analysis. Epi-Solve DEBc demonstrated attenuation of NIH over no intervention and a trend to inhibition of NIH over PABA. Gene expression analysis and immunohistochemical studies identified significant anti-proliferative and anti-inflammatory signatures and reduced vascular endothelial cell activation compared to PABA. Epi-Solve is a novel HDACi-coated DEBc which demonstrates significant anti-proliferative and anti-inflammatory signatures and reduced vascular endothelial cell activation compared to PABA in an ovine model and may afford endothelial protection.
Publisher: Elsevier BV
Date: 08-2020
Publisher: Wiley
Date: 07-04-2015
Publisher: Springer Science and Business Media LLC
Date: 27-10-2016
DOI: 10.1038/SREP35223
Abstract: pH-sensitive drug carriers that are sensitive to the acidic (pH = ~6.5) microenvironments of tumor tissues have been primarily used as effective drug/gene/siRNA/microRNA carriers for releasing their payloads to tumor cells/tissues. Resistance to various drugs has become a big hurdle in systemic chemotherapy in cancer. Therefore delivery of chemotherapeutic agents and siRNA’s targeting anti apoptotic genes possess advantages to overcome the efflux pump mediated and anti apoptosis-related drug resistance. Here, we report the development of nanocarrier system prepared from kojic acid backbone-based cationic hiphile containing endosomal pH-sensitive imidazole ring. This pH-sensitive liposomal nanocarrier effectively delivers anti-cancer drug (Paclitaxel PTX) and siRNA (Bcl-2), and significantly inhibits cell proliferation and reduces tumor growth. Tumor inhibition response attributes to the synergistic effect of PTX potency and MDR reversing ability of Bcl-2 siRNA in the tumor supporting that kojic acid based liposomal pH-sensitive nanocarrier as efficient vehicle for systemic co-delivery of drugs and siRNA.
Publisher: Royal Society of Chemistry (RSC)
Date: 28-07-2014
DOI: 10.1039/C4OB01188K
Abstract: A novel Lewis acid catalyzed Prins inacol cascade process has been developed for the synthesis of 7-substituted-8-oxaspiro[4.5]decan-1-ones in good yields with excellent selectivity. This is the first ex le of the synthesis of oxaspirocycles from aldehydes and 1-(4-hydroxybut-1-en-2-yl)cyclobutanol through a cascade of Prins inacol rearrangement. This method is applicable to a wide range of aldehydes such as aromatic, aliphatic, heteroaromatic, and α,β-unsaturated aldehydes.
Publisher: Elsevier BV
Date: 08-2014
Publisher: American Chemical Society (ACS)
Date: 20-11-2015
Abstract: A stereoselective synthesis of decahydrofuro[3,2-d]isochromene derivatives has been achieved by the condensation of 2-cyclohexenylbutane-1,4-diol with aldehydes in the presence of a stochiometric amount of BF3·OEt2 in dichloromethane at -78 °C. Similarly, the condensation of 2-cyclopentenylbutan-1,4-diol with aldehydes provides the corresponding octahydro-2H-cyclopenta[c]furo[2,3-d]pyran derivatives in good yields with high diastereoselectivity. It is an elegant strategy for the quick construction of tricyclic architectures with four contiguous stereogenic centers in a single step. These tricyclic frameworks are the integral part of numerous natural products.
Publisher: Wiley
Date: 19-10-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6OB01641C
Abstract: A broad range of aldehydes undergo a smooth cascade cyclization with ( E )-5-(3-phenylprop-2-ynylamino)pent-3-en-1-ol in the presence of BF 3 ·OEt 2 at room temperature.
Publisher: Bentham Science Publishers Ltd.
Date: 11-12-2017
Publisher: Springer Science and Business Media LLC
Date: 11-03-2021
No related grants have been discovered for GOPAL REDDY SAMA.