ORCID Profile
0000-0002-9772-7438
Current Organisations
Icahn School of Medicine at Mount Sinai
,
Van Yüzüncü Yil Üniversitesi Ziraat Fakültesi
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Publisher: Springer Science and Business Media LLC
Date: 03-2023
DOI: 10.1038/S41588-023-01305-1
Abstract: Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes 1 . This recent study—and most other large-scale human genetics studies—was mainly composed of in iduals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of erse ancestries. Replicating earlier work, we found that cases carried a significantly higher burden of rare protein-truncating variants (PTVs) among evolutionarily constrained genes (odds ratio = 1.48 P = 5.4 × 10 −6 ). In meta-analyses with existing datasets totaling up to 35,828 cases and 107,877 controls, this excess burden was largely consistent across five ancestral populations. Two genes ( SRRM2 and AKAP11 ) were newly implicated as SCZ risk genes, and one gene ( PCLO ) was identified as shared by in iduals with SCZ and those with autism. Overall, our results lend robust support to the rare allelic spectrum of the genetic architecture of SCZ being conserved across erse human populations.
Publisher: Springer Science and Business Media LLC
Date: 23-10-2013
DOI: 10.1007/S00253-012-4499-9
Abstract: Is it possible to create conditions in the anaerobic digesters to control nutrients without changing the performance of a reactor? This study investigates an answer for this question. To this purpose, anaerobic reactors are operated at high concentrations of Mg(2+) ion to harvest the nutrient ions (NH4 (+) and PO4 (3-)) in the form of struvite, that is, magnesium ammonium phosphate. The effects of this modification on the anaerobic digestion of sewage sludge were investigated in terms of chemical oxygen demand (COD) removal and cumulative CH4 production as well as the changes in the biological ersity. The results showed that approximately 50 % of the nutrients (NH4 (+) and PO4 (3-)) were removed regardless of the method adopted for the addition of Mg(2+) ion, slug or daily dosing. The numbers of Methanosaeta and Methanosarcina in the s les withdrawn prior to and after the addition of Mg(2+) did not show significant difference according to the results obtained from qPCR analyses. The research results showed that the addition of Mg(2+) into the anaerobic digesters in municipal wastewater treatment facilities may help to remove the nutrients from the effluent while recovering in their solid forms.
Location: United States of America
Location: United States of America
No related grants have been discovered for Bilgin Taskin.