ORCID Profile
0000-0002-9496-9423
Current Organisation
University Medical Center Göttingen
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Publisher: JMIR Publications Inc.
Date: 26-06-2023
Abstract: ost COVID-19 condition (Long COVID) is a relatively novel disease comprising physical, psychological, and cognitive complaints persisting several weeks to months after acute infection with SARS-CoV-2. Around 10% of persons experiencing COVID-19 are affected by long-term symptoms. Thus far, effective treatment strategies against Long COVID are scarce. rgoLoCo strives to develop and evaluate a novel, online-delivered occupational therapy for long COVID. The primary objective of this study is to assess the feasibility of online occupational therapy in long COVID. The secondary aims are the evaluation of online occupational therapy's effects on cognitive problems and occupational performance and data collection on the in idual experiences of clients and medical professionals with digital occupational therapy. his randomized controlled interventional pilot study has parallel mixed-methods process analyses and a realist evaluation approach. We plan to enrol 80 long COVID clients aged 16 years or older in an interventional group. The control cohort consists of n=80 long COVID clients without digital occupational therapy. Treatment is provided through an online occupational therapy protocol (occupational therapy twice weekly over 12 weeks, delivered either via live online meetings (n=40) or in prerecorded video sessions (n=40). To analyze the central question of this pilot study (Is online occupational therapy feasible in long COVID?), quantitative questionnaires and qualitative interviews based on the Theoretical Framework of Acceptability (TFA) will be used. Furthermore, focus group meetings assess how helpful and acceptable the intervention was to occupational therapists. To assess neurocognitive impairments and limitations in mobility, self-care, usual activities, pain, disabilities, anxiety, as well as depression in Post COVID-19 condition (Long COVID) and the possible effects of online occupational therapy on these problems, standardized tests such as WIT-2, D2r, NeuroQual, COPM, and EQ-5D-5L will be used. The study is registered in the German Clinical Trial Registry (# DRKS00029990) and reviewed by the institutional review boards of participating sites. e will assess whether digital occupational therapy is a feasible treatment for long COVID. We will furthermore test possible improvements in cognitive symptoms and performance in relevant daily activities after completion of the online occupational therapy program and analyze differences in occupational therapy acceptance when comparing personal care to prerecorded video therapy. his randomized controlled pilot study is designed to evaluate the feasibility, acceptability and effectiveness of occupational therapy in long COVID and gain first insights into possible beneficial effects of digital occupational therapy in this disease. erman Clinical Trial Registry (# DRKS00029990)
Publisher: JMIR Publications Inc.
Date: 26-10-2022
DOI: 10.2196/38718
Abstract: With population-wide vaccination availability, the global COVID-19 pandemic entered a new phase. Despite vaccination status, some people who were infected with SARS-CoV-2 experience long-term symptoms. In this study, we aim to characterize the long-term effects of SARS-CoV-2 infection and the pandemic. We also aim to build symptom clusters and determine risk factors for developing long COVID symptoms. Furthermore, we assess social participation and health-related quality of life in patients with long COVID and in the general population during a global pandemic. With a mixed-methods, web-based approach, we aim to recruit 2000 people in Germany who are older than 18 years and can provide informed consent. In the quantitative arm of the study, we identify symptoms of and predictive factors for long COVID manifestations with cluster analysis and assess social participation during the pandemic with standardized questionnaires. The qualitative arm of the study uses in idual interviews and focus group discussions to better understand the illness experience of persons who experience long COVID. Recruitment started in September 2021. Up until July 2022, we recruited approximately 4500 participants via our web-based database. This study aims to build an innovative, patient-centered, web-based research platform appropriate for the pandemic by minimizing physical contact between study personnel and participants. All study activities are designed to better understand the long COVID syndrome, social participation during the pandemic, and the illness experiences of persons affected by long COVID. German Clinical Trial Registry DRKS00026007 h282fkt DERR1-10.2196/38718
Publisher: MDPI AG
Date: 11-08-2022
Abstract: Background: Patients who are post-COVID-19 will require more treatment soon. Therefore, it is important to understand the root cause of their psychological and somatic conditions. Previous studies showed contradictory results on the influence of pre-existing mental conditions. The present study examines the influence of these pre-existing conditions and their pre-treatment on the severity of post-COVID-19 symptoms. Methods: This analysis employs questionnaire data from a large study s le in Germany. Overall, 801 participants were included. All participants rated their health status on a scale from 0 to 100. Fatigue, depression, and anxiety were measured using the FAS, PHQ-9, and GAD-7 scales. Results: All pre-pandemic values showed no significant differences between the groups. The current health status was rated similarly by the recovered patients (μ = 80.5 ± 17.0) and the control group (μ = 81.2 ± 18.0) but significantly worse by acutely infected (μ = 59.0 ± 21.5) and post-COVID-19 patients (μ = 54.2 ± 21.1). Fatigue, depression, and anxiety were similar for recovered patients and the control group. By contrast, there were significant differences between the control and the post-COVID-19 groups concerning fatigue (45.9% vs. 93.1%), depression (19.3% vs. 53.8%), and anxiety (19.3% vs. 22.3%). Conclusion: Fatigue and psychological conditions of post-COVID-19 patients are not associated with pre-existing conditions.
No related grants have been discovered for Frank Müller.