ORCID Profile
0000-0003-4883-9940
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Publisher: American Association for the Advancement of Science (AAAS)
Date: 30-06-2017
Abstract: Drugs that show promise in preclinical models often fail in the clinic, in part because of limited information on drug localization within cells and across tissues. In a proof-of-concept study, Tyler et al. applied click chemistry methods to study the localization of bromodomain inhibitors. These are cancer drugs that alter chromatin structure and gene expression. Clickable derivatives of the drugs localized within chromatin and showed that the drugs exhibit distinct modes of binding at responsive and unresponsive genes. In a mouse leukemia model, the click-probes revealed that the drugs accumulate to different extents in the spleen and bone marrow, which are two tissue sources of leukemic cells. Science , this issue p. 1397
Publisher: Public Library of Science (PLoS)
Date: 11-12-2014
Publisher: Oxford University Press (OUP)
Date: 19-03-2012
DOI: 10.1093/NAR/GKS245
Publisher: Public Library of Science (PLoS)
Date: 15-11-2012
Start Date: 2016
End Date: 2018
Funder: Swedish Research Council
View Funded ActivityStart Date: 2010
End Date: 2015
Funder: Fundação para a Ciência e a Tecnologia
View Funded Activity