ORCID Profile
0000-0001-9206-4885
Current Organisations
Universität Zürich
,
University of Oxford
,
Universitat Bern
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Publisher: Wiley
Date: 09-11-2022
DOI: 10.1111/DMCN.15430
Abstract: To evaluate the association between ambient particulate matter no larger than 2.5 μm in diameter (PM We conducted a population-based birth cohort study using the Taiwan Birth Cohort Study. Participants were assessed for developmental conditions through home interviews at 6 months and 18 months of age. Exposure to PM A total of 17 683 term singletons without congenital malformations were included in the final analysis. PM Exposure to ambient PM
Publisher: Elsevier BV
Date: 03-2021
Publisher: Springer Science and Business Media LLC
Date: 09-01-2022
DOI: 10.1007/S00420-021-01821-9
Abstract: Attention deficit hyperactivity disorder (ADHD) is the most common neurobehavioral disorders. Although studies have suggested relationships between ADHD in children and maternal psychosocial stress during pregnancy, little is known about the effects of work-related mental stress. Considering the increasing number of pregnant women who continue to work during the gestation period, this study investigated whether work-related stress during pregnancy is related to offspring ADHD. The Taiwan Birth Cohort Study followed selected representative mother-infant pairs in a face-to-face interview since a child was 6 months old. A total of 10,556 working pregnant women who completed follow-up 8 years later were included. Whether the 8-year-old child had ever received a diagnosis of ADHD were inquired. Self-reported job stress during pregnant period was obtained 6 months after delivery. Factors including perinatal and socioeconomic factors as well as the mother's job conditions were further analyzed with logistic regression. Among those who continued working during pregnancy, 3850 (36.5%) mothers reported having job stress during pregnancy, and 210 (2.0%) of the children were diagnosed as having ADHD before 8 years of age. Compared with mothers who reported no job stress, the adjusted odds ratio of child ADHD was 1.91 (95% CI 1.21-3.07) for mothers with "very stressful" jobs during pregnancy and 1.53 (95% CI 1.04-2.25) for mothers with "rather stressful" jobs. Among pregnant female workers, higher levels of job stress were related to the higher occurrence of ADHD in their children.
Publisher: IOP Publishing
Date: 26-07-2021
Abstract: Epidemiological evidence shows the association between air pollutants and several mental health outcomes, including depression, sleep disturbance, dementia, childhood neurodevelopment and suicide. Pregnant women are believed to be more susceptible and vulnerable to environmental pollutants, and postpartum depression (PPD) is a prevalent debilitating mental disorder. However, data on the effects of exposure to air pollution during pregnancy and postpartum period on the risk of PPD remain limited. This study aimed to evaluate the association between exposure to ambient air pollution during pregnancy and postpartum period and the incidence of PPD. The Taiwan Birth Cohort Study recruited representative 12% of all newborn in 2005 and their mothers by two-stage stratified s ling, including 21 248 mother–infant pairs. The occurrence of PPD was assessed by a self-reported questionnaire. Exposure to air pollutants during pregnancy and postpartum period was estimated using hybrid kriging/land-use regression (LUR) and integrated LUR-machine learning model based on data from the air monitoring stations. Logistic regression was then conducted to determine adjusted odds ratios (aORs) of PPD in relation to air pollutants. A total of 21 188 women were included in the final analysis, among whom 3,648 (17.2%) developed PPD within 6 months postpartum. The occurrence of PPD was significantly related to exposure to ambient concentrations of nitrogen dioxide (NO 2 ) during first trimester after adjustment [aOR: 1.081 per interquartile range (10.67 ppb), 95% confidence interval: 1.003, 1.165], but not to particulate matter ⩽2.5 µ m in diameter or carbon monoxide. Exposure to ambient NO 2 during early pregnancy was significantly related to the occurrence of PPD among the women investigated in this population-based study.
Publisher: BMJ
Date: 12-12-2017
DOI: 10.1136/GUTJNL-2017-315333
Abstract: Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science risk prevention early diagnosis and screening pathology curative treatment stage IV disease and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants. Fifteen critical RGs are summarised below: RG1 : Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment RG2 : Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk RG3 : Pressing need for prevention trials RG4 : Lack of integration of different prevention approaches RG5 : Lack of optimal strategies for CRC screening RG6 : Lack of effective triage systems for invasive investigations RG7 : Imprecise pathological assessment of CRC RG8 : Lack of qualified personnel in genomics, data sciences and digital pathology RG9 : Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices RG10 : Need for novel technologies/interventions to improve curative outcomes RG11 : Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment RG12 : Lack of reliable biomarkers to guide stage IV treatment RG13 : Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution RG14 : Lack of coordination of CRC research/funding RG15 : Lack of effective communication between relevant stakeholders. Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Viktor Koelzer.