ORCID Profile
0000-0002-4380-2615
Current Organisations
Norwegian University of Science and Technology
,
New York University Abu Dhabi
,
Tata Institute of Fundamental Research
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Publisher: The Royal Society
Date: 05-07-2015
Abstract: Certain neurodegenerative diseases are thought to be initiated by the aggregation of amyloidogenic proteins. However, the mechanism underlying toxicity remains obscure. Most of the suggested mechanisms are generic in nature and do not directly explain the neuron-type specific lesions observed in many of these diseases. Some recent reports suggest that the toxic aggregates impair the synaptic vesicular machinery. This may lead to an understanding of the neuron-type specificity observed in these diseases. A disruption of the vesicular machinery can also be deleterious for extra-synaptic, especially somatic, neurotransmission (common in serotonergic and dopaminergic systems which are specifically affected in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively), though this relationship has remained unexplored. In this review, we discuss amyloid-induced damage to the neurotransmitter vesicular machinery, with an eye on the possible implications for somatic exocytosis. We argue that the larger size of the system, and the availability of multi-photon microscopy techniques for directly visualizing monoamines, make the somatic exocytosis machinery a more tractable model for understanding the effect of amyloids on all types of vesicular neurotransmission. Indeed, exploring this neglected connection may not just be important, it may be a more fruitful route for understanding AD and PD.
Publisher: John Benjamins Publishing Company
Date: 31-12-2018
DOI: 10.1075/IS.17010.BIE
Abstract: Collaborative remembering is essential to enabling teams to build shared understanding of projects and their progress. This article presents an analysis of collaborative remembering sequences in a corpus of interactions collected in a workplace where a team of designers developed a video television commercial. On the basis of coding and analysing linguistic and bodily behaviors in 158 such sequences, extracted from over 45 hours of video recordings, recurrent patterns of collaborative remembering processes were identified, relating to the interplay of work roles. This article shows that collaborative remembering in the design studio is structured by behavioural, interactive and social factors.
Publisher: Center for Open Science
Date: 07-02-2018
Abstract: Storytelling represents a key element in the creation and propagation of culture. Three main accounts of the adaptive function of storytelling include (1) manipulating the behavior of the audience to enhance the fitness of the narrator, (2) transmitting survival-relevant information while avoiding the costs involved in the first-hand acquisition of that information, and (3) maintaining social bonds or group-level cooperation. We assess the substantial evidence collected in experimental and ethnographic studies for each account. These accounts do not always appeal to the specific features of storytelling above and beyond language use in general. We propose that the specific adaptive value of storytelling lies in making sense of non-routine, uncertain or novel situations, thereby enabling the collaborative development of previously acquired skills and knowledge, but also promoting social cohesion by strengthening intra-group identity and clarifying intergroup relations.
Publisher: SAGE Publications
Date: 17-06-2014
Publisher: Wiley
Date: 28-06-2018
DOI: 10.1111/TOPS.12358
Publisher: SAGE Publications
Date: 07-06-2012
Abstract: This article provides a new cognitive- and discourse-based theory to memory research. Despite the fact that a large proportion of studies in memory research are based on investigations of (interactional) cognitive and discourse processes, neither linguistics nor cognitive and social psychologists have proposed an integrative, interdisciplinary and discursive-based theory to memory research. In this article I explore how groups of people who did not know each other jointly coordinate the interlocking of their in idual experiences during a period of dictatorship and their self-positioning in the here and now. The interlocking of autobiographical memories is performed by discourse strategies such as agreements and corrections, which are dependent on the participants’ shifting representations of the communicative interaction. The conversations were about personal experiences related to the 1976–83 military dictatorship in Argentina.
Publisher: American Chemical Society (ACS)
Date: 20-05-2015
DOI: 10.1021/ACSCHEMNEURO.5B00074
Abstract: Small hydrophobic oligomers of aggregation-prone proteins are thought to be generically toxic. Here we examine this view by perturbing an early folding contact between Phe19 and Leu34 formed during the aggregation of Alzheimer's amyloid-β (Aβ40) peptide. We find that even conservative single mutations altering this interaction can abolish Aβ40 toxicity. Significantly, the mutants are not distinguishable either by the oligomers size or by the end-state fibrillar structure from the wild type Aβ40. We trace the change in their toxicity to a drastic lowering of membrane affinity. Therefore, nonlocal folding contacts play a key role in steering the oligomeric intermediates through specific conformations with very different properties and toxicity levels. Our results suggest that engineering the folding energy landscape may provide an alternative route to Alzheimer therapeutics.
Publisher: John Benjamins Publishing Company
Date: 31-10-2011
Abstract: In December 2001, Argentina underwent the worst socio-economic crisis in its history. Strong criticisms were raised by society against almost all the social injustices encouraged by the policies promoted by the former governments. Forgiveness of the crimes committed by the dictatorship during the “Dirty War” which took place in the late 70’s, and reconciliation between the members of the dictatorship and society, was the position held by the post-dictatorship governments. However, the official discourse has radically changed since 2003, because of the administration of elected president Nestor Kirchner (2003–2007). The aim of this paper is to explore some of the changes in relation to the creation of two time-frames (TF1/TF2) to represent actors from the past and the present, and reinforce the current exceptionality of Néstor Kirchner’s political stance. To do this, I will analyse four political speeches given by ex- president Néstor Kirchner to commemorate the anniversary of the coup d’état of March 24th, 1976, the date which marks the beginning of the 1976–1983 military dictatorship.
Publisher: Center for Open Science
Date: 29-03-2021
Abstract: Researchers have been interested in the investigation of the social functions of questions in conversational contexts. However, limited research has been conducted on the social functions of questions in embodied collaborative work, i.e. work that involves the manipulation of physical objects. The aim of this study was to identify the social functions of questions in embodied collaborative work and to determine whether such functions correlate with performance outcomes. To do so, we conducted qualitative and quantitative analyses of a dataset of 1751 question-answer sequences collected from an experimental study where pairs of participants (N=134) completed a collaborative food preparation task. Qualitative analysis enabled us to identify three functions of questions: Anticipation questions, exploration questions and confirmation questions. Quantitative analyses revealed that there was no correlation between the types of questions and group performance. However, they showed that groups that contributed the most to performance presented a similar distribution of question types. The identification of such patterns is a first step towards the design and implementation of interaction-focused interventions aimed at increasing group productivity in embodied collaborative work.
Publisher: ACM
Date: 07-2015
Publisher: IEEE
Date: 12-2020
Publisher: SAGE Publications
Date: 23-12-2011
Abstract: This brief article particularly focuses on my ‘piercing memories’ of the 1976—83 military dictatorship when visiting a photography exhibition about the missing people. As an Argentinean born in Buenos Aires 30 years ago, I do not have many personal recollections of the period of dictatorship, yet the photographs of the exhibition act as external memory devices, enabling me to reconstruct and re-encounter both the largely forgotten and unarticulated personal experiences as well as the socially shared memories about what happened under the dictatorship. Despite the lack of first-hand knowledge and direct suffering — I do not have a missing relative - my ‘piercing memories’ of this traumatic period in Argentinean history are still very emotionally loaded and play a central role in defining my identity and personal motivations.
Publisher: Public Library of Science (PLoS)
Date: 18-09-2019
Publisher: SAGE Publications
Date: 30-03-2018
Abstract: A s le of 1015 educational staff members, exhibiting various levels of burnout and depressive symptoms, underwent a memory test involving incident encoding of positive and negative words and a free recall task. Burnout and depression were each found to be associated with increased recall of negative items and decreased recall of positive items. Results remained statistically significant when controlling for history of depressive disorders. Burnout and depression were not related to mistakes in the reported words, or to the overall number of recalled words. This study suggests that burnout and depression overlap in terms of memory biases toward emotional information.
Publisher: John Benjamins Publishing Company
Date: 07-05-2012
Abstract: This article aims to provide a cognitive and discourse based theory to collective memory research. Despite the fact that a large proportion of studies in collective memory research in social, cognitive, and discourse psychology are based on investigations of (interactional) cognitive and discourse processes, neither linguistics nor cognitive and social psychologists have proposed an integrative, interdisciplinary and discursive-based theory to memory research. I argue that processes of remembering are always embodied and action oriented reconstructions of the past, which are highly dynamic and malleable by means of communication and context. This new approach aims to provide the grounds for a new ecologically valid theory on memory studies which accounts for the mutual interdependencies between communication, cognition, meaning, and interaction, as guiding collective remembering processes in the real-world activities.
Publisher: Elsevier BV
Date: 05-2017
DOI: 10.1016/J.IJNURSTU.2017.01.015
Abstract: Researchers in nursing science interested in the study of nurse-patient and nurse-relative interactions have displayed an ever increasing interest in ethnomethodology and conversation analysis. This review assesses the scope of this literature. We categorize the papers in thematic categories determined both inductively and deductively and synthesize the main findings of this literature within category. Finally we discuss the interactional determinants of the lack patient participation, the limitations of the field, and focus on implications. A scoping review on nurse-patient and nurse-relative interactions. Forty articles focusing on nurse-patient interactions and nurse-relative interactions. All the articles relied on ethnomethodology and/or conversation analysis. A literature search has been carried out on Medline (all articles until June 2016 keywords were: nurs*.ab. and "conversation analysis" nurs*.ab. and ethnomethodology). A similar search was performed on other platforms. The scope of the literature was identified by inductively and deductively analyzing the themes of the relevant articles. Six thematic categories emerged: Organization of nurse-patient interaction (eleven articles) Organization of mediated nurse-patient interaction (seven articles) Information, explanation and advice (eight articles) Negotiation and influence asymmetry (six articles) Managing emotions in critical illness (two articles) and Interacting with patients presenting reduced interactional competences (six articles). Across most thematic categories it appeared that patient participation is far from ideal as interactional asymmetry was most observed in favor of nurses. When the encounters occurred at the patients' homes this pattern was reversed. Computer-mediated interactions were often reported as non-optimal as the standardized process constrained communication and delayed patients' presentation of their ailments. Micro-analyses of interaction present a clear potential for the development of guidelines for nurse-patient interactions. Implications for practice are described.
Publisher: Psychology Press
Date: 16-09-2015
Publisher: SAGE Publications
Date: 04-07-2013
Abstract: The aim of our study is to show the ways in which family members coordinate their minds, bodies and language in a functional and goal-oriented manner when they are jointly remembering shared events that they had experienced together as a group. So far, little attention has been paid to the influence that the interplay of multiple behavioral channels have in collaborative remembering in small groups. Our goal is to specifically examine the central role that direct questions have when they act as embodied reminders through the interanimation of multiple behavioral channels (language, pointing, eye-gaze, etc.) in family interactions. The video data for analysis comes from an ongoing project on how collaborative remembering takes places among small groups of Argentinean Spanish speakers as each group recalls a vacation taken together several years ago.
Publisher: John Benjamins Publishing Company
Date: 30-12-2015
Publisher: Wiley
Date: 22-07-2019
DOI: 10.1111/TOPS.12443
Abstract: Remembering the past through conversations with others is a uniquely human endeavor. Conversational remembering consists of specific dynamics and can lead to mnemonic outcomes. While conversational dynamics refer to the interactive processes (e.g., the roles speakers and listeners may undertake during the conversation) shaping collaborative remembering, conversational outcomes are about the mnemonic and functional consequences (e.g., forging social bonds) of those processes. Thus, the aim of the present article is to introduce the reader to key concepts and paradigms that have been rigorously developed to empirically investigate the dynamics and outcomes of conversational remembering in cognitive research. The collected review and empirical articles gathered in this topic provide the state-of-the-art in the field.
Publisher: SAGE Publications
Date: 07-2013
Abstract: Current approaches to socially distributed remembering maintain that remembering is a fluid action coordinating minds, bodies, and the physical and the social world to accomplish particular goals. That is, the act of remembering is always an active reconstruction of the past in the present. How this act of remembering unfolds is highly dynamic and malleable and is contingent on the means by which the recollection is communicated and the social and material environments in which these processes unfold. These communicative acts of remembering are always embodied, multimodal, and interactive. However, so far, little attention has been paid to the influence that the interplay of multiple behavioral channels have in collaborative remembering in small groups. The aim of this exploratory study is to demonstrate the central role that questions have as embodied and interactive tools for collaborative remembering in two small group multimodal interactions in natural settings. This study suggests that questions acting as a reminder in multimodal activities of collaborative remembering foster the formation of specific types of interactional sequences with their own temporal dynamics.
Publisher: Frontiers Media SA
Date: 30-08-2021
DOI: 10.3389/FPSYG.2021.704275
Abstract: Researchers have been interested in the investigation of the interactive functions of questions in conversational contexts. However, limited research has been conducted on the interactive functions of questions in embodied collaborative work, that is, work that involves the manipulation of physical objects. This study aimed to identify the interactive functions of questions in embodied collaborative work. To do so, we conducted a systematic qualitative analysis of a dataset of 1,751 question-answer sequences collected from an experimental study where pairs of participants ( N = 67) completed a collaborative food preparation task. The qualitative analysis enabled us to identify three functions of questions: anticipation questions , exploration questions , and confirmation questions . We have discussed in this study how the types of questions identified are associated with: (i) the accomplishment of interactional goals and (ii) complementary temporalities in the collaborative activities.
Publisher: SAGE Publications
Date: 17-06-2014
Abstract: This article investigates the roles that interactive alignment of manual gesture, postural sway, and eye-gaze play in small groups engaged in collaborative remembering. Qualitative analyses of a video corpus demonstrate that the coordination of these behaviors may contribute to joint remembering in various ways, depending upon the cognitive and communicative affordances of these behaviors. The observation that these behaviors are different in their nature and their contributory potential to shared remembering is corroborated by the results of a quantitative analysis, which suggests that co-speech gesture, postural sway, and eye-gaze have different interactional dynamics. This supports the conclusion that in order to understand the role of multimodal alignment in the discourse of shared remembering, co-verbal behavior should not be treated as a homogeneous category. Finally, we discuss the potential of combined qualitative–quantitative approaches to inform the interplay of verbal and bodily coordination during interactive memory construction.
Publisher: Informa UK Limited
Date: 09-11-2015
Publisher: John Benjamins Publishing Company
Date: 30-12-2015
Abstract: Everyday joint remembering, from family remembering around the dinner table to team remembering in the operating theatre, relies on the successful interweaving of multiple cognitive, bodily, social and material resources, anchored in specific cultural ecosystems. Such systems for joint remembering in social interactions are composed of processes unfolding over multiple but complementary timescales, which we distinguish for analytic purposes so as better to study their interanimation in practice: (i) faster, lower-level coordination processes of behavioral matching and interactional synchrony occurring at timescale t 1 (ii) mid-range collaborative processes which re-evoke past experiences in groups, unfolding at timescale t 2 (iii) cooperative processes involved in the transmission of memories over longer periods occurring at timescale t 3 and (iv) cultural processes and practices operating within distributed socio-cognitive networks over evolutionary and historical timeframes, unfolding at timescale t 4 . In this paper we survey studies of how the processes operating across these overlapping and complementary timescales constitute joint remembering in social interactions. We describe coordination, collaboration, cooperation, and culture as complementary aspects of interacting to remember, which we consider as a complex phenomenon unfolding over multiple timescales (t 1 , t 2 , t 3 , t 4 ).
Publisher: Springer Science and Business Media LLC
Date: 25-07-2022
DOI: 10.3758/S13428-022-01917-1
Abstract: Sentiment analysis is the automated coding of emotions expressed in text. Sentiment analysis and other types of analyses focusing on the automatic coding of textual documents are increasingly popular in psychology and computer science. However, the potential of treating automatically coded text collected with regular s ling intervals as a signal is currently overlooked. We use the phrase "text as signal" to refer to the application of signal processing techniques to coded textual documents s led with regularity. In order to illustrate the potential of treating text as signal, we introduce the reader to a variety of such techniques in a tutorial with two case studies in the realm of social media analysis. First, we apply finite response impulse filtering to emotion-coded tweets posted during the US Election Week of 2020 and discuss the visualization of the resulting variation in the filtered signal. We use changepoint detection to highlight the important changes in the emotional signals. Then we examine data interpolation, analysis of periodicity via the fast Fourier transform (FFT), and FFT filtering to personal value-coded tweets from November 2019 to October 2020 and link the variation in the filtered signal to some of the epoch-defining events occurring during this period. Finally, we use block bootstrapping to estimate the variability/uncertainty in the resulting filtered signals. After working through the tutorial, the readers will understand the basics of signal processing to analyze regularly s led coded text.
Publisher: Center for Open Science
Date: 09-10-2022
Abstract: Collective remembering in conversations creates a feeling of connection, strengthens social bonds, fosters entrainment, and consolidates community identity. COVID-19 lockdown policies and social distancing measures have significantly affected social interactions, including conversations in which collective remembering occurs. We tested whether lockdown policies were associated with an increase in collective remembering in WhatsApp group messages (N= 32,810) collected over a period of 700 consecutive days, before, during and after imposed lockdown. Messages were produced by members of a small community with strong ties living in one of the most populated metropolitan areas in Latin America. We found higher number of WhatsApp group messages where participants collaborated in the retrieval of memories of past, shared experiences during the lockdown period, in comparison to pre-lockdown and post-lockdown periods. We also found that the use of verbs in the past tense predicted collective remembering in WhatsApp group messages. Our analysis also includes an ex le of those instances to show the interactional dynamics that forged the formation of collective memories in the small community (Supplementary information 1). The increase of collective remembering in WhatsApp group messages may represent an adaptive collective behavior in response to changes in global social norms.
Publisher: American Chemical Society (ACS)
Date: 14-02-2019
DOI: 10.1021/ACSCHEMNEURO.9B00015
Abstract: While the roles of intrinsically disordered protein domains in driving interprotein interactions are increasingly well-appreciated, the mechanism of toxicity of disease-causing disordered proteins remains poorly understood. A prime ex le is Alzheimer's disease (AD) associated amyloid beta (Aβ). Aβ oligomers are highly toxic partially structured peptide assemblies with a distinct ordered region (residues ∼10-40) and a shorter disordered region (residues ∼1-9). Here, we investigate the role of this disordered domain and its relation to the ordered domain in the manifestation of toxicity through a set of Aβ fragments and stereoisomers designed for this purpose. We measure their effects on lipid membranes and cultured neurons, probing their toxicity, intracellular distributions, and specific molecular interactions using the techniques of confocal imaging, lattice light sheet imaging, fluorescence lifetime imaging, and fluorescence correlation spectroscopy. Remarkably, we find that neither part-Aβ
Publisher: Hipatia Press
Date: 23-06-2018
Publisher: Center for Open Science
Date: 22-09-2022
Abstract: Did you know that humans can develop friendly or even romantic feelings towards social chatbots that can turn into close human-chatbot relationships? The phenomenon of human-chatbot relationship is starting to gain substantial media attention, and research on this topic is now emerging. Social chatbots –what are they? you may ask. Well, you have probably seen them on the App store or on Google play under names such as Replika or Kuki. To put it simple, a social chatbot is a form of conversational AI developed with the purpose of having normal day-to-day conversations with its users. New developments in AI and NLP created the conditions for the design and development of sophisticated social chatbots capable of becoming your best friend or even romantic partner. Social chatbots are generally good at showing empathy, providing emotional support and companionship. They have essentially grown into conversational affective machines which makes it possible for the users to form close relationships with them. This makes you wonder how does such relationship develop?
Publisher: SAGE Publications
Date: 09-2010
Abstract: Shared memories play a central role in everyday communications. They are usually based on interpersonal and cultural knowledge of a shared past among group members (e.g. family, friends, partners, etc.). These memories are verbally conveyed in everyday conversations in real-world settings. Shared memories are also utilized to create a feeling of connection and maintain a consistent feeling of identity among group members. In family conversations, shared memories function to structure and synchronize the shareable life story of the family as a group. Family members are strategically engaged in processes of remembering and forgetting, which are modelled according to the specific goals of a particular interaction. In these cases, family members construct a sociocognitive system shaped by the physical and social environment in which they are located. This system operates by connecting autobiographical knowledge, which is distributed among family members, but forms part of shared past experiences. By interrelating distributed episodic memories, this sociocognitive system endows family members with the ability to manage distributed autobiographical knowledge. In order to perform this cognitive task, they make use of a wide set of discursive epistemic strategies such as presuppositions and implicatures, justifications, rejections and reminders of shared knowledge of the past. The aim of this article is to show the ways in which a shared past is managed, communicated and negotiated in an everyday family conversation by means of discursive epistemic strategies. The conversation was about five historical dates linked to Argentinean political history.
Publisher: No publisher found
Date: 2021
DOI: 10.1098/RSOS.201900
Location: Germany
Start Date: 2011
End Date: 2013
Funder: Alexander von Humboldt-Stiftung
View Funded ActivityStart Date: 2014
End Date: 2014
Funder: Deutsche Forschungsgemeinschaft
View Funded ActivityStart Date: 2013
End Date: 2015
Funder: European Commission
View Funded ActivityStart Date: 2015
End Date: 2018
Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
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