ORCID Profile
0000-0002-6634-6800
Current Organisation
Kyung Hee University - Global Campus
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Publisher: Human Kinetics
Date: 11-2015
Abstract: A cardiovascular comorbidity in obese adolescents is increased aortic pulse wave velocity (aPWV), carotid intima-media thickness (cIMT) and left ventricular mass (LVM). We investigated in obese adolescents 1) the risk factors associated with aPWV, cIMT and LVM, and 2) the effects of aerobic (AE) versus resistance (RE) exercise alone (without calorie restriction) on aPWV, cIMT, LVM index (LVMI) and cardiometabolic risk factors. Eighty-one obese adolescents (12–18 yrs, BMI ≥95th percentile) were randomized to 3 months of AE ( n = 30), RE ( n = 27) or a control group ( n = 24). Outcome measures included aPWV, cIMT, LVMI, body composition, cardiorespiratory fitness (CRF), blood pressure (BP) and lipids. At baseline, the strongest correlates of aPWV were body weight ( r = .31) and diastolic BP ( r = .28) of cIMT were body weight ( r =0.26) and CRF ( r =-0.25) and of LVMI was CRF ( r =0.32) after adjusting for sex and race ( p .05 for all). Despite significant reductions in total fat and improvements in CRF in the AE and RE groups, aPWV, cIMT, LVMI, BP, lipids and body weight did not change as compared with controls ( p .05 for all). Interventions of longer duration or together with weight loss may be required to improve these early biomarkers of CVD in obese adolescents.
Publisher: The Endocrine Society
Date: 12-2010
DOI: 10.1210/JC.2010-1047
Publisher: Canadian Science Publishing
Date: 11-2015
Abstract: During childhood and adolescence, a number of factors, including age, puberty, sex, race, and body composition, may contribute to differences in satiety, food intake, and appetite-related peptides. These peptides include the orexigenic peptide ghrelin and anorexigenic gut peptides peptide YY (PYY) and glucagon-like peptide-1 (GLP-1). For ex le, lower fasting ghrelin levels, lower postprandial ghrelin suppression, and blunted PYY and GLP-1 responses to food intake could contribute to a dysregulation of appetite in already obese children and adolescents. Whereas, changes in these peptides observed during puberty could facilitate growth. A greater understanding of the major moderating factors of appetite-related peptides in the pediatric population is essential to improve interpretation of study findings and for effective tailoring of strategies targeting appetite control to in iduals. While more studies are needed, there is some evidence to suggest that exercise-based lifestyle interventions could be a potential therapeutic strategy to improve appetite-peptide profiles in overweight and obese children and adolescents. The aim of this review is (i) to discuss the potential moderating factors of ghrelin, PYY, and GLP-1, including age and puberty, sex, race and body composition and (ii) to examine the effects of exercise interventions on these appetite-related gut peptides in children and adolescents.
Location: United States of America
No related grants have been discovered for SoJung Lee.