ORCID Profile
0000-0003-3046-0983
Current Organisations
University of Belgrade, Faculty of Biology
,
South China University of Technology
,
University of Belgrade Faculty of Philosophy
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Publications
Intermittent Theta Burst Stimulation Improves Motor and Behavioral Dysfunction through Modulation of NMDA Receptor Subunit Composition in Experimental Model of Parkinson’s Disease
Publisher: MDPI AG
Date: 06-2023
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the progressive degeneration of the dopaminergic system, leading to a variety of motor and nonmotor symptoms. The currently available symptomatic therapy loses efficacy over time, indicating the need for new therapeutic approaches. Repetitive transcranial magnetic stimulation (rTMS) has emerged as one of the potential candidates for PD therapy. Intermittent theta burst stimulation (iTBS), an excitatory protocol of rTMS, has been shown to be beneficial in several animal models of neurodegeneration, including PD. The aim of this study was to investigate the effects of prolonged iTBS on motor performance and behavior and the possible association with changes in the NMDAR subunit composition in the 6-hydroxydopamine (6-OHDA)-induced experimental model of PD. Two-month-old male Wistar rats were ided into four groups: controls, 6-OHDA rats, 6-OHDA + iTBS protocol (two times/day/three weeks) and the sham group. The therapeutic effect of iTBS was evaluated by examining motor coordination, balance, spontaneous forelimb use, exploratory behavior, anxiety-like, depressive/anhedonic-like behavior and short-term memory, histopathological changes and changes at the molecular level. We demonstrated the positive effects of iTBS at both motor and behavioral levels. In addition, the beneficial effects were reflected in reduced degeneration of dopaminergic neurons and a subsequent increase in the level of DA in the caudoputamen. Finally, iTBS altered protein expression and NMDAR subunit composition, suggesting a sustained effect. Applied early in the disease course, the iTBS protocol may be a promising candidate for early-stage PD therapy, affecting motor and nonmotor deficits.
Facile fabrication of highly efficient ETL-free perovskite solar cells with 20% efficiency by defect passivation and interface engineering
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC00312F
Abstract: Modification of an FTO surface using tetramethylammonium hydroxide achieves 20.1% efficiency for ETL-free perovskite solar cells with a reduced hysteresis.
Black phosphorus quantum dots as dual-functional electron-selective materials for efficient plastic perovskite solar cells
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA01408F
Abstract: Dual-functional black phosphorus quantum dot electron selective layer was designed for plastic perovskite solar cells. The efficient electron extraction and improved perovskite film quality contributed to the reasonably high efficiency.
Related Organisations
Institute Of Nuclear Sciences Vinca, University Of Belgrade
Location: Serbia
University Of Belgrade, Faculty Of Natural Sciences And Mathematics
Location: Serbia
Related Funding Activities
No related grants have been discovered for Nadezda Nedeljkovic.