Sok Leang Chheang

Recommendations for use of balanced presentation order of terms in CATA questions

Publisher: Elsevier BV

Date: 12-2015

DOI: 10.1016/J.FOODQUAL.2015.07.012

Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS‐TIMI 54 Trial

Publisher: Ovid Technologies (Wolters Kluwer Health)

Date: 18-05-2020

DOI: 10.1161/JAHA.119.015785

Abstract: A proposed cause of dyspnea induced by ticagrelor is an increase in adenosine blood levels. Because caffeine is an adenosine antagonist, it can potentially improve drug tolerability with regard to dyspnea. Furthermore, association between caffeine and cardiovascular events is of clinical interest. This prespecified analysis used data from the PEGASUS TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis in Myocardial Infarction 54) trial, which randomized 21 162 patients with prior myocardial infarction to ticagrelor 60 mg or 90 mg or matching placebo (twice daily). Baseline caffeine intake in cups per week was prospectively collected for 9694 patients. Outcomes of interest included dyspnea, major adverse cardiovascular events (ie, the composite of cardiovascular death, myocardial infarction, or stroke), and arrhythmias. Dyspnea analyses considered the pooled ticagrelor group, whereas cardiovascular outcome analyses included patients from the 3 randomized arms. After adjustment, caffeine intake, compared with no intake, was not associated with lower rates of dyspnea in patients taking ticagrelor (adjusted hazard ratio (HR), 0.91 95% CI , 0.76–1.10 P =0.34). There was no excess risk with caffeine for major adverse cardiovascular events (adjusted HR, 0.78 95% CI, 0.63–0.98 P =0.031), sudden cardiac death (adjusted HR, 0.98 95% CI, 0.57–1.70 P =0.95), or atrial fibrillation (adjusted odds ratio, 1.07 95% CI, 0.56–2.04 P =0.84). In patients taking ticagrelor for secondary prevention after myocardial infarction, caffeine intake at baseline was not associated with lower rates of dyspnea compared with no intake. Otherwise, caffeine appeared to be safe in this population, with no apparent increase in atherothrombotic events or clinically significant arrhythmias. URL : www.clini​caltr​ials.gov Unique identifier: NCT 01225562.

Identification of Regions Associated with Variation in Sensitivity to Food-Related Odors in the Human Genome

Publisher: Elsevier BV

Date: 07-2014

DOI: 10.1016/J.CUB.2014.06.026

Concurrent elicitation of hedonic and CATA/RATA responses with Chinese and Korean consumers: Hedonic bias is unlikely to occur

Publisher: Elsevier BV

Date: 03-2017

DOI: 10.1016/J.FOODQUAL.2016.10.005

The concurrent use of JAR and CATA questions in hedonic scaling is unlikely to cause hedonic bias, but may increase product discrimination

Publisher: Elsevier BV

Date: 09-2015

DOI: 10.1016/J.FOODQUAL.2015.04.001

Comparison of check-all-that-apply and forced-choice Yes/No question formats for sensory characterisation

Publisher: Elsevier BV

Date: 07-2014

DOI: 10.1016/J.FOODQUAL.2014.02.004

What does it mean to check-all-that-apply? Four case studies with beverages

Publisher: Elsevier BV

Date: 03-2020

DOI: 10.1016/J.FOODQUAL.2019.103794

Sensory characterisation of food and beverage stimuli containing β-ionone and differences between individuals by genotype for rs6591536

Publisher: Elsevier BV

Date: 08-2014

DOI: 10.1016/J.FOODRES.2014.02.038

Toward a new scale to measure consumers’ “need for uniqueness” in foods and beverages: The 31-item FBNFU scale

Publisher: Elsevier BV

Date: 03-2019

DOI: 10.1016/J.FOODQUAL.2018.10.008

A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection

Publisher: Elsevier BV

Date: 08-2013

DOI: 10.1016/J.CUB.2013.07.030

Abstract: Humans vary in acuity to many odors [1-4], with variation within olfactory receptor (OR) genes contributing to these differences [5-9]. How such variation also affects odor experience and food selection remains uncertain [10], given that such effects occur for taste [11-15]. Here we investigate β-ionone, which shows extreme sensitivity differences [4, 16, 17]. β-ionone is a key aroma in foods and beverages [18-21] and is added to products in order to give a pleasant floral note [22, 23]. Genome-wide and in vitro assays demonstrate rs6591536 as the causal variant for β-ionone odor sensitivity. rs6591536 encodes a N183D substitution in the second extracellular loop of OR5A1 and explains >96% of the observed phenotypic variation, resembling a monogenic Mendelian trait. In iduals carrying genotypes for β-ionone sensitivity can more easily differentiate between food and beverage stimuli with and without added β-ionone. Sensitive in iduals typically describe β-ionone in foods and beverages as "fragrant" and "floral," whereas less-sensitive in iduals describe these stimuli differently. rs6591536 genotype also influences emotional associations and explains differences in food and product choices. These studies demonstrate that an OR variant that influences olfactory sensitivity can affect how people experience and respond to foods, beverages, and other products.

An assessment of the CATA-variant of the EsSense Profile®

Publisher: Elsevier BV

Date: 09-2018

DOI: 10.1016/J.FOODQUAL.2018.04.005

Azienda Ospedaliero Universitaria Di Parma

Location: Italy

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The New Zealand Institute For Plant & Food Research Limited

Location: New Zealand

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