ORCID Profile
0000-0002-1464-9850
Current Organisation
Nottingham Trent University
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Publisher: Springer Science and Business Media LLC
Date: 21-11-2017
DOI: 10.1038/S41598-017-15769-9
Abstract: The bacterial flora of nasogastric feeding tubes and faecal s les were analysed for a low-birth weight (725 g) neonate EGA 25 weeks in intensive care. S les were collected at age 6 and 8 weeks of life. Optical coherence tomography (OCT) was used to visualise bacterial biofilms inside the nasogastric feeding tubes. The biofilm was heterogeneously distributed along the tube lumen wall, and had a depth of up to 500 µm. The bacterial biofilm and faecal s les included Enterococcus faecalis and Enterobacter hormaechei . Representative strains, recovered from both feeding tubes and faecal s les, were whole genome sequenced using Illumina, Mi-Seq, which revealed indistinguishable strains, each with less than 28 SNP differences, of E. faecalis and E. hormaechei . The E. faecalis strains were from two sequence types (ST191 and ST211) and encoded for a number of traits related to biofilm formation ( BopD ), adherence ( Epb pili), virulence ( cps loci, gelatinase, SprE ) and antibiotic resistances (IsaA, tetM). The E. hormaechei were all ST106, and encoded for bla ACT-15 β–lactamase and fosfomycin resistance ( fosA ). This proof of concept study demonstrates that bacterial flora within the neonatal feeding tubes may influence the bacterial colonisation of the intestinal tract and can be visualised non-destructively using OCT.
Publisher: Elsevier BV
Date: 09-2020
Publisher: The Optical Society
Date: 13-04-2015
DOI: 10.1364/OE.23.010145
Publisher: American Physical Society (APS)
Date: 11-2018
Publisher: The Optical Society
Date: 14-10-2019
DOI: 10.1364/OE.27.031338
Publisher: British Institute of Non-Destructive Testing (BINDT)
Date: 05-2017
Publisher: The Optical Society
Date: 26-01-2015
DOI: 10.1364/OE.23.001992
Publisher: The Optical Society
Date: 08-01-2015
DOI: 10.1364/OE.23.000471
Publisher: The Optical Society
Date: 04-08-2017
DOI: 10.1364/OE.25.019640
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Chi Cheung.