ORCID Profile
0000-0001-9826-4896
Current Organisation
Vrije Universiteit Amsterdam
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Publisher: SAGE Publications
Date: 25-10-2021
DOI: 10.1177/15480518211044166
Abstract: Most prior research has examined procrastination as a type of self-defeating behavior. The present research, however, focused on the social consequences of procrastination, by investigating how decisional leader procrastination as a leader trait affects others in the workplace. We specifically developed the argument that the way in which employees deal with changes plays a critical moderating role in the relationship between leader procrastination and employee innovation. More precisely, we hypothesized that decisional leader procrastination negatively impacts employee innovation, but only so for employees who are low (compared to high) in resistance to change. This prediction was tested in an experimental study (Study 1) and two double-source survey studies (Studies 2 and 3). In support of our prediction, the results showed that an indecisive leader indeed undermines the innovation of those employees who embrace—rather than resist—changes. Critically, however, our findings also illustrated that when being supervised by a decisive leader, these particular employees are actually most likely to bring forward the process of innovation. Theoretical and practical implications of our results are discussed.
Publisher: Springer Science and Business Media LLC
Date: 11-07-2016
DOI: 10.1038/NCOMMS12166
Abstract: The precise identity of a tumour’s cell of origin can influence disease prognosis and outcome. Methods to reliably define tumour cell of origin from primary, bulk tumour cell s les has been a challenge. Here we use a well-defined model of MLL -rearranged acute myeloid leukaemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and multipotent progenitors results in more aggressive AML than transforming committed progenitor cells. Transcriptome profiling reveals a gene expression signature broadly distinguishing stem cell-derived versus progenitor cell-derived AML, including genes involved in immune escape, extravasation and small GTPase signal transduction. However, whole-genome profiling of open chromatin reveals precise and robust biomarkers reflecting each cell of origin tested, from bulk AML tumour cell s ling. We find that bulk AML tumour cells exhibit distinct open chromatin loci that reflect the transformed cell of origin and suggest that open chromatin patterns may be leveraged as prognostic signatures in human AML.
Publisher: Elsevier BV
Date: 09-2023
Publisher: SAGE Publications
Date: 12-2018
Abstract: We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across s les and settings. Each protocol was administered to approximately half of 125 s les that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance ( p .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion ( p .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small ( 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the s le or setting in which it was studied.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Leander De Schutter.