ORCID Profile
0000-0002-6535-3750
Current Organisation
Universidad de los Andes
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Publisher: Springer Science and Business Media LLC
Date: 15-01-2018
Publisher: Informa UK Limited
Date: 09-02-2019
DOI: 10.1080/01635581.2018.1542011
Abstract: Combination gemcitabine and nab-paclitaxel (Gem-Nab-P) is a common regimen used to treat metastatic pancreatic ductal adenocarcinoma (PDAC). Toxicity from this regimen is associated with significant morbidity. Currently, Gem-Nab-P is dosed using estimated body surface area, derived from height and weight. This study investigates whether skeletal muscle assessment could be a useful tool in the dosing of Gem-Nab-P in metastatic PDAC. This study included 52 patients who had received first-line treatment with Gem-Nab-P for PDAC. Demographic and chemotherapy treatment information was gathered from medical records and body composition analysis was performed using single slice computed tomography methods, at spinal level L3. Patients who experienced first-cycle chemotherapy-associated toxicity did not have a different median skeletal muscle area (SkMA) to those who did not (128.6 cm
Publisher: Elsevier BV
Date: 2019
Publisher: Elsevier BV
Date: 10-2018
Publisher: Proceedings of the National Academy of Sciences
Date: 20-03-2019
Abstract: Episodic development of “oxygen oases” during the Archean Eon characterizes the hundreds of millions of years transition to permanent oxygenation in the atmosphere–hydrosphere system at the Great Oxidation Event (∼2.4–2.3 Ga). One of these well-characterized oxygen oases is recorded in Mesoarchean sediments of the Pongola Supergroup. We show that in contrast to the Neoarchean, biological oxygen production in a shallow ocean having Mo-based nitrogen fixation was not sufficient to result in a dissolved nitrogen reservoir that would carry the isotopic effects of an aerobic nitrogen cycle. Nevertheless, it appears that low concentrations of bioavailable phosphorus, rather than nitrogen, suppressed the growth and expansion of oxygenic photosynthesizers and may explain why pervasive and permanent oxygenation was delayed during the Archean Eon.
Publisher: Elsevier BV
Date: 10-2016
No related grants have been discovered for Benjamin Eickmann.