ORCID Profile
0009-0000-7815-7460
Current Organisations
Universidad de Oviedo Facultad de Medicina
,
Royal College of Surgeons in Ireland
,
Harvard University
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Publisher: Wiley
Date: 25-11-2021
Abstract: After spinal cord injury (SCI), tissue engineering scaffolds offer a potential bridge for regeneration across the lesion and support repair through proregenerative signaling. Ideal biomaterial scaffolds that mimic the physicochemical properties of native tissue have the potential to provide innate trophic signaling while also minimizing damaging inflammation. To address this challenge, taking cues from the spinal cord's structure, the proregenerative signaling capabilities of native cord components are compared in vitro. A synergistic mix of collagen‐IV and fibronectin (Coll‐IV/Fn) is found to optimally enhance axonal extension from neuronal cell lines (SHSY‐5Y and NSC‐34) and induce morphological features typical of quiescent astrocytes. This optimal composition is incorporated into hyaluronic acid scaffolds with aligned pore architectures but varying stiffnesses (0.8–3 kPa). Scaffolds with biomimetic mechanical properties ( kPa), functionalized with Coll‐IV/Fn, not only modulate primary astrocyte behavior but also stimulate the production of anti‐inflammatory cytokine IL‐10 in a stiffness‐dependent manner. Seeded SHSY‐5Y neurons generate distributed neuronal networks, while softer biomimetic scaffolds promote axonal outgrowth in an ex vivo model of axonal regrowth. These results indicate that the interaction of stiffness and biomaterial composition plays an essential role in vitro in generating repair‐critical cellular responses and demonstrates the potential of biomimetic scaffold design.
Publisher: Elsevier BV
Date: 09-2020
Publisher: MDPI AG
Date: 19-05-2023
DOI: 10.3390/HEALTHCARE11101482
Abstract: (1) Background: To develop an instrument in Spanish to assess beliefs and feelings about vaginal penetration and assess its psychometric properties. (2) Methods: This study translated and adapted the Vaginal Penetration Cognition Questionnaire into Spanish, and a total of 225 women who suffered from Genito-Pelvic Pain/Penetration Disorder were included in the study. The psychometric properties, including construct, convergent and discriminant validity, test–retest reliability, and internal consistency of the translated version were assessed. (3) Results: The Spanish version of the Vaginal Penetration Cognition Questionnaire is a valid, reliable, and consistent tool to assess beliefs and thoughts about vaginal penetration in women suffering from Genito-Pelvic Pain/Penetration Disorder. The exploratory factor analysis yielded four domains that explained 62.5% of the variance. Convergent and discriminant validity was also confirmed. Test–retest reliability was high, with an intraclass correlation coefficient value of 0.90, a standard error of measurement of 4.21, and a minimal detectable change of 11.66 points. Every domain also showed good internal consistency levels, with Cronbach’s α values ranging from 0.84 to 0.89. (4) Conclusion: The Spanish version of the Vaginal Penetration Cognition Questionnaire is a valid, reliable, and consistent tool to assess vaginal penetration cognition in women suffering from Genito-Pelvic Pain/Penetration Disorder.
Publisher: Elsevier BV
Date: 09-2019
DOI: 10.1016/J.IJMEDINF.2019.06.005
Abstract: In recent years, numerous health-related apps have appeared on the market, and assessing their quality has become crucial. A very popular tool worldwide, created especially for this purpose, is the Mobile Application Rating Scale (MARS). However, there are no similar tools in Spanish. Therefore, the aim of this paper is to adapt MARS to the Spanish language and validate the resultant version. The design consists of three processes: cross-cultural adaptation, translation, and metric evaluation. 46 mobile applications, 23 of which were for Apple telephones and 23 of which were for telephones running Android, were included in the study. The main objective of these applications was to promote physical activity. The internal factor structure and reliability of MARS were examined. No major differences were observed in the two Spanish translations, which were carried out independently. The blind back-translation, reviewed by the original author of MARS, suggested minor edits. Discrimination indices (item-scale correlation) obtained appropriate results for both raters. The reliability of the scores was found to be appropriate both in terms of internal consistency (α > 0.77), temporal stability (r > 0.72), and inter-rater reliability (IC > 0.76). The correlations between the subscales have shown high values with range between 0.47 and 0.83. The Spanish version of MARS was shown to have appropriate metric properties to assess the quality of health apps.
No related grants have been discovered for Cameron Curtin.