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ORCID Profile
Orcid icon. 0000-0001-6776-3414

Current Organisations
Universitair Medisch Centrum Groningen , TiasNimbas Business School , University of Leeds

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Publications

Publication

Validation of continuous QTc measurement in critically ill patients

Publisher: Elsevier BV

Date: 2016

DOI: 10.1016/J.JELECTROCARD.2015.10.001

Abstract: Prolongation of the corrected QT interval (QTc) can lead to torsades de pointes. This study is designed to determine the validity of the continuous QTc (cQTc) measurement in critically ill patients. In a retrospective cohort study, QTc analysis was performed with manual measurements on a single selected lead from a 12-lead ECG and cQTc measurement obtained at the same time. In addition, automated QTc measurement from the 12-lead ECG was also included in the study. Validation was performed by calculating intraclass correlation coefficient (ICC), Pearson's correlation and Bland-Altman plot. 119 patients with QRS<120 ms were included with a mean cQTc of 468 ms (standard deviation (SD) 37) and mean manually measured QTc of 449 ms (SD 41) (p<0.001). Pearson's correlation was 0.65 (p<0.01), ICC was 0.65 (95% CI: 0.53-0.74). Bland-Altman plot shows a mean difference of 19.5 ms (limits of agreement (LOA) -44.6 to 83.7). For cQTc compared to automated QTc from the 12-lead ECG the intraclass correlation coefficient was 0.77 (95% CI: 0.68-0.83, p<0.001) and the Bland-Altman plot shows a mean difference of 7.8 ms (LOA -40.2 to 55.8). cQTc measurement in critically ill patients with a QRS duration shorter than 120 ms shows an acceptable accuracy to be used in routine care.

Publication

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Publisher: British Academy

Date: 2018

Location: United Kingdom of Great Britain and Northern Ireland

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Andrew Kirton

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Publications

Validation of continuous QTc measurement in critically ill patients

Do corporations have a duty to be trustworthy?

Related Organisations

Vrije Universiteit Amsterdam

Universitair Medisch Centrum Groningen

TiasNimbas Business School

Onze Lieve Vrouwe Gasthuis

Medisch Centrum Leeuwarden

AMC

University Of Manchester

University Of Leeds

University Of Oxford

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