ORCID Profile
0000-0003-4909-6296
Current Organisations
General Sir John Kotelawala Defence University
,
Edith Cowan University
,
Edith Cowan University School of Medical and Health Sciences
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Publisher: Liceo de Cagayan University
Date: 10-12-2014
Publisher: Sciencedomain International
Date: 09-2021
DOI: 10.9734/JPRI/2021/V33I42B32439
Abstract: Aims: Plumbago indica is a medicinal plant widely grown in the tropics and temperate region to use in traditional systems of medicine. Different parts of this plant are used to treat rheumatoid arthritis, dysmenorrhea, cancer, leprosy, syphilis, rheumatism, paralysis, headache, leukoderma, enlarged glands, scabies, ophthalmia, dyspepsia, haemorrhage, piles, flatulence, loss of appetite etc. Various kinds of researches were carried out in different countries on propagation and pharmacology of this medicinal plant. Scientifically proven data were concentrated on this paper to facilitate reliable convenience data source and encourage further studies. Methodology: Scientific data published on full papers, abstracts about morphology, growth, propagation, traditional medicinal uses and pharmacology of P. indica over 70 years (1949-2020) by researchers in different countries were collected and categorized under suitable topics. Results: According to literature P. indica leaves, stems, roots contain phytochemical compound that are responsible for its medicinal properties. Tissue culture of this plant can be uses as effective propagation method to fulfill the increasing demand of raw materials (dried plant parts) for medicinal preparations as well as preserve the plant in their natural habitat. Value: P. indica is used to treat vast range of diseases in traditional medicinal systems in different countries and currently pharmacological experiments are conducting to prove it scientifically. Plumbagin present in P. indica roots was already identified as a potential anti-cancer agent and subjected to more research interest. Therefore this review article helps new researchers to get wide knowledge about the plant and its pharmacology.
Publisher: Springer Science and Business Media LLC
Date: 26-08-2022
DOI: 10.1186/S13256-022-03528-Y
Abstract: Low blood pressure and associated postural symptoms are well-recognized manifestations of anaphylaxis. Nonetheless, anaphylaxis can present with high blood pressure and is rarely reported in the literature. We report an unusual presentation of anaphylaxis with severe supine hypertension and orthostatic intolerance. A 43-year-old Asian female presented to the emergency department with generalized itching, hives, and postural dizziness after taking a slow-release diclofenac sodium 100 mg tablet. On admission, the patient was tachycardic with a supine blood pressure of 200/100 mmHg. She had urticaria and bilateral rhonchi. A clinical diagnosis of anaphylaxis was made. She was treated with intravenous hydrocortisone and chlorpheniramine, but intramuscular adrenaline was withheld owing to her high blood pressure. She was kept in the supine position, and her vital parameters were closely monitored. Although the respiratory and cutaneous symptoms improved with treatment, her blood pressure remained elevated. Forty minutes later, the postural dizziness recurred as she sat up on the bed and her blood pressure plummeted from 198/100 mmHg to 80/60 mmHg. She was put back in the supine position immediately, and the blood pressure was restored with three doses of intramuscular adrenaline and a fluid bolus. Her postural symptoms completely resolved after adrenaline, but her blood pressure remained elevated. Two weeks after the initial presentation, a diagnosis of essential hypertension was made, which probably had been undetected. In anaphylaxis, where the cardiovascular system is involved, a blood pressure reduction from baseline is expected in patients with preexisting hypertension. Despite cardiovascular involvement, our patients’ blood pressure on presentation to the emergency department was much higher than her pretreatment ambulatory blood pressure, thus making this presentation unusual. Diagnosis and treatment of anaphylaxis can be delayed in patients presenting with high blood pressure. Postural symptoms should alert the clinician to cardiovascular involvement despite elevated supine blood pressure. Early treatment with adrenaline should be considered in these patients with extreme caution.
Publisher: Sri Lanka Journals Online (JOL)
Date: 23-06-2022
Abstract: Introduction Phased distribution of the ChAdOx1nCoV-19 (Covisheild) vaccine was commenced in Sri Lanka in January 2021. Although the vaccine was well tolerated with a low reactogenicity profile in the clinical trials, there were safety concerns shortly after initiating vaccine rollouts in many countries. Objectives This prospective observational study aimed to profile the adverse events following immunization (AEFI) amongst recipients of the ChAdOx1nCoV-19 between 30th January to 5th February at the University Hospital, KDU. The associations of AEFI were also evaluated. Methods A cohort of 688 was followed up till the completion of vaccination. Data were collected using an interviewer-administered questionnaire and through telephone interviews. AEFI were classified according to WHO criteria. Results A total of 516(74.9%) participants experienced AEFI after the first dose, of which 377(73.0%) reported both systemic and local symptoms. By contrast, the incidence of AEFI were significantly lower after the second dose (n=134,21.1%, p .001). Fever being the commonest adverse event after the first dose (n=389,75.2%), injection site pain was frequent (n=85,63.43%) following the second dose. Of the four participants reported serious AEFI (0.6%) after the first dose, two had seizures. AEFI predominantly occurred within first 24 hours after each dose (77.1% and 67.9%, respectively) and lasted less than 72 hours in the majority (79.1% and 81.3%, respectively). The incidence of AEFI were significantly higher in females after the second dose (P=0.007). Conclusions The reactogenicity to the ChAdOx1nCoV-19 vaccine amongst our population was lower than expected in clinical trials. The absence of life-threatening adverse events indicates a good safety profile of the vaccine.
Publisher: Springer Science and Business Media LLC
Date: 18-05-2013
Publisher: Sciencedomain International
Date: 25-05-2021
DOI: 10.9734/JPRI/2021/V33I29B31593
Abstract: Aims: Stevia rebaudiana which is commonly known as sweet leaf herb is used to extract non caloric sweet steviol glycosides. Thus based on available reports about its chemical composition, biosynthesis of steviol glycosides, application, cultivation, and phytochemical screening an attempt has been made to review to Stevia rebaudiana in context of its medicinal and pharmaceutical importance. Methodology: Literature search have been done in the web using google scholar, PubMed as search platform. More than two-thirds of the references are within 15 years. Results: According to the literature search S. rebaudiana leaves contain non caloric steviol glycosides and pharmaceutically important other phytochemicals. Miccropropagation is the best propagation method to overcome difficulties in conventional propagation methods. Conclusion: It is concluded that in vitro cultures has potential to extract important phytochemicals used in various pharmaceutical, food (flavoring agents, food additives) and perfume industries.
Publisher: MedCrave Group, LLC
Date: 20-03-2017
Location: Sri Lanka
Location: Sri Lanka
Location: Australia
No related grants have been discovered for R Mudiyanselage Uththara Sachinthanie Senarath.