ORCID Profile
0000-0002-1424-5960
Current Organisations
University of Engineering and Technology Peshawar
,
Universita degli Studi di Trento Facoltà di Scienze Matematiche Fisiche e Naturali
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Society for Neuroscience
Date: 09-05-2012
DOI: 10.1523/JNEUROSCI.3353-11.2012
Abstract: Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions including stroke, Huntington's disease, and Parkinson's disease. However, unifying schemes by which these cross-linking or polyaminating enzymes participate broadly in neuronal death have yet to be presented. Unexpectedly, we found that in addition to TG2, TG1 gene expression level is significantly induced following stroke in vivo or due to oxidative stress in vitro . Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro . Accordingly, molecular deletion of TG2 alone is insufficient to protect Mus musculus neurons from oxidative death. By contrast, structurally erse inhibitors used at concentrations that inhibit TG1 and TG2 simultaneously are neuroprotective. These small molecules inhibit increases in neuronal transamidating activity induced by oxidative stress they also protect neurons downstream of pathological ERK activation when added well after the onset of the death stimulus. Together, these studies suggest that multiple TG isoforms, not only TG2, participate in oxidative stress-induced cell death signaling and that isoform nonselective inhibitors of TG will be most efficacious in combating oxidative death in neurological disorders.
Publisher: MDPI AG
Date: 04-01-2023
DOI: 10.3390/SU15020910
Abstract: Integrating sustainability, a flexible manufacturing system, and Industry 4.0 resolves the issues of fluctuating market demand arising from customization requirements. Modular products allow flexibility to adapt to changing requirements and optimize resource utilization. In this study, a method was proposed and applied to two products, i.e., a 3D printer and an electric toothbrush featuring modular architecture, multiple product versions, and customization, to contribute to the development of sustainable flexible manufacturing systems. From the results of the two case studies nine modules were identified that contain specific functions and related interface information. From these modules, one platform was developed that comprises common entities used in all variants of the products. This platform was further extended to product families. From the modules, product architecture was developed that supports the product and process relationships. These relationships can be developed concurrently, enabling product features to be linked to the manufacturing setup. Thus, when a modular architecture is developed, the factory has to be reorganized accordingly, or reconfiguration is possible. Hence, the main aim of the research was to develop modular product architecture to identify product and process relationships for a sustainable flexible manufacturing system.
Publisher: EMBO
Date: 09-2010
Location: No location found
Location: Japan
Location: Italy
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Tufail Habib.