ORCID Profile
0000-0001-6400-0366
Current Organisation
Edith Cowan University
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Publisher: American Chemical Society (ACS)
Date: 18-03-2022
Publisher: Elsevier BV
Date: 06-2023
Publisher: American Chemical Society (ACS)
Date: 29-03-2023
Publisher: Elsevier BV
Date: 09-2023
Publisher: American Chemical Society (ACS)
Date: 06-05-2022
Publisher: American Chemical Society (ACS)
Date: 26-08-2022
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 10-2014
Publisher: Elsevier BV
Date: 11-2023
Publisher: Elsevier BV
Date: 10-2018
Publisher: Cold Spring Harbor Laboratory
Date: 10-2018
DOI: 10.1101/431775
Abstract: The ubiquitous intracellular protease dipeptidyl peptidase 9 (DPP9) has roles in antigen presentation and B cell signaling. To investigate the importance of DPP9 in immune regeneration, primary and secondary chimeric mice were created in irradiated recipients using fetal liver cells and adult bone marrow cells, respectively, using wild-type (WT) and DPP9 gene-knockin (DPP9 S729A ) enzyme-inactive mice. Immune cell reconstitution was assessed at 6 and 16 weeks post-transplant. Primary chimeric mice successfully regenerated neutrophils, natural killer, T and B cells, irrespective of donor cell genotype. There were no significant differences in total myeloid cell or neutrophil numbers between DPP9-WT and DPP9 S729A -reconstituted mice. There were fewer B cells in the DPP9 S729A -origin compared to DPP9 WT-origin mice in primary chimeric mice. In secondary chimeric mice, cells of DPP9 S729A -origin cells displayed enhanced engraftment compared to WT. However, we observed no differences in myeloid or lymphoid lineage reconstitution between WT and DPP9 S729A donors, indicating that hematopoietic stem cell (HSC) engraftment and self-renewal is not diminished by the absence of DPP9 enzymatic activity. This is the first report on transplantation of bone marrow cells that lack DPP9 enzymatic activity.
Publisher: Elsevier BV
Date: 10-2022
Publisher: Springer Science and Business Media LLC
Date: 13-05-2019
DOI: 10.1038/S41598-019-43739-W
Abstract: The ubiquitous intracellular protease dipeptidyl peptidase 9 (DPP9) has roles in antigen presentation and B cell signaling. To investigate the importance of DPP9 in immune regeneration, primary and secondary chimeric mice were created in irradiated recipients using fetal liver cells and adult bone marrow cells, respectively, using wild-type (WT) and DPP9 gene-knockin (DPP9 S729A ) enzyme-inactive mice. Immune cell reconstitution was assessed at 6 and 16 weeks post-transplant. Primary chimeric mice successfully regenerated neutrophils, natural killer, T and B cells, irrespective of donor cell genotype. There were no significant differences in total myeloid cell or neutrophil numbers between DPP9-WT and DPP9 S729A -reconstituted mice. In secondary chimeric mice, cells of DPP9 S729A -origin cells displayed enhanced engraftment compared to WT. However, we observed no differences in myeloid or lymphoid lineage reconstitution between WT and DPP9 S729A donors, indicating that hematopoietic stem cell (HSC) engraftment and self-renewal is not diminished by the absence of DPP9 enzymatic activity. This is the first report on transplantation of bone marrow cells that lack DPP9 enzymatic activity.
Publisher: Oxford University Press (OUP)
Date: 03-08-2018
Publisher: Cold Spring Harbor Laboratory
Date: 18-05-2009
DOI: 10.1101/732537
Abstract: Mouse kidney parvovirus (MKPV) is a member of the provisional Chapparvovirus genus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four MKPV transcripts, created by alternative splicing, to a common transcription initiation region, and use mass spectrometry to identify “p10” and “p15” as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and a splicing-dependent putative accessory protein NS2 are conserved in all near-complete tetrapod chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with % amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that chapparvoviruses with % VP1 amino acid identity to MKPV be classified into a genus dubbed Nephroparvovirus , which is consistent with nomenclature for the genus Erythroparvovirus .
Publisher: Elsevier BV
Date: 03-2023
Publisher: Elsevier BV
Date: 06-2022
Publisher: Elsevier BV
Date: 04-2023
Publisher: Elsevier BV
Date: 05-2022
DOI: 10.1016/J.JCIS.2022.01.068
Abstract: The mitigation of anthropogenic greenhouse gas emissions and increasing global energy demand are two driving forces toward the hydrogen economy. The large-scale hydrogen storage at the surface is not feasible as hydrogen is very volatile and highly compressible. An effective way for solving this problem is to store it in underground geological formations (i.e. carbonate reservoirs). The wettability of the rock/H As there is an intensive lack of literature on hydrogen wettability of calcite-rich formations, advancing (θ The results of the study show that at ambient conditions, the system was strongly water-wet, but became intermediate wet at high pressure. The water contact angle strongly increased with stearic acid concentration making the calcite surface H
Publisher: Elsevier BV
Date: 07-2022
Publisher: Elsevier BV
Date: 07-2016
Publisher: Elsevier BV
Date: 08-2022
Location: Iran (Islamic Republic of)
Location: Iran (Islamic Republic of)
No related grants have been discovered for Mirhasan Hosseini.