ORCID Profile
0000-0002-4408-7588
Current Organisation
Royan Institute for biotechnology
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Publisher: Elsevier BV
Date: 10-2018
DOI: 10.1016/J.BIOS.2018.07.019
Abstract: Water pollution and habitat degradation are the cause of increasing water scarcity and decline in aquatic bio ersity. While the freshwater availability has been declining through past decades, water demand has continued to increase particularly in areas with arid and semi-arid climate. Monitoring of pollutants in wastewater effluents are critical to identifying water pollution area for treatment. Conventional detection methods are not effective in tracing multiple harmful components in wastewater due to their variability along different times and sources. Currently, the development of biosensing instruments attracted significant attention because of their high sensitivity, selectivity, reliability, simplicity, low-cost and real-time response. This paper provides a general overview on reported biosensors, which have been applied for the recognition of important organic chemicals, heavy metals, and microorganisms in dark waters. The significance and successes of nanotechnology in the field of biomolecular detection are also reviewed. The commercially available biosensors and their main challenges in wastewater monitoring are finally discussed.
Publisher: Elsevier BV
Date: 08-2019
Publisher: Elsevier BV
Date: 12-2021
Publisher: Springer Science and Business Media LLC
Date: 03-04-2020
DOI: 10.1038/S41598-020-62569-9
Abstract: Inertial microfluidics has been broadly investigated, resulting in the development of various applications, mainly for particle or cell separation. Lateral migrations of these particles within a microchannel strictly depend on the channel design and its cross-section. Nonetheless, the fabrication of these microchannels is a continuous challenging issue for the microfluidic community, where the most studied channel cross-sections are limited to only rectangular and more recently trapezoidal microchannels. As a result, a huge amount of potential remains intact for other geometries with cross-sections difficult to fabricate with standard microfabrication techniques. In this study, by leveraging on benefits of additive manufacturing, we have proposed a new method for the fabrication of inertial microfluidic devices. In our proposed workflow, parts are first printed via a high-resolution DLP/SLA 3D printer and then bonded to a transparent PMMA sheet using a double-coated pressure-sensitive adhesive tape. Using this method, we have fabricated and tested a plethora of existing inertial microfluidic devices, whether in a single or multiplexed manner, such as straight, spiral, serpentine, curvilinear, and contraction-expansion arrays. Our characterizations using both particles and cells revealed that the produced chips could withstand a pressure up to 150 psi with minimum interference of the tape to the total functionality of the device and viability of cells. As a showcase of the versatility of our method, we have proposed a new spiral microchannel with right-angled triangular cross-section which is technically impossible to fabricate using the standard lithography. We are of the opinion that the method proposed in this study will open the door for more complex geometries with the bespoke passive internal flow. Furthermore, the proposed fabrication workflow can be adopted at the production level, enabling large-scale manufacturing of inertial microfluidic devices.
Publisher: Elsevier BV
Date: 08-2022
DOI: 10.1016/J.CHROMA.2022.463295
Abstract: Deterministic lateral displacement (DLD) is a hydrodynamic method known for its high-resolution sorting of particles. It achieves this through a periodic array of obstacles and laminar flow that passively directs particles along in two different directions depending on the particles' diameter. Many prior publications have been dedicated to the structural and geometrical development of DLD arrays to improve separation performance however, a successful separation requires much more than a well-designed array. This paper shows how separation performance is affected by process parameters. For this purpose, the design and fabrication of a DLD device are described. Then three experiments show how process parameters affect the performance of the device. The first experiment uses dye solutions to visualize the formation of a hydrodynamically focused s le stream. The second experiment shows that the particle separation performance (of 7- & 15-µm particles) is affected by the way output fluids are collected. Finally, the third experiment looks at the particle separation efficiency as the input flow rates and the ratio of buffer to s le are changed. The results show that the proper range for buffer and s le flow rate in this device is 1-10 and 0.1-1 (µl/min), respectively. The buffer to s le flow rate ratio of 10 gives the highest separation efficiency, but at a lower s le throughput. The optimized values are specific for our device but demonstrate processes that we believe are universal for DLD separations.
Publisher: Informa UK Limited
Date: 25-07-2020
Publisher: Informa UK Limited
Date: 12-2020
DOI: 10.2147/IJN.S269169
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0RA04090H
Abstract: Mussel inspired ZIF8 microcarriers with high surface area, biocompatibility, and nanoscale surface roughness are applied to enhance mesenchymal stem cell attachment and proliferation in 3D cell culture.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3LC00039G
Abstract: We demonstrate a highly efficient DLD separation device and process that is driven by a paper wick yet allows direct collection of products from reservoirs.
Publisher: Elsevier BV
Date: 07-2017
DOI: 10.1016/J.ACTBIO.2017.04.030
Abstract: A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content and report in vitro and preliminary in vivo data. The gel-cast foaming process was adapted, employing temperature controlled gelation of gelatin, rather than the in situ acrylic polymerisation used previously. To form a 3D construct from melt derived glasses, particles must be fused via thermal processing, termed sintering. The original Bioglass® 45S5 composition crystallises upon sintering, altering its bioactivity, due to the temperature difference between the glass transition temperature and the crystallisation onset being small. Here, we optimised and compared scaffolds from three glass compositions, ICIE16, PSrBG and 13-93, which were selected due to their widened sintering windows. Amorphous scaffolds with modal pore interconnect diameters between 100-150µm and porosities of 75% had compressive strengths of 3.4±0.3MPa, 8.4±0.8MPa and 15.3±1.8MPa, for ICIE16, PSrBG and 13-93 respectively. These porosities and compressive strength values are within the range of cancellous bone, and greater than previously reported foamed scaffolds. Dental pulp stem cells attached to the scaffold surfaces during in vitro culture and were viable. In vivo, the scaffolds were found to regenerate bone in a rabbit model according to X-ray micro tomography imaging. This manuscript describes a new method for making scaffolds from bioactive glasses using highly bioactive glass compositions. The glass compositions have lower silica content that those that have been previously made into amorphous scaffolds and they have been designed to have similar network connectivity to that of the original (and commercially used) 45S5 Bioglass. The aim was to match Bioglass' bioactivity. The scaffolds retain the amorphous nature of bioactive glass while having an open pore structure and compressive strength similar to porous bone (the original 45S5 Bioglass crystallises during sintering, which can cause reduced bioactivity or instability). The new scaffolds showed unexpectedly rapid bone regeneration in a rabbit model.
Publisher: Elsevier BV
Date: 04-2021
Publisher: American Chemical Society (ACS)
Date: 06-2021
Abstract: The limited knowledge on how biological systems sense and respond to the mechanical properties of metal-organic framework (MOF) thin films is a critical restriction factor for their extensive usage. To bridge this gap, we performed an
Publisher: Elsevier BV
Date: 11-2020
Location: Iran (Islamic Republic of)
No related grants have been discovered for Fatemeh Ejeian.