ORCID Profile
0000-0002-5103-8717
Current Organisation
Monash University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Nanomanufacturing | Nanotechnology | Regenerative Medicine (incl. Stem Cells and Tissue Engineering) | Biomaterials | Biomechanical Engineering | Nanomanufacturing | Nanometrology | Nanotechnology | Geophysical Fluid Dynamics | Medical Biotechnology | Logistics and Supply Chain Management | Regenerative medicine (incl. stem cells) | Fluidisation and Fluid Mechanics | Interdisciplinary Engineering | Nanobiotechnology | Nanobiotechnology
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in Technology | Expanding Knowledge in the Biological Sciences | Technological and Organisational Innovation | Manufacturing not elsewhere classified | Expanding Knowledge in the Medical and Health Sciences | Expanding Knowledge in the Environmental Sciences | Expanding Knowledge in the Physical Sciences | Expanding Knowledge in Engineering | Human Pharmaceutical Products not elsewhere classified |
Related Links
Publications
Fluid-mediated parallel self-assembly of polymeric micro-capsules for liquid encapsulation and release
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3SM51923F
Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research
Publisher: MDPI AG
Date: 18-11-2019
DOI: 10.3390/S19225027
Abstract: Lab-on-a-chip sensing technologies have changed how cell biology research is conducted. This review summarises the progress in the lab-on-a-chip devices implemented for the detection of cellular metabolites. The review is ided into two subsections according to the methods used for the metabolite detection. Each section includes a table which summarises the relevant literature and also elaborates the advantages of, and the challenges faced with that particular method. The review continues with a section discussing the achievements attained due to using lab-on-a-chip devices within the specific context. Finally, a concluding section summarises what is to be resolved and discusses the future perspectives.
Photonic nanofences for integrated sub-wavelength structures-based sensing applications
Publisher: IEEE
Date: 2016
Microfabricated silicon chip as lipid membrane sample holder for serial protein crystallography
Publisher: Elsevier BV
Date: 05-2019
Fabrication of epoxy spherical microstructures by controlled drop-on-demand inkjet printing
Publisher: IOP Publishing
Date: 27-06-2012
Organic-inorganic-hybrid-polymer microlens arrays with tailored optical characteristics and multi-focal properties
Publisher: The Optical Society
Date: 18-09-2015
DOI: 10.1364/OE.23.025365
Patterning of diamond like carbon films for sensor applications using silicon containing thermoplastic resist (SiPol) as a hard mask
Publisher: Elsevier BV
Date: 11-2016
Inkjet printed SU‐8 hemispherical microcapsules and silicon chip embedding
Publisher: Institution of Engineering and Technology (IET)
Date: 10-2013
Heterogeneous material micro-transfer by ink-jet print assisted mould filling
Publisher: Elsevier BV
Date: 10-2012
Direct writing laser of high aspect ratio epoxy microstructures
Publisher: IOP Publishing
Date: 21-12-2010
Inkjet printed superparamagnetic polymer composite hemispheres with programmed magnetic anisotropy
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3NR06442E
Abstract: We present the fabrication and characterization of large arrays of inkjet-printed superparamagnetic polymer composite (SPMPC) hemispherical microstructures.
High-aspect-ratio nanoimprint process chains
Publisher: Springer Science and Business Media LLC
Date: 17-07-2017
DOI: 10.1038/MICRONANO.2017.17
Abstract: Different methods capable of developing complex structures and building elements with high-aspect-ratio nanostructures combined with microstructures, which are of interest in nanophotonics, are presented. As originals for subsequent replication steps, two families of masters were developed: (i) 3.2 μm deep, 180 nm wide trenches were fabricated by silicon cryo-etching and (ii) 9.8 μm high, 350 nm wide ridges were fabricated using 2-photon polymerization direct laser writing. Both emerging technologies enable the vertical smooth sidewalls needed for a successful imprint into thin layers of polymers with aspect ratios exceeding 15. Nanoridges with high aspect ratios of up to 28 and no residual layer were produced in Ormocers using the micromoulding into capillaries (MIMIC) process with subsequent ultraviolet-curing. This work presents and balances the different fabrication routes and the subsequent generation of working tools from masters with inverted tones and the combination of hard and soft materials. This provides these techniques with a proof of concept for their compatibility with high volume manufacturing of complex micro- and nanostructures.
Design considerations of a hollow microneedle-optofluidic biosensing platform incorporating enzyme-linked assays
Publisher: IOP Publishing
Date: 29-12-2017
Micro-optical 1D moirés as anti-counterfeiting features
Publisher: IEEE
Date: 06-2013
Light coupling into an optical microcantilever by an embedded diffraction grating
Publisher: Optica Publishing Group
Date: 10-01-2006
DOI: 10.1364/AO.45.000229
Abstract: By measuring the excitation efficiency of an optical waveguide on a diffraction grating one can accurately register the changes in the incidence angle of the exciting light beam. This phenomenon was applied to detect ultrasmall deflections of silicon dioxide cantilevers of submicrometer thickness that were fabricated with corrugation on top to act as diffraction grating couplers. The power of light coupled into the cantilevers was monitored with a conventional photodetector and modulated using mechanical vibration of the cantilever, thus changing the spatial orientation of the coupler with respect to the incident light beam. The technique can be considered as an alternative to the methods known for detection of cantilever deflection.
Multimode interference devices based on silicon
Publisher: SPIE
Date: 16-09-2005
DOI: 10.1117/12.621647
Microfluidic Electrochemical Sensor for Cerebrospinal Fluid and Blood Dopamine Detection in a Mouse Model of Parkinson’s Disease
Publisher: American Chemical Society (ACS)
Date: 12-08-2020
Photonic nanofences: Combining the advantages of photonic nanowires and slot waveguides
Publisher: IEEE
Date: 08-2015
Special Issue on Micro/Nano Lithography with Photons, Electrons & Ions 2014
Publisher: Elsevier BV
Date: 08-2015
Reversible Light-Switching of Enzymatic Activity on Orthogonally Functionalized Polymer Brushes
Publisher: American Chemical Society (ACS)
Date: 08-03-2017
Abstract: Copolymer brushes, composed of glycidyl methacrylate and a furan-protected maleimide-containing monomer, were grafted from radical initiators at the surface of irradiation-activated fluoropolymer foils. After postpolymerization modification with enzymatically active microperoxidase-11 and photochromic spiropyran moieties, the polymer brushes catalyzed the oxidation of 3,3'5,5'-tetramethylbenzidine. Exposure to either UV or visible-light allowed switching the turnover by more than 1 order of magnitude, as consequence of the reversible, light-induced spiropyran-merocyanine transition. The modified s les were integrated into an optofluidic device that allowed the reversible switching of enzymatic activity for several cycles under flow, validating the potential for application in smart lab-on-a-chip systems.
Polymeric hemispherical pico-liter micro cups fabricated by inkjet printing
Publisher: IEEE
Date: 04-2013
Enhanced electrochemical sensing performance by in situ electrocopolymerization of pyrrole and thiophene-grafted chitosan
Publisher: Elsevier BV
Date: 2020
DOI: 10.1016/J.IJBIOMAC.2019.12.013
Abstract: Nowadays, there is increasing number of electrochemical biosensors which utilize chitosan (Ch) as an enzyme immobilization matrix, and conductive nanomaterials as electron carriers improving sensitivity of the biosensor. However, the challenge these sensors face is the lack of uniform dispersion of nanomaterials throughout the Ch film, which can negatively affect analytical performance of the biosensor. In this study, we report the development of an enzyme immobilization matrix that displays enhanced electrochemical performance thanks to a novel conductive thin film prepared via in situ electrocopolymerization of pyrrole (Py) and thiophene-grafted chitosan (Th-Ch). This is a simple thin film preparation method that can help overcome aforementioned challenges by providing a uniformly distributed conductive layer on the electrode. We are also for the first time reporting the synthesis and characterization of Th-Ch, where grafted Th plays an essential role as a linking group between Ch and Py. The resulting conductive Ch-based thin film was modified with glucose oxidase (GOx) which served as a model enzyme. In situ electrocopolymerization of Py with Th-Ch resulted in a highly conductive thin film enabling approximately 40% higher sensitivity when compared to a Py-Ch composite. This new type of composite thin film is promising in biosensor technology due to its biocompatibility, the chemically and physically modifiable structure, as well as its electrical conductivity.
Three-Dimensional Micropatterning Deters Early Bacterial Adherence and Can Eliminate Colonization
Publisher: American Chemical Society (ACS)
Date: 11-05-2021
A novel optical waveguide microcantilever sensor for the detection of nanomechanical forces
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2006
Curved transflective holographic screens for head-mounted display
Publisher: SPIE
Date: 03-2013
DOI: 10.1117/12.2000642
Optical biosensor based on arrays of waveguide microcantilevers
Publisher: SPIE
Date: 25-11-0088
DOI: 10.1117/12.698176
Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture
Publisher: Wiley
Date: 29-01-2021
Abstract: Cells are able to perceive complex mechanical cues from their microenvironment, which in turn influences their development. Although the understanding of these intricate mechanotransductive signals is evolving, the precise roles of substrate microtopography in directing cell fate is still poorly understood. Here, UV nanoimprint lithography is used to generate micropillar arrays ranging from 1 to 10 µm in height, width, and spacing to investigate the impact of microtopography on mechanotransduction. Using mesenchymal stem cells (MSCs) as a model, stark pattern‐specific changes in nuclear architecture, lamin A/C accumulation, chromatin positioning, and DNA methyltransferase expression, are demonstrated. MSC osteogenesis is also enhanced specifically on micropillars with 5 µm width/spacing and 5 µm height. Intriguingly, the highest degree of osteogenesis correlates with patterns that stimulated maximal nuclear deformation which is shown to be dependent on myosin‐II‐generated tension. The outcomes determine new insights into nuclear mechanotransduction by demonstrating that force transmission across the nuclear envelope can be modulated by substrate topography, and that this can alter chromatin organisation and impact upon cell fate. These findings have potential to inform the development of microstructured cell culture substrates that can direct cell mechanotransduction and fate for therapeutic applications in both research and clinical sectors.
Characterization of Ferrofluid-Based Stimuli-Responsive Elastomers
Publisher: Frontiers Media SA
Date: 12-12-2016
Next Generation Cell Culture Tools Featuring Micro- and Nanotopographies for Biological Screening
Publisher: Wiley
Date: 21-04-2022
Abstract: Cells can perceive complex mechanical cues across both the micro‐ and nanoscale which can influence their development. While causative effects between surface topography and cellular function can be demonstrated, the variability in materials used in this screening process makes it difficult to discern whether the observed phenotypic changes are indeed a result of topographical cues alone or the inherent difference in material properties. A novel approach to directly imprint micro‐ and nanoscaled topographical features into the base of conventional cell cultureware is thus developed, facilitating its compatibility with standard biological techniques and methods of analysis. The utility of this technology is demonstrated by performing high‐throughput screening across five distinct cell types to interrogate the effects of 12 surface topographies, exemplifying unique cell‐specific responses to both behavior and cell morphological characteristics. The ability of this technology to underpin new insights into how surface topographies can regulate key image descriptors to drive cell fate determination is further demonstrated. These findings will inform the future development of advanced micro‐ and nanostructured cell culture substrates that can regulate cell behavior and fate determination across the life sciences, including fundamental cell biology, drug screening, and cell therapy.
High-resolution 1D moirés as counterfeit security features
Publisher: Springer Science and Business Media LLC
Date: 19-07-2013
DOI: 10.1038/LSA.2013.42
Direct imprinting of organic–inorganic hybrid materials into high aspect ratio sub-100 nm structures
Publisher: Springer Science and Business Media LLC
Date: 11-12-2013
The Bumpy Road to Stem Cell Therapies: Rational Design of Surface Topographies to Dictate Stem Cell Mechanotransduction and Fate
Publisher: American Chemical Society (ACS)
Date: 22-02-2022
Abstract: Cells sense and respond to a variety of physical cues from their surrounding microenvironment, and these are interpreted through mechanotransductive processes to inform their behavior. These mechanisms have particular relevance to stem cells, where control of stem cell proliferation, potency, and differentiation is key to their successful application in regenerative medicine. It is increasingly recognized that surface micro- and nanotopographies influence stem cell behavior and may represent a powerful tool with which to direct the morphology and fate of stem cells. Current progress toward this goal has been driven by combined advances in fabrication technologies and cell biology. Here, the capacity to generate precisely defined micro- and nanoscale topographies has facilitated the studies that provide knowledge of the mechanotransducive processes that govern the cellular response as well as knowledge of the specific features that can drive cells toward a defined differentiation outcome. However, the path forward is not fully defined, and the "bumpy road" that lays ahead must be crossed before the full potential of these approaches can be fully exploited. This review focuses on the challenges and opportunities in applying micro- and nanotopographies to dictate stem cell fate for regenerative medicine. Here, key techniques used to produce topographic features are reviewed, such as photolithography, block copolymer lithography, electron beam lithography, nanoimprint lithography, soft lithography, scanning probe lithography, colloidal lithography, electrospinning, and surface roughening, alongside their advantages and disadvantages. The biological impacts of surface topographies are then discussed, including the current understanding of the mechanotransductive mechanisms by which these cues are interpreted by the cells, as well as the specific effects of surface topographies on cell differentiation and fate. Finally, considerations in translating these technologies and their future prospects are evaluated.
Inkjet Printing of High Aspect Ratio Superparamagnetic SU-8 Microstructures with Preferential Magnetic Directions
Publisher: MDPI AG
Date: 25-08-2014
DOI: 10.3390/MI5030583
Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes
Publisher: Springer Science and Business Media LLC
Date: 06-07-2016
DOI: 10.1038/SREP29075
Abstract: Therapeutic drug monitoring (TDM) typically requires painful blood drawn from patients. We propose a painless and minimally-invasive alternative for TDM using hollow microneedles suitable to extract extremely small volumes ( nL) of interstitial fluid to measure drug concentrations. The inner lumen of a microneedle is functionalized to be used as a micro-reactor during s le collection to trap and bind target drug candidates during extraction, without requirements of s le transfer. An optofluidic device is integrated with this microneedle to rapidly quantify drug analytes with high sensitivity using a straightforward absorbance scheme. Vancomycin is currently detected by using volumes ranging between 50–100 μL with a limit of detection (LoD) of 1.35 μM. The proposed microneedle-optofluidic biosensor can detect vancomycin with a s le volume of 0.6 nL and a LoD of nM, validating this painless point of care system with significant potential to reduce healthcare costs and patients suffering.
High-Aspect-Ratio SU-8-Based Optofluidic Device for Ammonia Detection in Cell Culture Media
Publisher: American Chemical Society (ACS)
Date: 15-07-2020
Butt coupled microcantilever in sensing applications
Publisher: SPIE
Date: 21-04-2006
DOI: 10.1117/12.662393
Photonic lab-on-a-chip device with UV light responsive smart surfaces
Publisher: IEEE
Date: 06-2017
Highly Selective Nanostructured Electrochemical Sensor Utilizing Densely Packed Ultrathin Gold Nanowires Film
Publisher: Wiley
Date: 18-05-2020
The emerging role of microfluidics in multi-material 3D bioprinting
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9LC01184F
Abstract: To assist the transition of 3D bioprinting technology from simple lab-based tissue fabrication, to fully functional and implantable organs, the technology must not only provide shape control, but also functional control.
Biomimetic soft lithography on curved nanostructured surfaces
Publisher: Elsevier BV
Date: 09-2012
Colorimetric Detection of Extracellular Hydrogen Peroxide Using an Integrated Microfluidic Device
Publisher: American Chemical Society (ACS)
Date: 11-01-2022
DOI: 10.1021/ACS.ANALCHEM.1C04312
Abstract: It is well known that hydrogen peroxide (H
Integratable micro-optical compound objective lens using soft lithography
Publisher: Elsevier BV
Date: 10-2023
Curved Holographic Combiner for Color Head Worn Display
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2014
Related Organisations
Universitat Autònoma De Barcelona Facultat De Ciències
Location: Spain
Related Funding Activities
Discovery Projects - Grant ID: DP230101614
Start Date: 09-2023
End Date: 08-2026
Amount: $477,230.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE180100166
Start Date: 03-2018
End Date: 12-2019
Amount: $637,800.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE200100186
Start Date: 2020
End Date: 12-2020
Amount: $233,000.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Training Centres - Grant ID: IC190100026
Start Date: 01-2021
End Date: 11-2027
Amount: $4,969,663.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP190100129
Start Date: 06-2019
End Date: 12-2022
Amount: $440,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE200100174
Start Date: 11-2020
End Date: 12-2022
Amount: $425,000.00
Funder: Australian Research Council
View Funded Activity