ORCID Profile
0000-0001-5126-7424
Current Organisation
EBONYI STATE UNIVERSITY
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: African Journals Online (AJOL)
Date: 29-04-2022
DOI: 10.4314/AHS.V22I1.55
Abstract: Introduction: Blood transfusion poses a high public health risk to recipients hence no effort recommended to eradicate or minimize the danger of transmitting the infections.bReproductive Biology should be underestimated at minimizing the risk of TTIs. This study determined the prevalence and trend of HIV and syphilis infections in voluntary blood donors. Method: A retrospective analysis of secondary data from consecutive prospective voluntary blood donors who accessed Nkenkaasu District Hospital’s Blood Bank from January 2010 to December 2018 was conducted. Result: Cumulatively, HIV and Treponema pallidum seropositivity identified in the present study was high (19.1%, [95% C.I (0.026-0.028)]) . The prevalence of HIV and syphilis infections were 10.9% (95% C.I (0.098-0.120)) and 8.9% (95% C.I (0.073-0.92)) respectively. Prospective female blood donors were less likely to test positive for T. pallidum than males (OR 0.511, [0.340 – 0.769], p=0.001), but the infection was similar among different ages. The data showed downward trend for both HIV and T. pallidum seropositivity, (slope=-2.9467, p .0001) and (slope=-0.7117, p .0001) respectively. Conclusion: Seroprevalence of HIV and Treponema pallidum were high, and their in idual or combined seropositivity pose a significant threat to the safety of blood. Extensive and continuous screening for high-risk behaviours and infectious markers before blood donation is therefore Unit, Department of Obstetrics and Gynaecology, College of Medicine, Pan African University of Life and Earth Sciences Institute (PAULESI), University of Ibadan, Ibadan, Nigeria. Keywords: Blood donors HIV magnitude trend Treponema pallidum.
Publisher: Informa UK Limited
Date: 21-09-2021
Publisher: Public Library of Science (PLoS)
Date: 02-12-2021
DOI: 10.1371/JOURNAL.PGPH.0000052
Abstract: Diabetes mellitus, an endocrine disorder, has been implicated in many including hypogonadism in men. Given the fact that diabetes mellitus is becoming a fast-growing epidemic and the morbidity associated with it is more disabling than the disease itself. This study sought to assess the prevalence of low testosterone levels and predictors in type 2 diabetes mellitus patients and non-diabetic men in a district hospital in Ghana. This hospital-based case-control study comprised 150 type 2 diabetics and 150 healthy men. A pre-structured questionnaire and patient case notes were used to document relevant demographic and clinical information. Venous blood s le of about 6 ml was taken to measure FBS, HbA1c, FSH, LH, and testosterone levels. All data were analyzed using STATA version 12 (STATA Corporation, Texas, USA). The overall hypogonadism in the study population was 48% (144/300). The prevalence of hypogonadism in type 2 diabetic subjects was almost three times more than in healthy men (70.7% vs 25.3%). The odds of having hypogonadism was lower in the men with normal weight and overweight with their underweight counterparts (AOR = 0.33, 95% CI 0.12–0.96, p = 0.042) and (AOR = 0.29, 95% CI 0.10–0.84, p = 0.023) respectively. Also, the odds of suffering from hypogonadism was lower in non-smokers compared with smokers (AOR: 0.16, 95% CI 0.05–0.58, p = 0.005). Participants who were engaged in light (AOR: 0.29, 95% CI 0.14–0.61, p = 0.001), moderate (AOR: 0.26, 95% CI 0.13–0.54, p .001) and heavy (AOR: 0.25, 95% CI 0.10–0.67, p = 0.006) leisure time activities had lower odds hypogonadal compared to those engaged in sedentary living. Type 2 diabetic men have high incidence of hypogonadism, irrespective of their baseline clinical, lifestyle or demographic characteristics. Smoking and sedentary lifestyle and BMI were associated with hypogonadism in the study population. Routine testosterone assessment and replacement therapy for high risk patients is recommended to prevent the detrimental effect of hypogonadism in diabetic men.
Publisher: Public Library of Science (PLoS)
Date: 15-04-2021
DOI: 10.1371/JOURNAL.PONE.0250090
Abstract: Hypofibrinolysis resulting from the up-regulation of plasminogen activator inhibitor-1 (PAI-1) usually occurs in patients with type 2 diabetes mellitus (T2DM), rendering them hypercoagulable. This study assessed the plasma antigen and activity levels of the PAI-1 enzyme in T2DM patients in a district hospital in Ghana. This was a hospital-based case-control study conducted from December 2018 to May 2019 at Nkenkaasu District Hospital. Sixty subjects with T2DM (30 T2DM subjects with good glycemic control and 30 with poor glycemic control), and 30 apparently healthy blood donors were recruited into the study. Blood specimens were collected for complete blood count, lipid profile, PAI-1 Ag and PAI-1 activity levels. A pre-tested questionnaire was used to obtain demographic and clinical information. The data was analyzed using SPSS version 22.0. Elevated PAI-1 Ag and activity levels were observed in the T2DM subjects compared to the healthy controls, with the levels and activity significantly higher (PAI-1 Ag p 0.001, PAI-1 activity level p = 0.004) in the T2DM subjects with poor glycemic control in comparison to those with good glycemic control. A significant positive correlation was observed between HbA1c and PAI-1 enzymes. PAI-1 Ag levels significantly increased along with increased total cholesterol ( Β = 0.262, p = 0.033), triglyceride ( Β = -0.273, p = 0.034) and HbA1c ( Β = 0.419, p = 0.001). Similarly, PAI-1 activity level was associated with total cholesterol ( Β = 0.325, p = 0.009), triglyceride ( Β = -0.262, p = 0.042), HbA1c ( Β = 0.389, p = 0.003) and VLDL-c ( Β = -0.227, p = 0.029). PAI-1 antigen/activity is enhanced in poorly controlled Ghanaian T2DM subjects. The hypercoagulable state of the affected in iduals put them at higher risk of developing cardiovascular diseases. Good glycemic control to regulate plasma PAI-1 levels is essential during T2DM lifelong management. Markers of fibrinolysis should be assessed in these in iduals and appropriate anticoagulants given to prevent thrombosis and adverse cardiovascular diseases.
Publisher: Informa UK Limited
Date: 22-10-2020
DOI: 10.1080/15321819.2019.1682601
Abstract: Hepatitis infections are among the greatest threats to human existence and survival and hence poses a serious public health challenge in blood donation. This study aimed to determine the prevalence and trend of hepatitis infections among voluntary blood donors at Nkenkaasu District Hospital. A retrospective study of voluntary blood donors' records from January 2010 to December 2018 was conducted. Data on the donors' age, sex and serum HBsAg and Hepatitis C virus results were retrieved from the Laboratory's register and analyzed with SPSS version 16.0. Out of the 3306 total donors, the seroprevalence of hepatitis C infection was 11.7% and hepatitis B infection was 10.3%. Only 1.4% of the donors were co-infected with both pathogens and 82.7% had no infection. Rhesus blood group had a significant association with Hepatitis B (
Publisher: Wiley
Date: 07-2023
DOI: 10.1002/HSR2.1436
Abstract: Impaired coagulation and fibrinolysis have been implicated in thromboembolism in human immunodeficiency virus (HIV)‐infected in iduals. This study evaluated the plasma levels of plasminogen activator inhibitor‐1 (PAI‐1) and coagulation biomarkers in HIV‐infected in iduals on highly active antiretroviral therapy (HAART). This matched case‐control study from March to December, 2020 comprised 76 participants: 38 HIV‐positive in iduals on HAART and 38 apparently healthy HIV‐negative in iduals as controls. Blood s les were collected for prothrombin time (PT), activated partial thromboplastin time (aPTT), D‐dimers, PAI‐1, and soluble fibrin monomer complex (SFMC) estimations. The data were analysed using SPSS version 22.0 and statistical significance was set at p 0.05. Activated partial thromboplastin time was significantly lower in HIV seropositive in iduals on HAART compared with HIV seronegative controls (25.90 s vs. 29.0 s, p = 0.030) however, PT, SFMC, D‐dimers, and PAI‐1 were significantly higher among the HIV‐seropositive in iduals compared with the controls: PT: (16.29 s ± 2.16 vs. 15.15 s ± 2.60, p = 0.010), SFMC: [8.53 ng/mL (8.03–9.12) vs. 7.84 ng/mL (7.32–8.58), p = 0.005]), D‐Dimer: [463.37 ng/mL (402.70–526.33) vs. 421.11 ng/mL (341.11–462.52), p = 0.015], and PAI‐1: [12.77 ng/mL (10.63–14.65) vs. 11.27 ng/mL (10.08–12.95), p = 0.039]. PAI‐1 showed a moderate positive correlation with D‐Dimer ( r = 0.659, p 0.001) and SFMC ( r = 0.463, p = 0.003) among HIV‐positive in iduals on HAART. There was a strong positive correlation between the plasma PAI‐1 concentration and the HIV viral load ( r = 0.955, p 0.001). HIV‐seropositive in iduals on HAART have deranged coagulation and fibrinolytic markers. Higher HIV viral load correlates strongly with elevated plasma levels of PAI‐1 antigens. Periodic assessment of markers of coagulation and fibrinolysis be included in the management of HIV/AIDS in Ghana.
Publisher: Pan African Medical Journal
Date: 16-06-2020
No related grants have been discovered for Felix Osei-Boakye.