ORCID Profile
0000-0002-2426-6028
Current Organisation
University of Aberdeen
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Publisher: Springer Science and Business Media LLC
Date: 29-01-2014
DOI: 10.1038/NATURE13049
Publisher: Springer Science and Business Media LLC
Date: 05-09-2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NP90040A
Publisher: MDPI AG
Date: 29-06-2020
DOI: 10.3390/MOLECULES25132979
Abstract: In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D1 2, have been isolated, together with four known hydroxamates, desferrioxamine D1 3, desferrioxamine B 4, desoxy-nocardamine 5 and nocardamine 6, and a diketopiperazine (DKP) 7. The structures of 1–7 were characterized by the analysis of HRESIMS and 1D and 2D NMR data, as well as by comparison with the relevant literature. Three new dehydroxy desferrioxamine derivatives 8–10 were tentatively identified in the molecular network of K. speibonae strain SK5 extracts, and structures were proposed based on their MS/MS fragmentation patterns. A plausible spb biosynthetic pathway was proposed. To the best of our knowledge, this is the first report of the isolation of desferrioxamines from the actinobacterial genus Kribbella.
Publisher: Wiley
Date: 03-2022
DOI: 10.1002/AQC.3796
Abstract: Few States are able to undertake scientific research in the half of the planet that lies in marine areas beyond national jurisdiction. Capacity building is therefore a key part of the development of a new international legally binding instrument for the conservation and sustainable use of marine biological ersity of areas beyond national jurisdiction, under the United Nations Convention on the Law of the Sea (BBNJ Agreement). The final negotiations for the BBNJ Agreement are scheduled for early 2022, after almost two decades of development. There is an urgent need to address remaining questions relating to capacity building to secure an effective and equitable outcome from this process and safeguard the global ocean commons. Persisting gaps in scientific capacity cast doubt on the adequacy of past and current approaches to implement long‐standing international commitments. There is a need to build equitable partnerships for long‐term outcomes. As an international legally binding instrument, the BBNJ Agreement is a critical opportunity to change the course of capacity building by strengthening the international legal framework, including funding, information‐sharing, monitoring and decision‐making. This rapidly closing window to develop international legal obligations, collaboration frameworks and funding mechanisms is relevant not only to the conservation of the global ocean commons, but also for ocean sustainability more generally as the UN Ocean Decade begins.
Publisher: Elsevier BV
Date: 02-2012
Publisher: MDPI AG
Date: 03-12-2015
DOI: 10.3390/MD13127059
Publisher: MDPI AG
Date: 06-03-2022
DOI: 10.3390/MOLECULES27051721
Abstract: Natural products derived from marine sponges have exhibited bioactivity and, in some cases, serve as potent quorum sensing inhibitory agents that prevent biofilm formation and attenuate virulence factor expression by pathogenic microorganisms. In this study, the inhibitory activity of the psammaplin-type compounds, psammaplin A (1) and bisaprasin (2), isolated from the marine sponge, Aplysinellarhax, are evaluated in quorum sensing inhibitory assays based on the Pseudomonas aeruginosa PAO1 lasB-gfp(ASV) and rhlA-gfp(ASV) biosensor strains. The results indicate that psammaplin A (1) showed moderate inhibition on lasB-gfp expression, but significantly inhibited the QS-gene promoter, rhlA-gfp, with IC50 values at 14.02 μM and 4.99 μM, respectively. In contrast, bisaprasin (2) displayed significant florescence inhibition in both biosensors, PAO1 lasB-gfp and rhlA-gfp, with IC50 values at 3.53 μM and 2.41 μM, respectively. Preliminary analysis suggested the importance of the bromotyrosine and oxime functionalities for QSI activity in these molecules. In addition, psammaplin A and bisaprasin downregulated elastase expression as determined by the standard enzymatic elastase assay, although greater reduction in elastase production was observed with 1 at 50 μM and 100 μM. Furthermore, the study revealed that bisaprasin (2) reduced biofilm formation in P. aeruginosa.
Publisher: Elsevier BV
Date: 09-2009
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Marcel Jaspars.