ORCID Profile
0000-0002-5543-5701
Current Organisation
James Cook University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 05-1998
DOI: 10.1038/BJC.1998.239
Publisher: Springer Science and Business Media LLC
Date: 11-1998
Abstract: Port-side recurrence after laparoscopic surgery on known and unsuspected gastrointestinal malignancies has been reported. The mechanisms of this type of metastatic spread are poorly understood. For in situ malignancies, microperforation of the viscus by laparoscopic instruments may liberate cells to facilitate malignant cell movement. Twenty-three patients undergoing laparoscopic cholecystectomy for benign disease were prospectively studied. The laparoscopic fundal grasper was washed with sterile saline at the start and conclusion of surgery. These washings were examined for the presence of mucosal cells as evidence that gallbladder perforation occurred during the operation. No mucosal cells were seen from washings at the start of surgery. Thirteen cases (56%) of perforation or attempted choledochogram were recorded during surgery. Four of these 13 washings contained mucosal cells. One washing was positive for mucosal cells in the absence of perforation or attempted choledochogram. Microperforation of the gallbladder by laparoscopic instruments occurs during laparoscopic cholecystectomy.
Publisher: Elsevier BV
Date: 08-1999
DOI: 10.1016/S0304-3835(99)00176-7
Abstract: Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/ 31 colonic carcinomas and adenomas when compared to normal mucosa (P < 0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P < 0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.
Publisher: Oxford University Press (OUP)
Date: 06-1998
DOI: 10.1046/J.1365-2168.1998.00769.X
Abstract: Application of laparoscopy to the resection of malignancy has been followed by a literature describing cases of metastatic involvement at laparoscopic port sites. These include patients who underwent surgery for early stage carcinoma and instances following laparoscopic procedures during which tumours were not dissected. Recently published clinical and experimental studies, and case reports related to this problem are reviewed their relevance is discussed. Experimental studies incorporating bench top and large animal models have confirmed that tumour cells may be redistributed to port sites during laparoscopic surgery either directly from contaminated instruments or indirectly via the insufflation gas. Small animal models suggest that the incidence of wound metastasis is increased following conventional laparoscopic surgery, and that it may be decreased by gasless laparoscopy or helium insufflation. This evidence suggests that the development of port-site metastases depends not only on the physical redistribution of tumour cells but also on the specific insufflation gas used, possibly because of influences on local metabolic or immune factors acting at the wound site. Further research in this area is urgent. Until the issue is better understood, patients undergoing laparoscopic surgery for malignancy should be entered into clinical trials.
Publisher: Wiley
Date: 05-1998
Publisher: Elsevier BV
Date: 11-2021
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 2018
Publisher: Informa UK Limited
Date: 14-10-2022
Publisher: Springer Science and Business Media LLC
Date: 25-04-2013
Publisher: Springer Science and Business Media LLC
Date: 08-09-2019
Publisher: Wiley
Date: 04-1924
Publisher: Wiley
Date: 1999
Publisher: Oxford University Press (OUP)
Date: 12-2015
No related grants have been discovered for Helen McCoy-West.